Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP71_LEIMU

TriTrypDb:

LmxM.13.0470

Length:

492

Annotations

LeishMANIAdb annotations

A putative 7TM transporter or receptor protein limited to Kinetoplastids. Very little similarity to animal GPCRs

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 5
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AP71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP71

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	434	438	PF00656	0.562
CLV_NRD_NRD_1	245	247	PF00675	0.448
CLV_NRD_NRD_1	367	369	PF00675	0.435
CLV_NRD_NRD_1	462	464	PF00675	0.751
CLV_PCSK_KEX2_1	245	247	PF00082	0.452
CLV_PCSK_KEX2_1	367	369	PF00082	0.437
CLV_PCSK_KEX2_1	462	464	PF00082	0.751
CLV_PCSK_SKI1_1	246	250	PF00082	0.500
DEG_SPOP_SBC_1	469	473	PF00917	0.628
DOC_CDC14_PxL_1	175	183	PF14671	0.472
DOC_CKS1_1	268	273	PF01111	0.347
DOC_CKS1_1	457	462	PF01111	0.590
DOC_CYCLIN_yCln2_LP_2	176	182	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.453
DOC_MAPK_gen_1	116	123	PF00069	0.650
DOC_MAPK_gen_1	298	305	PF00069	0.356
DOC_MAPK_gen_1	364	374	PF00069	0.634
DOC_MAPK_MEF2A_6	116	123	PF00069	0.650
DOC_MAPK_MEF2A_6	304	312	PF00069	0.269
DOC_MAPK_MEF2A_6	367	374	PF00069	0.517
DOC_MAPK_NFAT4_5	367	375	PF00069	0.407
DOC_PP1_RVXF_1	194	201	PF00149	0.582
DOC_PP1_RVXF_1	8	14	PF00149	0.500
DOC_PP2B_LxvP_1	176	179	PF13499	0.472
DOC_PP2B_LxvP_1	310	313	PF13499	0.450
DOC_PP2B_LxvP_1	378	381	PF13499	0.227
DOC_PP2B_LxvP_1	408	411	PF13499	0.433
DOC_USP7_MATH_1	18	22	PF00917	0.471
DOC_USP7_MATH_1	23	27	PF00917	0.445
DOC_USP7_MATH_1	238	242	PF00917	0.472
DOC_USP7_MATH_1	394	398	PF00917	0.523
DOC_USP7_MATH_1	468	472	PF00917	0.572
DOC_WW_Pin1_4	267	272	PF00397	0.347
DOC_WW_Pin1_4	456	461	PF00397	0.610
LIG_14-3-3_CanoR_1	10	14	PF00244	0.481
LIG_14-3-3_CanoR_1	367	373	PF00244	0.655
LIG_APCC_ABBA_1	156	161	PF00400	0.450
LIG_BRCT_BRCA1_1	257	261	PF00533	0.663
LIG_BRCT_BRCA1_1	370	374	PF00533	0.582
LIG_Clathr_ClatBox_1	387	391	PF01394	0.472
LIG_CSL_BTD_1	94	97	PF09270	0.347
LIG_deltaCOP1_diTrp_1	361	365	PF00928	0.625
LIG_deltaCOP1_diTrp_1	90	95	PF00928	0.490
LIG_eIF4E_1	166	172	PF01652	0.453
LIG_eIF4E_1	279	285	PF01652	0.430
LIG_FHA_1	100	106	PF00498	0.361
LIG_FHA_1	193	199	PF00498	0.561
LIG_FHA_1	227	233	PF00498	0.430
LIG_FHA_1	383	389	PF00498	0.472
LIG_FHA_1	397	403	PF00498	0.474
LIG_FHA_1	474	480	PF00498	0.612
LIG_FHA_2	430	436	PF00498	0.564
LIG_HP1_1	111	115	PF01393	0.430
LIG_LIR_Gen_1	164	173	PF02991	0.367
LIG_LIR_Gen_1	234	244	PF02991	0.328
LIG_LIR_Gen_1	258	269	PF02991	0.522
LIG_LIR_Gen_1	338	349	PF02991	0.472
LIG_LIR_Gen_1	40	49	PF02991	0.478
LIG_LIR_Gen_1	90	101	PF02991	0.337
LIG_LIR_Nem_3	164	169	PF02991	0.367
LIG_LIR_Nem_3	174	180	PF02991	0.347
LIG_LIR_Nem_3	188	194	PF02991	0.662
LIG_LIR_Nem_3	234	240	PF02991	0.328
LIG_LIR_Nem_3	258	264	PF02991	0.522
LIG_LIR_Nem_3	338	344	PF02991	0.472
LIG_LIR_Nem_3	40	44	PF02991	0.451
LIG_LIR_Nem_3	84	89	PF02991	0.408
LIG_LIR_Nem_3	90	96	PF02991	0.325
LIG_NRBOX	171	177	PF00104	0.388
LIG_NRBOX	78	84	PF00104	0.491
LIG_PCNA_PIPBox_1	150	159	PF02747	0.487
LIG_Pex14_1	211	215	PF04695	0.430
LIG_Pex14_2	132	136	PF04695	0.439
LIG_Pex14_2	257	261	PF04695	0.663
LIG_SH2_CRK	166	170	PF00017	0.347
LIG_SH2_CRK	173	177	PF00017	0.347
LIG_SH2_CRK	237	241	PF00017	0.430
LIG_SH2_CRK	332	336	PF00017	0.302
LIG_SH2_GRB2like	51	54	PF00017	0.367
LIG_SH2_PTP2	239	242	PF00017	0.430
LIG_SH2_SRC	237	240	PF00017	0.430
LIG_SH2_STAP1	101	105	PF00017	0.312
LIG_SH2_STAP1	173	177	PF00017	0.472
LIG_SH2_STAP1	280	284	PF00017	0.371
LIG_SH2_STAP1	392	396	PF00017	0.509
LIG_SH2_STAP1	51	55	PF00017	0.411
LIG_SH2_STAT3	306	309	PF00017	0.408
LIG_SH2_STAT5	101	104	PF00017	0.386
LIG_SH2_STAT5	166	169	PF00017	0.381
LIG_SH2_STAT5	173	176	PF00017	0.373
LIG_SH2_STAT5	226	229	PF00017	0.422
LIG_SH2_STAT5	239	242	PF00017	0.260
LIG_SH2_STAT5	243	246	PF00017	0.495
LIG_SH2_STAT5	263	266	PF00017	0.472
LIG_SH2_STAT5	283	286	PF00017	0.402
LIG_SH2_STAT5	353	356	PF00017	0.587
LIG_SH2_STAT5	43	46	PF00017	0.485
LIG_SH3_3	265	271	PF00018	0.347
LIG_SH3_3	438	444	PF00018	0.616
LIG_SH3_3	60	66	PF00018	0.467
LIG_SH3_3	91	97	PF00018	0.317
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.281
LIG_SUMO_SIM_anti_2	54	59	PF11976	0.482
LIG_SUMO_SIM_par_1	111	117	PF11976	0.453
LIG_SUMO_SIM_par_1	385	391	PF11976	0.472
LIG_SUMO_SIM_par_1	78	84	PF11976	0.364
LIG_TYR_ITIM	171	176	PF00017	0.381
LIG_TYR_ITIM	277	282	PF00017	0.451
MOD_CDK_SPxK_1	456	462	PF00069	0.590
MOD_CDK_SPxxK_3	456	463	PF00069	0.450
MOD_CK1_1	379	385	PF00069	0.472
MOD_CK1_1	449	455	PF00069	0.633
MOD_CK1_1	61	67	PF00069	0.448
MOD_CK2_1	285	291	PF00069	0.494
MOD_CK2_1	429	435	PF00069	0.552
MOD_CMANNOS	362	365	PF00535	0.429
MOD_CMANNOS	92	95	PF00535	0.493
MOD_GlcNHglycan	150	153	PF01048	0.614
MOD_GlcNHglycan	20	23	PF01048	0.653
MOD_GlcNHglycan	25	28	PF01048	0.667
MOD_GlcNHglycan	396	399	PF01048	0.615
MOD_GlcNHglycan	405	408	PF01048	0.673
MOD_GlcNHglycan	60	63	PF01048	0.707
MOD_GSK3_1	18	25	PF00069	0.492
MOD_GSK3_1	382	389	PF00069	0.399
MOD_GSK3_1	394	401	PF00069	0.415
MOD_GSK3_1	431	438	PF00069	0.569
MOD_GSK3_1	442	449	PF00069	0.613
MOD_GSK3_1	469	476	PF00069	0.574
MOD_GSK3_1	49	56	PF00069	0.413
MOD_GSK3_1	61	68	PF00069	0.367
MOD_GSK3_1	95	102	PF00069	0.381
MOD_LATS_1	366	372	PF00433	0.684
MOD_N-GLC_1	185	190	PF02516	0.475
MOD_N-GLC_1	28	33	PF02516	0.709
MOD_N-GLC_1	37	42	PF02516	0.621
MOD_N-GLC_1	394	399	PF02516	0.733
MOD_N-GLC_1	435	440	PF02516	0.815
MOD_NEK2_1	114	119	PF00069	0.555
MOD_NEK2_1	135	140	PF00069	0.401
MOD_NEK2_1	171	176	PF00069	0.439
MOD_NEK2_1	192	197	PF00069	0.581
MOD_NEK2_1	231	236	PF00069	0.411
MOD_NEK2_1	28	33	PF00069	0.439
MOD_NEK2_1	285	290	PF00069	0.460
MOD_NEK2_1	325	330	PF00069	0.432
MOD_NEK2_1	429	434	PF00069	0.496
MOD_NEK2_1	49	54	PF00069	0.448
MOD_NEK2_1	67	72	PF00069	0.333
MOD_NEK2_2	238	243	PF00069	0.430
MOD_PKA_2	9	15	PF00069	0.473
MOD_Plk_1	185	191	PF00069	0.646
MOD_Plk_1	28	34	PF00069	0.449
MOD_Plk_1	37	43	PF00069	0.452
MOD_Plk_4	101	107	PF00069	0.248
MOD_Plk_4	161	167	PF00069	0.303
MOD_Plk_4	171	177	PF00069	0.347
MOD_Plk_4	185	191	PF00069	0.544
MOD_Plk_4	231	237	PF00069	0.443
MOD_Plk_4	238	244	PF00069	0.492
MOD_Plk_4	335	341	PF00069	0.393
MOD_Plk_4	348	354	PF00069	0.372
MOD_Plk_4	37	43	PF00069	0.458
MOD_Plk_4	9	15	PF00069	0.473
MOD_ProDKin_1	267	273	PF00069	0.347
MOD_ProDKin_1	456	462	PF00069	0.610
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.640
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.359
TRG_ENDOCYTIC_2	166	169	PF00928	0.347
TRG_ENDOCYTIC_2	173	176	PF00928	0.347
TRG_ENDOCYTIC_2	210	213	PF00928	0.446
TRG_ENDOCYTIC_2	237	240	PF00928	0.347
TRG_ENDOCYTIC_2	279	282	PF00928	0.366
TRG_ENDOCYTIC_2	86	89	PF00928	0.389
TRG_ER_diArg_1	115	118	PF00400	0.663
TRG_ER_diArg_1	244	246	PF00400	0.637
TRG_ER_diArg_1	462	464	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8F6	Leptomonas seymouri	54%	93%
A0A3Q8ICT8	Leishmania donovani	89%	100%
A0A3R7NUA8	Trypanosoma rangeli	41%	88%
A4HVH6	Leishmania infantum	89%	100%
Q4QGA7	Leishmania major	88%	100%
V5BAW0	Trypanosoma cruzi	37%	82%