Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP49_LEIMU

TriTrypDb:

LmxM.13.0150

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	3
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AP49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.467
CLV_NRD_NRD_1	136	138	PF00675	0.644
CLV_NRD_NRD_1	146	148	PF00675	0.583
CLV_NRD_NRD_1	154	156	PF00675	0.636
CLV_NRD_NRD_1	167	169	PF00675	0.623
CLV_NRD_NRD_1	435	437	PF00675	0.460
CLV_PCSK_FUR_1	144	148	PF00082	0.647
CLV_PCSK_KEX2_1	144	146	PF00082	0.707
CLV_PCSK_KEX2_1	154	156	PF00082	0.614
CLV_PCSK_KEX2_1	167	169	PF00082	0.666
CLV_PCSK_KEX2_1	435	437	PF00082	0.596
CLV_PCSK_KEX2_1	452	454	PF00082	0.581
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.566
CLV_PCSK_SKI1_1	12	16	PF00082	0.469
CLV_PCSK_SKI1_1	154	158	PF00082	0.689
CLV_PCSK_SKI1_1	429	433	PF00082	0.426
DEG_SPOP_SBC_1	103	107	PF00917	0.785
DOC_CKS1_1	81	86	PF01111	0.782
DOC_CKS1_1	97	102	PF01111	0.518
DOC_MAPK_gen_1	137	143	PF00069	0.618
DOC_MAPK_gen_1	21	31	PF00069	0.287
DOC_PP4_FxxP_1	303	306	PF00568	0.490
DOC_USP7_MATH_1	101	105	PF00917	0.781
DOC_USP7_MATH_1	114	118	PF00917	0.753
DOC_USP7_MATH_1	297	301	PF00917	0.418
DOC_USP7_MATH_1	366	370	PF00917	0.601
DOC_WW_Pin1_4	241	246	PF00397	0.443
DOC_WW_Pin1_4	289	294	PF00397	0.469
DOC_WW_Pin1_4	80	85	PF00397	0.741
DOC_WW_Pin1_4	96	101	PF00397	0.590
LIG_14-3-3_CanoR_1	137	143	PF00244	0.672
LIG_14-3-3_CanoR_1	162	169	PF00244	0.531
LIG_14-3-3_CanoR_1	339	343	PF00244	0.587
LIG_14-3-3_CanoR_1	435	440	PF00244	0.461
LIG_14-3-3_CanoR_1	67	73	PF00244	0.746
LIG_APCC_ABBA_1	275	280	PF00400	0.388
LIG_BRCT_BRCA1_1	299	303	PF00533	0.320
LIG_BRCT_BRCA1_1	419	423	PF00533	0.218
LIG_deltaCOP1_diTrp_1	232	239	PF00928	0.560
LIG_EH1_1	355	363	PF00400	0.627
LIG_eIF4E_1	451	457	PF01652	0.573
LIG_FHA_1	97	103	PF00498	0.762
LIG_FHA_2	172	178	PF00498	0.649
LIG_FHA_2	194	200	PF00498	0.587
LIG_FHA_2	241	247	PF00498	0.470
LIG_FHA_2	319	325	PF00498	0.621
LIG_HP1_1	372	376	PF01393	0.393
LIG_Integrin_RGD_1	54	56	PF01839	0.612
LIG_LIR_Apic_2	300	306	PF02991	0.539
LIG_LIR_Gen_1	196	204	PF02991	0.573
LIG_LIR_Gen_1	236	245	PF02991	0.417
LIG_LIR_Gen_1	420	431	PF02991	0.227
LIG_LIR_Nem_3	13	18	PF02991	0.498
LIG_LIR_Nem_3	150	156	PF02991	0.611
LIG_LIR_Nem_3	196	200	PF02991	0.546
LIG_LIR_Nem_3	236	240	PF02991	0.400
LIG_LIR_Nem_3	295	299	PF02991	0.335
LIG_LIR_Nem_3	420	426	PF02991	0.371
LIG_LIR_Nem_3	460	466	PF02991	0.402
LIG_LIR_Nem_3	56	62	PF02991	0.601
LIG_MYND_1	377	381	PF01753	0.533
LIG_Pex14_2	11	15	PF04695	0.537
LIG_Pex14_2	229	233	PF04695	0.602
LIG_RPA_C_Fungi	140	152	PF08784	0.430
LIG_SH2_CRK	153	157	PF00017	0.612
LIG_SH2_CRK	26	30	PF00017	0.473
LIG_SH2_STAP1	278	282	PF00017	0.505
LIG_SH2_STAP1	421	425	PF00017	0.372
LIG_SH2_STAT5	172	175	PF00017	0.627
LIG_SH2_STAT5	195	198	PF00017	0.693
LIG_SH2_STAT5	268	271	PF00017	0.478
LIG_SH2_STAT5	390	393	PF00017	0.392
LIG_SH3_3	11	17	PF00018	0.544
LIG_SH3_3	371	377	PF00018	0.443
LIG_SH3_3	69	75	PF00018	0.538
LIG_SH3_3	91	97	PF00018	0.765
LIG_TRAF2_1	174	177	PF00917	0.598
LIG_TRFH_1	423	427	PF08558	0.207
MOD_CDK_SPxxK_3	241	248	PF00069	0.489
MOD_CK1_1	104	110	PF00069	0.748
MOD_CK1_1	193	199	PF00069	0.618
MOD_CK1_1	207	213	PF00069	0.575
MOD_CK1_1	289	295	PF00069	0.557
MOD_CK1_1	320	326	PF00069	0.585
MOD_CK1_1	438	444	PF00069	0.477
MOD_CK2_1	171	177	PF00069	0.647
MOD_CK2_1	240	246	PF00069	0.510
MOD_CK2_1	278	284	PF00069	0.465
MOD_Cter_Amidation	433	436	PF01082	0.522
MOD_GlcNHglycan	163	166	PF01048	0.594
MOD_GlcNHglycan	252	255	PF01048	0.584
MOD_GlcNHglycan	280	283	PF01048	0.509
MOD_GlcNHglycan	309	312	PF01048	0.538
MOD_GSK3_1	200	207	PF00069	0.609
MOD_GSK3_1	276	283	PF00069	0.547
MOD_GSK3_1	316	323	PF00069	0.561
MOD_GSK3_1	417	424	PF00069	0.444
MOD_GSK3_1	42	49	PF00069	0.449
MOD_N-GLC_1	181	186	PF02516	0.648
MOD_N-GLC_1	289	294	PF02516	0.497
MOD_NEK2_1	102	107	PF00069	0.785
MOD_NEK2_1	200	205	PF00069	0.683
MOD_NEK2_1	212	217	PF00069	0.509
MOD_NEK2_1	240	245	PF00069	0.518
MOD_NEK2_1	392	397	PF00069	0.491
MOD_NEK2_1	46	51	PF00069	0.458
MOD_NEK2_1	68	73	PF00069	0.714
MOD_PIKK_1	131	137	PF00454	0.477
MOD_PIKK_1	392	398	PF00454	0.533
MOD_PKA_1	154	160	PF00069	0.704
MOD_PKA_1	435	441	PF00069	0.533
MOD_PKA_2	136	142	PF00069	0.608
MOD_PKA_2	154	160	PF00069	0.620
MOD_PKA_2	161	167	PF00069	0.684
MOD_PKA_2	207	213	PF00069	0.569
MOD_PKA_2	316	322	PF00069	0.370
MOD_PKA_2	338	344	PF00069	0.560
MOD_PKA_2	435	441	PF00069	0.468
MOD_Plk_1	283	289	PF00069	0.593
MOD_Plk_1	366	372	PF00069	0.598
MOD_Plk_4	212	218	PF00069	0.512
MOD_Plk_4	225	231	PF00069	0.631
MOD_Plk_4	324	330	PF00069	0.554
MOD_Plk_4	357	363	PF00069	0.564
MOD_ProDKin_1	241	247	PF00069	0.436
MOD_ProDKin_1	289	295	PF00069	0.466
MOD_ProDKin_1	80	86	PF00069	0.741
MOD_ProDKin_1	96	102	PF00069	0.594
MOD_SUMO_rev_2	244	250	PF00179	0.513
MOD_SUMO_rev_2	341	347	PF00179	0.557
TRG_DiLeu_BaEn_2	224	230	PF01217	0.375
TRG_ENDOCYTIC_2	153	156	PF00928	0.646
TRG_ENDOCYTIC_2	197	200	PF00928	0.553
TRG_ENDOCYTIC_2	26	29	PF00928	0.415
TRG_ENDOCYTIC_2	390	393	PF00928	0.505
TRG_ER_diArg_1	143	146	PF00400	0.706
TRG_ER_diArg_1	153	155	PF00400	0.703
TRG_ER_diArg_1	167	169	PF00400	0.651
TRG_ER_diArg_1	51	54	PF00400	0.571
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I6	Leptomonas seymouri	53%	100%
A0A0S4JBB6	Bodo saltans	26%	96%
A0A1X0NPY5	Trypanosomatidae	37%	100%
A0A3R7KWR6	Trypanosoma rangeli	39%	100%
A0A3S7WSC4	Leishmania donovani	93%	100%
A4H722	Leishmania braziliensis	80%	100%
A4HVF1	Leishmania infantum	93%	100%
D0A6V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4QGD9	Leishmania major	93%	100%
V5BDY2	Trypanosoma cruzi	39%	100%