HARE-HTH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AP53_LEIMU

TriTrypDb:

LmxM.13.0190

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.522
CLV_NRD_NRD_1	120	122	PF00675	0.601
CLV_NRD_NRD_1	134	136	PF00675	0.677
CLV_NRD_NRD_1	139	141	PF00675	0.525
CLV_NRD_NRD_1	148	150	PF00675	0.628
CLV_NRD_NRD_1	208	210	PF00675	0.563
CLV_NRD_NRD_1	66	68	PF00675	0.432
CLV_PCSK_KEX2_1	139	141	PF00082	0.573
CLV_PCSK_KEX2_1	27	29	PF00082	0.654
CLV_PCSK_KEX2_1	66	68	PF00082	0.553
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.654
CLV_PCSK_PC7_1	135	141	PF00082	0.555
CLV_PCSK_SKI1_1	121	125	PF00082	0.722
CLV_PCSK_SKI1_1	76	80	PF00082	0.563
DEG_Nend_Nbox_1	1	3	PF02207	0.611
DEG_SPOP_SBC_1	151	155	PF00917	0.614
DOC_CKS1_1	54	59	PF01111	0.545
DOC_CKS1_1	82	87	PF01111	0.620
DOC_USP7_MATH_1	142	146	PF00917	0.572
DOC_USP7_MATH_1	15	19	PF00917	0.740
DOC_USP7_MATH_1	151	155	PF00917	0.678
DOC_USP7_MATH_1	156	160	PF00917	0.702
DOC_USP7_UBL2_3	59	63	PF12436	0.619
DOC_WW_Pin1_4	152	157	PF00397	0.726
DOC_WW_Pin1_4	53	58	PF00397	0.558
DOC_WW_Pin1_4	81	86	PF00397	0.700
LIG_14-3-3_CanoR_1	121	127	PF00244	0.587
LIG_14-3-3_CanoR_1	149	157	PF00244	0.510
LIG_14-3-3_CanoR_1	28	36	PF00244	0.628
LIG_14-3-3_CanoR_1	41	50	PF00244	0.503
LIG_14-3-3_CanoR_1	51	57	PF00244	0.682
LIG_APCC_ABBA_1	230	235	PF00400	0.546
LIG_DCNL_PONY_1	1	4	PF03556	0.653
LIG_EVH1_1	81	85	PF00568	0.621
LIG_FHA_1	1	7	PF00498	0.689
LIG_FHA_1	42	48	PF00498	0.549
LIG_LIR_Gen_1	159	167	PF02991	0.618
LIG_LIR_Nem_3	125	129	PF02991	0.562
LIG_LIR_Nem_3	130	134	PF02991	0.543
LIG_LIR_Nem_3	154	160	PF02991	0.650
LIG_LIR_Nem_3	64	68	PF02991	0.572
LIG_PTB_Apo_2	125	132	PF02174	0.523
LIG_SH2_CRK	201	205	PF00017	0.469
LIG_SH2_GRB2like	160	163	PF00017	0.622
LIG_SH2_NCK_1	160	164	PF00017	0.619
LIG_SH2_NCK_1	69	73	PF00017	0.655
LIG_SH2_STAT5	236	239	PF00017	0.584
LIG_SH2_STAT5	24	27	PF00017	0.681
LIG_SH2_STAT5	245	248	PF00017	0.554
LIG_SH2_STAT5	36	39	PF00017	0.537
LIG_SH3_3	51	57	PF00018	0.631
LIG_SH3_3	79	85	PF00018	0.615
LIG_SUMO_SIM_anti_2	3	8	PF11976	0.594
LIG_TYR_ITIM	124	129	PF00017	0.599
MOD_CDK_SPxK_1	53	59	PF00069	0.633
MOD_CK1_1	145	151	PF00069	0.755
MOD_CK1_1	171	177	PF00069	0.705
MOD_CK1_1	55	61	PF00069	0.620
MOD_CK2_1	105	111	PF00069	0.480
MOD_CK2_1	158	164	PF00069	0.619
MOD_CK2_1	190	196	PF00069	0.591
MOD_GlcNHglycan	144	147	PF01048	0.572
MOD_GlcNHglycan	17	20	PF01048	0.628
MOD_GlcNHglycan	170	173	PF01048	0.704
MOD_GlcNHglycan	220	223	PF01048	0.528
MOD_GlcNHglycan	240	243	PF01048	0.360
MOD_GlcNHglycan	31	34	PF01048	0.625
MOD_GSK3_1	145	152	PF00069	0.661
MOD_GSK3_1	167	174	PF00069	0.650
MOD_GSK3_1	39	46	PF00069	0.562
MOD_GSK3_1	72	79	PF00069	0.588
MOD_N-GLC_1	218	223	PF02516	0.507
MOD_N-GLC_1	29	34	PF02516	0.686
MOD_NEK2_1	167	172	PF00069	0.645
MOD_NEK2_1	2	7	PF00069	0.778
MOD_OFUCOSY	103	109	PF10250	0.606
MOD_PKA_1	135	141	PF00069	0.688
MOD_PKA_1	149	155	PF00069	0.557
MOD_PKB_1	39	47	PF00069	0.504
MOD_PKB_1	74	82	PF00069	0.650
MOD_Plk_1	76	82	PF00069	0.576
MOD_Plk_4	2	8	PF00069	0.781
MOD_ProDKin_1	152	158	PF00069	0.725
MOD_ProDKin_1	53	59	PF00069	0.558
MOD_ProDKin_1	81	87	PF00069	0.695
TRG_ENDOCYTIC_2	126	129	PF00928	0.563
TRG_ENDOCYTIC_2	160	163	PF00928	0.635
TRG_ENDOCYTIC_2	201	204	PF00928	0.471
TRG_ENDOCYTIC_2	69	72	PF00928	0.706
TRG_ER_diArg_1	65	67	PF00400	0.431
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ69	Leptomonas seymouri	60%	100%
A0A3Q8I9J1	Leishmania donovani	92%	100%
A4H726	Leishmania braziliensis	76%	100%
A4HVF5	Leishmania infantum	91%	100%
Q4QGD5	Leishmania major	90%	100%