Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP38_LEIMU

TriTrypDb:

LmxM.13.0040

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.386
CLV_NRD_NRD_1	159	161	PF00675	0.493
CLV_NRD_NRD_1	49	51	PF00675	0.399
CLV_NRD_NRD_1	82	84	PF00675	0.480
CLV_PCSK_FUR_1	113	117	PF00082	0.412
CLV_PCSK_KEX2_1	115	117	PF00082	0.576
CLV_PCSK_KEX2_1	135	137	PF00082	0.613
CLV_PCSK_KEX2_1	159	161	PF00082	0.493
CLV_PCSK_KEX2_1	49	51	PF00082	0.427
CLV_PCSK_KEX2_1	59	61	PF00082	0.344
CLV_PCSK_KEX2_1	82	84	PF00082	0.425
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.488
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.613
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.348
CLV_PCSK_SKI1_1	105	109	PF00082	0.460
CLV_PCSK_SKI1_1	229	233	PF00082	0.460
CLV_PCSK_SKI1_1	273	277	PF00082	0.450
DEG_APCC_DBOX_1	102	110	PF00400	0.458
DEG_APCC_DBOX_1	172	180	PF00400	0.337
DOC_MAPK_gen_1	113	122	PF00069	0.436
DOC_USP7_MATH_1	137	141	PF00917	0.635
DOC_USP7_MATH_1	146	150	PF00917	0.529
DOC_USP7_MATH_1	22	26	PF00917	0.599
DOC_WW_Pin1_4	140	145	PF00397	0.634
LIG_14-3-3_CanoR_1	105	110	PF00244	0.478
LIG_14-3-3_CanoR_1	136	146	PF00244	0.592
LIG_14-3-3_CanoR_1	202	208	PF00244	0.585
LIG_14-3-3_CanoR_1	217	221	PF00244	0.421
LIG_14-3-3_CanoR_1	273	280	PF00244	0.471
LIG_14-3-3_CanoR_1	49	54	PF00244	0.511
LIG_Actin_WH2_2	67	84	PF00022	0.355
LIG_FHA_1	150	156	PF00498	0.494
LIG_FHA_1	164	170	PF00498	0.436
LIG_FHA_2	194	200	PF00498	0.560
LIG_FHA_2	217	223	PF00498	0.395
LIG_FHA_2	254	260	PF00498	0.489
LIG_FHA_2	35	41	PF00498	0.646
LIG_LIR_Gen_1	123	132	PF02991	0.439
LIG_LIR_Gen_1	256	266	PF02991	0.473
LIG_LIR_Nem_3	123	129	PF02991	0.437
LIG_LIR_Nem_3	256	261	PF02991	0.501
LIG_PTAP_UEV_1	279	284	PF05743	0.485
LIG_SH2_GRB2like	151	154	PF00017	0.496
LIG_SH2_STAP1	151	155	PF00017	0.492
LIG_SH2_STAT5	151	154	PF00017	0.496
LIG_SH3_3	277	283	PF00018	0.511
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.444
MOD_CK1_1	140	146	PF00069	0.506
MOD_CK1_1	149	155	PF00069	0.392
MOD_CK1_1	52	58	PF00069	0.542
MOD_CK2_1	220	226	PF00069	0.472
MOD_GlcNHglycan	187	190	PF01048	0.496
MOD_GlcNHglycan	25	28	PF01048	0.636
MOD_GSK3_1	142	149	PF00069	0.473
MOD_GSK3_1	216	223	PF00069	0.430
MOD_GSK3_1	7	14	PF00069	0.503
MOD_N-GLC_1	227	232	PF02516	0.338
MOD_NEK2_1	1	6	PF00069	0.613
MOD_NEK2_1	169	174	PF00069	0.497
MOD_NEK2_1	288	293	PF00069	0.556
MOD_NEK2_1	94	99	PF00069	0.318
MOD_PIKK_1	137	143	PF00454	0.544
MOD_PIKK_1	43	49	PF00454	0.620
MOD_PIKK_1	61	67	PF00454	0.424
MOD_PIKK_1	7	13	PF00454	0.618
MOD_PK_1	232	238	PF00069	0.491
MOD_PK_1	49	55	PF00069	0.358
MOD_PKA_1	49	55	PF00069	0.387
MOD_PKA_2	201	207	PF00069	0.617
MOD_PKA_2	216	222	PF00069	0.420
MOD_PKA_2	49	55	PF00069	0.524
MOD_PKB_1	103	111	PF00069	0.389
MOD_Plk_1	169	175	PF00069	0.498
MOD_Plk_1	227	233	PF00069	0.348
MOD_Plk_4	216	222	PF00069	0.420
MOD_Plk_4	253	259	PF00069	0.522
MOD_Plk_4	283	289	PF00069	0.552
MOD_Plk_4	49	55	PF00069	0.516
MOD_ProDKin_1	140	146	PF00069	0.630
MOD_SUMO_rev_2	86	92	PF00179	0.486
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.482
TRG_ER_diArg_1	102	105	PF00400	0.428
TRG_ER_diArg_1	173	176	PF00400	0.491
TRG_ER_diArg_1	81	83	PF00400	0.489
TRG_ER_diArg_1	98	101	PF00400	0.353
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V4	Leptomonas seymouri	56%	92%
A0A3Q8IBM3	Leishmania donovani	87%	100%
A4H712	Leishmania braziliensis	67%	100%
A4HVE0	Leishmania infantum	87%	100%
Q4QGF0	Leishmania major	84%	100%