Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AP44_LEIMU

TriTrypDb:

LmxM.13.0100

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	300	302	PF00675	0.706
CLV_NRD_NRD_1	404	406	PF00675	0.735
CLV_NRD_NRD_1	418	420	PF00675	0.587
CLV_NRD_NRD_1	468	470	PF00675	0.785
CLV_NRD_NRD_1	481	483	PF00675	0.628
CLV_NRD_NRD_1	512	514	PF00675	0.797
CLV_NRD_NRD_1	92	94	PF00675	0.544
CLV_PCSK_KEX2_1	284	286	PF00082	0.708
CLV_PCSK_KEX2_1	300	302	PF00082	0.457
CLV_PCSK_KEX2_1	418	420	PF00082	0.692
CLV_PCSK_KEX2_1	468	470	PF00082	0.775
CLV_PCSK_KEX2_1	481	483	PF00082	0.618
CLV_PCSK_KEX2_1	589	591	PF00082	0.611
CLV_PCSK_KEX2_1	92	94	PF00082	0.544
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.708
CLV_PCSK_PC1ET2_1	589	591	PF00082	0.611
CLV_PCSK_SKI1_1	2	6	PF00082	0.524
CLV_PCSK_SKI1_1	329	333	PF00082	0.586
CLV_PCSK_SKI1_1	344	348	PF00082	0.518
CLV_PCSK_SKI1_1	92	96	PF00082	0.545
DEG_COP1_1	470	479	PF00400	0.587
DEG_MDM2_SWIB_1	218	226	PF02201	0.681
DEG_Nend_UBRbox_1	1	4	PF02207	0.528
DEG_SCF_FBW7_1	529	536	PF00400	0.791
DEG_SPOP_SBC_1	209	213	PF00917	0.693
DEG_SPOP_SBC_1	434	438	PF00917	0.580
DEG_SPOP_SBC_1	84	88	PF00917	0.518
DOC_CKS1_1	100	105	PF01111	0.581
DOC_CKS1_1	201	206	PF01111	0.553
DOC_CKS1_1	530	535	PF01111	0.812
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.524
DOC_MAPK_MEF2A_6	194	201	PF00069	0.551
DOC_MAPK_MEF2A_6	492	501	PF00069	0.778
DOC_MAPK_RevD_3	499	514	PF00069	0.575
DOC_PP2B_LxvP_1	47	50	PF13499	0.519
DOC_PP2B_LxvP_1	95	98	PF13499	0.561
DOC_PP4_FxxP_1	503	506	PF00568	0.572
DOC_USP7_MATH_1	174	178	PF00917	0.549
DOC_USP7_MATH_1	227	231	PF00917	0.733
DOC_USP7_MATH_1	269	273	PF00917	0.613
DOC_USP7_MATH_1	29	33	PF00917	0.540
DOC_USP7_MATH_1	387	391	PF00917	0.534
DOC_USP7_MATH_1	434	438	PF00917	0.580
DOC_USP7_MATH_1	84	88	PF00917	0.518
DOC_USP7_MATH_1	96	100	PF00917	0.502
DOC_USP7_UBL2_3	284	288	PF12436	0.706
DOC_WW_Pin1_4	132	137	PF00397	0.570
DOC_WW_Pin1_4	138	143	PF00397	0.530
DOC_WW_Pin1_4	165	170	PF00397	0.549
DOC_WW_Pin1_4	200	205	PF00397	0.588
DOC_WW_Pin1_4	261	266	PF00397	0.791
DOC_WW_Pin1_4	31	36	PF00397	0.530
DOC_WW_Pin1_4	388	393	PF00397	0.622
DOC_WW_Pin1_4	413	418	PF00397	0.776
DOC_WW_Pin1_4	422	427	PF00397	0.657
DOC_WW_Pin1_4	467	472	PF00397	0.808
DOC_WW_Pin1_4	502	507	PF00397	0.805
DOC_WW_Pin1_4	525	530	PF00397	0.807
DOC_WW_Pin1_4	533	538	PF00397	0.701
DOC_WW_Pin1_4	557	562	PF00397	0.759
DOC_WW_Pin1_4	571	576	PF00397	0.566
DOC_WW_Pin1_4	77	82	PF00397	0.503
DOC_WW_Pin1_4	99	104	PF00397	0.580
LIG_14-3-3_CanoR_1	348	354	PF00244	0.729
LIG_14-3-3_CanoR_1	386	392	PF00244	0.612
LIG_14-3-3_CanoR_1	418	428	PF00244	0.774
LIG_14-3-3_CanoR_1	431	439	PF00244	0.540
LIG_14-3-3_CanoR_1	507	511	PF00244	0.787
LIG_14-3-3_CanoR_1	594	600	PF00244	0.799
LIG_Actin_WH2_2	230	247	PF00022	0.633
LIG_Actin_WH2_2	334	350	PF00022	0.697
LIG_Actin_WH2_2	596	611	PF00022	0.581
LIG_BRCT_BRCA1_1	171	175	PF00533	0.552
LIG_BRCT_BRCA1_1	70	74	PF00533	0.526
LIG_BRCT_BRCA1_1	90	94	PF00533	0.467
LIG_CtBP_PxDLS_1	103	107	PF00389	0.551
LIG_EH1_1	35	43	PF00400	0.519
LIG_FHA_1	291	297	PF00498	0.708
LIG_FHA_1	402	408	PF00498	0.570
LIG_FHA_1	423	429	PF00498	0.769
LIG_FHA_2	129	135	PF00498	0.564
LIG_FHA_2	348	354	PF00498	0.484
LIG_FHA_2	394	400	PF00498	0.711
LIG_FHA_2	450	456	PF00498	0.794
LIG_GBD_Chelix_1	407	415	PF00786	0.735
LIG_LIR_Gen_1	113	121	PF02991	0.583
LIG_LIR_Gen_1	212	219	PF02991	0.685
LIG_LIR_Gen_1	239	247	PF02991	0.684
LIG_LIR_Gen_1	24	33	PF02991	0.512
LIG_LIR_Gen_1	274	282	PF02991	0.578
LIG_LIR_Gen_1	359	370	PF02991	0.698
LIG_LIR_Gen_1	71	81	PF02991	0.531
LIG_LIR_Nem_3	113	118	PF02991	0.579
LIG_LIR_Nem_3	212	218	PF02991	0.657
LIG_LIR_Nem_3	221	225	PF02991	0.515
LIG_LIR_Nem_3	235	241	PF02991	0.485
LIG_LIR_Nem_3	24	28	PF02991	0.519
LIG_LIR_Nem_3	274	279	PF02991	0.582
LIG_LIR_Nem_3	359	365	PF02991	0.707
LIG_LIR_Nem_3	559	565	PF02991	0.738
LIG_LIR_Nem_3	71	77	PF02991	0.530
LIG_LIR_Nem_3	91	97	PF02991	0.475
LIG_MYND_1	502	506	PF01753	0.571
LIG_Pex14_2	218	222	PF04695	0.673
LIG_Pex14_2	276	280	PF04695	0.711
LIG_Pex14_2	330	334	PF04695	0.711
LIG_REV1ctd_RIR_1	328	336	PF16727	0.712
LIG_RPA_C_Fungi	546	558	PF08784	0.592
LIG_SH2_CRK	241	245	PF00017	0.686
LIG_SH2_CRK	25	29	PF00017	0.515
LIG_SH2_GRB2like	66	69	PF00017	0.508
LIG_SH2_NCK_1	362	366	PF00017	0.697
LIG_SH2_SRC	138	141	PF00017	0.559
LIG_SH2_SRC	354	357	PF00017	0.489
LIG_SH2_SRC	362	365	PF00017	0.632
LIG_SH2_STAP1	25	29	PF00017	0.515
LIG_SH2_STAP1	362	366	PF00017	0.697
LIG_SH2_STAT5	138	141	PF00017	0.559
LIG_SH3_3	440	446	PF00018	0.793
LIG_SH3_3	95	101	PF00018	0.546
LIG_SUMO_SIM_anti_2	198	203	PF11976	0.558
LIG_SUMO_SIM_par_1	39	44	PF11976	0.523
LIG_SUMO_SIM_par_1	461	466	PF11976	0.818
LIG_TRAF2_1	120	123	PF00917	0.597
LIG_TRAF2_1	581	584	PF00917	0.816
LIG_TYR_ITIM	23	28	PF00017	0.518
MOD_CDC14_SPxK_1	416	419	PF00782	0.550
MOD_CDC14_SPxK_1	470	473	PF00782	0.807
MOD_CDC14_SPxK_1	536	539	PF00782	0.604
MOD_CDC14_SPxK_1	560	563	PF00782	0.744
MOD_CDK_SPK_2	413	418	PF00069	0.776
MOD_CDK_SPK_2	502	507	PF00069	0.762
MOD_CDK_SPxK_1	413	419	PF00069	0.535
MOD_CDK_SPxK_1	467	473	PF00069	0.809
MOD_CDK_SPxK_1	533	539	PF00069	0.772
MOD_CDK_SPxK_1	557	563	PF00069	0.755
MOD_CDK_SPxxK_3	138	145	PF00069	0.558
MOD_CDK_SPxxK_3	388	395	PF00069	0.508
MOD_CDK_SPxxK_3	571	578	PF00069	0.700
MOD_CK1_1	141	147	PF00069	0.553
MOD_CK1_1	162	168	PF00069	0.547
MOD_CK1_1	200	206	PF00069	0.660
MOD_CK1_1	213	219	PF00069	0.609
MOD_CK1_1	230	236	PF00069	0.443
MOD_CK1_1	24	30	PF00069	0.515
MOD_CK1_1	253	259	PF00069	0.777
MOD_CK1_1	261	267	PF00069	0.656
MOD_CK1_1	413	419	PF00069	0.780
MOD_CK1_1	421	427	PF00069	0.673
MOD_CK1_1	433	439	PF00069	0.586
MOD_CK1_1	574	580	PF00069	0.790
MOD_CK1_1	86	92	PF00069	0.545
MOD_CK1_1	99	105	PF00069	0.528
MOD_CK2_1	116	122	PF00069	0.591
MOD_CK2_1	253	259	PF00069	0.784
MOD_CK2_1	357	363	PF00069	0.705
MOD_CK2_1	434	440	PF00069	0.634
MOD_CK2_1	449	455	PF00069	0.748
MOD_Cter_Amidation	466	469	PF01082	0.575
MOD_GlcNHglycan	118	121	PF01048	0.592
MOD_GlcNHglycan	229	233	PF01048	0.714
MOD_GlcNHglycan	238	241	PF01048	0.553
MOD_GlcNHglycan	252	255	PF01048	0.561
MOD_GlcNHglycan	259	263	PF01048	0.626
MOD_GlcNHglycan	31	34	PF01048	0.544
MOD_GlcNHglycan	43	46	PF01048	0.494
MOD_GlcNHglycan	432	435	PF01048	0.822
MOD_GlcNHglycan	465	468	PF01048	0.579
MOD_GlcNHglycan	552	555	PF01048	0.797
MOD_GlcNHglycan	579	582	PF01048	0.809
MOD_GlcNHglycan	70	73	PF01048	0.510
MOD_GlcNHglycan	88	91	PF01048	0.467
MOD_GSK3_1	124	131	PF00069	0.572
MOD_GSK3_1	143	150	PF00069	0.570
MOD_GSK3_1	165	172	PF00069	0.541
MOD_GSK3_1	203	210	PF00069	0.631
MOD_GSK3_1	24	31	PF00069	0.448
MOD_GSK3_1	250	257	PF00069	0.749
MOD_GSK3_1	261	268	PF00069	0.587
MOD_GSK3_1	295	302	PF00069	0.600
MOD_GSK3_1	303	310	PF00069	0.528
MOD_GSK3_1	4	11	PF00069	0.561
MOD_GSK3_1	418	425	PF00069	0.782
MOD_GSK3_1	429	436	PF00069	0.588
MOD_GSK3_1	463	470	PF00069	0.825
MOD_GSK3_1	502	509	PF00069	0.637
MOD_GSK3_1	521	528	PF00069	0.605
MOD_GSK3_1	529	536	PF00069	0.700
MOD_GSK3_1	538	545	PF00069	0.578
MOD_GSK3_1	546	553	PF00069	0.728
MOD_GSK3_1	84	91	PF00069	0.540
MOD_LATS_1	108	114	PF00433	0.539
MOD_N-GLC_1	113	118	PF02516	0.579
MOD_NEK2_1	208	213	PF00069	0.702
MOD_NEK2_1	28	33	PF00069	0.506
MOD_NEK2_1	295	300	PF00069	0.621
MOD_NEK2_1	312	317	PF00069	0.688
MOD_NEK2_1	347	352	PF00069	0.722
MOD_NEK2_1	401	406	PF00069	0.728
MOD_NEK2_1	411	416	PF00069	0.598
MOD_NEK2_1	603	608	PF00069	0.582
MOD_NEK2_1	75	80	PF00069	0.510
MOD_NEK2_1	83	88	PF00069	0.511
MOD_NEK2_2	357	362	PF00069	0.458
MOD_PIKK_1	159	165	PF00454	0.552
MOD_PIKK_1	305	311	PF00454	0.714
MOD_PKA_1	418	424	PF00069	0.687
MOD_PKA_2	299	305	PF00069	0.721
MOD_PKA_2	347	353	PF00069	0.726
MOD_PKA_2	418	424	PF00069	0.722
MOD_PKA_2	430	436	PF00069	0.761
MOD_PKA_2	506	512	PF00069	0.783
MOD_PKA_2	51	57	PF00069	0.530
MOD_PKA_2	550	556	PF00069	0.675
MOD_PKA_2	577	583	PF00069	0.807
MOD_PKA_2	593	599	PF00069	0.801
MOD_Plk_1	113	119	PF00069	0.579
MOD_Plk_1	290	296	PF00069	0.667
MOD_Plk_4	102	108	PF00069	0.644
MOD_Plk_4	197	203	PF00069	0.577
MOD_Plk_4	210	216	PF00069	0.425
MOD_Plk_4	312	318	PF00069	0.690
MOD_Plk_4	357	363	PF00069	0.705
MOD_Plk_4	376	382	PF00069	0.712
MOD_Plk_4	475	481	PF00069	0.634
MOD_Plk_4	492	498	PF00069	0.720
MOD_ProDKin_1	132	138	PF00069	0.570
MOD_ProDKin_1	165	171	PF00069	0.553
MOD_ProDKin_1	200	206	PF00069	0.586
MOD_ProDKin_1	261	267	PF00069	0.787
MOD_ProDKin_1	31	37	PF00069	0.532
MOD_ProDKin_1	388	394	PF00069	0.616
MOD_ProDKin_1	413	419	PF00069	0.780
MOD_ProDKin_1	422	428	PF00069	0.659
MOD_ProDKin_1	467	473	PF00069	0.809
MOD_ProDKin_1	502	508	PF00069	0.805
MOD_ProDKin_1	525	531	PF00069	0.808
MOD_ProDKin_1	533	539	PF00069	0.702
MOD_ProDKin_1	557	563	PF00069	0.755
MOD_ProDKin_1	571	577	PF00069	0.568
MOD_ProDKin_1	77	83	PF00069	0.505
MOD_ProDKin_1	99	105	PF00069	0.581
TRG_DiLeu_BaEn_1	221	226	PF01217	0.684
TRG_DiLeu_BaEn_1	397	402	PF01217	0.740
TRG_ENDOCYTIC_2	241	244	PF00928	0.685
TRG_ENDOCYTIC_2	25	28	PF00928	0.519
TRG_ENDOCYTIC_2	362	365	PF00928	0.702
TRG_ENDOCYTIC_2	562	565	PF00928	0.730
TRG_ER_diArg_1	299	301	PF00400	0.685
TRG_ER_diArg_1	417	419	PF00400	0.558
TRG_ER_diArg_1	480	482	PF00400	0.609
TRG_ER_diArg_1	92	94	PF00400	0.544
TRG_NES_CRM1_1	359	372	PF08389	0.696
TRG_NLS_MonoCore_2	512	517	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	567	571	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSA8	Leishmania donovani	78%	100%
A4HVE6	Leishmania infantum	78%	100%
Q4QGE4	Leishmania major	63%	100%