Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine phosphatase superfamily (branch 1), putative

Species:

Leishmania mexicana

UniProt:

E9AP73_LEIMU

TriTrypDb:

LmxM.13.0490

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.660
CLV_NRD_NRD_1	16	18	PF00675	0.583
CLV_NRD_NRD_1	183	185	PF00675	0.726
CLV_NRD_NRD_1	21	23	PF00675	0.550
CLV_NRD_NRD_1	217	219	PF00675	0.455
CLV_NRD_NRD_1	250	252	PF00675	0.561
CLV_NRD_NRD_1	338	340	PF00675	0.617
CLV_NRD_NRD_1	358	360	PF00675	0.447
CLV_PCSK_FUR_1	336	340	PF00082	0.653
CLV_PCSK_KEX2_1	183	185	PF00082	0.748
CLV_PCSK_KEX2_1	21	23	PF00082	0.538
CLV_PCSK_KEX2_1	217	219	PF00082	0.455
CLV_PCSK_KEX2_1	336	338	PF00082	0.568
CLV_PCSK_KEX2_1	358	360	PF00082	0.772
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.486
CLV_PCSK_PC7_1	17	23	PF00082	0.568
CLV_PCSK_PC7_1	179	185	PF00082	0.693
CLV_PCSK_SKI1_1	24	28	PF00082	0.356
CLV_PCSK_SKI1_1	9	13	PF00082	0.325
CLV_PCSK_SKI1_1	96	100	PF00082	0.585
DEG_Nend_UBRbox_3	1	3	PF02207	0.310
DEG_SCF_FBW7_1	370	376	PF00400	0.708
DOC_ANK_TNKS_1	85	92	PF00023	0.498
DOC_CDC14_PxL_1	71	79	PF14671	0.575
DOC_CKS1_1	370	375	PF01111	0.790
DOC_CYCLIN_yCln2_LP_2	278	281	PF00134	0.444
DOC_MAPK_DCC_7	375	384	PF00069	0.668
DOC_MAPK_gen_1	21	31	PF00069	0.505
DOC_MAPK_gen_1	375	384	PF00069	0.636
DOC_PP1_RVXF_1	94	100	PF00149	0.584
DOC_PP2B_LxvP_1	278	281	PF13499	0.444
DOC_USP7_MATH_1	159	163	PF00917	0.544
DOC_USP7_MATH_1	169	173	PF00917	0.570
DOC_USP7_MATH_1	185	189	PF00917	0.468
DOC_USP7_MATH_1	232	236	PF00917	0.542
DOC_USP7_MATH_1	314	318	PF00917	0.457
DOC_USP7_MATH_1	341	345	PF00917	0.666
DOC_USP7_UBL2_3	303	307	PF12436	0.608
DOC_USP7_UBL2_3	354	358	PF12436	0.735
DOC_WW_Pin1_4	189	194	PF00397	0.792
DOC_WW_Pin1_4	30	35	PF00397	0.432
DOC_WW_Pin1_4	369	374	PF00397	0.696
DOC_WW_Pin1_4	377	382	PF00397	0.725
LIG_14-3-3_CanoR_1	107	111	PF00244	0.498
LIG_14-3-3_CanoR_1	184	193	PF00244	0.798
LIG_14-3-3_CanoR_1	24	30	PF00244	0.567
LIG_14-3-3_CanoR_1	9	14	PF00244	0.559
LIG_APCC_ABBA_1	54	59	PF00400	0.385
LIG_APCC_ABBAyCdc20_2	53	59	PF00400	0.396
LIG_BRCT_BRCA1_1	223	227	PF00533	0.466
LIG_deltaCOP1_diTrp_1	64	71	PF00928	0.526
LIG_FHA_1	120	126	PF00498	0.572
LIG_FHA_1	159	165	PF00498	0.468
LIG_FHA_1	173	179	PF00498	0.665
LIG_FHA_1	223	229	PF00498	0.493
LIG_FHA_1	26	32	PF00498	0.483
LIG_FHA_1	369	375	PF00498	0.755
LIG_FHA_1	39	45	PF00498	0.282
LIG_FHA_1	392	398	PF00498	0.525
LIG_FHA_1	71	77	PF00498	0.615
LIG_FHA_2	138	144	PF00498	0.541
LIG_FHA_2	286	292	PF00498	0.420
LIG_FHA_2	293	299	PF00498	0.518
LIG_FHA_2	330	336	PF00498	0.608
LIG_FHA_2	80	86	PF00498	0.423
LIG_LIR_Gen_1	136	146	PF02991	0.420
LIG_LIR_Gen_1	312	321	PF02991	0.467
LIG_LIR_Nem_3	136	141	PF02991	0.464
LIG_LIR_Nem_3	312	318	PF02991	0.483
LIG_MYND_1	276	280	PF01753	0.560
LIG_SH2_CRK	311	315	PF00017	0.518
LIG_SH2_CRK	328	332	PF00017	0.410
LIG_SH2_NCK_1	311	315	PF00017	0.592
LIG_SH2_PTP2	57	60	PF00017	0.503
LIG_SH2_SRC	57	60	PF00017	0.503
LIG_SH2_STAT5	10	13	PF00017	0.575
LIG_SH2_STAT5	201	204	PF00017	0.388
LIG_SH2_STAT5	258	261	PF00017	0.555
LIG_SH2_STAT5	315	318	PF00017	0.459
LIG_SH2_STAT5	57	60	PF00017	0.503
LIG_SH2_STAT5	81	84	PF00017	0.479
LIG_SH3_1	375	381	PF00018	0.666
LIG_SH3_3	203	209	PF00018	0.551
LIG_SH3_3	296	302	PF00018	0.496
LIG_SH3_3	375	381	PF00018	0.743
LIG_SH3_3	84	90	PF00018	0.657
LIG_SUMO_SIM_par_1	239	245	PF11976	0.601
LIG_SxIP_EBH_1	107	117	PF03271	0.564
LIG_TRAF2_1	118	121	PF00917	0.558
LIG_TRAF2_1	332	335	PF00917	0.571
LIG_TYR_ITIM	313	318	PF00017	0.474
LIG_TYR_ITIM	8	13	PF00017	0.540
LIG_UBA3_1	110	115	PF00899	0.568
LIG_WRC_WIRS_1	1	6	PF05994	0.504
MOD_CDK_SPK_2	189	194	PF00069	0.714
MOD_CDK_SPxK_1	369	375	PF00069	0.714
MOD_CDK_SPxxK_3	30	37	PF00069	0.437
MOD_CK1_1	172	178	PF00069	0.619
MOD_CK1_1	188	194	PF00069	0.797
MOD_CK1_1	3	9	PF00069	0.494
MOD_CK1_1	317	323	PF00069	0.479
MOD_CK1_1	342	348	PF00069	0.723
MOD_CK1_1	80	86	PF00069	0.640
MOD_CK2_1	137	143	PF00069	0.461
MOD_CK2_1	159	165	PF00069	0.500
MOD_CK2_1	292	298	PF00069	0.450
MOD_CK2_1	329	335	PF00069	0.572
MOD_CK2_1	79	85	PF00069	0.554
MOD_DYRK1A_RPxSP_1	377	381	PF00069	0.732
MOD_GlcNHglycan	135	138	PF01048	0.528
MOD_GlcNHglycan	161	164	PF01048	0.456
MOD_GlcNHglycan	271	274	PF01048	0.671
MOD_GSK3_1	129	136	PF00069	0.517
MOD_GSK3_1	169	176	PF00069	0.561
MOD_GSK3_1	185	192	PF00069	0.764
MOD_GSK3_1	369	376	PF00069	0.724
MOD_GSK3_1	77	84	PF00069	0.599
MOD_NEK2_1	106	111	PF00069	0.422
MOD_NEK2_1	113	118	PF00069	0.368
MOD_NEK2_1	285	290	PF00069	0.408
MOD_NEK2_1	396	401	PF00069	0.689
MOD_NEK2_1	77	82	PF00069	0.566
MOD_NEK2_2	25	30	PF00069	0.551
MOD_PIKK_1	186	192	PF00454	0.804
MOD_PK_1	339	345	PF00069	0.521
MOD_PKA_2	106	112	PF00069	0.525
MOD_PKA_2	178	184	PF00069	0.743
MOD_PKA_2	250	256	PF00069	0.577
MOD_PKA_2	269	275	PF00069	0.641
MOD_PKA_2	85	91	PF00069	0.678
MOD_PKB_1	337	345	PF00069	0.650
MOD_Plk_1	339	345	PF00069	0.521
MOD_Plk_4	106	112	PF00069	0.410
MOD_Plk_4	234	240	PF00069	0.532
MOD_Plk_4	292	298	PF00069	0.516
MOD_ProDKin_1	189	195	PF00069	0.790
MOD_ProDKin_1	30	36	PF00069	0.432
MOD_ProDKin_1	369	375	PF00069	0.696
MOD_ProDKin_1	377	383	PF00069	0.721
MOD_SUMO_rev_2	162	169	PF00179	0.511
TRG_DiLeu_BaEn_1	120	125	PF01217	0.583
TRG_DiLeu_BaEn_4	120	126	PF01217	0.585
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.375
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.519
TRG_ENDOCYTIC_2	10	13	PF00928	0.543
TRG_ENDOCYTIC_2	258	261	PF00928	0.574
TRG_ENDOCYTIC_2	315	318	PF00928	0.500
TRG_ENDOCYTIC_2	327	330	PF00928	0.476
TRG_ER_diArg_1	21	24	PF00400	0.372
TRG_ER_diArg_1	216	218	PF00400	0.491
TRG_ER_diArg_1	336	339	PF00400	0.609
TRG_ER_diArg_1	374	377	PF00400	0.740
TRG_ER_diArg_1	397	400	PF00400	0.711

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P925	Leptomonas seymouri	63%	79%
A0A1X0NN77	Trypanosomatidae	32%	88%
A0A3Q8I8G2	Leishmania donovani	92%	79%
A0A3R7KJL2	Trypanosoma rangeli	31%	100%
A4H738	Leishmania braziliensis	81%	100%
A4HVH8	Leishmania infantum	92%	79%
D0A6T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	95%
Q4QGA5	Leishmania major	91%	100%
V5BFH7	Trypanosoma cruzi	37%	100%