Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP37_LEIMU

TriTrypDb:

LmxM.13.0030

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.723
CLV_NRD_NRD_1	36	38	PF00675	0.433
CLV_NRD_NRD_1	46	48	PF00675	0.449
CLV_PCSK_KEX2_1	36	38	PF00082	0.552
CLV_PCSK_SKI1_1	122	126	PF00082	0.589
CLV_PCSK_SKI1_1	189	193	PF00082	0.633
DEG_APCC_DBOX_1	121	129	PF00400	0.585
DOC_CKS1_1	132	137	PF01111	0.540
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.449
DOC_PP1_RVXF_1	170	176	PF00149	0.613
DOC_USP7_MATH_1	105	109	PF00917	0.525
DOC_USP7_MATH_1	120	124	PF00917	0.522
DOC_WW_Pin1_4	131	136	PF00397	0.494
DOC_WW_Pin1_4	145	150	PF00397	0.370
LIG_14-3-3_CanoR_1	167	175	PF00244	0.533
LIG_14-3-3_CanoR_1	47	51	PF00244	0.599
LIG_BIR_II_1	1	5	PF00653	0.566
LIG_BIR_III_1	1	5	PF00653	0.579
LIG_BIR_III_3	1	5	PF00653	0.579
LIG_FHA_1	132	138	PF00498	0.549
LIG_FHA_1	96	102	PF00498	0.496
LIG_FHA_2	58	64	PF00498	0.439
LIG_LIR_Gen_1	81	87	PF02991	0.439
LIG_LIR_Nem_3	145	150	PF02991	0.500
LIG_PCNA_yPIPBox_3	174	187	PF02747	0.378
LIG_PTB_Apo_2	127	134	PF02174	0.595
LIG_PTB_Phospho_1	127	133	PF10480	0.596
LIG_SH2_CRK	133	137	PF00017	0.421
LIG_SH2_NCK_1	28	32	PF00017	0.547
LIG_SH2_STAT3	75	78	PF00017	0.465
LIG_SH2_STAT5	133	136	PF00017	0.481
LIG_SH2_STAT5	144	147	PF00017	0.391
LIG_SUMO_SIM_anti_2	123	129	PF11976	0.578
LIG_SUMO_SIM_anti_2	156	163	PF11976	0.621
MOD_CK1_1	86	92	PF00069	0.558
MOD_CK2_1	57	63	PF00069	0.432
MOD_GSK3_1	145	152	PF00069	0.515
MOD_GSK3_1	155	162	PF00069	0.480
MOD_GSK3_1	42	49	PF00069	0.504
MOD_N-GLC_1	167	172	PF02516	0.627
MOD_N-GLC_1	42	47	PF02516	0.491
MOD_NEK2_1	66	71	PF00069	0.449
MOD_NEK2_2	142	147	PF00069	0.489
MOD_PIKK_1	113	119	PF00454	0.662
MOD_PIKK_1	66	72	PF00454	0.558
MOD_PIKK_1	86	92	PF00454	0.364
MOD_PKA_2	166	172	PF00069	0.512
MOD_PKA_2	46	52	PF00069	0.594
MOD_Plk_4	142	148	PF00069	0.504
MOD_Plk_4	155	161	PF00069	0.474
MOD_Plk_4	46	52	PF00069	0.496
MOD_ProDKin_1	131	137	PF00069	0.491
MOD_ProDKin_1	145	151	PF00069	0.370
MOD_SUMO_rev_2	42	50	PF00179	0.531
TRG_ENDOCYTIC_2	133	136	PF00928	0.443
TRG_ENDOCYTIC_2	144	147	PF00928	0.466
TRG_ENDOCYTIC_2	28	31	PF00928	0.618
TRG_ER_diArg_1	172	175	PF00400	0.573
TRG_ER_diArg_1	36	39	PF00400	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBD1	Leptomonas seymouri	66%	100%
A0A1X0NGP9	Trypanosomatidae	53%	96%
A0A3R7KHE2	Trypanosoma rangeli	51%	97%
A0A3S7WS88	Leishmania donovani	94%	100%
A4H711	Leishmania braziliensis	81%	100%
A4HVD9	Leishmania infantum	94%	100%
C9ZTQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
Q4QGF1	Leishmania major	94%	100%