Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP48_LEIMU

TriTrypDb:

LmxM.13.0140

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP48

PDB structure(s): 7aih_BP , 7am2_BP

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.431
CLV_NRD_NRD_1	156	158	PF00675	0.409
CLV_NRD_NRD_1	163	165	PF00675	0.381
CLV_PCSK_KEX2_1	156	158	PF00082	0.410
CLV_PCSK_KEX2_1	162	164	PF00082	0.455
CLV_PCSK_KEX2_1	35	37	PF00082	0.421
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.552
CLV_PCSK_SKI1_1	164	168	PF00082	0.394
CLV_PCSK_SKI1_1	36	40	PF00082	0.405
DEG_Nend_Nbox_1	1	3	PF02207	0.517
DOC_CKS1_1	70	75	PF01111	0.474
DOC_MAPK_MEF2A_6	76	84	PF00069	0.424
DOC_PP4_FxxP_1	171	174	PF00568	0.433
DOC_PP4_FxxP_1	92	95	PF00568	0.545
DOC_USP7_MATH_1	113	117	PF00917	0.624
DOC_USP7_MATH_1	145	149	PF00917	0.463
DOC_USP7_UBL2_3	180	184	PF12436	0.539
DOC_WW_Pin1_4	116	121	PF00397	0.485
DOC_WW_Pin1_4	173	178	PF00397	0.487
DOC_WW_Pin1_4	25	30	PF00397	0.415
DOC_WW_Pin1_4	69	74	PF00397	0.473
LIG_14-3-3_CanoR_1	164	174	PF00244	0.428
LIG_APCC_ABBA_1	82	87	PF00400	0.439
LIG_BRCT_BRCA1_1	167	171	PF00533	0.549
LIG_CtBP_PxDLS_1	120	124	PF00389	0.586
LIG_FHA_1	103	109	PF00498	0.371
LIG_FHA_2	180	186	PF00498	0.536
LIG_LIR_Apic_2	168	174	PF02991	0.418
LIG_LIR_Apic_2	90	95	PF02991	0.535
LIG_LIR_Nem_3	136	141	PF02991	0.466
LIG_LIR_Nem_3	8	13	PF02991	0.481
LIG_SH2_NCK_1	141	145	PF00017	0.563
LIG_SH2_SRC	141	144	PF00017	0.578
LIG_SH2_SRC	24	27	PF00017	0.509
LIG_SH3_3	128	134	PF00018	0.482
LIG_SH3_3	152	158	PF00018	0.484
LIG_SH3_3	171	177	PF00018	0.441
LIG_SH3_3	64	70	PF00018	0.433
LIG_SH3_3	77	83	PF00018	0.425
LIG_SH3_3	92	98	PF00018	0.487
LIG_WW_3	94	98	PF00397	0.635
MOD_CDK_SPK_2	173	178	PF00069	0.468
MOD_CDK_SPxxK_3	173	180	PF00069	0.496
MOD_CDK_SPxxK_3	69	76	PF00069	0.470
MOD_CK1_1	116	122	PF00069	0.640
MOD_CK1_1	30	36	PF00069	0.496
MOD_Cter_Amidation	33	36	PF01082	0.420
MOD_GlcNHglycan	114	118	PF01048	0.663
MOD_GlcNHglycan	32	35	PF01048	0.429
MOD_GlcNHglycan	52	55	PF01048	0.245
MOD_GSK3_1	133	140	PF00069	0.473
MOD_NEK2_1	50	55	PF00069	0.456
MOD_NEK2_2	179	184	PF00069	0.531
MOD_Plk_2-3	74	80	PF00069	0.459
MOD_Plk_4	133	139	PF00069	0.482
MOD_ProDKin_1	116	122	PF00069	0.487
MOD_ProDKin_1	173	179	PF00069	0.490
MOD_ProDKin_1	25	31	PF00069	0.417
MOD_ProDKin_1	69	75	PF00069	0.471
MOD_SUMO_for_1	183	186	PF00179	0.574
TRG_DiLeu_BaEn_1	61	66	PF01217	0.550
TRG_DiLeu_BaEn_2	80	86	PF01217	0.502
TRG_DiLeu_BaEn_4	61	67	PF01217	0.553
TRG_ER_diArg_1	155	157	PF00400	0.440
TRG_ER_diArg_1	162	164	PF00400	0.379
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ7	Leptomonas seymouri	83%	73%
A0A0S4ILM8	Bodo saltans	61%	74%
A0A1X0NNA3	Trypanosomatidae	65%	70%
A0A3R7N9U2	Trypanosoma rangeli	66%	74%
A0A3S7WSB9	Leishmania donovani	97%	100%
A4H721	Leishmania braziliensis	92%	100%
A4HVF0	Leishmania infantum	97%	100%
Q4QGE0	Leishmania major	97%	100%
V5B9B1	Trypanosoma cruzi	69%	73%