Putative serine peptidase (Serine peptidase, clan sc, family s9d)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase domain-containing protein

Species:

Leishmania mexicana

UniProt:

E9AP33_LEIMU

TriTrypDb:

LmxM.12.1330

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AP33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP33

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0019538	protein metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016787	hydrolase activity	2	4
GO:0008233	peptidase activity	3	3
GO:0008236	serine-type peptidase activity	4	3
GO:0017171	serine hydrolase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.455
CLV_C14_Caspase3-7	406	410	PF00656	0.570
CLV_C14_Caspase3-7	6	10	PF00656	0.603
CLV_NRD_NRD_1	126	128	PF00675	0.492
CLV_NRD_NRD_1	354	356	PF00675	0.446
CLV_PCSK_KEX2_1	126	128	PF00082	0.492
CLV_PCSK_KEX2_1	443	445	PF00082	0.521
CLV_PCSK_KEX2_1	487	489	PF00082	0.359
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.508
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.286
CLV_PCSK_SKI1_1	135	139	PF00082	0.351
CLV_PCSK_SKI1_1	21	25	PF00082	0.591
CLV_PCSK_SKI1_1	266	270	PF00082	0.562
CLV_PCSK_SKI1_1	281	285	PF00082	0.564
CLV_PCSK_SKI1_1	369	373	PF00082	0.515
CLV_PCSK_SKI1_1	444	448	PF00082	0.400
DEG_APCC_DBOX_1	159	167	PF00400	0.460
DEG_SCF_FBW7_2	104	111	PF00400	0.523
DEG_SPOP_SBC_1	536	540	PF00917	0.560
DOC_CDC14_PxL_1	411	419	PF14671	0.520
DOC_CYCLIN_yCln2_LP_2	166	172	PF00134	0.439
DOC_CYCLIN_yCln2_LP_2	412	418	PF00134	0.594
DOC_MAPK_JIP1_4	160	166	PF00069	0.414
DOC_MAPK_MEF2A_6	88	96	PF00069	0.416
DOC_PP1_RVXF_1	11	18	PF00149	0.548
DOC_PP1_RVXF_1	474	481	PF00149	0.400
DOC_PP2B_LxvP_1	275	278	PF13499	0.533
DOC_PP2B_LxvP_1	412	415	PF13499	0.561
DOC_PP4_FxxP_1	129	132	PF00568	0.441
DOC_PP4_FxxP_1	154	157	PF00568	0.539
DOC_PP4_FxxP_1	17	20	PF00568	0.456
DOC_PP4_FxxP_1	320	323	PF00568	0.424
DOC_USP7_MATH_1	285	289	PF00917	0.366
DOC_USP7_MATH_1	308	312	PF00917	0.532
DOC_USP7_MATH_1	419	423	PF00917	0.601
DOC_USP7_MATH_1	516	520	PF00917	0.669
DOC_USP7_MATH_1	536	540	PF00917	0.471
DOC_WW_Pin1_4	104	109	PF00397	0.568
DOC_WW_Pin1_4	143	148	PF00397	0.427
DOC_WW_Pin1_4	379	384	PF00397	0.368
DOC_WW_Pin1_4	432	437	PF00397	0.427
DOC_WW_Pin1_4	512	517	PF00397	0.640
LIG_14-3-3_CanoR_1	266	275	PF00244	0.564
LIG_14-3-3_CanoR_1	392	399	PF00244	0.553
LIG_14-3-3_CanoR_1	444	450	PF00244	0.509
LIG_14-3-3_CanoR_1	514	522	PF00244	0.698
LIG_14-3-3_CanoR_1	535	545	PF00244	0.583
LIG_14-3-3_CanoR_1	560	565	PF00244	0.532
LIG_Actin_WH2_2	592	607	PF00022	0.514
LIG_Actin_WH2_2	71	86	PF00022	0.497
LIG_BRCT_BRCA1_1	13	17	PF00533	0.509
LIG_BRCT_BRCA1_1	279	283	PF00533	0.393
LIG_BRCT_BRCA1_1	316	320	PF00533	0.552
LIG_BRCT_BRCA1_1	523	527	PF00533	0.559
LIG_deltaCOP1_diTrp_1	532	537	PF00928	0.476
LIG_FHA_1	196	202	PF00498	0.369
LIG_FHA_1	217	223	PF00498	0.560
LIG_FHA_1	267	273	PF00498	0.569
LIG_FHA_1	331	337	PF00498	0.418
LIG_FHA_1	394	400	PF00498	0.566
LIG_FHA_1	421	427	PF00498	0.481
LIG_FHA_1	433	439	PF00498	0.367
LIG_FHA_1	61	67	PF00498	0.419
LIG_FHA_1	611	617	PF00498	0.661
LIG_FHA_2	302	308	PF00498	0.467
LIG_FHA_2	404	410	PF00498	0.593
LIG_FHA_2	446	452	PF00498	0.449
LIG_FHA_2	480	486	PF00498	0.465
LIG_HCF-1_HBM_1	223	226	PF13415	0.517
LIG_LIR_Apic_2	14	20	PF02991	0.460
LIG_LIR_Apic_2	317	323	PF02991	0.419
LIG_LIR_Apic_2	532	536	PF02991	0.477
LIG_LIR_Apic_2	600	606	PF02991	0.535
LIG_LIR_Gen_1	120	129	PF02991	0.401
LIG_LIR_Gen_1	288	294	PF02991	0.333
LIG_LIR_Gen_1	326	336	PF02991	0.409
LIG_LIR_Gen_1	524	534	PF02991	0.529
LIG_LIR_Gen_1	590	601	PF02991	0.477
LIG_LIR_Nem_3	120	125	PF02991	0.363
LIG_LIR_Nem_3	288	293	PF02991	0.321
LIG_LIR_Nem_3	326	332	PF02991	0.422
LIG_LIR_Nem_3	52	56	PF02991	0.383
LIG_LIR_Nem_3	524	530	PF02991	0.536
LIG_LIR_Nem_3	551	557	PF02991	0.441
LIG_LIR_Nem_3	590	596	PF02991	0.427
LIG_LIR_Nem_3	98	102	PF02991	0.347
LIG_MAD2	266	274	PF02301	0.569
LIG_MYND_1	274	278	PF01753	0.482
LIG_MYND_1	415	419	PF01753	0.320
LIG_NRBOX	327	333	PF00104	0.387
LIG_NRBOX	488	494	PF00104	0.470
LIG_PCNA_PIPBox_1	116	125	PF02747	0.489
LIG_PCNA_yPIPBox_3	116	127	PF02747	0.472
LIG_PDZ_Class_1	615	620	PF00595	0.683
LIG_Pex14_2	150	154	PF04695	0.510
LIG_PTB_Apo_2	45	52	PF02174	0.511
LIG_PTB_Apo_2	503	510	PF02174	0.440
LIG_PTB_Phospho_1	503	509	PF10480	0.435
LIG_SH2_CRK	290	294	PF00017	0.469
LIG_SH2_CRK	350	354	PF00017	0.510
LIG_SH2_CRK	53	57	PF00017	0.392
LIG_SH2_NCK_1	68	72	PF00017	0.442
LIG_SH2_PTP2	329	332	PF00017	0.399
LIG_SH2_SRC	68	71	PF00017	0.433
LIG_SH2_STAP1	290	294	PF00017	0.410
LIG_SH2_STAT3	226	229	PF00017	0.508
LIG_SH2_STAT3	242	245	PF00017	0.435
LIG_SH2_STAT5	122	125	PF00017	0.356
LIG_SH2_STAT5	128	131	PF00017	0.376
LIG_SH2_STAT5	242	245	PF00017	0.481
LIG_SH2_STAT5	329	332	PF00017	0.398
LIG_SH2_STAT5	350	353	PF00017	0.374
LIG_SH2_STAT5	55	58	PF00017	0.424
LIG_SH2_STAT5	557	560	PF00017	0.421
LIG_SH2_STAT5	593	596	PF00017	0.549
LIG_SH2_STAT5	603	606	PF00017	0.404
LIG_SH2_STAT5	85	88	PF00017	0.389
LIG_SH3_3	202	208	PF00018	0.389
LIG_SH3_3	32	38	PF00018	0.456
LIG_SH3_5	553	557	PF00018	0.546
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.390
LIG_SUMO_SIM_anti_2	91	96	PF11976	0.408
LIG_SUMO_SIM_par_1	197	204	PF11976	0.521
LIG_SUMO_SIM_par_1	422	431	PF11976	0.557
LIG_TRAF2_1	526	529	PF00917	0.544
LIG_TRAF2_1	575	578	PF00917	0.548
LIG_TRAF2_1	582	585	PF00917	0.523
LIG_UBA3_1	272	281	PF00899	0.581
LIG_UBA3_1	438	443	PF00899	0.483
LIG_WRC_WIRS_1	336	341	PF05994	0.326
MOD_CK1_1	255	261	PF00069	0.529
MOD_CK1_1	335	341	PF00069	0.395
MOD_CK1_1	515	521	PF00069	0.627
MOD_CK1_1	523	529	PF00069	0.584
MOD_CK1_1	610	616	PF00069	0.449
MOD_CK2_1	392	398	PF00069	0.581
MOD_CK2_1	425	431	PF00069	0.409
MOD_CK2_1	523	529	PF00069	0.574
MOD_CK2_1	572	578	PF00069	0.530
MOD_GlcNHglycan	119	122	PF01048	0.340
MOD_GlcNHglycan	255	258	PF01048	0.451
MOD_GlcNHglycan	296	300	PF01048	0.489
MOD_GlcNHglycan	467	470	PF01048	0.481
MOD_GlcNHglycan	598	602	PF01048	0.562
MOD_GlcNHglycan	98	102	PF01048	0.441
MOD_GSK3_1	139	146	PF00069	0.448
MOD_GSK3_1	21	28	PF00069	0.521
MOD_GSK3_1	212	219	PF00069	0.536
MOD_GSK3_1	498	505	PF00069	0.463
MOD_GSK3_1	512	519	PF00069	0.527
MOD_GSK3_1	536	543	PF00069	0.626
MOD_GSK3_1	583	590	PF00069	0.493
MOD_GSK3_1	84	91	PF00069	0.389
MOD_N-GLC_1	21	26	PF02516	0.303
MOD_N-GLC_1	215	220	PF02516	0.470
MOD_N-GLC_1	252	257	PF02516	0.450
MOD_N-GLC_1	285	290	PF02516	0.263
MOD_N-GLC_1	393	398	PF02516	0.631
MOD_N-GLC_1	502	507	PF02516	0.602
MOD_N-GLC_1	570	575	PF02516	0.531
MOD_N-GLC_2	357	359	PF02516	0.553
MOD_NEK2_1	11	16	PF00069	0.462
MOD_NEK2_1	332	337	PF00069	0.350
MOD_NEK2_1	558	563	PF00069	0.550
MOD_NEK2_1	570	575	PF00069	0.519
MOD_NEK2_1	97	102	PF00069	0.380
MOD_NEK2_2	285	290	PF00069	0.363
MOD_NEK2_2	314	319	PF00069	0.523
MOD_NEK2_2	403	408	PF00069	0.587
MOD_OFUCOSY	401	407	PF10250	0.585
MOD_PIKK_1	178	184	PF00454	0.577
MOD_PK_1	560	566	PF00069	0.485
MOD_PK_1	88	94	PF00069	0.468
MOD_PKA_2	231	237	PF00069	0.528
MOD_PKA_2	365	371	PF00069	0.478
MOD_PKA_2	540	546	PF00069	0.665
MOD_PKA_2	604	610	PF00069	0.544
MOD_PKB_1	264	272	PF00069	0.566
MOD_Plk_1	110	116	PF00069	0.402
MOD_Plk_1	21	27	PF00069	0.365
MOD_Plk_1	215	221	PF00069	0.544
MOD_Plk_1	222	228	PF00069	0.491
MOD_Plk_1	285	291	PF00069	0.250
MOD_Plk_1	570	576	PF00069	0.457
MOD_Plk_1	88	94	PF00069	0.432
MOD_Plk_2-3	572	578	PF00069	0.564
MOD_Plk_4	11	17	PF00069	0.437
MOD_Plk_4	238	244	PF00069	0.523
MOD_Plk_4	255	261	PF00069	0.504
MOD_Plk_4	285	291	PF00069	0.311
MOD_Plk_4	308	314	PF00069	0.488
MOD_Plk_4	425	431	PF00069	0.435
MOD_Plk_4	591	597	PF00069	0.540
MOD_ProDKin_1	104	110	PF00069	0.567
MOD_ProDKin_1	143	149	PF00069	0.426
MOD_ProDKin_1	379	385	PF00069	0.367
MOD_ProDKin_1	432	438	PF00069	0.423
MOD_ProDKin_1	512	518	PF00069	0.645
MOD_SUMO_rev_2	483	489	PF00179	0.280
TRG_DiLeu_BaEn_3	456	462	PF01217	0.389
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.487
TRG_ENDOCYTIC_2	122	125	PF00928	0.364
TRG_ENDOCYTIC_2	128	131	PF00928	0.383
TRG_ENDOCYTIC_2	193	196	PF00928	0.412
TRG_ENDOCYTIC_2	290	293	PF00928	0.414
TRG_ENDOCYTIC_2	329	332	PF00928	0.399
TRG_ENDOCYTIC_2	350	353	PF00928	0.483
TRG_ENDOCYTIC_2	509	512	PF00928	0.550
TRG_ENDOCYTIC_2	53	56	PF00928	0.394
TRG_ENDOCYTIC_2	593	596	PF00928	0.510
TRG_ENDOCYTIC_2	80	83	PF00928	0.478
TRG_ER_diArg_1	125	127	PF00400	0.481
TRG_ER_diArg_1	559	562	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4W3	Leptomonas seymouri	65%	100%
A0A0S4IVT2	Bodo saltans	22%	78%
A0A1X0NMT5	Trypanosomatidae	39%	100%
A0A3S7WSC7	Leishmania donovani	93%	100%
A0A422NV23	Trypanosoma rangeli	40%	100%
C9ZI47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	83%
E9AGJ6	Leishmania infantum	93%	100%
E9AIN2	Leishmania braziliensis	84%	100%
Q4QGF5	Leishmania major	93%	100%
V5BP52	Trypanosoma cruzi	39%	100%