| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 6 |
| NetGPI | no | yes: 0, no: 6 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005737 | cytoplasm | 2 | 7 |
| GO:0110165 | cellular anatomical entity | 1 | 7 |
| GO:0032299 | ribonuclease H2 complex | 3 | 1 |
| GO:0032991 | protein-containing complex | 1 | 1 |
| GO:0140535 | intracellular protein-containing complex | 2 | 1 |
| GO:1902494 | catalytic complex | 2 | 1 |
Related structures:
AlphaFold database: E9AP39
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 1 |
| GO:0006259 | DNA metabolic process | 4 | 1 |
| GO:0006281 | DNA repair | 5 | 1 |
| GO:0006298 | mismatch repair | 6 | 1 |
| GO:0006401 | RNA catabolic process | 5 | 1 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 1 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 1 |
| GO:0006950 | response to stress | 2 | 1 |
| GO:0006974 | DNA damage response | 4 | 1 |
| GO:0008152 | metabolic process | 1 | 1 |
| GO:0009056 | catabolic process | 2 | 1 |
| GO:0009057 | macromolecule catabolic process | 4 | 1 |
| GO:0009987 | cellular process | 1 | 1 |
| GO:0016070 | RNA metabolic process | 5 | 1 |
| GO:0019439 | aromatic compound catabolic process | 4 | 1 |
| GO:0033554 | cellular response to stress | 3 | 1 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 1 |
| GO:0034655 | nucleobase-containing compound catabolic process | 4 | 1 |
| GO:0043137 | DNA replication, removal of RNA primer | 6 | 1 |
| GO:0043170 | macromolecule metabolic process | 3 | 1 |
| GO:0044237 | cellular metabolic process | 2 | 1 |
| GO:0044238 | primary metabolic process | 2 | 1 |
| GO:0044248 | cellular catabolic process | 3 | 1 |
| GO:0044260 | obsolete cellular macromolecule metabolic process | 3 | 1 |
| GO:0044265 | obsolete cellular macromolecule catabolic process | 4 | 1 |
| GO:0044270 | cellular nitrogen compound catabolic process | 4 | 1 |
| GO:0046483 | heterocycle metabolic process | 3 | 1 |
| GO:0046700 | heterocycle catabolic process | 4 | 1 |
| GO:0050896 | response to stimulus | 1 | 1 |
| GO:0051716 | cellular response to stimulus | 2 | 1 |
| GO:0071704 | organic substance metabolic process | 2 | 1 |
| GO:0090304 | nucleic acid metabolic process | 4 | 1 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 1 |
| GO:1901361 | organic cyclic compound catabolic process | 4 | 1 |
| GO:1901575 | organic substance catabolic process | 3 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | 3 | 7 |
| GO:0003723 | RNA binding | 4 | 7 |
| GO:0003824 | catalytic activity | 1 | 7 |
| GO:0004518 | nuclease activity | 4 | 7 |
| GO:0004519 | endonuclease activity | 5 | 7 |
| GO:0004521 | RNA endonuclease activity | 5 | 7 |
| GO:0004523 | RNA-DNA hybrid ribonuclease activity | 7 | 7 |
| GO:0004540 | RNA nuclease activity | 4 | 7 |
| GO:0005488 | binding | 1 | 7 |
| GO:0016787 | hydrolase activity | 2 | 7 |
| GO:0016788 | hydrolase activity, acting on ester bonds | 3 | 7 |
| GO:0016891 | RNA endonuclease activity, producing 5'-phosphomonoesters | 6 | 7 |
| GO:0016893 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 6 | 7 |
| GO:0043167 | ion binding | 2 | 7 |
| GO:0043169 | cation binding | 3 | 7 |
| GO:0046872 | metal ion binding | 4 | 7 |
| GO:0097159 | organic cyclic compound binding | 2 | 7 |
| GO:0140098 | catalytic activity, acting on RNA | 3 | 7 |
| GO:0140640 | catalytic activity, acting on a nucleic acid | 2 | 7 |
| GO:1901363 | heterocyclic compound binding | 2 | 7 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 44 | 48 | PF00656 | 0.563 |
| CLV_C14_Caspase3-7 | 57 | 61 | PF00656 | 0.474 |
| CLV_NRD_NRD_1 | 152 | 154 | PF00675 | 0.609 |
| CLV_NRD_NRD_1 | 157 | 159 | PF00675 | 0.566 |
| CLV_NRD_NRD_1 | 70 | 72 | PF00675 | 0.529 |
| CLV_PCSK_KEX2_1 | 159 | 161 | PF00082 | 0.580 |
| CLV_PCSK_KEX2_1 | 257 | 259 | PF00082 | 0.688 |
| CLV_PCSK_KEX2_1 | 70 | 72 | PF00082 | 0.529 |
| CLV_PCSK_PC1ET2_1 | 159 | 161 | PF00082 | 0.580 |
| CLV_PCSK_PC1ET2_1 | 257 | 259 | PF00082 | 0.688 |
| CLV_PCSK_SKI1_1 | 27 | 31 | PF00082 | 0.563 |
| CLV_PCSK_SKI1_1 | 90 | 94 | PF00082 | 0.579 |
| DEG_APCC_DBOX_1 | 70 | 78 | PF00400 | 0.550 |
| DEG_APCC_KENBOX_2 | 29 | 33 | PF00400 | 0.325 |
| DOC_CKS1_1 | 119 | 124 | PF01111 | 0.378 |
| DOC_MAPK_gen_1 | 194 | 204 | PF00069 | 0.520 |
| DOC_USP7_MATH_1 | 187 | 191 | PF00917 | 0.520 |
| DOC_WW_Pin1_4 | 118 | 123 | PF00397 | 0.446 |
| DOC_WW_Pin1_4 | 14 | 19 | PF00397 | 0.493 |
| DOC_WW_Pin1_4 | 232 | 237 | PF00397 | 0.489 |
| DOC_WW_Pin1_4 | 256 | 261 | PF00397 | 0.663 |
| LIG_14-3-3_CanoR_1 | 13 | 21 | PF00244 | 0.479 |
| LIG_14-3-3_CanoR_1 | 133 | 139 | PF00244 | 0.466 |
| LIG_14-3-3_CanoR_1 | 258 | 264 | PF00244 | 0.657 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.442 |
| LIG_BIR_III_1 | 1 | 5 | PF00653 | 0.442 |
| LIG_BIR_III_3 | 1 | 5 | PF00653 | 0.442 |
| LIG_FHA_1 | 122 | 128 | PF00498 | 0.534 |
| LIG_FHA_1 | 172 | 178 | PF00498 | 0.593 |
| LIG_FHA_2 | 55 | 61 | PF00498 | 0.614 |
| LIG_LIR_Gen_1 | 110 | 119 | PF02991 | 0.584 |
| LIG_LIR_Gen_1 | 235 | 245 | PF02991 | 0.593 |
| LIG_LIR_Nem_3 | 164 | 168 | PF02991 | 0.481 |
| LIG_LIR_Nem_3 | 235 | 240 | PF02991 | 0.539 |
| LIG_LIR_Nem_3 | 241 | 245 | PF02991 | 0.499 |
| LIG_LYPXL_yS_3 | 165 | 168 | PF13949 | 0.593 |
| LIG_SH2_CRK | 242 | 246 | PF00017 | 0.520 |
| LIG_SH2_NCK_1 | 21 | 25 | PF00017 | 0.334 |
| LIG_SH2_SRC | 242 | 245 | PF00017 | 0.520 |
| LIG_SH2_STAP1 | 200 | 204 | PF00017 | 0.505 |
| LIG_SH2_STAT5 | 220 | 223 | PF00017 | 0.505 |
| LIG_SUMO_SIM_anti_2 | 115 | 121 | PF11976 | 0.290 |
| LIG_SUMO_SIM_anti_2 | 83 | 89 | PF11976 | 0.456 |
| LIG_SUMO_SIM_par_1 | 80 | 85 | PF11976 | 0.545 |
| LIG_TRAF2_1 | 140 | 143 | PF00917 | 0.646 |
| LIG_TYR_ITIM | 163 | 168 | PF00017 | 0.488 |
| LIG_TYR_ITIM | 19 | 24 | PF00017 | 0.454 |
| LIG_TYR_ITIM | 240 | 245 | PF00017 | 0.520 |
| MOD_CDK_SPxK_1 | 14 | 20 | PF00069 | 0.534 |
| MOD_CDK_SPxxK_3 | 232 | 239 | PF00069 | 0.385 |
| MOD_CK1_1 | 115 | 121 | PF00069 | 0.290 |
| MOD_CK2_1 | 137 | 143 | PF00069 | 0.615 |
| MOD_CK2_1 | 45 | 51 | PF00069 | 0.369 |
| MOD_GlcNHglycan | 100 | 103 | PF01048 | 0.454 |
| MOD_GlcNHglycan | 114 | 117 | PF01048 | 0.371 |
| MOD_GlcNHglycan | 139 | 142 | PF01048 | 0.556 |
| MOD_GlcNHglycan | 14 | 17 | PF01048 | 0.485 |
| MOD_GlcNHglycan | 252 | 255 | PF01048 | 0.560 |
| MOD_GlcNHglycan | 47 | 50 | PF01048 | 0.422 |
| MOD_N-GLC_1 | 93 | 98 | PF02516 | 0.451 |
| MOD_NEK2_1 | 171 | 176 | PF00069 | 0.563 |
| MOD_NEK2_1 | 45 | 50 | PF00069 | 0.528 |
| MOD_NEK2_1 | 53 | 58 | PF00069 | 0.539 |
| MOD_PKA_2 | 12 | 18 | PF00069 | 0.473 |
| MOD_Plk_1 | 179 | 185 | PF00069 | 0.593 |
| MOD_Plk_1 | 82 | 88 | PF00069 | 0.493 |
| MOD_Plk_1 | 93 | 99 | PF00069 | 0.366 |
| MOD_Plk_4 | 115 | 121 | PF00069 | 0.451 |
| MOD_Plk_4 | 172 | 178 | PF00069 | 0.543 |
| MOD_Plk_4 | 179 | 185 | PF00069 | 0.506 |
| MOD_Plk_4 | 187 | 193 | PF00069 | 0.465 |
| MOD_Plk_4 | 200 | 206 | PF00069 | 0.520 |
| MOD_Plk_4 | 7 | 13 | PF00069 | 0.437 |
| MOD_Plk_4 | 82 | 88 | PF00069 | 0.448 |
| MOD_ProDKin_1 | 118 | 124 | PF00069 | 0.448 |
| MOD_ProDKin_1 | 14 | 20 | PF00069 | 0.498 |
| MOD_ProDKin_1 | 232 | 238 | PF00069 | 0.489 |
| MOD_ProDKin_1 | 256 | 262 | PF00069 | 0.697 |
| TRG_ENDOCYTIC_2 | 111 | 114 | PF00928 | 0.565 |
| TRG_ENDOCYTIC_2 | 165 | 168 | PF00928 | 0.583 |
| TRG_ENDOCYTIC_2 | 21 | 24 | PF00928 | 0.553 |
| TRG_ENDOCYTIC_2 | 242 | 245 | PF00928 | 0.520 |
| TRG_ER_diArg_1 | 144 | 147 | PF00400 | 0.574 |
| TRG_ER_diArg_1 | 158 | 161 | PF00400 | 0.516 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1IHU4 | Leptomonas seymouri | 64% | 94% |
| A0A0S4J8A1 | Bodo saltans | 25% | 100% |
| A0A3S7WSB6 | Leishmania donovani | 93% | 100% |
| A0L4Z0 | Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) | 29% | 100% |
| A1B3V0 | Paracoccus denitrificans (strain Pd 1222) | 31% | 100% |
| A1K6Q7 | Azoarcus sp. (strain BH72) | 34% | 100% |
| A1KMP6 | Mycobacterium bovis (strain BCG / Pasteur 1173P2) | 28% | 100% |
| A1T759 | Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1) | 31% | 100% |
| A1U3P0 | Marinobacter nauticus (strain ATCC 700491 / DSM 11845 / VT8) | 32% | 100% |
| A2SH85 | Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1) | 31% | 100% |
| A3DDG7 | Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) | 26% | 100% |
| A3QG89 | Shewanella loihica (strain ATCC BAA-1088 / PV-4) | 33% | 100% |
| A4H713 | Leishmania braziliensis | 80% | 100% |
| A4HVE1 | Leishmania infantum | 93% | 100% |
| A4VJT5 | Pseudomonas stutzeri (strain A1501) | 30% | 100% |
| A5FIL7 | Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101) | 26% | 100% |
| A5U6Q7 | Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) | 28% | 100% |
| A5VF46 | Rhizorhabdus wittichii (strain DSM 6014 / CCUG 31198 / JCM 15750 / NBRC 105917 / EY 4224 / RW1) | 33% | 100% |
| A5WDY2 | Psychrobacter sp. (strain PRwf-1) | 36% | 89% |
| A6GYW0 | Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86) | 29% | 100% |
| A6V1E6 | Pseudomonas aeruginosa (strain PA7) | 31% | 100% |
| A6VUT6 | Marinomonas sp. (strain MWYL1) | 30% | 100% |
| A6WLC0 | Shewanella baltica (strain OS185) | 31% | 100% |
| A7HQZ3 | Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) | 28% | 100% |
| B0U235 | Xylella fastidiosa (strain M12) | 30% | 100% |
| B1GZ18 | Endomicrobium trichonymphae | 29% | 100% |
| B1IQF8 | Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) | 31% | 100% |
| B1LGY5 | Escherichia coli (strain SMS-3-5 / SECEC) | 31% | 100% |
| B2I7N7 | Xylella fastidiosa (strain M23) | 30% | 100% |
| B2T5I0 | Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) | 30% | 100% |
| B2U326 | Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) | 31% | 100% |
| B3CM59 | Wolbachia pipientis subsp. Culex pipiens (strain wPip) | 26% | 100% |
| B3PRG0 | Rhizobium etli (strain CIAT 652) | 34% | 100% |
| B5EBC6 | Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem) | 31% | 100% |
| B5Z0G2 | Escherichia coli O157:H7 (strain EC4115 / EHEC) | 31% | 100% |
| B5ZS20 | Rhizobium leguminosarum bv. trifolii (strain WSM2304) | 34% | 100% |
| B7LW62 | Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) | 31% | 100% |
| B7MP43 | Escherichia coli O81 (strain ED1a) | 31% | 100% |
| B7N850 | Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) | 31% | 100% |
| B7NIE5 | Escherichia coli O7:K1 (strain IAI39 / ExPEC) | 31% | 100% |
| B7UJ84 | Escherichia coli O127:H6 (strain E2348/69 / EPEC) | 31% | 100% |
| B7V7U6 | Pseudomonas aeruginosa (strain LESB58) | 31% | 100% |
| B8E7Q2 | Shewanella baltica (strain OS223) | 31% | 100% |
| B8GQ66 | Thioalkalivibrio sulfidiphilus (strain HL-EbGR7) | 31% | 100% |
| B9M597 | Geotalea daltonii (strain DSM 22248 / JCM 15807 / FRC-32) | 35% | 100% |
| C1AG17 | Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019) | 28% | 100% |
| P9WH00 | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) | 28% | 100% |
| P9WH01 | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | 28% | 100% |
| Q02RB4 | Pseudomonas aeruginosa (strain UCBPP-PA14) | 31% | 100% |
| Q0A7J3 | Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1) | 33% | 100% |
| Q0AEI5 | Nitrosomonas eutropha (strain DSM 101675 / C91 / Nm57) | 27% | 100% |
| Q0BYK9 | Hyphomonas neptunium (strain ATCC 15444) | 31% | 100% |
| Q0TLF0 | Escherichia coli O6:K15:H31 (strain 536 / UPEC) | 31% | 100% |
| Q12A45 | Polaromonas sp. (strain JS666 / ATCC BAA-500) | 28% | 100% |
| Q13XD0 | Paraburkholderia xenovorans (strain LB400) | 30% | 100% |
| Q18BC9 | Clostridioides difficile (strain 630) | 26% | 100% |
| Q1MKS7 | Rhizobium leguminosarum bv. viciae (strain 3841) | 35% | 100% |
| Q1QAL9 | Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5) | 34% | 94% |
| Q21HI6 | Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) | 31% | 100% |
| Q21WX6 | Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) | 29% | 100% |
| Q2GFP8 | Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas) | 27% | 100% |
| Q2KBV7 | Rhizobium etli (strain CFN 42 / ATCC 51251) | 35% | 100% |
| Q325V7 | Shigella boydii serotype 4 (strain Sb227) | 31% | 100% |
| Q3YST1 | Ehrlichia canis (strain Jake) | 26% | 100% |
| Q470F1 | Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) | 28% | 100% |
| Q48F73 | Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) | 34% | 100% |
| Q4FPF7 | Pelagibacter ubique (strain HTCC1062) | 27% | 100% |
| Q4FT93 | Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4) | 35% | 93% |
| Q4QGE9 | Leishmania major | 91% | 100% |
| Q5LIL2 | Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) | 32% | 100% |
| Q5NZG1 | Aromatoleum aromaticum (strain EbN1) | 32% | 100% |
| Q5WFP1 | Alkalihalobacillus clausii (strain KSM-K16) | 33% | 100% |
| Q64ZN7 | Bacteroides fragilis (strain YCH46) | 32% | 100% |
| Q6MLA0 | Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100) | 29% | 100% |
| Q73G60 | Wolbachia pipientis wMel | 26% | 100% |
| Q7NPS3 | Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757) | 34% | 100% |
| Q82U06 | Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298) | 32% | 100% |
| Q87EI6 | Xylella fastidiosa (strain Temecula1 / ATCC 700964) | 30% | 100% |
| Q886M9 | Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) | 34% | 100% |
| Q8A293 | Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) | 31% | 100% |
| Q8FL06 | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) | 31% | 100% |
| Q8PML9 | Xanthomonas axonopodis pv. citri (strain 306) | 33% | 100% |
| Q8X8X6 | Escherichia coli O157:H7 | 31% | 100% |
| Q9HXY9 | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 31% | 100% |
| Q9PEI7 | Xylella fastidiosa (strain 9a5c) | 30% | 100% |
| Q9Z962 | Chlamydia pneumoniae | 28% | 100% |