DUF4200 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagella-associated protein 73, putative

Species:

Leishmania mexicana

UniProt:

E9AP58_LEIMU

TriTrypDb:

LmxM.13.0240

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9AP58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP58

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.613
CLV_C14_Caspase3-7	3	7	PF00656	0.616
CLV_NRD_NRD_1	15	17	PF00675	0.212
CLV_NRD_NRD_1	157	159	PF00675	0.381
CLV_NRD_NRD_1	179	181	PF00675	0.422
CLV_NRD_NRD_1	34	36	PF00675	0.212
CLV_NRD_NRD_1	84	86	PF00675	0.256
CLV_PCSK_FUR_1	177	181	PF00082	0.478
CLV_PCSK_KEX2_1	105	107	PF00082	0.265
CLV_PCSK_KEX2_1	143	145	PF00082	0.450
CLV_PCSK_KEX2_1	15	17	PF00082	0.212
CLV_PCSK_KEX2_1	179	181	PF00082	0.395
CLV_PCSK_KEX2_1	28	30	PF00082	0.212
CLV_PCSK_KEX2_1	34	36	PF00082	0.212
CLV_PCSK_KEX2_1	70	72	PF00082	0.212
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.324
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.450
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.212
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.220
CLV_PCSK_PC7_1	139	145	PF00082	0.513
CLV_PCSK_SKI1_1	144	148	PF00082	0.506
CLV_PCSK_SKI1_1	203	207	PF00082	0.385
CLV_PCSK_SKI1_1	214	218	PF00082	0.415
CLV_PCSK_SKI1_1	73	77	PF00082	0.233
DOC_MAPK_gen_1	13	21	PF00069	0.347
DOC_MAPK_gen_1	168	175	PF00069	0.387
DOC_MAPK_gen_1	177	187	PF00069	0.364
DOC_MAPK_gen_1	70	80	PF00069	0.492
DOC_MAPK_gen_1	96	104	PF00069	0.437
DOC_MAPK_RevD_3	90	106	PF00069	0.432
DOC_PP1_RVXF_1	237	244	PF00149	0.336
DOC_USP7_MATH_1	4	8	PF00917	0.559
LIG_14-3-3_CanoR_1	144	149	PF00244	0.359
LIG_14-3-3_CanoR_1	158	166	PF00244	0.370
LIG_14-3-3_CanoR_1	168	174	PF00244	0.384
LIG_14-3-3_CanoR_1	177	187	PF00244	0.524
LIG_14-3-3_CanoR_1	224	231	PF00244	0.425
LIG_14-3-3_CanoR_1	239	244	PF00244	0.508
LIG_Actin_WH2_2	1	17	PF00022	0.470
LIG_BIR_II_1	1	5	PF00653	0.471
LIG_FHA_1	150	156	PF00498	0.362
LIG_FHA_1	180	186	PF00498	0.523
LIG_FHA_1	221	227	PF00498	0.488
LIG_FHA_1	231	237	PF00498	0.441
LIG_FHA_2	119	125	PF00498	0.385
LIG_FHA_2	145	151	PF00498	0.357
LIG_FHA_2	158	164	PF00498	0.371
LIG_LIR_Apic_2	133	138	PF02991	0.395
LIG_LIR_Gen_1	117	127	PF02991	0.511
LIG_LIR_Gen_1	197	205	PF02991	0.401
LIG_LIR_Gen_1	272	279	PF02991	0.392
LIG_LIR_Nem_3	117	122	PF02991	0.409
LIG_LIR_Nem_3	197	201	PF02991	0.460
LIG_LIR_Nem_3	272	277	PF02991	0.373
LIG_LRP6_Inhibitor_1	64	70	PF00058	0.223
LIG_PCNA_PIPBox_1	54	63	PF02747	0.412
LIG_PCNA_yPIPBox_3	203	216	PF02747	0.404
LIG_PCNA_yPIPBox_3	50	61	PF02747	0.415
LIG_Pex14_1	243	247	PF04695	0.412
LIG_SH2_CRK	61	65	PF00017	0.412
LIG_SH2_NCK_1	113	117	PF00017	0.432
LIG_SH2_SRC	113	116	PF00017	0.528
LIG_SH2_SRC	135	138	PF00017	0.457
LIG_SH2_STAP1	237	241	PF00017	0.346
LIG_SH2_STAT3	91	94	PF00017	0.515
LIG_SH2_STAT5	91	94	PF00017	0.515
LIG_TRAF2_1	79	82	PF00917	0.455
LIG_WRC_WIRS_1	119	124	PF05994	0.432
MOD_CK1_1	197	203	PF00069	0.567
MOD_CK1_1	220	226	PF00069	0.446
MOD_CK1_1	227	233	PF00069	0.444
MOD_CK2_1	118	124	PF00069	0.509
MOD_CK2_1	157	163	PF00069	0.391
MOD_CK2_1	24	30	PF00069	0.337
MOD_GlcNHglycan	2	5	PF01048	0.576
MOD_GlcNHglycan	246	250	PF01048	0.463
MOD_GSK3_1	218	225	PF00069	0.406
MOD_GSK3_1	227	234	PF00069	0.413
MOD_N-GLC_1	150	155	PF02516	0.486
MOD_NEK2_1	166	171	PF00069	0.520
MOD_NEK2_1	231	236	PF00069	0.325
MOD_NEK2_1	53	58	PF00069	0.455
MOD_PIKK_1	157	163	PF00454	0.385
MOD_PKA_1	179	185	PF00069	0.525
MOD_PKA_2	157	163	PF00069	0.380
MOD_PKA_2	169	175	PF00069	0.375
MOD_PKA_2	178	184	PF00069	0.526
MOD_PKB_1	177	185	PF00069	0.525
MOD_Plk_1	149	155	PF00069	0.500
MOD_Plk_4	118	124	PF00069	0.528
MOD_Plk_4	150	156	PF00069	0.487
MOD_Plk_4	239	245	PF00069	0.401
MOD_Plk_4	53	59	PF00069	0.455
MOD_SUMO_rev_2	103	111	PF00179	0.467
MOD_SUMO_rev_2	66	72	PF00179	0.432
TRG_ENDOCYTIC_2	113	116	PF00928	0.515
TRG_ENDOCYTIC_2	119	122	PF00928	0.515
TRG_ENDOCYTIC_2	60	63	PF00928	0.412
TRG_ER_diArg_1	14	16	PF00400	0.249
TRG_ER_diArg_1	167	170	PF00400	0.523
TRG_ER_diArg_1	177	180	PF00400	0.530
TRG_ER_diArg_1	34	36	PF00400	0.320
TRG_NES_CRM1_1	254	269	PF08389	0.408
TRG_NES_CRM1_1	94	108	PF08389	0.380
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ4	Leptomonas seymouri	84%	100%
A0A0S4JBA5	Bodo saltans	51%	100%
A0A1X0NNL1	Trypanosomatidae	60%	100%
A0A3S5H6N0	Leishmania donovani	96%	100%
A0A422NNY8	Trypanosoma rangeli	61%	100%
A4HHR6	Leishmania braziliensis	89%	100%
A4HVF9	Leishmania infantum	96%	100%
A6QQM8	Bos taurus	25%	97%
A7S8T5	Nematostella vectensis	29%	98%
A9UQN0	Monosiga brevicollis	27%	100%
B0BMJ2	Xenopus tropicalis	29%	98%
D0A6V1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
M1V4Y8	Chlamydomonas reinhardtii	31%	100%
Q4QGD0	Leishmania major	96%	100%
Q5SV66	Mus musculus	25%	97%
Q6NTM6	Xenopus laevis	28%	98%
Q96M95	Homo sapiens	25%	97%
V5ATV5	Trypanosoma cruzi	59%	100%