RIC1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP48

Species:

Leishmania mexicana

UniProt:

E9AP59_LEIMU

TriTrypDb:

LmxM.13.0250

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AP59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP59

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.532
CLV_NRD_NRD_1	119	121	PF00675	0.496
CLV_NRD_NRD_1	126	128	PF00675	0.624
CLV_NRD_NRD_1	171	173	PF00675	0.608
CLV_NRD_NRD_1	177	179	PF00675	0.583
CLV_NRD_NRD_1	180	182	PF00675	0.636
CLV_NRD_NRD_1	222	224	PF00675	0.286
CLV_NRD_NRD_1	466	468	PF00675	0.420
CLV_PCSK_FUR_1	178	182	PF00082	0.437
CLV_PCSK_KEX2_1	119	121	PF00082	0.648
CLV_PCSK_KEX2_1	126	128	PF00082	0.618
CLV_PCSK_KEX2_1	171	173	PF00082	0.605
CLV_PCSK_KEX2_1	177	179	PF00082	0.586
CLV_PCSK_KEX2_1	180	182	PF00082	0.639
CLV_PCSK_KEX2_1	222	224	PF00082	0.286
CLV_PCSK_KEX2_1	465	467	PF00082	0.441
CLV_PCSK_SKI1_1	160	164	PF00082	0.534
CLV_PCSK_SKI1_1	171	175	PF00082	0.508
CLV_PCSK_SKI1_1	246	250	PF00082	0.399
CLV_PCSK_SKI1_1	323	327	PF00082	0.523
DEG_APCC_DBOX_1	126	134	PF00400	0.678
DEG_Nend_Nbox_1	1	3	PF02207	0.608
DEG_SPOP_SBC_1	92	96	PF00917	0.668
DOC_CKS1_1	399	404	PF01111	0.519
DOC_CYCLIN_RxL_1	169	179	PF00134	0.588
DOC_MAPK_HePTP_8	430	442	PF00069	0.516
DOC_MAPK_MEF2A_6	433	442	PF00069	0.509
DOC_PP1_RVXF_1	233	239	PF00149	0.431
DOC_PP1_RVXF_1	321	327	PF00149	0.529
DOC_PP2B_PxIxI_1	435	441	PF00149	0.499
DOC_PP4_FxxP_1	154	157	PF00568	0.520
DOC_USP7_MATH_1	176	180	PF00917	0.641
DOC_USP7_MATH_1	208	212	PF00917	0.503
DOC_USP7_MATH_1	294	298	PF00917	0.563
DOC_USP7_MATH_1	315	319	PF00917	0.377
DOC_USP7_MATH_1	387	391	PF00917	0.642
DOC_USP7_MATH_1	393	397	PF00917	0.554
DOC_USP7_MATH_1	503	507	PF00917	0.530
DOC_USP7_MATH_1	78	82	PF00917	0.717
DOC_WW_Pin1_4	263	268	PF00397	0.406
DOC_WW_Pin1_4	378	383	PF00397	0.627
DOC_WW_Pin1_4	398	403	PF00397	0.218
LIG_14-3-3_CanoR_1	107	113	PF00244	0.665
LIG_14-3-3_CanoR_1	126	130	PF00244	0.634
LIG_14-3-3_CanoR_1	296	302	PF00244	0.475
LIG_14-3-3_CanoR_1	77	85	PF00244	0.760
LIG_BRCT_BRCA1_1	416	420	PF00533	0.501
LIG_deltaCOP1_diTrp_1	272	281	PF00928	0.518
LIG_EH_1	434	438	PF12763	0.454
LIG_FHA_1	210	216	PF00498	0.458
LIG_FHA_1	320	326	PF00498	0.509
LIG_FHA_1	339	345	PF00498	0.509
LIG_FHA_1	421	427	PF00498	0.472
LIG_FHA_1	472	478	PF00498	0.400
LIG_FHA_1	510	516	PF00498	0.531
LIG_FHA_2	364	370	PF00498	0.521
LIG_GBD_Chelix_1	442	450	PF00786	0.529
LIG_LIR_Apic_2	153	157	PF02991	0.569
LIG_LIR_Gen_1	106	115	PF02991	0.703
LIG_LIR_Nem_3	106	112	PF02991	0.729
LIG_LIR_Nem_3	191	195	PF02991	0.462
LIG_LYPXL_S_1	46	50	PF13949	0.683
LIG_LYPXL_yS_3	47	50	PF13949	0.691
LIG_MLH1_MIPbox_1	416	420	PF16413	0.501
LIG_MYND_1	138	142	PF01753	0.609
LIG_NBox_RRM_1	163	173	PF00076	0.516
LIG_SH2_PTP2	39	42	PF00017	0.325
LIG_SH2_STAT5	39	42	PF00017	0.488
LIG_SH2_STAT5	419	422	PF00017	0.473
LIG_SH3_3	330	336	PF00018	0.549
LIG_SH3_3	339	345	PF00018	0.542
LIG_SH3_3	396	402	PF00018	0.490
LIG_SUMO_SIM_anti_2	372	377	PF11976	0.437
LIG_SUMO_SIM_par_1	340	346	PF11976	0.586
LIG_SxIP_EBH_1	485	498	PF03271	0.407
LIG_TRAF2_1	202	205	PF00917	0.536
LIG_WRC_WIRS_1	504	509	PF05994	0.538
MOD_CK1_1	266	272	PF00069	0.680
MOD_CK1_1	297	303	PF00069	0.561
MOD_CK1_1	381	387	PF00069	0.590
MOD_CK1_1	444	450	PF00069	0.555
MOD_CK1_1	70	76	PF00069	0.715
MOD_CK1_1	81	87	PF00069	0.740
MOD_CK2_1	363	369	PF00069	0.501
MOD_CMANNOS	238	241	PF00535	0.491
MOD_Cter_Amidation	124	127	PF01082	0.628
MOD_GlcNHglycan	135	138	PF01048	0.619
MOD_GlcNHglycan	164	167	PF01048	0.379
MOD_GlcNHglycan	268	271	PF01048	0.606
MOD_GlcNHglycan	275	278	PF01048	0.531
MOD_GlcNHglycan	285	289	PF01048	0.554
MOD_GlcNHglycan	296	299	PF01048	0.467
MOD_GlcNHglycan	383	386	PF01048	0.694
MOD_GlcNHglycan	389	392	PF01048	0.617
MOD_GlcNHglycan	72	75	PF01048	0.757
MOD_GlcNHglycan	80	83	PF01048	0.761
MOD_GlcNHglycan	85	88	PF01048	0.747
MOD_GSK3_1	103	110	PF00069	0.665
MOD_GSK3_1	158	165	PF00069	0.552
MOD_GSK3_1	315	322	PF00069	0.535
MOD_GSK3_1	383	390	PF00069	0.601
MOD_GSK3_1	441	448	PF00069	0.564
MOD_GSK3_1	66	73	PF00069	0.655
MOD_GSK3_1	76	83	PF00069	0.703
MOD_N-GLC_1	66	71	PF02516	0.762
MOD_NEK2_1	133	138	PF00069	0.627
MOD_NEK2_1	234	239	PF00069	0.343
MOD_NEK2_1	299	304	PF00069	0.470
MOD_NEK2_1	363	368	PF00069	0.498
MOD_NEK2_1	420	425	PF00069	0.506
MOD_NEK2_1	445	450	PF00069	0.405
MOD_NEK2_1	461	466	PF00069	0.402
MOD_NEK2_1	93	98	PF00069	0.763
MOD_NEK2_2	158	163	PF00069	0.586
MOD_PKA_1	119	125	PF00069	0.681
MOD_PKA_2	119	125	PF00069	0.679
MOD_PKA_2	176	182	PF00069	0.573
MOD_PKA_2	185	191	PF00069	0.407
MOD_PKA_2	409	415	PF00069	0.514
MOD_PKA_2	76	82	PF00069	0.771
MOD_Plk_1	472	478	PF00069	0.479
MOD_Plk_4	234	240	PF00069	0.538
MOD_Plk_4	338	344	PF00069	0.546
MOD_Plk_4	414	420	PF00069	0.506
MOD_Plk_4	441	447	PF00069	0.561
MOD_Plk_4	511	517	PF00069	0.409
MOD_ProDKin_1	263	269	PF00069	0.415
MOD_ProDKin_1	378	384	PF00069	0.637
MOD_ProDKin_1	398	404	PF00069	0.216
TRG_DiLeu_BaEn_1	473	478	PF01217	0.423
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.512
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.599
TRG_ENDOCYTIC_2	196	199	PF00928	0.505
TRG_ENDOCYTIC_2	39	42	PF00928	0.568
TRG_ENDOCYTIC_2	47	50	PF00928	0.610
TRG_ER_diArg_1	171	173	PF00400	0.607
TRG_ER_diArg_1	177	180	PF00400	0.592
TRG_ER_diArg_1	222	224	PF00400	0.286
TRG_ER_diArg_1	465	467	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	466	471	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I3	Leptomonas seymouri	54%	100%
A0A0S4JJV4	Bodo saltans	26%	100%
A0A1X0NPX8	Trypanosomatidae	42%	100%
A0A3Q8ICS9	Leishmania donovani	92%	100%
A0A3R7KGG9	Trypanosoma rangeli	38%	100%
A4HHS4	Leishmania braziliensis	81%	100%
A4HVH0	Leishmania infantum	92%	100%
D0A6U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4QGC9	Leishmania major	93%	100%
V5D9X2	Trypanosoma cruzi	42%	100%