Putative class 3 lipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Triglyceride lipase, putative

Species:

Leishmania mexicana

UniProt:

E9AP55_LEIMU

TriTrypDb:

LmxM.13.0210

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP55

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0008152	metabolic process	1	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004806	triglyceride lipase activity	5	1
GO:0016298	lipase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0052689	carboxylic ester hydrolase activity	4	1
GO:0005488	binding	1	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.592
CLV_C14_Caspase3-7	450	454	PF00656	0.656
CLV_C14_Caspase3-7	468	472	PF00656	0.654
CLV_NRD_NRD_1	248	250	PF00675	0.521
CLV_NRD_NRD_1	307	309	PF00675	0.346
CLV_NRD_NRD_1	51	53	PF00675	0.401
CLV_NRD_NRD_1	547	549	PF00675	0.665
CLV_NRD_NRD_1	604	606	PF00675	0.463
CLV_PCSK_KEX2_1	307	309	PF00082	0.346
CLV_PCSK_KEX2_1	51	53	PF00082	0.401
CLV_PCSK_KEX2_1	547	549	PF00082	0.665
CLV_PCSK_KEX2_1	604	606	PF00082	0.463
CLV_PCSK_PC7_1	47	53	PF00082	0.383
CLV_PCSK_SKI1_1	114	118	PF00082	0.546
CLV_PCSK_SKI1_1	127	131	PF00082	0.364
CLV_PCSK_SKI1_1	137	141	PF00082	0.320
CLV_PCSK_SKI1_1	47	51	PF00082	0.443
CLV_PCSK_SKI1_1	604	608	PF00082	0.461
DEG_APCC_DBOX_1	136	144	PF00400	0.361
DEG_SCF_FBW7_1	424	430	PF00400	0.509
DEG_SPOP_SBC_1	460	464	PF00917	0.504
DOC_CKS1_1	424	429	PF01111	0.542
DOC_CYCLIN_RxL_1	111	121	PF00134	0.577
DOC_CYCLIN_RxL_1	134	141	PF00134	0.521
DOC_MAPK_gen_1	200	208	PF00069	0.646
DOC_MAPK_gen_1	307	313	PF00069	0.334
DOC_PP1_RVXF_1	185	191	PF00149	0.433
DOC_PP2B_LxvP_1	152	155	PF13499	0.572
DOC_PP2B_LxvP_1	182	185	PF13499	0.427
DOC_PP2B_LxvP_1	311	314	PF13499	0.399
DOC_PP2B_LxvP_1	329	332	PF13499	0.399
DOC_USP7_MATH_1	314	318	PF00917	0.508
DOC_USP7_MATH_1	414	418	PF00917	0.806
DOC_USP7_MATH_1	520	524	PF00917	0.707
DOC_USP7_MATH_1	546	550	PF00917	0.633
DOC_USP7_MATH_1	596	600	PF00917	0.740
DOC_WW_Pin1_4	318	323	PF00397	0.427
DOC_WW_Pin1_4	399	404	PF00397	0.724
DOC_WW_Pin1_4	405	410	PF00397	0.664
DOC_WW_Pin1_4	423	428	PF00397	0.541
DOC_WW_Pin1_4	442	447	PF00397	0.505
DOC_WW_Pin1_4	452	457	PF00397	0.483
DOC_WW_Pin1_4	516	521	PF00397	0.720
DOC_WW_Pin1_4	576	581	PF00397	0.738
LIG_14-3-3_CanoR_1	127	134	PF00244	0.475
LIG_14-3-3_CanoR_1	137	143	PF00244	0.417
LIG_14-3-3_CanoR_1	171	175	PF00244	0.491
LIG_14-3-3_CanoR_1	210	216	PF00244	0.537
LIG_14-3-3_CanoR_1	307	312	PF00244	0.411
LIG_14-3-3_CanoR_1	364	373	PF00244	0.478
LIG_14-3-3_CanoR_1	378	386	PF00244	0.514
LIG_14-3-3_CanoR_1	433	441	PF00244	0.796
LIG_14-3-3_CanoR_1	509	515	PF00244	0.586
LIG_14-3-3_CanoR_1	554	564	PF00244	0.706
LIG_14-3-3_CanoR_1	6	11	PF00244	0.501
LIG_14-3-3_CanoR_1	604	612	PF00244	0.415
LIG_14-3-3_CterR_2	663	667	PF00244	0.420
LIG_Actin_WH2_2	157	173	PF00022	0.544
LIG_BIR_III_2	453	457	PF00653	0.647
LIG_BIR_III_4	471	475	PF00653	0.665
LIG_BRCT_BRCA1_1	454	458	PF00533	0.510
LIG_BRCT_BRCA1_1	463	467	PF00533	0.782
LIG_eIF4E_1	299	305	PF01652	0.356
LIG_FHA_1	104	110	PF00498	0.460
LIG_FHA_1	128	134	PF00498	0.469
LIG_FHA_1	156	162	PF00498	0.538
LIG_FHA_1	199	205	PF00498	0.556
LIG_FHA_1	210	216	PF00498	0.483
LIG_FHA_1	282	288	PF00498	0.388
LIG_FHA_1	299	305	PF00498	0.240
LIG_FHA_1	319	325	PF00498	0.387
LIG_FHA_1	366	372	PF00498	0.570
LIG_FHA_1	378	384	PF00498	0.442
LIG_FHA_1	424	430	PF00498	0.762
LIG_FHA_1	461	467	PF00498	0.686
LIG_FHA_1	48	54	PF00498	0.443
LIG_FHA_1	67	73	PF00498	0.263
LIG_FHA_2	16	22	PF00498	0.636
LIG_FHA_2	178	184	PF00498	0.430
LIG_FHA_2	216	222	PF00498	0.590
LIG_FHA_2	225	231	PF00498	0.511
LIG_FHA_2	271	277	PF00498	0.411
LIG_FHA_2	471	477	PF00498	0.689
LIG_FHA_2	587	593	PF00498	0.777
LIG_Integrin_RGD_1	19	21	PF01839	0.617
LIG_LIR_Gen_1	177	185	PF02991	0.470
LIG_LIR_Gen_1	201	211	PF02991	0.528
LIG_LIR_Gen_1	213	223	PF02991	0.538
LIG_LIR_Gen_1	280	287	PF02991	0.446
LIG_LIR_Gen_1	296	305	PF02991	0.236
LIG_LIR_Gen_1	345	356	PF02991	0.347
LIG_LIR_Nem_3	110	116	PF02991	0.573
LIG_LIR_Nem_3	177	182	PF02991	0.473
LIG_LIR_Nem_3	205	211	PF02991	0.515
LIG_LIR_Nem_3	213	219	PF02991	0.501
LIG_LIR_Nem_3	280	286	PF02991	0.446
LIG_LIR_Nem_3	296	302	PF02991	0.236
LIG_LIR_Nem_3	345	351	PF02991	0.347
LIG_LIR_Nem_3	607	612	PF02991	0.375
LIG_LIR_Nem_3	629	635	PF02991	0.476
LIG_PCNA_yPIPBox_3	245	258	PF02747	0.515
LIG_PCNA_yPIPBox_3	497	509	PF02747	0.467
LIG_Pex14_1	348	352	PF04695	0.399
LIG_Pex14_2	113	117	PF04695	0.461
LIG_SH2_CRK	283	287	PF00017	0.399
LIG_SH2_CRK	612	616	PF00017	0.435
LIG_SH2_CRK	620	624	PF00017	0.503
LIG_SH2_NCK_1	337	341	PF00017	0.499
LIG_SH2_STAP1	120	124	PF00017	0.571
LIG_SH2_STAP1	166	170	PF00017	0.374
LIG_SH2_STAP1	283	287	PF00017	0.399
LIG_SH2_STAT5	151	154	PF00017	0.482
LIG_SH2_STAT5	179	182	PF00017	0.392
LIG_SH2_STAT5	283	286	PF00017	0.399
LIG_SH2_STAT5	29	32	PF00017	0.633
LIG_SH2_STAT5	299	302	PF00017	0.399
LIG_SH2_STAT5	503	506	PF00017	0.553
LIG_SH2_STAT5	622	625	PF00017	0.417
LIG_SH3_3	264	270	PF00018	0.399
LIG_SH3_3	421	427	PF00018	0.598
LIG_SH3_3	575	581	PF00018	0.729
LIG_SH3_3	61	67	PF00018	0.428
LIG_SH3_3	69	75	PF00018	0.417
LIG_SUMO_SIM_par_1	157	163	PF11976	0.545
LIG_SxIP_EBH_1	157	171	PF03271	0.444
LIG_TRAF2_1	317	320	PF00917	0.411
LIG_TRAF2_1	479	482	PF00917	0.742
LIG_TYR_ITIM	147	152	PF00017	0.459
MOD_CDK_SPK_2	318	323	PF00069	0.411
MOD_CK1_1	377	383	PF00069	0.497
MOD_CK1_1	385	391	PF00069	0.561
MOD_CK1_1	399	405	PF00069	0.802
MOD_CK1_1	447	453	PF00069	0.717
MOD_CK1_1	461	467	PF00069	0.702
MOD_CK1_1	487	493	PF00069	0.777
MOD_CK2_1	177	183	PF00069	0.440
MOD_CK2_1	215	221	PF00069	0.574
MOD_CK2_1	224	230	PF00069	0.509
MOD_CK2_1	270	276	PF00069	0.499
MOD_CK2_1	314	320	PF00069	0.411
MOD_CK2_1	470	476	PF00069	0.684
MOD_GlcNHglycan	144	147	PF01048	0.449
MOD_GlcNHglycan	279	282	PF01048	0.499
MOD_GlcNHglycan	404	407	PF01048	0.813
MOD_GlcNHglycan	416	419	PF01048	0.613
MOD_GlcNHglycan	430	433	PF01048	0.801
MOD_GlcNHglycan	446	449	PF01048	0.570
MOD_GlcNHglycan	463	466	PF01048	0.750
MOD_GlcNHglycan	488	493	PF01048	0.761
MOD_GlcNHglycan	548	551	PF01048	0.612
MOD_GSK3_1	138	145	PF00069	0.450
MOD_GSK3_1	155	162	PF00069	0.258
MOD_GSK3_1	211	218	PF00069	0.524
MOD_GSK3_1	277	284	PF00069	0.499
MOD_GSK3_1	314	321	PF00069	0.411
MOD_GSK3_1	342	349	PF00069	0.354
MOD_GSK3_1	385	392	PF00069	0.620
MOD_GSK3_1	410	417	PF00069	0.678
MOD_GSK3_1	423	430	PF00069	0.599
MOD_GSK3_1	440	447	PF00069	0.587
MOD_GSK3_1	461	468	PF00069	0.756
MOD_GSK3_1	470	477	PF00069	0.675
MOD_GSK3_1	484	491	PF00069	0.710
MOD_GSK3_1	504	511	PF00069	0.759
MOD_GSK3_1	516	523	PF00069	0.708
MOD_GSK3_1	546	553	PF00069	0.654
MOD_GSK3_1	62	69	PF00069	0.513
MOD_GSK3_1	621	628	PF00069	0.427
MOD_N-GLC_1	155	160	PF02516	0.429
MOD_N-GLC_1	509	514	PF02516	0.616
MOD_N-GLC_1	516	521	PF02516	0.816
MOD_NEK2_1	142	147	PF00069	0.501
MOD_NEK2_1	170	175	PF00069	0.405
MOD_NEK2_1	325	330	PF00069	0.395
MOD_NEK2_1	382	387	PF00069	0.524
MOD_NEK2_1	458	463	PF00069	0.563
MOD_OFUCOSY	41	46	PF10250	0.471
MOD_PIKK_1	314	320	PF00454	0.411
MOD_PIKK_1	377	383	PF00454	0.396
MOD_PIKK_1	396	402	PF00454	0.703
MOD_PIKK_1	62	68	PF00454	0.466
MOD_PKA_1	307	313	PF00069	0.346
MOD_PKA_1	604	610	PF00069	0.434
MOD_PKA_2	170	176	PF00069	0.489
MOD_PKA_2	177	183	PF00069	0.404
MOD_PKA_2	209	215	PF00069	0.535
MOD_PKA_2	307	313	PF00069	0.388
MOD_PKA_2	314	320	PF00069	0.350
MOD_PKA_2	363	369	PF00069	0.340
MOD_PKA_2	377	383	PF00069	0.522
MOD_PKA_2	432	438	PF00069	0.780
MOD_PKA_2	5	11	PF00069	0.515
MOD_PKA_2	508	514	PF00069	0.645
MOD_PKA_2	546	552	PF00069	0.728
MOD_PKA_2	555	561	PF00069	0.622
MOD_PKA_2	604	610	PF00069	0.402
MOD_Plk_1	155	161	PF00069	0.387
MOD_Plk_1	488	494	PF00069	0.682
MOD_Plk_1	504	510	PF00069	0.644
MOD_Plk_1	574	580	PF00069	0.674
MOD_Plk_1	640	646	PF00069	0.544
MOD_Plk_2-3	177	183	PF00069	0.440
MOD_Plk_4	138	144	PF00069	0.413
MOD_Plk_4	177	183	PF00069	0.429
MOD_Plk_4	211	217	PF00069	0.584
MOD_Plk_4	270	276	PF00069	0.453
MOD_Plk_4	281	287	PF00069	0.308
MOD_Plk_4	307	313	PF00069	0.442
MOD_Plk_4	382	388	PF00069	0.558
MOD_Plk_4	389	395	PF00069	0.593
MOD_Plk_4	59	65	PF00069	0.547
MOD_Plk_4	6	12	PF00069	0.625
MOD_Plk_4	640	646	PF00069	0.678
MOD_Plk_4	78	84	PF00069	0.287
MOD_ProDKin_1	318	324	PF00069	0.427
MOD_ProDKin_1	399	405	PF00069	0.726
MOD_ProDKin_1	423	429	PF00069	0.724
MOD_ProDKin_1	442	448	PF00069	0.505
MOD_ProDKin_1	452	458	PF00069	0.483
MOD_ProDKin_1	516	522	PF00069	0.717
MOD_ProDKin_1	576	582	PF00069	0.737
MOD_SUMO_rev_2	535	543	PF00179	0.639
TRG_DiLeu_BaEn_1	320	325	PF01217	0.411
TRG_DiLeu_BaEn_4	495	501	PF01217	0.665
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.460
TRG_DiLeu_LyEn_5	320	325	PF01217	0.411
TRG_ENDOCYTIC_2	120	123	PF00928	0.562
TRG_ENDOCYTIC_2	149	152	PF00928	0.470
TRG_ENDOCYTIC_2	179	182	PF00928	0.439
TRG_ENDOCYTIC_2	283	286	PF00928	0.399
TRG_ENDOCYTIC_2	299	302	PF00928	0.399
TRG_ENDOCYTIC_2	612	615	PF00928	0.363
TRG_ENDOCYTIC_2	620	623	PF00928	0.449
TRG_ER_diArg_1	199	202	PF00400	0.657
TRG_ER_diArg_1	51	53	PF00400	0.401
TRG_ER_diArg_1	604	606	PF00400	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R6	Leptomonas seymouri	27%	85%
A0A0N1I7D8	Leptomonas seymouri	52%	79%
A0A3Q8I9H1	Leishmania donovani	89%	100%
A4HHR9	Leishmania braziliensis	78%	100%
A4HVF6	Leishmania infantum	89%	100%
Q4QGD3	Leishmania major	88%	100%