Alkyl transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Alkyl transferase

Gene product:

cis-prenyltransferase-like protein

Species:

Leishmania mexicana

UniProt:

E9AP36_LEIMU

TriTrypDb:

LmxM.13.0020

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AP36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP36

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006720	isoprenoid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016093	polyprenol metabolic process	4	1
GO:0016094	polyprenol biosynthetic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046165	alcohol biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12
GO:0002094	polyprenyltransferase activity	5	1
GO:0004659	prenyltransferase activity	4	5
GO:0008834	di-trans,poly-cis-decaprenylcistransferase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.212
CLV_NRD_NRD_1	213	215	PF00675	0.444
CLV_NRD_NRD_1	255	257	PF00675	0.441
CLV_NRD_NRD_1	281	283	PF00675	0.477
CLV_NRD_NRD_1	382	384	PF00675	0.422
CLV_NRD_NRD_1	385	387	PF00675	0.415
CLV_NRD_NRD_1	97	99	PF00675	0.482
CLV_PCSK_FUR_1	144	148	PF00082	0.423
CLV_PCSK_FUR_1	383	387	PF00082	0.408
CLV_PCSK_KEX2_1	146	148	PF00082	0.501
CLV_PCSK_KEX2_1	255	257	PF00082	0.422
CLV_PCSK_KEX2_1	281	283	PF00082	0.452
CLV_PCSK_KEX2_1	382	384	PF00082	0.411
CLV_PCSK_KEX2_1	385	387	PF00082	0.406
CLV_PCSK_KEX2_1	97	99	PF00082	0.482
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.512
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.480
CLV_PCSK_PC7_1	277	283	PF00082	0.512
CLV_PCSK_SKI1_1	102	106	PF00082	0.446
CLV_PCSK_SKI1_1	215	219	PF00082	0.451
CLV_PCSK_SKI1_1	220	224	PF00082	0.415
CLV_PCSK_SKI1_1	256	260	PF00082	0.477
CLV_PCSK_SKI1_1	306	310	PF00082	0.416
CLV_PCSK_SKI1_1	374	378	PF00082	0.423
CLV_PCSK_SKI1_1	72	76	PF00082	0.675
CLV_Separin_Metazoa	307	311	PF03568	0.275
DEG_APCC_DBOX_1	305	313	PF00400	0.299
DOC_CDC14_PxL_1	122	130	PF14671	0.241
DOC_MAPK_gen_1	255	263	PF00069	0.225
DOC_MAPK_MEF2A_6	255	263	PF00069	0.222
DOC_PP1_RVXF_1	235	242	PF00149	0.255
DOC_PP4_FxxP_1	232	235	PF00568	0.238
DOC_USP7_MATH_1	110	114	PF00917	0.425
DOC_USP7_MATH_1	201	205	PF00917	0.261
DOC_USP7_MATH_1	68	72	PF00917	0.490
LIG_14-3-3_CanoR_1	102	112	PF00244	0.346
LIG_14-3-3_CanoR_1	16	21	PF00244	0.634
LIG_14-3-3_CanoR_1	225	231	PF00244	0.257
LIG_Actin_WH2_2	322	340	PF00022	0.257
LIG_Actin_WH2_2	44	62	PF00022	0.264
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BRCT_BRCA1_1	203	207	PF00533	0.353
LIG_FHA_1	247	253	PF00498	0.303
LIG_FHA_1	35	41	PF00498	0.381
LIG_FHA_2	298	304	PF00498	0.257
LIG_FHA_2	311	317	PF00498	0.195
LIG_FHA_2	337	343	PF00498	0.208
LIG_FHA_2	362	368	PF00498	0.209
LIG_FHA_2	379	385	PF00498	0.264
LIG_LIR_Apic_2	189	195	PF02991	0.275
LIG_LIR_Apic_2	229	235	PF02991	0.223
LIG_LIR_Gen_1	352	361	PF02991	0.211
LIG_LIR_Nem_3	204	210	PF02991	0.219
LIG_LIR_Nem_3	346	351	PF02991	0.219
LIG_LIR_Nem_3	352	358	PF02991	0.208
LIG_LIR_Nem_3	362	368	PF02991	0.208
LIG_LIR_Nem_3	37	41	PF02991	0.335
LIG_MLH1_MIPbox_1	203	207	PF16413	0.223
LIG_NRP_CendR_1	386	389	PF00754	0.459
LIG_Pex14_2	206	210	PF04695	0.208
LIG_REV1ctd_RIR_1	206	216	PF16727	0.233
LIG_RPA_C_Fungi	272	284	PF08784	0.388
LIG_SH2_NCK_1	351	355	PF00017	0.258
LIG_SH2_STAP1	351	355	PF00017	0.246
LIG_SH2_STAT3	265	268	PF00017	0.388
LIG_SH3_3	248	254	PF00018	0.143
LIG_SUMO_SIM_par_1	165	172	PF11976	0.217
LIG_SUMO_SIM_par_1	27	33	PF11976	0.487
LIG_TRAF2_1	300	303	PF00917	0.177
LIG_TRFH_1	232	236	PF08558	0.264
LIG_WW_3	234	238	PF00397	0.388
MOD_CK1_1	266	272	PF00069	0.388
MOD_CK1_1	286	292	PF00069	0.122
MOD_CK1_1	378	384	PF00069	0.209
MOD_CK2_1	130	136	PF00069	0.540
MOD_CK2_1	297	303	PF00069	0.258
MOD_CK2_1	310	316	PF00069	0.265
MOD_CK2_1	336	342	PF00069	0.243
MOD_CK2_1	361	367	PF00069	0.194
MOD_CK2_1	378	384	PF00069	0.343
MOD_GlcNHglycan	132	135	PF01048	0.484
MOD_GlcNHglycan	265	268	PF01048	0.272
MOD_GlcNHglycan	285	289	PF01048	0.198
MOD_GlcNHglycan	290	293	PF01048	0.308
MOD_GlcNHglycan	339	342	PF01048	0.243
MOD_GSK3_1	284	291	PF00069	0.284
MOD_GSK3_1	30	37	PF00069	0.271
MOD_GSK3_1	68	75	PF00069	0.611
MOD_N-GLC_1	22	27	PF02516	0.551
MOD_N-GLC_2	260	262	PF02516	0.243
MOD_NEK2_1	128	133	PF00069	0.484
MOD_NEK2_1	283	288	PF00069	0.222
MOD_NEK2_1	308	313	PF00069	0.243
MOD_NEK2_1	361	366	PF00069	0.232
MOD_NEK2_1	59	64	PF00069	0.663
MOD_NEK2_2	201	206	PF00069	0.386
MOD_PIKK_1	22	28	PF00454	0.343
MOD_PIKK_1	310	316	PF00454	0.248
MOD_PKA_2	246	252	PF00069	0.445
MOD_PKA_2	283	289	PF00069	0.308
MOD_PKA_2	337	343	PF00069	0.243
MOD_PKA_2	68	74	PF00069	0.632
MOD_PKB_1	282	290	PF00069	0.308
MOD_Plk_1	327	333	PF00069	0.309
MOD_Plk_1	361	367	PF00069	0.202
MOD_Plk_4	110	116	PF00069	0.514
MOD_Plk_4	180	186	PF00069	0.258
MOD_Plk_4	201	207	PF00069	0.238
TRG_DiLeu_BaEn_1	198	203	PF01217	0.243
TRG_DiLeu_BaEn_2	218	224	PF01217	0.314
TRG_ENDOCYTIC_2	145	148	PF00928	0.316
TRG_ENDOCYTIC_2	355	358	PF00928	0.243
TRG_ER_diArg_1	254	256	PF00400	0.260
TRG_ER_diArg_1	281	284	PF00400	0.341
TRG_ER_diArg_1	97	99	PF00400	0.346
TRG_ER_diLys_1	385	389	PF00400	0.370
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P394	Leptomonas seymouri	57%	100%
A0A0S4JA70	Bodo saltans	48%	88%
A0A1X0NGI2	Trypanosomatidae	47%	96%
A0A3S7WSB2	Leishmania donovani	89%	99%
A0A422NM12	Trypanosoma rangeli	47%	94%
A0R2W4	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	29%	100%
A4H710	Leishmania braziliensis	76%	100%
A4HVD8	Leishmania infantum	90%	99%
C9ZTQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	93%
K4CA50	Solanum lycopersicum	27%	100%
K7W9N9	Solanum lycopersicum	28%	100%
K7X479	Solanum lycopersicum	27%	100%
O59258	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	30%	100%
Q4QGF2	Leishmania major	87%	100%
Q7V6T7	Prochlorococcus marinus (strain MIT 9313)	32%	100%
Q7VBI9	Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)	30%	100%
Q82BS5	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	29%	100%
Q8EGH1	Shewanella oneidensis (strain MR-1)	27%	100%
Q8G7Y3	Bifidobacterium longum (strain NCC 2705)	23%	100%
Q8GDY3	Heliobacterium mobile	30%	100%
Q8GY03	Arabidopsis thaliana	26%	100%
Q8RX73	Arabidopsis thaliana	26%	100%
Q9ACU1	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	29%	69%
V5BT78	Trypanosoma cruzi	47%	94%