LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AP65_LEIMU
TriTrypDb:
LmxM.13.0410
Length:
1098

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AP65
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP65

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1063 1067 PF00656 0.478
CLV_C14_Caspase3-7 135 139 PF00656 0.400
CLV_C14_Caspase3-7 441 445 PF00656 0.564
CLV_C14_Caspase3-7 70 74 PF00656 0.624
CLV_NRD_NRD_1 381 383 PF00675 0.447
CLV_NRD_NRD_1 401 403 PF00675 0.333
CLV_NRD_NRD_1 682 684 PF00675 0.483
CLV_NRD_NRD_1 771 773 PF00675 0.493
CLV_NRD_NRD_1 803 805 PF00675 0.519
CLV_NRD_NRD_1 866 868 PF00675 0.611
CLV_NRD_NRD_1 876 878 PF00675 0.680
CLV_NRD_NRD_1 883 885 PF00675 0.725
CLV_NRD_NRD_1 987 989 PF00675 0.459
CLV_PCSK_FUR_1 881 885 PF00082 0.541
CLV_PCSK_KEX2_1 401 403 PF00082 0.579
CLV_PCSK_KEX2_1 682 684 PF00082 0.483
CLV_PCSK_KEX2_1 771 773 PF00082 0.493
CLV_PCSK_KEX2_1 803 805 PF00082 0.519
CLV_PCSK_KEX2_1 865 867 PF00082 0.615
CLV_PCSK_KEX2_1 875 877 PF00082 0.683
CLV_PCSK_KEX2_1 883 885 PF00082 0.738
CLV_PCSK_KEX2_1 987 989 PF00082 0.466
CLV_PCSK_SKI1_1 1050 1054 PF00082 0.428
CLV_PCSK_SKI1_1 216 220 PF00082 0.489
CLV_PCSK_SKI1_1 394 398 PF00082 0.311
CLV_PCSK_SKI1_1 602 606 PF00082 0.491
CLV_PCSK_SKI1_1 772 776 PF00082 0.472
CLV_PCSK_SKI1_1 779 783 PF00082 0.491
CLV_PCSK_SKI1_1 846 850 PF00082 0.400
DEG_APCC_DBOX_1 1034 1042 PF00400 0.420
DEG_APCC_DBOX_1 152 160 PF00400 0.359
DEG_APCC_DBOX_1 673 681 PF00400 0.444
DEG_APCC_DBOX_1 771 779 PF00400 0.467
DEG_APCC_DBOX_1 947 955 PF00400 0.409
DEG_APCC_DBOX_1 986 994 PF00400 0.430
DEG_MDM2_SWIB_1 533 540 PF02201 0.325
DEG_Nend_UBRbox_3 1 3 PF02207 0.511
DEG_SCF_FBW7_1 253 260 PF00400 0.395
DEG_SPOP_SBC_1 293 297 PF00917 0.443
DEG_SPOP_SBC_1 357 361 PF00917 0.504
DEG_SPOP_SBC_1 67 71 PF00917 0.509
DOC_CYCLIN_RxL_1 569 579 PF00134 0.372
DOC_CYCLIN_RxL_1 809 821 PF00134 0.400
DOC_CYCLIN_yCln2_LP_2 965 971 PF00134 0.500
DOC_MAPK_DCC_7 1020 1030 PF00069 0.396
DOC_MAPK_gen_1 1077 1086 PF00069 0.348
DOC_MAPK_gen_1 347 355 PF00069 0.568
DOC_MAPK_gen_1 771 777 PF00069 0.473
DOC_MAPK_gen_1 811 820 PF00069 0.437
DOC_MAPK_gen_1 987 995 PF00069 0.536
DOC_MAPK_MEF2A_6 216 225 PF00069 0.559
DOC_MAPK_MEF2A_6 238 246 PF00069 0.455
DOC_MAPK_MEF2A_6 370 378 PF00069 0.362
DOC_MAPK_MEF2A_6 602 610 PF00069 0.351
DOC_MAPK_MEF2A_6 811 819 PF00069 0.365
DOC_PP1_RVXF_1 1008 1015 PF00149 0.274
DOC_PP1_RVXF_1 481 488 PF00149 0.313
DOC_PP2B_LxvP_1 1084 1087 PF13499 0.440
DOC_PP2B_LxvP_1 154 157 PF13499 0.357
DOC_PP2B_LxvP_1 353 356 PF13499 0.586
DOC_PP2B_LxvP_1 915 918 PF13499 0.480
DOC_PP4_FxxP_1 64 67 PF00568 0.502
DOC_USP7_MATH_1 1085 1089 PF00917 0.597
DOC_USP7_MATH_1 214 218 PF00917 0.468
DOC_USP7_MATH_1 236 240 PF00917 0.413
DOC_USP7_MATH_1 257 261 PF00917 0.505
DOC_USP7_MATH_1 288 292 PF00917 0.610
DOC_USP7_MATH_1 494 498 PF00917 0.343
DOC_USP7_MATH_1 589 593 PF00917 0.458
DOC_USP7_MATH_1 615 619 PF00917 0.566
DOC_USP7_MATH_1 65 69 PF00917 0.656
DOC_USP7_MATH_1 668 672 PF00917 0.434
DOC_USP7_UBL2_3 174 178 PF12436 0.536
DOC_WW_Pin1_4 253 258 PF00397 0.417
DOC_WW_Pin1_4 363 368 PF00397 0.566
DOC_WW_Pin1_4 63 68 PF00397 0.532
DOC_WW_Pin1_4 910 915 PF00397 0.665
DOC_WW_Pin1_4 993 998 PF00397 0.422
LIG_14-3-3_CanoR_1 493 499 PF00244 0.395
LIG_14-3-3_CanoR_1 602 607 PF00244 0.502
LIG_14-3-3_CanoR_1 700 706 PF00244 0.569
LIG_14-3-3_CanoR_1 710 716 PF00244 0.658
LIG_14-3-3_CanoR_1 724 732 PF00244 0.504
LIG_14-3-3_CanoR_1 758 768 PF00244 0.531
LIG_14-3-3_CanoR_1 772 778 PF00244 0.398
LIG_14-3-3_CanoR_1 803 812 PF00244 0.499
LIG_14-3-3_CanoR_1 956 962 PF00244 0.462
LIG_AP2alpha_1 34 38 PF02296 0.476
LIG_APCC_Cbox_2 348 354 PF00515 0.527
LIG_BIR_III_2 49 53 PF00653 0.523
LIG_BRCT_BRCA1_1 718 722 PF00533 0.585
LIG_Clathr_ClatBox_1 112 116 PF01394 0.470
LIG_Clathr_ClatBox_1 817 821 PF01394 0.378
LIG_deltaCOP1_diTrp_1 922 925 PF00928 0.641
LIG_eIF4E_1 479 485 PF01652 0.305
LIG_eIF4E_1 928 934 PF01652 0.430
LIG_EVH1_1 915 919 PF00568 0.658
LIG_FAT_LD_1 23 31 PF03623 0.371
LIG_FHA_1 147 153 PF00498 0.523
LIG_FHA_1 210 216 PF00498 0.497
LIG_FHA_1 287 293 PF00498 0.624
LIG_FHA_1 371 377 PF00498 0.578
LIG_FHA_1 452 458 PF00498 0.511
LIG_FHA_1 504 510 PF00498 0.583
LIG_FHA_1 603 609 PF00498 0.456
LIG_FHA_1 648 654 PF00498 0.266
LIG_FHA_1 704 710 PF00498 0.666
LIG_FHA_1 743 749 PF00498 0.403
LIG_FHA_1 750 756 PF00498 0.477
LIG_FHA_1 847 853 PF00498 0.383
LIG_FHA_1 929 935 PF00498 0.576
LIG_FHA_2 1041 1047 PF00498 0.482
LIG_FHA_2 145 151 PF00498 0.377
LIG_FHA_2 388 394 PF00498 0.503
LIG_FHA_2 446 452 PF00498 0.559
LIG_FHA_2 547 553 PF00498 0.405
LIG_FHA_2 68 74 PF00498 0.648
LIG_FHA_2 829 835 PF00498 0.443
LIG_FHA_2 857 863 PF00498 0.508
LIG_FHA_2 899 905 PF00498 0.559
LIG_GBD_Chelix_1 264 272 PF00786 0.396
LIG_GBD_Chelix_1 566 574 PF00786 0.311
LIG_HCF-1_HBM_1 1058 1061 PF13415 0.321
LIG_HP1_1 1027 1031 PF01393 0.447
LIG_IRF3_LxIS_1 187 194 PF10401 0.429
LIG_LIR_Apic_2 519 525 PF02991 0.538
LIG_LIR_Apic_2 62 67 PF02991 0.500
LIG_LIR_Gen_1 3 13 PF02991 0.523
LIG_LIR_Gen_1 314 324 PF02991 0.424
LIG_LIR_Gen_1 459 465 PF02991 0.435
LIG_LIR_Gen_1 534 545 PF02991 0.393
LIG_LIR_Gen_1 556 565 PF02991 0.455
LIG_LIR_Gen_1 607 617 PF02991 0.479
LIG_LIR_Gen_1 821 832 PF02991 0.484
LIG_LIR_Gen_1 859 868 PF02991 0.543
LIG_LIR_Gen_1 960 970 PF02991 0.382
LIG_LIR_LC3C_4 482 486 PF02991 0.338
LIG_LIR_Nem_3 3 9 PF02991 0.429
LIG_LIR_Nem_3 314 319 PF02991 0.434
LIG_LIR_Nem_3 348 353 PF02991 0.530
LIG_LIR_Nem_3 459 464 PF02991 0.399
LIG_LIR_Nem_3 467 471 PF02991 0.348
LIG_LIR_Nem_3 534 540 PF02991 0.349
LIG_LIR_Nem_3 556 560 PF02991 0.469
LIG_LIR_Nem_3 607 612 PF02991 0.451
LIG_LIR_Nem_3 821 827 PF02991 0.459
LIG_LIR_Nem_3 859 863 PF02991 0.533
LIG_LIR_Nem_3 922 928 PF02991 0.632
LIG_LIR_Nem_3 953 958 PF02991 0.345
LIG_LIR_Nem_3 960 965 PF02991 0.338
LIG_NRBOX 641 647 PF00104 0.476
LIG_NRBOX 960 966 PF00104 0.349
LIG_PALB2_WD40_1 124 132 PF16756 0.453
LIG_Pex14_2 34 38 PF04695 0.360
LIG_Pex14_2 533 537 PF04695 0.361
LIG_REV1ctd_RIR_1 98 107 PF16727 0.441
LIG_SH2_CRK 461 465 PF00017 0.380
LIG_SH2_CRK 557 561 PF00017 0.462
LIG_SH2_CRK 790 794 PF00017 0.498
LIG_SH2_CRK 824 828 PF00017 0.474
LIG_SH2_GRB2like 787 790 PF00017 0.453
LIG_SH2_NCK_1 266 270 PF00017 0.397
LIG_SH2_SRC 266 269 PF00017 0.390
LIG_SH2_STAP1 461 465 PF00017 0.427
LIG_SH2_STAT5 166 169 PF00017 0.377
LIG_SH2_STAT5 327 330 PF00017 0.496
LIG_SH2_STAT5 398 401 PF00017 0.536
LIG_SH2_STAT5 479 482 PF00017 0.301
LIG_SH2_STAT5 609 612 PF00017 0.342
LIG_SH2_STAT5 787 790 PF00017 0.489
LIG_SH2_STAT5 958 961 PF00017 0.383
LIG_SH3_3 497 503 PF00018 0.443
LIG_SH3_3 506 512 PF00018 0.572
LIG_SH3_3 537 543 PF00018 0.320
LIG_SH3_3 6 12 PF00018 0.505
LIG_SH3_3 913 919 PF00018 0.644
LIG_SUMO_SIM_anti_2 329 335 PF11976 0.221
LIG_SUMO_SIM_anti_2 676 681 PF11976 0.554
LIG_SUMO_SIM_par_1 142 147 PF11976 0.356
LIG_SUMO_SIM_par_1 317 323 PF11976 0.419
LIG_SUMO_SIM_par_1 649 656 PF11976 0.292
LIG_SUMO_SIM_par_1 816 821 PF11976 0.376
LIG_TRAF2_1 1087 1090 PF00917 0.569
LIG_TRAF2_1 731 734 PF00917 0.553
LIG_TRAF2_1 74 77 PF00917 0.434
LIG_TRFH_1 1081 1085 PF08558 0.564
LIG_TRFH_1 38 42 PF08558 0.551
LIG_TYR_ITIM 264 269 PF00017 0.374
LIG_UBA3_1 10 16 PF00899 0.500
LIG_UBA3_1 112 119 PF00899 0.469
LIG_WW_1 499 502 PF00397 0.397
MOD_CDK_SPxxK_3 363 370 PF00069 0.499
MOD_CK1_1 194 200 PF00069 0.413
MOD_CK1_1 248 254 PF00069 0.451
MOD_CK1_1 298 304 PF00069 0.630
MOD_CK1_1 66 72 PF00069 0.510
MOD_CK1_1 698 704 PF00069 0.716
MOD_CK1_1 807 813 PF00069 0.506
MOD_CK2_1 1040 1046 PF00069 0.491
MOD_CK2_1 144 150 PF00069 0.377
MOD_CK2_1 25 31 PF00069 0.387
MOD_CK2_1 326 332 PF00069 0.448
MOD_CK2_1 359 365 PF00069 0.656
MOD_CK2_1 445 451 PF00069 0.644
MOD_CK2_1 546 552 PF00069 0.398
MOD_CK2_1 589 595 PF00069 0.592
MOD_CK2_1 728 734 PF00069 0.576
MOD_Cter_Amidation 769 772 PF01082 0.489
MOD_GlcNHglycan 15 19 PF01048 0.513
MOD_GlcNHglycan 212 215 PF01048 0.548
MOD_GlcNHglycan 226 229 PF01048 0.461
MOD_GlcNHglycan 247 250 PF01048 0.439
MOD_GlcNHglycan 328 331 PF01048 0.320
MOD_GlcNHglycan 576 579 PF01048 0.516
MOD_GlcNHglycan 59 62 PF01048 0.765
MOD_GlcNHglycan 6 9 PF01048 0.506
MOD_GlcNHglycan 617 620 PF01048 0.557
MOD_GlcNHglycan 697 700 PF01048 0.755
MOD_GlcNHglycan 718 721 PF01048 0.562
MOD_GlcNHglycan 725 728 PF01048 0.578
MOD_GlcNHglycan 806 809 PF01048 0.541
MOD_GSK3_1 1036 1043 PF00069 0.543
MOD_GSK3_1 210 217 PF00069 0.547
MOD_GSK3_1 236 243 PF00069 0.379
MOD_GSK3_1 244 251 PF00069 0.350
MOD_GSK3_1 253 260 PF00069 0.296
MOD_GSK3_1 288 295 PF00069 0.680
MOD_GSK3_1 307 314 PF00069 0.353
MOD_GSK3_1 356 363 PF00069 0.715
MOD_GSK3_1 41 48 PF00069 0.613
MOD_GSK3_1 585 592 PF00069 0.575
MOD_GSK3_1 59 66 PF00069 0.645
MOD_GSK3_1 716 723 PF00069 0.629
MOD_GSK3_1 754 761 PF00069 0.568
MOD_GSK3_1 803 810 PF00069 0.573
MOD_GSK3_1 836 843 PF00069 0.399
MOD_GSK3_1 846 853 PF00069 0.384
MOD_GSK3_1 875 882 PF00069 0.490
MOD_GSK3_1 946 953 PF00069 0.494
MOD_GSK3_1 96 103 PF00069 0.457
MOD_LATS_1 172 178 PF00433 0.520
MOD_N-GLC_1 45 50 PF02516 0.711
MOD_N-GLC_1 526 531 PF02516 0.305
MOD_N-GLC_1 759 764 PF02516 0.511
MOD_N-GLC_2 789 791 PF02516 0.481
MOD_NEK2_1 1073 1078 PF00069 0.517
MOD_NEK2_1 117 122 PF00069 0.393
MOD_NEK2_1 144 149 PF00069 0.410
MOD_NEK2_1 186 191 PF00069 0.317
MOD_NEK2_1 224 229 PF00069 0.566
MOD_NEK2_1 240 245 PF00069 0.244
MOD_NEK2_1 311 316 PF00069 0.412
MOD_NEK2_1 336 341 PF00069 0.364
MOD_NEK2_1 604 609 PF00069 0.411
MOD_NEK2_1 646 651 PF00069 0.401
MOD_NEK2_1 673 678 PF00069 0.400
MOD_NEK2_1 713 718 PF00069 0.602
MOD_NEK2_1 741 746 PF00069 0.374
MOD_NEK2_1 851 856 PF00069 0.505
MOD_NEK2_1 89 94 PF00069 0.439
MOD_NEK2_1 999 1004 PF00069 0.425
MOD_PIKK_1 1050 1056 PF00454 0.522
MOD_PIKK_1 1085 1091 PF00454 0.677
MOD_PIKK_1 876 882 PF00454 0.552
MOD_PKA_1 803 809 PF00069 0.481
MOD_PKA_1 875 881 PF00069 0.548
MOD_PKA_2 369 375 PF00069 0.478
MOD_PKA_2 451 457 PF00069 0.527
MOD_PKA_2 673 679 PF00069 0.419
MOD_PKA_2 711 717 PF00069 0.596
MOD_PKA_2 723 729 PF00069 0.630
MOD_PKA_2 749 755 PF00069 0.385
MOD_PKA_2 802 808 PF00069 0.500
MOD_PKA_2 875 881 PF00069 0.548
MOD_Plk_1 370 376 PF00069 0.309
MOD_Plk_1 445 451 PF00069 0.520
MOD_Plk_2-3 25 31 PF00069 0.387
MOD_Plk_2-3 45 51 PF00069 0.480
MOD_Plk_4 199 205 PF00069 0.458
MOD_Plk_4 219 225 PF00069 0.263
MOD_Plk_4 236 242 PF00069 0.299
MOD_Plk_4 25 31 PF00069 0.387
MOD_Plk_4 257 263 PF00069 0.407
MOD_Plk_4 288 294 PF00069 0.690
MOD_Plk_4 307 313 PF00069 0.328
MOD_Plk_4 376 382 PF00069 0.456
MOD_Plk_4 566 572 PF00069 0.344
MOD_Plk_4 59 65 PF00069 0.639
MOD_Plk_4 604 610 PF00069 0.479
MOD_Plk_4 638 644 PF00069 0.413
MOD_Plk_4 647 653 PF00069 0.370
MOD_Plk_4 668 674 PF00069 0.390
MOD_Plk_4 704 710 PF00069 0.570
MOD_Plk_4 773 779 PF00069 0.398
MOD_Plk_4 950 956 PF00069 0.418
MOD_Plk_4 957 963 PF00069 0.334
MOD_Plk_4 96 102 PF00069 0.414
MOD_ProDKin_1 253 259 PF00069 0.409
MOD_ProDKin_1 363 369 PF00069 0.556
MOD_ProDKin_1 63 69 PF00069 0.530
MOD_ProDKin_1 910 916 PF00069 0.664
MOD_ProDKin_1 993 999 PF00069 0.414
MOD_SUMO_rev_2 1058 1067 PF00179 0.358
MOD_SUMO_rev_2 43 48 PF00179 0.463
MOD_SUMO_rev_2 71 81 PF00179 0.414
TRG_DiLeu_BaEn_1 1007 1012 PF01217 0.486
TRG_DiLeu_BaEn_1 638 643 PF01217 0.461
TRG_DiLeu_BaEn_1 76 81 PF01217 0.377
TRG_DiLeu_BaEn_3 24 30 PF01217 0.468
TRG_DiLeu_BaEn_4 1046 1052 PF01217 0.514
TRG_DiLeu_BaEn_4 76 82 PF01217 0.395
TRG_DiLeu_BaLyEn_6 864 869 PF01217 0.496
TRG_DiLeu_LyEn_5 1007 1012 PF01217 0.486
TRG_ENDOCYTIC_2 266 269 PF00928 0.374
TRG_ENDOCYTIC_2 461 464 PF00928 0.476
TRG_ENDOCYTIC_2 557 560 PF00928 0.468
TRG_ENDOCYTIC_2 609 612 PF00928 0.342
TRG_ENDOCYTIC_2 824 827 PF00928 0.460
TRG_ENDOCYTIC_2 958 961 PF00928 0.343
TRG_ER_diArg_1 101 104 PF00400 0.466
TRG_ER_diArg_1 401 404 PF00400 0.511
TRG_ER_diArg_1 682 684 PF00400 0.522
TRG_ER_diArg_1 709 712 PF00400 0.562
TRG_ER_diArg_1 865 867 PF00400 0.624
TRG_ER_diArg_1 875 877 PF00400 0.676
TRG_ER_diArg_1 881 884 PF00400 0.718
TRG_NES_CRM1_1 133 145 PF08389 0.387
TRG_NES_CRM1_1 598 613 PF08389 0.476
TRG_Pf-PMV_PEXEL_1 1010 1015 PF00026 0.502
TRG_Pf-PMV_PEXEL_1 130 135 PF00026 0.421
TRG_Pf-PMV_PEXEL_1 216 220 PF00026 0.446
TRG_Pf-PMV_PEXEL_1 866 870 PF00026 0.578
TRG_Pf-PMV_PEXEL_1 988 992 PF00026 0.467

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEI3 Leptomonas seymouri 57% 96%
A0A1X0NN90 Trypanosomatidae 37% 100%
A0A3S7WSD9 Leishmania donovani 93% 100%
A4H730 Leishmania braziliensis 84% 100%
A4HVG4 Leishmania infantum 93% 100%
D0A6U5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
Q4QGB3 Leishmania major 92% 100%
V5ATV9 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS