Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AP52_LEIMU

TriTrypDb:

LmxM.13.0180

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AP52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.447
CLV_C14_Caspase3-7	300	304	PF00656	0.443
CLV_C14_Caspase3-7	319	323	PF00656	0.594
CLV_C14_Caspase3-7	82	86	PF00656	0.714
CLV_NRD_NRD_1	184	186	PF00675	0.660
CLV_NRD_NRD_1	310	312	PF00675	0.574
CLV_NRD_NRD_1	362	364	PF00675	0.544
CLV_PCSK_KEX2_1	184	186	PF00082	0.660
CLV_PCSK_KEX2_1	310	312	PF00082	0.564
CLV_PCSK_KEX2_1	361	363	PF00082	0.530
CLV_PCSK_SKI1_1	175	179	PF00082	0.483
CLV_PCSK_SKI1_1	256	260	PF00082	0.439
CLV_PCSK_SKI1_1	328	332	PF00082	0.460
CLV_PCSK_SKI1_1	379	383	PF00082	0.454
CLV_PCSK_SKI1_1	393	397	PF00082	0.446
DEG_APCC_DBOX_1	255	263	PF00400	0.431
DEG_APCC_DBOX_1	289	297	PF00400	0.515
DEG_Nend_UBRbox_4	1	3	PF02207	0.664
DEG_SCF_FBW7_1	408	414	PF00400	0.556
DEG_SPOP_SBC_1	219	223	PF00917	0.796
DEG_SPOP_SBC_1	412	416	PF00917	0.539
DOC_ANK_TNKS_1	455	462	PF00023	0.504
DOC_CKS1_1	408	413	PF01111	0.632
DOC_CYCLIN_RxL_1	250	261	PF00134	0.599
DOC_CYCLIN_RxL_1	388	400	PF00134	0.602
DOC_MAPK_gen_1	9	17	PF00069	0.551
DOC_MAPK_MEF2A_6	21	28	PF00069	0.515
DOC_MAPK_MEF2A_6	285	293	PF00069	0.568
DOC_MAPK_NFAT4_5	21	29	PF00069	0.504
DOC_USP7_MATH_1	150	154	PF00917	0.617
DOC_USP7_MATH_1	159	163	PF00917	0.510
DOC_USP7_MATH_1	213	217	PF00917	0.622
DOC_USP7_MATH_1	219	223	PF00917	0.765
DOC_USP7_MATH_1	224	228	PF00917	0.745
DOC_USP7_MATH_1	254	258	PF00917	0.315
DOC_USP7_MATH_1	412	416	PF00917	0.608
DOC_USP7_MATH_1	433	437	PF00917	0.530
DOC_WW_Pin1_4	183	188	PF00397	0.572
DOC_WW_Pin1_4	226	231	PF00397	0.607
DOC_WW_Pin1_4	407	412	PF00397	0.679
DOC_WW_Pin1_4	428	433	PF00397	0.663
DOC_WW_Pin1_4	59	64	PF00397	0.565
LIG_14-3-3_CanoR_1	11	16	PF00244	0.636
LIG_14-3-3_CanoR_1	127	136	PF00244	0.434
LIG_14-3-3_CanoR_1	139	147	PF00244	0.537
LIG_14-3-3_CanoR_1	21	27	PF00244	0.412
LIG_14-3-3_CanoR_1	212	220	PF00244	0.739
LIG_14-3-3_CanoR_1	247	253	PF00244	0.613
LIG_APCC_ABBA_1	61	66	PF00400	0.422
LIG_BIR_III_2	210	214	PF00653	0.479
LIG_BRCT_BRCA1_1	435	439	PF00533	0.471
LIG_CaM_IQ_9	277	292	PF13499	0.480
LIG_CaM_NSCaTE_8	136	143	PF13499	0.542
LIG_FHA_1	12	18	PF00498	0.649
LIG_FHA_1	21	27	PF00498	0.574
LIG_FHA_1	263	269	PF00498	0.525
LIG_FHA_1	322	328	PF00498	0.499
LIG_FHA_1	366	372	PF00498	0.595
LIG_FHA_1	373	379	PF00498	0.433
LIG_FHA_1	408	414	PF00498	0.508
LIG_FHA_2	150	156	PF00498	0.696
LIG_Integrin_RGD_1	193	195	PF01839	0.646
LIG_LIR_Gen_1	113	123	PF02991	0.482
LIG_LIR_Nem_3	113	119	PF02991	0.468
LIG_LYPXL_SIV_4	172	180	PF13949	0.480
LIG_RPA_C_Fungi	44	56	PF08784	0.581
LIG_SH2_CRK	116	120	PF00017	0.488
LIG_SH2_NCK_1	122	126	PF00017	0.486
LIG_SH2_NCK_1	271	275	PF00017	0.581
LIG_SH2_NCK_1	33	37	PF00017	0.485
LIG_SH2_SRC	122	125	PF00017	0.482
LIG_SH2_SRC	33	36	PF00017	0.488
LIG_SH2_STAT5	276	279	PF00017	0.465
LIG_SH2_STAT5	364	367	PF00017	0.451
LIG_SH3_1	184	190	PF00018	0.618
LIG_SH3_1	364	370	PF00018	0.479
LIG_SH3_1	427	433	PF00018	0.413
LIG_SH3_3	184	190	PF00018	0.618
LIG_SH3_3	364	370	PF00018	0.456
LIG_SH3_3	405	411	PF00018	0.593
LIG_SH3_3	427	433	PF00018	0.453
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.457
LIG_SUMO_SIM_par_1	108	114	PF11976	0.400
LIG_SUMO_SIM_par_1	53	60	PF11976	0.512
LIG_SxIP_EBH_1	212	224	PF03271	0.786
LIG_TRAF2_1	419	422	PF00917	0.607
LIG_TRAF2_1	51	54	PF00917	0.576
MOD_CDC14_SPxK_1	62	65	PF00782	0.423
MOD_CDK_SPxK_1	59	65	PF00069	0.385
MOD_CDK_SPxxK_3	186	193	PF00069	0.657
MOD_CK1_1	142	148	PF00069	0.661
MOD_CK1_1	149	155	PF00069	0.614
MOD_CK1_1	189	195	PF00069	0.626
MOD_CK1_1	226	232	PF00069	0.588
MOD_CK1_1	27	33	PF00069	0.577
MOD_CK1_1	437	443	PF00069	0.557
MOD_CK2_1	149	155	PF00069	0.607
MOD_GlcNHglycan	148	151	PF01048	0.587
MOD_GlcNHglycan	152	155	PF01048	0.549
MOD_GlcNHglycan	226	229	PF01048	0.651
MOD_GlcNHglycan	399	402	PF01048	0.519
MOD_GlcNHglycan	415	418	PF01048	0.600
MOD_GSK3_1	138	145	PF00069	0.617
MOD_GSK3_1	146	153	PF00069	0.604
MOD_GSK3_1	20	27	PF00069	0.502
MOD_GSK3_1	214	221	PF00069	0.640
MOD_GSK3_1	229	236	PF00069	0.557
MOD_GSK3_1	248	255	PF00069	0.332
MOD_GSK3_1	353	360	PF00069	0.476
MOD_GSK3_1	407	414	PF00069	0.631
MOD_GSK3_1	433	440	PF00069	0.537
MOD_GSK3_1	55	62	PF00069	0.524
MOD_GSK3_1	65	72	PF00069	0.615
MOD_GSK3_1	7	14	PF00069	0.532
MOD_LATS_1	144	150	PF00433	0.628
MOD_NEK2_1	105	110	PF00069	0.437
MOD_NEK2_1	111	116	PF00069	0.372
MOD_NEK2_1	140	145	PF00069	0.626
MOD_NEK2_1	220	225	PF00069	0.594
MOD_NEK2_1	24	29	PF00069	0.484
MOD_NEK2_1	248	253	PF00069	0.493
MOD_NEK2_1	342	347	PF00069	0.426
MOD_NEK2_1	353	358	PF00069	0.502
MOD_NEK2_1	372	377	PF00069	0.231
MOD_NEK2_1	386	391	PF00069	0.570
MOD_NEK2_1	413	418	PF00069	0.524
MOD_NEK2_1	443	448	PF00069	0.580
MOD_NEK2_1	57	62	PF00069	0.495
MOD_NEK2_1	7	12	PF00069	0.725
MOD_PIKK_1	91	97	PF00454	0.661
MOD_PKA_2	10	16	PF00069	0.637
MOD_PKA_2	138	144	PF00069	0.605
MOD_PKA_2	145	151	PF00069	0.615
MOD_PKA_2	20	26	PF00069	0.425
MOD_PKA_2	211	217	PF00069	0.751
MOD_PKA_2	397	403	PF00069	0.535
MOD_PKB_1	137	145	PF00069	0.568
MOD_PKB_1	9	17	PF00069	0.578
MOD_Plk_1	34	40	PF00069	0.570
MOD_Plk_2-3	344	350	PF00069	0.605
MOD_Plk_2-3	85	91	PF00069	0.427
MOD_Plk_4	105	111	PF00069	0.441
MOD_Plk_4	199	205	PF00069	0.548
MOD_Plk_4	229	235	PF00069	0.411
MOD_Plk_4	27	33	PF00069	0.285
MOD_Plk_4	434	440	PF00069	0.473
MOD_ProDKin_1	183	189	PF00069	0.584
MOD_ProDKin_1	226	232	PF00069	0.599
MOD_ProDKin_1	407	413	PF00069	0.680
MOD_ProDKin_1	428	434	PF00069	0.669
MOD_ProDKin_1	59	65	PF00069	0.576
MOD_SUMO_rev_2	322	330	PF00179	0.479
TRG_DiLeu_BaEn_1	124	129	PF01217	0.471
TRG_DiLeu_BaEn_1	349	354	PF01217	0.495
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.572
TRG_DiLeu_LyEn_5	124	129	PF01217	0.471
TRG_ENDOCYTIC_2	116	119	PF00928	0.480
TRG_ENDOCYTIC_2	340	343	PF00928	0.497
TRG_ER_diArg_1	101	104	PF00400	0.451
TRG_ER_diArg_1	183	185	PF00400	0.547
TRG_ER_diArg_1	296	299	PF00400	0.578
TRG_ER_diArg_1	309	311	PF00400	0.533
TRG_ER_diArg_1	361	363	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	256	261	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN7	Leptomonas seymouri	44%	100%
A0A0S4JF77	Bodo saltans	30%	93%
A0A3S7WSE7	Leishmania donovani	87%	100%
A4H725	Leishmania braziliensis	76%	100%
A4HVF4	Leishmania infantum	87%	100%
Q4QGD6	Leishmania major	88%	99%