CCHC NOA-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TATA element modulatory factor 1 TATA binding, putative

Species:

Leishmania mexicana

UniProt:

E9AP72_LEIMU

TriTrypDb:

LmxM.13.0480

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AP72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	7	11	PF00656	0.603
CLV_MEL_PAP_1	242	248	PF00089	0.582
CLV_NRD_NRD_1	41	43	PF00675	0.507
CLV_NRD_NRD_1	510	512	PF00675	0.481
CLV_NRD_NRD_1	538	540	PF00675	0.598
CLV_NRD_NRD_1	679	681	PF00675	0.552
CLV_PCSK_KEX2_1	320	322	PF00082	0.425
CLV_PCSK_KEX2_1	41	43	PF00082	0.507
CLV_PCSK_KEX2_1	486	488	PF00082	0.495
CLV_PCSK_KEX2_1	611	613	PF00082	0.641
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.317
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.495
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.629
CLV_PCSK_SKI1_1	355	359	PF00082	0.493
CLV_Separin_Metazoa	630	634	PF03568	0.434
DEG_APCC_DBOX_1	400	408	PF00400	0.543
DEG_Kelch_Keap1_1	97	102	PF01344	0.513
DEG_Nend_UBRbox_1	1	4	PF02207	0.501
DEG_SCF_FBW7_2	121	126	PF00400	0.557
DEG_SIAH_1	44	52	PF03145	0.626
DOC_CDC14_PxL_1	598	606	PF14671	0.602
DOC_MAPK_gen_1	539	545	PF00069	0.566
DOC_PIKK_1	22	29	PF02985	0.500
DOC_PP2B_LxvP_1	135	138	PF13499	0.581
DOC_PP2B_LxvP_1	29	32	PF13499	0.628
DOC_PP4_FxxP_1	580	583	PF00568	0.593
DOC_PP4_FxxP_1	77	80	PF00568	0.511
DOC_USP7_MATH_1	107	111	PF00917	0.638
DOC_USP7_MATH_1	140	144	PF00917	0.580
DOC_USP7_MATH_1	168	172	PF00917	0.664
DOC_USP7_MATH_1	182	186	PF00917	0.511
DOC_USP7_MATH_1	190	194	PF00917	0.642
DOC_USP7_MATH_1	256	260	PF00917	0.609
DOC_USP7_MATH_1	440	444	PF00917	0.520
DOC_USP7_MATH_1	5	9	PF00917	0.594
DOC_USP7_MATH_1	57	61	PF00917	0.759
DOC_USP7_MATH_1	689	693	PF00917	0.681
DOC_USP7_MATH_1	694	698	PF00917	0.758
DOC_WW_Pin1_4	119	124	PF00397	0.711
DOC_WW_Pin1_4	145	150	PF00397	0.560
DOC_WW_Pin1_4	188	193	PF00397	0.701
DOC_WW_Pin1_4	198	203	PF00397	0.655
DOC_WW_Pin1_4	585	590	PF00397	0.576
DOC_WW_Pin1_4	59	64	PF00397	0.636
DOC_WW_Pin1_4	68	73	PF00397	0.553
DOC_WW_Pin1_4	81	86	PF00397	0.692
LIG_14-3-3_CanoR_1	237	243	PF00244	0.575
LIG_14-3-3_CanoR_1	401	405	PF00244	0.543
LIG_14-3-3_CanoR_1	41	45	PF00244	0.737
LIG_14-3-3_CanoR_1	435	441	PF00244	0.475
LIG_14-3-3_CanoR_1	459	465	PF00244	0.554
LIG_14-3-3_CanoR_1	499	503	PF00244	0.542
LIG_14-3-3_CanoR_1	597	602	PF00244	0.594
LIG_14-3-3_CanoR_1	633	641	PF00244	0.544
LIG_Actin_WH2_2	28	43	PF00022	0.488
LIG_Actin_WH2_2	356	374	PF00022	0.516
LIG_Actin_WH2_2	386	403	PF00022	0.547
LIG_APCC_Cbox_2	519	525	PF00515	0.541
LIG_CtBP_PxDLS_1	132	136	PF00389	0.547
LIG_EH_1	604	608	PF12763	0.651
LIG_FHA_1	164	170	PF00498	0.655
LIG_FHA_1	255	261	PF00498	0.683
LIG_FHA_1	413	419	PF00498	0.545
LIG_FHA_1	474	480	PF00498	0.541
LIG_FHA_1	569	575	PF00498	0.509
LIG_FHA_1	60	66	PF00498	0.679
LIG_FHA_2	379	385	PF00498	0.511
LIG_FHA_2	407	413	PF00498	0.547
LIG_FHA_2	444	450	PF00498	0.491
LIG_FHA_2	469	475	PF00498	0.539
LIG_FHA_2	529	535	PF00498	0.588
LIG_FHA_2	74	80	PF00498	0.575
LIG_GBD_Chelix_1	346	354	PF00786	0.514
LIG_GSK3_LRP6_1	188	193	PF00069	0.474
LIG_LIR_Apic_2	579	583	PF02991	0.536
LIG_LIR_Apic_2	75	80	PF02991	0.520
LIG_LIR_Gen_1	474	483	PF02991	0.489
LIG_LIR_Gen_1	518	528	PF02991	0.562
LIG_LIR_Nem_3	474	478	PF02991	0.543
LIG_LIR_Nem_3	480	485	PF02991	0.549
LIG_LIR_Nem_3	518	524	PF02991	0.555
LIG_MYND_1	602	606	PF01753	0.591
LIG_MYND_1	91	95	PF01753	0.549
LIG_Pex14_1	517	521	PF04695	0.551
LIG_Pex14_1	651	655	PF04695	0.522
LIG_SH2_CRK	475	479	PF00017	0.562
LIG_SH2_CRK	482	486	PF00017	0.520
LIG_SH2_CRK	655	659	PF00017	0.539
LIG_SH2_STAP1	375	379	PF00017	0.520
LIG_SH2_STAP1	475	479	PF00017	0.540
LIG_SH2_STAT3	375	378	PF00017	0.524
LIG_SH2_STAT5	475	478	PF00017	0.541
LIG_SH2_STAT5	521	524	PF00017	0.545
LIG_SH3_3	186	192	PF00018	0.778
LIG_SH3_3	199	205	PF00018	0.571
LIG_SH3_3	47	53	PF00018	0.639
LIG_SH3_3	600	606	PF00018	0.619
LIG_SUMO_SIM_par_1	66	71	PF11976	0.498
LIG_TRAF2_1	131	134	PF00917	0.742
LIG_TRAF2_1	523	526	PF00917	0.532
LIG_UBA3_1	273	279	PF00899	0.564
MOD_CDK_SPK_2	68	73	PF00069	0.489
MOD_CK1_1	119	125	PF00069	0.628
MOD_CK1_1	142	148	PF00069	0.809
MOD_CK1_1	171	177	PF00069	0.677
MOD_CK1_1	386	392	PF00069	0.533
MOD_CK1_1	443	449	PF00069	0.546
MOD_CK1_1	457	463	PF00069	0.550
MOD_CK1_1	501	507	PF00069	0.589
MOD_CK1_1	581	587	PF00069	0.678
MOD_CK1_1	59	65	PF00069	0.633
MOD_CK1_1	66	72	PF00069	0.568
MOD_CK1_1	692	698	PF00069	0.649
MOD_CK1_1	78	84	PF00069	0.586
MOD_CK1_1	97	103	PF00069	0.653
MOD_CK2_1	244	250	PF00069	0.601
MOD_CK2_1	378	384	PF00069	0.533
MOD_CK2_1	449	455	PF00069	0.553
MOD_CK2_1	468	474	PF00069	0.369
MOD_CK2_1	528	534	PF00069	0.512
MOD_CK2_1	560	566	PF00069	0.770
MOD_CK2_1	576	582	PF00069	0.512
MOD_GlcNHglycan	105	108	PF01048	0.625
MOD_GlcNHglycan	144	147	PF01048	0.629
MOD_GlcNHglycan	157	160	PF01048	0.633
MOD_GlcNHglycan	174	177	PF01048	0.760
MOD_GlcNHglycan	205	208	PF01048	0.526
MOD_GlcNHglycan	246	249	PF01048	0.562
MOD_GlcNHglycan	316	319	PF01048	0.616
MOD_GlcNHglycan	32	35	PF01048	0.763
MOD_GlcNHglycan	375	378	PF01048	0.524
MOD_GlcNHglycan	42	45	PF01048	0.694
MOD_GlcNHglycan	423	426	PF01048	0.541
MOD_GlcNHglycan	460	463	PF01048	0.606
MOD_GlcNHglycan	507	510	PF01048	0.547
MOD_GlcNHglycan	554	557	PF01048	0.677
MOD_GlcNHglycan	585	588	PF01048	0.650
MOD_GlcNHglycan	59	62	PF01048	0.681
MOD_GlcNHglycan	599	602	PF01048	0.680
MOD_GlcNHglycan	634	637	PF01048	0.523
MOD_GlcNHglycan	673	679	PF01048	0.433
MOD_GlcNHglycan	687	690	PF01048	0.476
MOD_GlcNHglycan	692	695	PF01048	0.596
MOD_GlcNHglycan	698	701	PF01048	0.561
MOD_GlcNHglycan	7	10	PF01048	0.709
MOD_GlcNHglycan	85	88	PF01048	0.736
MOD_GSK3_1	103	110	PF00069	0.643
MOD_GSK3_1	112	119	PF00069	0.583
MOD_GSK3_1	163	170	PF00069	0.602
MOD_GSK3_1	171	178	PF00069	0.616
MOD_GSK3_1	184	191	PF00069	0.735
MOD_GSK3_1	256	263	PF00069	0.604
MOD_GSK3_1	378	385	PF00069	0.523
MOD_GSK3_1	406	413	PF00069	0.564
MOD_GSK3_1	454	461	PF00069	0.528
MOD_GSK3_1	481	488	PF00069	0.545
MOD_GSK3_1	5	12	PF00069	0.714
MOD_GSK3_1	501	508	PF00069	0.290
MOD_GSK3_1	52	59	PF00069	0.700
MOD_GSK3_1	524	531	PF00069	0.576
MOD_GSK3_1	581	588	PF00069	0.754
MOD_GSK3_1	68	75	PF00069	0.579
MOD_GSK3_1	685	692	PF00069	0.617
MOD_N-GLC_1	238	243	PF02516	0.584
MOD_N-GLC_1	405	410	PF02516	0.540
MOD_N-GLC_1	590	595	PF02516	0.529
MOD_NEK2_1	371	376	PF00069	0.599
MOD_NEK2_1	40	45	PF00069	0.608
MOD_NEK2_1	400	405	PF00069	0.476
MOD_NEK2_1	454	459	PF00069	0.549
MOD_NEK2_1	485	490	PF00069	0.533
MOD_NEK2_1	524	529	PF00069	0.543
MOD_NEK2_1	545	550	PF00069	0.626
MOD_NEK2_1	552	557	PF00069	0.613
MOD_NEK2_1	560	565	PF00069	0.660
MOD_NEK2_1	568	573	PF00069	0.533
MOD_NEK2_1	590	595	PF00069	0.685
MOD_NEK2_2	606	611	PF00069	0.529
MOD_PIKK_1	349	355	PF00454	0.573
MOD_PIKK_1	454	460	PF00454	0.547
MOD_PIKK_1	528	534	PF00454	0.506
MOD_PIKK_1	560	566	PF00454	0.742
MOD_PKA_2	244	250	PF00069	0.533
MOD_PKA_2	40	46	PF00069	0.739
MOD_PKA_2	400	406	PF00069	0.615
MOD_PKA_2	434	440	PF00069	0.453
MOD_PKA_2	458	464	PF00069	0.635
MOD_PKA_2	498	504	PF00069	0.560
MOD_PKA_2	538	544	PF00069	0.557
MOD_PKA_2	632	638	PF00069	0.479
MOD_PKA_2	97	103	PF00069	0.653
MOD_Plk_1	126	132	PF00069	0.560
MOD_Plk_1	238	244	PF00069	0.596
MOD_Plk_1	473	479	PF00069	0.520
MOD_Plk_1	545	551	PF00069	0.726
MOD_Plk_1	590	596	PF00069	0.529
MOD_Plk_1	674	680	PF00069	0.506
MOD_Plk_2-3	449	455	PF00069	0.477
MOD_Plk_2-3	474	480	PF00069	0.468
MOD_Plk_2-3	498	504	PF00069	0.556
MOD_Plk_4	474	480	PF00069	0.468
MOD_Plk_4	538	544	PF00069	0.613
MOD_Plk_4	63	69	PF00069	0.536
MOD_ProDKin_1	119	125	PF00069	0.711
MOD_ProDKin_1	145	151	PF00069	0.558
MOD_ProDKin_1	188	194	PF00069	0.706
MOD_ProDKin_1	198	204	PF00069	0.651
MOD_ProDKin_1	585	591	PF00069	0.579
MOD_ProDKin_1	59	65	PF00069	0.638
MOD_ProDKin_1	68	74	PF00069	0.548
MOD_ProDKin_1	81	87	PF00069	0.693
MOD_SUMO_rev_2	369	374	PF00179	0.453
MOD_SUMO_rev_2	616	623	PF00179	0.629
TRG_DiLeu_BaEn_1	25	30	PF01217	0.623
TRG_DiLeu_BaEn_1	474	479	PF01217	0.539
TRG_DiLeu_BaEn_1	660	665	PF01217	0.525
TRG_DiLeu_BaEn_4	289	295	PF01217	0.491
TRG_ENDOCYTIC_2	475	478	PF00928	0.541
TRG_ENDOCYTIC_2	482	485	PF00928	0.540
TRG_ENDOCYTIC_2	521	524	PF00928	0.562
TRG_ENDOCYTIC_2	655	658	PF00928	0.502
TRG_ENDOCYTIC_2	669	672	PF00928	0.353
TRG_ER_diArg_1	308	311	PF00400	0.607
TRG_ER_diArg_1	40	42	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	520	525	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q0	Leptomonas seymouri	61%	88%
A0A3R7L520	Trypanosoma rangeli	27%	100%
A0A3S7WSC1	Leishmania donovani	90%	93%
A4H737	Leishmania braziliensis	74%	100%
A4HVH7	Leishmania infantum	94%	100%
D0A6T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4QGA6	Leishmania major	91%	100%
V5BJZ4	Trypanosoma cruzi	28%	100%