LeishMANIAdb
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TACC_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TACC_C domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AP46_LEIMU
TriTrypDb:
LmxM.13.0120
Length:
119

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AP46
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP46

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 54 58 PF00656 0.592
CLV_NRD_NRD_1 22 24 PF00675 0.495
CLV_NRD_NRD_1 72 74 PF00675 0.536
CLV_PCSK_KEX2_1 94 96 PF00082 0.404
CLV_PCSK_PC1ET2_1 94 96 PF00082 0.404
DEG_Nend_UBRbox_3 1 3 PF02207 0.381
DOC_MAPK_gen_1 94 100 PF00069 0.552
DOC_WW_Pin1_4 98 103 PF00397 0.594
LIG_14-3-3_CterR_2 115 119 PF00244 0.610
LIG_APCC_ABBA_1 63 68 PF00400 0.421
LIG_APCC_ABBAyCdc20_2 75 81 PF00400 0.515
LIG_BRCT_BRCA1_1 87 91 PF00533 0.509
LIG_LIR_Nem_3 3 7 PF02991 0.537
LIG_MLH1_MIPbox_1 87 91 PF16413 0.509
LIG_Rb_pABgroove_1 60 68 PF01858 0.479
LIG_REV1ctd_RIR_1 88 99 PF16727 0.519
LIG_SH2_SRC 79 82 PF00017 0.394
LIG_SH2_STAP1 79 83 PF00017 0.421
LIG_SH2_STAT3 42 45 PF00017 0.351
LIG_SH2_STAT5 103 106 PF00017 0.567
LIG_SH2_STAT5 89 92 PF00017 0.518
LIG_SUMO_SIM_par_1 61 68 PF11976 0.488
LIG_TRAF2_1 82 85 PF00917 0.430
LIG_WRC_WIRS_1 104 109 PF05994 0.450
MOD_CDK_SPxxK_3 98 105 PF00069 0.568
MOD_CK1_1 106 112 PF00069 0.499
MOD_PIKK_1 32 38 PF00454 0.649
MOD_ProDKin_1 98 104 PF00069 0.600
MOD_SUMO_for_1 14 17 PF00179 0.515
MOD_SUMO_rev_2 86 96 PF00179 0.518
TRG_ENDOCYTIC_2 66 69 PF00928 0.510
TRG_ENDOCYTIC_2 97 100 PF00928 0.418
TRG_Pf-PMV_PEXEL_1 23 27 PF00026 0.495

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKU6 Leptomonas seymouri 67% 81%
A0A1X0NNB7 Trypanosomatidae 42% 100%
A0A3S7WSC0 Leishmania donovani 92% 100%
A0A422NBN3 Trypanosoma rangeli 40% 100%
A4H719 Leishmania braziliensis 79% 100%
A4HVE8 Leishmania infantum 92% 100%
D0A6W2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
Q4QGE2 Leishmania major 89% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS