C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP70_LEIMU

TriTrypDb:

LmxM.13.0460

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AP70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP70

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.556
CLV_C14_Caspase3-7	356	360	PF00656	0.461
CLV_NRD_NRD_1	225	227	PF00675	0.753
CLV_NRD_NRD_1	257	259	PF00675	0.469
CLV_NRD_NRD_1	346	348	PF00675	0.463
CLV_NRD_NRD_1	465	467	PF00675	0.620
CLV_NRD_NRD_1	489	491	PF00675	0.546
CLV_PCSK_FUR_1	190	194	PF00082	0.296
CLV_PCSK_KEX2_1	192	194	PF00082	0.301
CLV_PCSK_KEX2_1	257	259	PF00082	0.414
CLV_PCSK_KEX2_1	307	309	PF00082	0.550
CLV_PCSK_KEX2_1	489	491	PF00082	0.525
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.301
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.543
CLV_PCSK_SKI1_1	297	301	PF00082	0.485
CLV_PCSK_SKI1_1	453	457	PF00082	0.583
CLV_Separin_Metazoa	9	13	PF03568	0.530
DEG_APCC_DBOX_1	317	325	PF00400	0.419
DEG_SCF_FBW7_2	280	287	PF00400	0.583
DEG_SCF_FBW7_2	409	414	PF00400	0.482
DOC_CDC14_PxL_1	369	377	PF14671	0.529
DOC_MAPK_gen_1	106	115	PF00069	0.446
DOC_MAPK_gen_1	291	301	PF00069	0.414
DOC_MAPK_gen_1	86	94	PF00069	0.478
DOC_MAPK_MEF2A_6	86	94	PF00069	0.452
DOC_PP1_RVXF_1	144	150	PF00149	0.480
DOC_PP1_RVXF_1	167	174	PF00149	0.605
DOC_PP4_FxxP_1	111	114	PF00568	0.538
DOC_PP4_FxxP_1	402	405	PF00568	0.463
DOC_SPAK_OSR1_1	110	114	PF12202	0.546
DOC_USP7_MATH_1	181	185	PF00917	0.383
DOC_USP7_MATH_1	208	212	PF00917	0.532
DOC_USP7_UBL2_3	104	108	PF12436	0.585
DOC_USP7_UBL2_3	153	157	PF12436	0.642
DOC_USP7_UBL2_3	192	196	PF12436	0.589
DOC_USP7_UBL2_3	272	276	PF12436	0.592
DOC_USP7_UBL2_3	491	495	PF12436	0.614
DOC_WW_Pin1_4	234	239	PF00397	0.549
DOC_WW_Pin1_4	280	285	PF00397	0.586
DOC_WW_Pin1_4	401	406	PF00397	0.688
DOC_WW_Pin1_4	407	412	PF00397	0.610
DOC_WW_Pin1_4	41	46	PF00397	0.438
LIG_14-3-3_CanoR_1	257	263	PF00244	0.510
LIG_14-3-3_CanoR_1	265	273	PF00244	0.459
LIG_14-3-3_CanoR_1	340	345	PF00244	0.537
LIG_14-3-3_CanoR_1	418	424	PF00244	0.370
LIG_APCC_ABBA_1	113	118	PF00400	0.534
LIG_deltaCOP1_diTrp_1	194	201	PF00928	0.400
LIG_deltaCOP1_diTrp_1	319	325	PF00928	0.387
LIG_FHA_1	120	126	PF00498	0.588
LIG_FHA_1	129	135	PF00498	0.643
LIG_FHA_1	241	247	PF00498	0.590
LIG_FHA_1	25	31	PF00498	0.554
LIG_FHA_1	257	263	PF00498	0.374
LIG_FHA_2	243	249	PF00498	0.469
LIG_FHA_2	281	287	PF00498	0.561
LIG_FHA_2	328	334	PF00498	0.542
LIG_FHA_2	354	360	PF00498	0.537
LIG_FHA_2	428	434	PF00498	0.453
LIG_FHA_2	78	84	PF00498	0.469
LIG_LIR_Apic_2	400	405	PF02991	0.576
LIG_LIR_Gen_1	158	166	PF02991	0.661
LIG_LIR_Gen_1	184	191	PF02991	0.448
LIG_LIR_Gen_1	3	11	PF02991	0.369
LIG_LIR_Gen_1	322	332	PF02991	0.239
LIG_LIR_Gen_1	414	424	PF02991	0.514
LIG_LIR_LC3C_4	31	35	PF02991	0.252
LIG_LIR_Nem_3	158	164	PF02991	0.645
LIG_LIR_Nem_3	184	189	PF02991	0.467
LIG_LIR_Nem_3	3	8	PF02991	0.370
LIG_LIR_Nem_3	322	328	PF02991	0.235
LIG_LIR_Nem_3	414	419	PF02991	0.524
LIG_Pex14_1	197	201	PF04695	0.403
LIG_Pex14_2	416	420	PF04695	0.519
LIG_SH2_NCK_1	161	165	PF00017	0.648
LIG_SH2_PTP2	186	189	PF00017	0.483
LIG_SH2_STAP1	203	207	PF00017	0.500
LIG_SH2_STAT3	95	98	PF00017	0.465
LIG_SH2_STAT5	186	189	PF00017	0.460
LIG_SH3_3	333	339	PF00018	0.584
LIG_SH3_3	39	45	PF00018	0.501
LIG_SUMO_SIM_anti_2	27	34	PF11976	0.368
LIG_SUMO_SIM_par_1	130	136	PF11976	0.689
LIG_SUMO_SIM_par_1	30	36	PF11976	0.531
LIG_SxIP_EBH_1	365	376	PF03271	0.517
LIG_TRAF2_1	284	287	PF00917	0.582
LIG_TRAF2_1	393	396	PF00917	0.715
LIG_TRAF2_1	411	414	PF00917	0.481
LIG_UBA3_1	368	376	PF00899	0.527
LIG_UBA3_1	99	106	PF00899	0.557
LIG_WRC_WIRS_1	368	373	PF05994	0.520
LIG_WRC_WIRS_1	399	404	PF05994	0.464
LIG_WRC_WIRS_1	420	425	PF05994	0.472
MOD_CDK_SPK_2	280	285	PF00069	0.586
MOD_CDK_SPxxK_3	401	408	PF00069	0.679
MOD_CK1_1	242	248	PF00069	0.505
MOD_CK1_1	401	407	PF00069	0.563
MOD_CK1_1	82	88	PF00069	0.561
MOD_CK2_1	280	286	PF00069	0.536
MOD_CK2_1	397	403	PF00069	0.733
MOD_CK2_1	427	433	PF00069	0.468
MOD_CK2_1	77	83	PF00069	0.535
MOD_Cter_Amidation	487	490	PF01082	0.545
MOD_GlcNHglycan	143	146	PF01048	0.513
MOD_GlcNHglycan	166	169	PF01048	0.643
MOD_GlcNHglycan	2	5	PF01048	0.536
MOD_GlcNHglycan	38	41	PF01048	0.574
MOD_GlcNHglycan	476	479	PF01048	0.697
MOD_GSK3_1	155	162	PF00069	0.666
MOD_GSK3_1	222	229	PF00069	0.626
MOD_GSK3_1	24	31	PF00069	0.581
MOD_GSK3_1	327	334	PF00069	0.492
MOD_GSK3_1	367	374	PF00069	0.530
MOD_GSK3_1	397	404	PF00069	0.736
MOD_GSK3_1	419	426	PF00069	0.500
MOD_GSK3_1	75	82	PF00069	0.523
MOD_N-GLC_1	164	169	PF02516	0.517
MOD_N-GLC_1	60	65	PF02516	0.527
MOD_NEK2_1	240	245	PF00069	0.368
MOD_NEK2_1	327	332	PF00069	0.494
MOD_NEK2_1	367	372	PF00069	0.410
MOD_NEK2_1	423	428	PF00069	0.462
MOD_NEK2_1	474	479	PF00069	0.639
MOD_NEK2_1	77	82	PF00069	0.517
MOD_NEK2_2	469	474	PF00069	0.609
MOD_PIKK_1	119	125	PF00454	0.592
MOD_PIKK_1	181	187	PF00454	0.530
MOD_PIKK_1	25	31	PF00454	0.554
MOD_PIKK_1	353	359	PF00454	0.262
MOD_PIKK_1	409	415	PF00454	0.517
MOD_PKA_1	195	201	PF00069	0.528
MOD_PKA_1	226	232	PF00069	0.773
MOD_PKA_2	256	262	PF00069	0.482
MOD_Plk_1	169	175	PF00069	0.582
MOD_Plk_1	203	209	PF00069	0.583
MOD_Plk_1	278	284	PF00069	0.496
MOD_Plk_1	397	403	PF00069	0.693
MOD_Plk_1	60	66	PF00069	0.520
MOD_Plk_2-3	398	404	PF00069	0.607
MOD_Plk_2-3	429	435	PF00069	0.457
MOD_Plk_2-3	69	75	PF00069	0.432
MOD_Plk_4	28	34	PF00069	0.472
MOD_Plk_4	423	429	PF00069	0.494
MOD_Plk_4	469	475	PF00069	0.685
MOD_ProDKin_1	234	240	PF00069	0.545
MOD_ProDKin_1	280	286	PF00069	0.588
MOD_ProDKin_1	401	407	PF00069	0.681
MOD_ProDKin_1	41	47	PF00069	0.436
MOD_SUMO_for_1	284	287	PF00179	0.610
MOD_SUMO_for_1	375	378	PF00179	0.535
MOD_SUMO_rev_2	117	122	PF00179	0.475
TRG_DiLeu_BaEn_2	295	301	PF01217	0.481
TRG_ENDOCYTIC_2	161	164	PF00928	0.628
TRG_ENDOCYTIC_2	186	189	PF00928	0.470
TRG_ER_diArg_1	209	212	PF00400	0.602
TRG_NES_CRM1_1	319	333	PF08389	0.460
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8U7	Bodo saltans	27%	89%
A0A1X0NN86	Trypanosomatidae	33%	91%
A0A3R7ML15	Trypanosoma rangeli	33%	96%
A0A3S5H6N3	Leishmania donovani	92%	100%
A4H735	Leishmania braziliensis	77%	100%
A4HVH5	Leishmania infantum	92%	100%
D0A6T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QGA8	Leishmania major	91%	100%
V5AVH4	Trypanosoma cruzi	36%	100%