Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP40_LEIMU

TriTrypDb:

LmxM.13.0060

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP40

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.616
CLV_NRD_NRD_1	20	22	PF00675	0.711
CLV_NRD_NRD_1	266	268	PF00675	0.510
CLV_NRD_NRD_1	327	329	PF00675	0.732
CLV_NRD_NRD_1	74	76	PF00675	0.527
CLV_PCSK_FUR_1	90	94	PF00082	0.648
CLV_PCSK_KEX2_1	101	103	PF00082	0.465
CLV_PCSK_KEX2_1	180	182	PF00082	0.592
CLV_PCSK_KEX2_1	20	22	PF00082	0.640
CLV_PCSK_KEX2_1	213	215	PF00082	0.663
CLV_PCSK_KEX2_1	265	267	PF00082	0.552
CLV_PCSK_KEX2_1	327	329	PF00082	0.732
CLV_PCSK_KEX2_1	73	75	PF00082	0.555
CLV_PCSK_KEX2_1	92	94	PF00082	0.398
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.442
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.689
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.569
CLV_PCSK_SKI1_1	120	124	PF00082	0.564
CLV_PCSK_SKI1_1	20	24	PF00082	0.633
CLV_PCSK_SKI1_1	226	230	PF00082	0.656
CLV_Separin_Metazoa	324	328	PF03568	0.649
DOC_CKS1_1	24	29	PF01111	0.642
DOC_CYCLIN_RxL_1	17	26	PF00134	0.699
DOC_CYCLIN_yClb5_NLxxxL_5	378	387	PF00134	0.644
DOC_MAPK_gen_1	221	231	PF00069	0.645
DOC_MAPK_gen_1	40	48	PF00069	0.446
DOC_MAPK_gen_1	73	81	PF00069	0.592
DOC_MAPK_MEF2A_6	74	83	PF00069	0.643
DOC_PP1_RVXF_1	106	112	PF00149	0.408
DOC_PP2B_LxvP_1	22	25	PF13499	0.702
DOC_USP7_MATH_1	25	29	PF00917	0.612
DOC_USP7_MATH_1	314	318	PF00917	0.738
DOC_WW_Pin1_4	12	17	PF00397	0.679
DOC_WW_Pin1_4	23	28	PF00397	0.659
DOC_WW_Pin1_4	233	238	PF00397	0.618
DOC_WW_Pin1_4	310	315	PF00397	0.703
LIG_14-3-3_CanoR_1	108	112	PF00244	0.668
LIG_14-3-3_CanoR_1	120	129	PF00244	0.639
LIG_14-3-3_CanoR_1	224	231	PF00244	0.440
LIG_14-3-3_CanoR_1	244	250	PF00244	0.651
LIG_14-3-3_CanoR_1	253	263	PF00244	0.557
LIG_14-3-3_CanoR_1	43	47	PF00244	0.621
LIG_14-3-3_CanoR_1	51	59	PF00244	0.643
LIG_14-3-3_CterR_2	390	393	PF00244	0.456
LIG_Actin_WH2_2	311	329	PF00022	0.646
LIG_APCC_ABBA_1	375	380	PF00400	0.429
LIG_BIR_II_1	1	5	PF00653	0.473
LIG_BRCT_BRCA1_1	247	251	PF00533	0.668
LIG_FHA_1	201	207	PF00498	0.674
LIG_FHA_1	24	30	PF00498	0.661
LIG_FHA_1	310	316	PF00498	0.663
LIG_FHA_2	139	145	PF00498	0.639
LIG_FHA_2	215	221	PF00498	0.579
LIG_FHA_2	379	385	PF00498	0.705
LIG_Integrin_RGD_1	214	216	PF01839	0.698
LIG_LIR_Gen_1	145	154	PF02991	0.771
LIG_LIR_Gen_1	169	178	PF02991	0.673
LIG_LIR_Nem_3	145	151	PF02991	0.757
LIG_LIR_Nem_3	169	173	PF02991	0.621
LIG_PCNA_yPIPBox_3	73	87	PF02747	0.558
LIG_PDZ_Class_1	388	393	PF00595	0.531
LIG_SH2_CRK	170	174	PF00017	0.629
LIG_SH2_PTP2	234	237	PF00017	0.448
LIG_SH2_SRC	174	177	PF00017	0.523
LIG_SH2_STAP1	174	178	PF00017	0.500
LIG_SH2_STAT3	55	58	PF00017	0.534
LIG_SH2_STAT5	234	237	PF00017	0.448
LIG_SH2_STAT5	55	58	PF00017	0.609
LIG_SH3_3	21	27	PF00018	0.669
LIG_SH3_3	8	14	PF00018	0.736
LIG_SUMO_SIM_par_1	360	367	PF11976	0.636
LIG_TRAF2_1	236	239	PF00917	0.443
LIG_TRAF2_1	321	324	PF00917	0.646
MOD_CK1_1	166	172	PF00069	0.664
MOD_CK1_1	205	211	PF00069	0.481
MOD_CK1_1	257	263	PF00069	0.499
MOD_CK1_1	310	316	PF00069	0.717
MOD_CK1_1	317	323	PF00069	0.717
MOD_CK2_1	154	160	PF00069	0.679
MOD_CK2_1	192	198	PF00069	0.726
MOD_CK2_1	214	220	PF00069	0.560
MOD_CK2_1	233	239	PF00069	0.705
MOD_CK2_1	317	323	PF00069	0.615
MOD_DYRK1A_RPxSP_1	12	16	PF00069	0.733
MOD_GlcNHglycan	115	118	PF01048	0.685
MOD_GlcNHglycan	133	136	PF01048	0.721
MOD_GlcNHglycan	157	160	PF01048	0.685
MOD_GlcNHglycan	226	229	PF01048	0.556
MOD_GlcNHglycan	256	259	PF01048	0.556
MOD_GlcNHglycan	31	34	PF01048	0.536
MOD_GlcNHglycan	320	323	PF01048	0.582
MOD_GlcNHglycan	332	336	PF01048	0.644
MOD_GlcNHglycan	339	342	PF01048	0.757
MOD_GlcNHglycan	347	350	PF01048	0.595
MOD_GSK3_1	107	114	PF00069	0.625
MOD_GSK3_1	118	125	PF00069	0.569
MOD_GSK3_1	138	145	PF00069	0.717
MOD_GSK3_1	149	156	PF00069	0.531
MOD_GSK3_1	159	166	PF00069	0.508
MOD_GSK3_1	200	207	PF00069	0.692
MOD_GSK3_1	233	240	PF00069	0.505
MOD_GSK3_1	25	32	PF00069	0.624
MOD_GSK3_1	310	317	PF00069	0.667
MOD_GSK3_1	385	392	PF00069	0.739
MOD_N-GLC_1	245	250	PF02516	0.697
MOD_NEK2_1	122	127	PF00069	0.648
MOD_NEK2_1	154	159	PF00069	0.655
MOD_NEK2_1	209	214	PF00069	0.513
MOD_NEK2_1	331	336	PF00069	0.710
MOD_NEK2_1	385	390	PF00069	0.662
MOD_NEK2_2	107	112	PF00069	0.639
MOD_PIKK_1	183	189	PF00454	0.400
MOD_PIKK_1	297	303	PF00454	0.686
MOD_PK_1	202	208	PF00069	0.513
MOD_PKA_1	265	271	PF00069	0.566
MOD_PKA_2	107	113	PF00069	0.665
MOD_PKA_2	154	160	PF00069	0.701
MOD_PKA_2	265	271	PF00069	0.637
MOD_PKA_2	304	310	PF00069	0.725
MOD_PKA_2	42	48	PF00069	0.564
MOD_PKA_2	50	56	PF00069	0.522
MOD_Plk_1	237	243	PF00069	0.572
MOD_Plk_1	245	251	PF00069	0.582
MOD_Plk_1	284	290	PF00069	0.623
MOD_Plk_1	385	391	PF00069	0.642
MOD_Plk_2-3	144	150	PF00069	0.695
MOD_Plk_4	205	211	PF00069	0.457
MOD_Plk_4	314	320	PF00069	0.722
MOD_Plk_4	42	48	PF00069	0.555
MOD_Plk_4	6	12	PF00069	0.669
MOD_ProDKin_1	12	18	PF00069	0.681
MOD_ProDKin_1	23	29	PF00069	0.657
MOD_ProDKin_1	233	239	PF00069	0.618
MOD_ProDKin_1	310	316	PF00069	0.699
MOD_SUMO_rev_2	348	354	PF00179	0.751
TRG_DiLeu_BaEn_4	104	110	PF01217	0.388
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.566
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.694
TRG_ENDOCYTIC_2	170	173	PF00928	0.560
TRG_ER_diArg_1	20	22	PF00400	0.667
TRG_ER_diArg_1	265	267	PF00400	0.567
TRG_ER_diArg_1	326	328	PF00400	0.725
TRG_ER_diArg_1	73	75	PF00400	0.535
TRG_PTS1	390	393	PF00515	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S5	Leptomonas seymouri	45%	86%
A0A1X0NNN8	Trypanosomatidae	25%	72%
A0A3R7MBM6	Trypanosoma rangeli	25%	77%
A0A3S5H6M8	Leishmania donovani	89%	71%
A4H714	Leishmania braziliensis	75%	100%
A4HVE2	Leishmania infantum	88%	71%
Q4QGE8	Leishmania major	87%	100%