SURF1-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

SURF1-like protein

Gene product:

SURF1 family, putative

Species:

Leishmania mexicana

UniProt:

E9AP45_LEIMU

TriTrypDb:

LmxM.13.0110

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	12
GO:0016020	membrane	2	12
GO:0019866	organelle inner membrane	4	12
GO:0031090	organelle membrane	3	12
GO:0031966	mitochondrial membrane	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AP45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.478
CLV_NRD_NRD_1	192	194	PF00675	0.478
CLV_NRD_NRD_1	235	237	PF00675	0.476
CLV_NRD_NRD_1	27	29	PF00675	0.476
CLV_NRD_NRD_1	274	276	PF00675	0.375
CLV_NRD_NRD_1	282	284	PF00675	0.350
CLV_NRD_NRD_1	296	298	PF00675	0.369
CLV_NRD_NRD_1	62	64	PF00675	0.537
CLV_PCSK_FUR_1	313	317	PF00082	0.478
CLV_PCSK_KEX2_1	191	193	PF00082	0.477
CLV_PCSK_KEX2_1	234	236	PF00082	0.478
CLV_PCSK_KEX2_1	27	29	PF00082	0.476
CLV_PCSK_KEX2_1	274	276	PF00082	0.380
CLV_PCSK_KEX2_1	296	298	PF00082	0.418
CLV_PCSK_KEX2_1	315	317	PF00082	0.300
CLV_PCSK_KEX2_1	62	64	PF00082	0.537
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.457
CLV_PCSK_PC7_1	230	236	PF00082	0.525
CLV_PCSK_SKI1_1	129	133	PF00082	0.476
CLV_PCSK_SKI1_1	146	150	PF00082	0.476
CLV_PCSK_SKI1_1	277	281	PF00082	0.352
CLV_PCSK_SKI1_1	62	66	PF00082	0.553
DEG_SCF_SKP2-CKS1_1	336	343	PF00560	0.592
DOC_CKS1_1	101	106	PF01111	0.276
DOC_MAPK_MEF2A_6	2	10	PF00069	0.501
DOC_PP4_FxxP_1	160	163	PF00568	0.334
DOC_USP7_UBL2_3	284	288	PF12436	0.617
DOC_USP7_UBL2_3	39	43	PF12436	0.250
DOC_WW_Pin1_4	100	105	PF00397	0.276
DOC_WW_Pin1_4	161	166	PF00397	0.347
DOC_WW_Pin1_4	244	249	PF00397	0.337
DOC_WW_Pin1_4	337	342	PF00397	0.695
DOC_WW_Pin1_4	41	46	PF00397	0.381
LIG_Actin_WH2_2	301	317	PF00022	0.651
LIG_deltaCOP1_diTrp_1	174	183	PF00928	0.287
LIG_FHA_1	245	251	PF00498	0.294
LIG_FHA_2	101	107	PF00498	0.298
LIG_FHA_2	333	339	PF00498	0.735
LIG_FHA_2	53	59	PF00498	0.317
LIG_LIR_Apic_2	158	163	PF02991	0.334
LIG_LIR_Gen_1	110	121	PF02991	0.276
LIG_LIR_Gen_1	174	185	PF02991	0.276
LIG_LIR_Gen_1	240	250	PF02991	0.276
LIG_LIR_Gen_1	252	261	PF02991	0.276
LIG_LIR_LC3C_4	176	180	PF02991	0.325
LIG_LIR_Nem_3	110	116	PF02991	0.276
LIG_LIR_Nem_3	174	180	PF02991	0.284
LIG_LIR_Nem_3	240	246	PF02991	0.276
LIG_LIR_Nem_3	252	257	PF02991	0.276
LIG_LIR_Nem_3	265	270	PF02991	0.288
LIG_LIR_Nem_3	4	8	PF02991	0.459
LIG_LIR_Nem_3	58	64	PF02991	0.290
LIG_MAD2	225	233	PF02301	0.317
LIG_SH2_CRK	267	271	PF00017	0.475
LIG_SH2_CRK	5	9	PF00017	0.484
LIG_SH2_CRK	61	65	PF00017	0.381
LIG_SH2_PTP2	243	246	PF00017	0.276
LIG_SH2_STAT5	135	138	PF00017	0.276
LIG_SH2_STAT5	212	215	PF00017	0.276
LIG_SH2_STAT5	243	246	PF00017	0.276
LIG_SH2_STAT5	254	257	PF00017	0.309
LIG_SH3_3	176	182	PF00018	0.324
LIG_SH3_3	98	104	PF00018	0.276
LIG_TRAF2_1	307	310	PF00917	0.597
LIG_TYR_ITIM	241	246	PF00017	0.276
LIG_UBA3_1	279	284	PF00899	0.644
LIG_WRC_WIRS_1	15	20	PF05994	0.328
MOD_CDK_SPxK_1	337	343	PF00069	0.593
MOD_CK1_1	14	20	PF00069	0.449
MOD_CK1_1	337	343	PF00069	0.705
MOD_CK1_1	44	50	PF00069	0.374
MOD_CK1_1	82	88	PF00069	0.362
MOD_CK2_1	100	106	PF00069	0.318
MOD_CK2_1	332	338	PF00069	0.730
MOD_CK2_1	52	58	PF00069	0.319
MOD_GlcNHglycan	201	204	PF01048	0.549
MOD_GlcNHglycan	217	222	PF01048	0.420
MOD_GSK3_1	10	17	PF00069	0.328
MOD_N-GLC_1	52	57	PF02516	0.539
MOD_N-GLC_2	57	59	PF02516	0.562
MOD_NEK2_1	10	15	PF00069	0.332
MOD_NEK2_1	155	160	PF00069	0.297
MOD_NEK2_1	185	190	PF00069	0.350
MOD_NEK2_1	257	262	PF00069	0.344
MOD_PIKK_1	345	351	PF00454	0.750
MOD_Plk_1	173	179	PF00069	0.276
MOD_Plk_1	239	245	PF00069	0.276
MOD_Plk_1	52	58	PF00069	0.297
MOD_Plk_2-3	52	58	PF00069	0.381
MOD_Plk_4	11	17	PF00069	0.444
MOD_Plk_4	155	161	PF00069	0.276
MOD_Plk_4	173	179	PF00069	0.281
MOD_Plk_4	185	191	PF00069	0.276
MOD_Plk_4	239	245	PF00069	0.276
MOD_Plk_4	249	255	PF00069	0.264
MOD_Plk_4	262	268	PF00069	0.328
MOD_ProDKin_1	100	106	PF00069	0.276
MOD_ProDKin_1	161	167	PF00069	0.347
MOD_ProDKin_1	244	250	PF00069	0.337
MOD_ProDKin_1	337	343	PF00069	0.712
MOD_ProDKin_1	41	47	PF00069	0.381
TRG_DiLeu_BaEn_1	73	78	PF01217	0.276
TRG_DiLeu_BaEn_4	309	315	PF01217	0.650
TRG_ENDOCYTIC_2	212	215	PF00928	0.287
TRG_ENDOCYTIC_2	243	246	PF00928	0.276
TRG_ENDOCYTIC_2	254	257	PF00928	0.328
TRG_ENDOCYTIC_2	267	270	PF00928	0.284
TRG_ENDOCYTIC_2	5	8	PF00928	0.459
TRG_ENDOCYTIC_2	61	64	PF00928	0.362
TRG_ER_diArg_1	190	193	PF00400	0.280
TRG_ER_diArg_1	227	230	PF00400	0.296
TRG_ER_diArg_1	233	236	PF00400	0.262
TRG_ER_diArg_1	26	28	PF00400	0.276
TRG_ER_diArg_1	273	275	PF00400	0.578
TRG_ER_diArg_1	61	63	PF00400	0.337
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA6	Leptomonas seymouri	81%	100%
A0A0S4IJQ4	Bodo saltans	60%	74%
A0A1X0NNA6	Trypanosomatidae	68%	100%
A0A3R7MI38	Trypanosoma rangeli	66%	100%
A0A3S5H6M9	Leishmania donovani	95%	100%
A4H718	Leishmania braziliensis	88%	100%
A4HVE7	Leishmania infantum	95%	100%
D0A6W3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
Q4QGE3	Leishmania major	94%	100%
V5BIC3	Trypanosoma cruzi	66%	100%