RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-RING finger domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AP57_LEIMU

TriTrypDb:

LmxM.13.0230

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0000795	synaptonemal complex	3	6
GO:0099086	synaptonemal structure	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AP57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP57

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006310	DNA recombination	5	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0007131	reciprocal meiotic recombination	3	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0022402	cell cycle process	2	6
GO:0022414	reproductive process	1	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0035825	homologous recombination	6	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:0140527	reciprocal homologous recombination	7	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1903046	meiotic cell cycle process	2	6
GO:0006996	organelle organization	4	1
GO:0007129	homologous chromosome pairing at meiosis	4	1
GO:0016043	cellular component organization	3	1
GO:0016925	protein sumoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0051276	chromosome organization	5	1
GO:0070192	chromosome organization involved in meiotic cell cycle	3	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	4
GO:0016740	transferase activity	2	6
GO:0019787	ubiquitin-like protein transferase activity	3	6
GO:0019789	SUMO transferase activity	4	6
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0140096	catalytic activity, acting on a protein	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.670
CLV_NRD_NRD_1	149	151	PF00675	0.704
CLV_NRD_NRD_1	252	254	PF00675	0.753
CLV_NRD_NRD_1	306	308	PF00675	0.757
CLV_NRD_NRD_1	386	388	PF00675	0.770
CLV_NRD_NRD_1	88	90	PF00675	0.599
CLV_PCSK_KEX2_1	252	254	PF00082	0.673
CLV_PCSK_KEX2_1	293	295	PF00082	0.812
CLV_PCSK_KEX2_1	305	307	PF00082	0.640
CLV_PCSK_KEX2_1	386	388	PF00082	0.770
CLV_PCSK_KEX2_1	88	90	PF00082	0.507
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.812
CLV_PCSK_SKI1_1	327	331	PF00082	0.745
CLV_PCSK_SKI1_1	91	95	PF00082	0.662
DEG_APCC_DBOX_1	90	98	PF00400	0.667
DEG_SPOP_SBC_1	271	275	PF00917	0.545
DOC_CKS1_1	372	377	PF01111	0.820
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.822
DOC_MAPK_gen_1	293	303	PF00069	0.532
DOC_MAPK_HePTP_8	206	218	PF00069	0.530
DOC_MAPK_MEF2A_6	209	218	PF00069	0.532
DOC_PP1_RVXF_1	365	371	PF00149	0.603
DOC_PP2B_LxvP_1	301	304	PF13499	0.538
DOC_PP4_FxxP_1	411	414	PF00568	0.819
DOC_USP7_MATH_1	117	121	PF00917	0.519
DOC_USP7_MATH_1	228	232	PF00917	0.679
DOC_USP7_MATH_1	233	237	PF00917	0.621
DOC_USP7_MATH_1	241	245	PF00917	0.525
DOC_USP7_MATH_1	266	270	PF00917	0.810
DOC_USP7_MATH_1	271	275	PF00917	0.754
DOC_USP7_MATH_1	297	301	PF00917	0.535
DOC_USP7_MATH_1	345	349	PF00917	0.807
DOC_USP7_MATH_1	394	398	PF00917	0.766
DOC_USP7_MATH_1	400	404	PF00917	0.646
DOC_WW_Pin1_4	149	154	PF00397	0.530
DOC_WW_Pin1_4	158	163	PF00397	0.588
DOC_WW_Pin1_4	193	198	PF00397	0.820
DOC_WW_Pin1_4	224	229	PF00397	0.768
DOC_WW_Pin1_4	237	242	PF00397	0.684
DOC_WW_Pin1_4	328	333	PF00397	0.826
DOC_WW_Pin1_4	336	341	PF00397	0.720
DOC_WW_Pin1_4	360	365	PF00397	0.773
DOC_WW_Pin1_4	371	376	PF00397	0.669
DOC_WW_Pin1_4	410	415	PF00397	0.824
LIG_14-3-3_CanoR_1	145	153	PF00244	0.673
LIG_14-3-3_CanoR_1	175	183	PF00244	0.740
LIG_14-3-3_CanoR_1	312	316	PF00244	0.548
LIG_14-3-3_CanoR_1	409	414	PF00244	0.789
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BRCT_BRCA1_1	348	352	PF00533	0.776
LIG_Clathr_ClatBox_1	50	54	PF01394	0.661
LIG_FHA_1	188	194	PF00498	0.820
LIG_FHA_1	371	377	PF00498	0.821
LIG_FHA_1	64	70	PF00498	0.514
LIG_FHA_2	65	71	PF00498	0.463
LIG_LIR_Apic_2	231	235	PF02991	0.757
LIG_LIR_Nem_3	2	6	PF02991	0.485
LIG_SH2_CRK	48	52	PF00017	0.637
LIG_SH2_CRK	83	87	PF00017	0.640
LIG_SH2_STAP1	183	187	PF00017	0.531
LIG_SH2_STAT5	183	186	PF00017	0.533
LIG_SH2_STAT5	26	29	PF00017	0.570
LIG_SH3_1	209	215	PF00018	0.821
LIG_SH3_2	159	164	PF14604	0.538
LIG_SH3_2	381	386	PF14604	0.537
LIG_SH3_3	156	162	PF00018	0.822
LIG_SH3_3	209	215	PF00018	0.821
LIG_SH3_3	34	40	PF00018	0.337
LIG_SH3_3	378	384	PF00018	0.573
LIG_TRAF2_1	124	127	PF00917	0.566
MOD_CDC14_SPxK_1	161	164	PF00782	0.537
MOD_CDK_SPK_2	224	229	PF00069	0.741
MOD_CDK_SPK_2	410	415	PF00069	0.824
MOD_CDK_SPxK_1	158	164	PF00069	0.537
MOD_CDK_SPxxK_3	336	343	PF00069	0.661
MOD_CDK_SPxxK_3	360	367	PF00069	0.528
MOD_CK1_1	19	25	PF00069	0.401
MOD_CK1_1	236	242	PF00069	0.687
MOD_CK1_1	244	250	PF00069	0.563
MOD_CK1_1	269	275	PF00069	0.773
MOD_CK1_1	286	292	PF00069	0.595
MOD_CK1_1	299	305	PF00069	0.615
MOD_CK1_1	318	324	PF00069	0.504
MOD_CK2_1	64	70	PF00069	0.469
MOD_GlcNHglycan	179	182	PF01048	0.632
MOD_GlcNHglycan	274	277	PF01048	0.798
MOD_GlcNHglycan	285	288	PF01048	0.628
MOD_GlcNHglycan	317	320	PF01048	0.529
MOD_GlcNHglycan	324	327	PF01048	0.516
MOD_GlcNHglycan	332	335	PF01048	0.519
MOD_GlcNHglycan	357	360	PF01048	0.810
MOD_GSK3_1	137	144	PF00069	0.653
MOD_GSK3_1	145	152	PF00069	0.594
MOD_GSK3_1	154	161	PF00069	0.534
MOD_GSK3_1	177	184	PF00069	0.626
MOD_GSK3_1	224	231	PF00069	0.807
MOD_GSK3_1	233	240	PF00069	0.708
MOD_GSK3_1	26	33	PF00069	0.471
MOD_GSK3_1	265	272	PF00069	0.706
MOD_GSK3_1	311	318	PF00069	0.530
MOD_GSK3_1	346	353	PF00069	0.629
MOD_LATS_1	251	257	PF00433	0.677
MOD_NEK2_1	283	288	PF00069	0.809
MOD_NEK2_1	322	327	PF00069	0.530
MOD_NEK2_1	370	375	PF00069	0.821
MOD_PIKK_1	105	111	PF00454	0.640
MOD_PIKK_1	117	123	PF00454	0.413
MOD_PIKK_1	145	151	PF00454	0.710
MOD_PIKK_1	154	160	PF00454	0.698
MOD_PIKK_1	389	395	PF00454	0.560
MOD_PIKK_1	75	81	PF00454	0.534
MOD_PK_1	16	22	PF00069	0.420
MOD_PKA_2	105	111	PF00069	0.597
MOD_PKA_2	174	180	PF00069	0.809
MOD_PKA_2	228	234	PF00069	0.756
MOD_PKA_2	311	317	PF00069	0.745
MOD_PKA_2	400	406	PF00069	0.819
MOD_PKB_1	294	302	PF00069	0.824
MOD_Plk_1	297	303	PF00069	0.537
MOD_Plk_2-3	64	70	PF00069	0.391
MOD_Plk_4	286	292	PF00069	0.810
MOD_Plk_4	64	70	PF00069	0.544
MOD_ProDKin_1	149	155	PF00069	0.535
MOD_ProDKin_1	158	164	PF00069	0.590
MOD_ProDKin_1	193	199	PF00069	0.819
MOD_ProDKin_1	224	230	PF00069	0.771
MOD_ProDKin_1	237	243	PF00069	0.680
MOD_ProDKin_1	328	334	PF00069	0.828
MOD_ProDKin_1	336	342	PF00069	0.723
MOD_ProDKin_1	360	366	PF00069	0.772
MOD_ProDKin_1	371	377	PF00069	0.670
MOD_ProDKin_1	410	416	PF00069	0.820
TRG_DiLeu_BaEn_4	127	133	PF01217	0.567
TRG_ENDOCYTIC_2	48	51	PF00928	0.631
TRG_ENDOCYTIC_2	83	86	PF00928	0.642
TRG_ER_diArg_1	304	307	PF00400	0.754
TRG_ER_diArg_1	386	388	PF00400	0.770
TRG_ER_diArg_1	87	89	PF00400	0.554
TRG_NLS_MonoExtC_3	292	298	PF00514	0.814

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSB0	Leishmania donovani	86%	100%
A4HHR7	Leishmania braziliensis	64%	100%
A4HVF8	Leishmania infantum	87%	100%
Q4QGD1	Leishmania major	85%	100%