CNH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative

Species:

Leishmania mexicana

UniProt:

E9AP32_LEIMU

TriTrypDb:

LmxM.12.1320

Length:

971

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AP32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP32

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0016192	vesicle-mediated transport	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0006906	vesicle fusion	6	1
GO:0006914	autophagy	3	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0034058	endosomal vesicle fusion	7	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0061919	process utilizing autophagic mechanism	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	607	611	PF00656	0.590
CLV_C14_Caspase3-7	68	72	PF00656	0.494
CLV_C14_Caspase3-7	848	852	PF00656	0.447
CLV_MEL_PAP_1	49	55	PF00089	0.356
CLV_NRD_NRD_1	144	146	PF00675	0.417
CLV_NRD_NRD_1	186	188	PF00675	0.457
CLV_NRD_NRD_1	387	389	PF00675	0.373
CLV_NRD_NRD_1	526	528	PF00675	0.402
CLV_NRD_NRD_1	630	632	PF00675	0.474
CLV_NRD_NRD_1	73	75	PF00675	0.542
CLV_NRD_NRD_1	782	784	PF00675	0.521
CLV_NRD_NRD_1	86	88	PF00675	0.463
CLV_NRD_NRD_1	925	927	PF00675	0.438
CLV_PCSK_FUR_1	524	528	PF00082	0.402
CLV_PCSK_KEX2_1	146	148	PF00082	0.509
CLV_PCSK_KEX2_1	387	389	PF00082	0.459
CLV_PCSK_KEX2_1	526	528	PF00082	0.402
CLV_PCSK_KEX2_1	629	631	PF00082	0.462
CLV_PCSK_KEX2_1	73	75	PF00082	0.542
CLV_PCSK_KEX2_1	782	784	PF00082	0.495
CLV_PCSK_KEX2_1	86	88	PF00082	0.463
CLV_PCSK_KEX2_1	925	927	PF00082	0.428
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.509
CLV_PCSK_SKI1_1	115	119	PF00082	0.512
CLV_PCSK_SKI1_1	146	150	PF00082	0.445
CLV_PCSK_SKI1_1	234	238	PF00082	0.500
CLV_PCSK_SKI1_1	306	310	PF00082	0.522
CLV_PCSK_SKI1_1	465	469	PF00082	0.524
CLV_PCSK_SKI1_1	567	571	PF00082	0.535
CLV_PCSK_SKI1_1	658	662	PF00082	0.556
CLV_PCSK_SKI1_1	688	692	PF00082	0.522
CLV_PCSK_SKI1_1	730	734	PF00082	0.574
CLV_PCSK_SKI1_1	746	750	PF00082	0.486
CLV_PCSK_SKI1_1	78	82	PF00082	0.432
CLV_PCSK_SKI1_1	86	90	PF00082	0.350
CLV_Separin_Metazoa	506	510	PF03568	0.402
DEG_APCC_DBOX_1	566	574	PF00400	0.435
DEG_APCC_DBOX_1	85	93	PF00400	0.500
DEG_Nend_UBRbox_3	1	3	PF02207	0.725
DEG_SCF_FBW7_2	250	257	PF00400	0.606
DEG_SPOP_SBC_1	198	202	PF00917	0.448
DOC_CKS1_1	204	209	PF01111	0.601
DOC_CKS1_1	251	256	PF01111	0.605
DOC_CYCLIN_RxL_1	33	44	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.561
DOC_MAPK_gen_1	132	142	PF00069	0.421
DOC_MAPK_gen_1	524	534	PF00069	0.480
DOC_MAPK_gen_1	715	725	PF00069	0.538
DOC_MAPK_gen_1	86	92	PF00069	0.489
DOC_MAPK_gen_1	925	935	PF00069	0.428
DOC_MAPK_MEF2A_6	526	534	PF00069	0.476
DOC_MAPK_RevD_3	769	784	PF00069	0.287
DOC_PP1_RVXF_1	144	151	PF00149	0.466
DOC_PP1_RVXF_1	171	178	PF00149	0.397
DOC_PP1_RVXF_1	246	252	PF00149	0.589
DOC_PP1_RVXF_1	34	41	PF00149	0.460
DOC_PP1_RVXF_1	656	662	PF00149	0.539
DOC_PP2B_LxvP_1	214	217	PF13499	0.524
DOC_PP2B_LxvP_1	443	446	PF13499	0.577
DOC_PP4_FxxP_1	428	431	PF00568	0.544
DOC_PP4_FxxP_1	725	728	PF00568	0.611
DOC_USP7_MATH_1	105	109	PF00917	0.555
DOC_USP7_MATH_1	198	202	PF00917	0.483
DOC_USP7_MATH_1	244	248	PF00917	0.587
DOC_USP7_MATH_1	321	325	PF00917	0.518
DOC_USP7_MATH_1	350	354	PF00917	0.479
DOC_USP7_MATH_1	434	438	PF00917	0.563
DOC_USP7_MATH_1	608	612	PF00917	0.576
DOC_USP7_MATH_1	652	656	PF00917	0.375
DOC_USP7_MATH_1	813	817	PF00917	0.622
DOC_USP7_MATH_1	866	870	PF00917	0.480
DOC_WW_Pin1_4	203	208	PF00397	0.562
DOC_WW_Pin1_4	209	214	PF00397	0.545
DOC_WW_Pin1_4	250	255	PF00397	0.540
DOC_WW_Pin1_4	332	337	PF00397	0.519
DOC_WW_Pin1_4	432	437	PF00397	0.630
DOC_WW_Pin1_4	683	688	PF00397	0.607
DOC_WW_Pin1_4	724	729	PF00397	0.582
DOC_WW_Pin1_4	749	754	PF00397	0.587
DOC_WW_Pin1_4	831	836	PF00397	0.584
LIG_14-3-3_CanoR_1	135	141	PF00244	0.410
LIG_14-3-3_CanoR_1	145	151	PF00244	0.425
LIG_14-3-3_CanoR_1	17	22	PF00244	0.525
LIG_14-3-3_CanoR_1	351	361	PF00244	0.504
LIG_14-3-3_CanoR_1	658	667	PF00244	0.502
LIG_14-3-3_CanoR_1	704	710	PF00244	0.540
LIG_14-3-3_CanoR_1	78	83	PF00244	0.454
LIG_14-3-3_CanoR_1	788	794	PF00244	0.338
LIG_14-3-3_CanoR_1	836	844	PF00244	0.553
LIG_14-3-3_CanoR_1	884	892	PF00244	0.400
LIG_14-3-3_CanoR_1	906	914	PF00244	0.487
LIG_Actin_WH2_2	110	126	PF00022	0.503
LIG_APCC_ABBA_1	697	702	PF00400	0.468
LIG_FHA_1	163	169	PF00498	0.505
LIG_FHA_1	198	204	PF00498	0.527
LIG_FHA_1	210	216	PF00498	0.413
LIG_FHA_1	274	280	PF00498	0.349
LIG_FHA_1	299	305	PF00498	0.477
LIG_FHA_1	531	537	PF00498	0.482
LIG_FHA_1	558	564	PF00498	0.645
LIG_FHA_1	684	690	PF00498	0.577
LIG_FHA_1	790	796	PF00498	0.323
LIG_FHA_1	819	825	PF00498	0.525
LIG_FHA_1	832	838	PF00498	0.616
LIG_FHA_2	147	153	PF00498	0.464
LIG_FHA_2	154	160	PF00498	0.511
LIG_FHA_2	283	289	PF00498	0.575
LIG_FHA_2	676	682	PF00498	0.532
LIG_FHA_2	731	737	PF00498	0.560
LIG_FHA_2	945	951	PF00498	0.360
LIG_FHA_2	954	960	PF00498	0.438
LIG_HCF-1_HBM_1	261	264	PF13415	0.514
LIG_HP1_1	687	691	PF01393	0.268
LIG_Integrin_RGD_1	583	585	PF01839	0.354
LIG_LIR_Apic_2	201	207	PF02991	0.465
LIG_LIR_Apic_2	257	263	PF02991	0.418
LIG_LIR_Apic_2	722	728	PF02991	0.584
LIG_LIR_Gen_1	296	307	PF02991	0.492
LIG_LIR_Gen_1	494	503	PF02991	0.454
LIG_LIR_Gen_1	694	705	PF02991	0.419
LIG_LIR_Gen_1	817	828	PF02991	0.426
LIG_LIR_Gen_1	886	895	PF02991	0.383
LIG_LIR_Gen_1	963	971	PF02991	0.631
LIG_LIR_Nem_3	14	19	PF02991	0.487
LIG_LIR_Nem_3	296	302	PF02991	0.487
LIG_LIR_Nem_3	33	38	PF02991	0.511
LIG_LIR_Nem_3	694	700	PF02991	0.394
LIG_LIR_Nem_3	714	720	PF02991	0.209
LIG_LIR_Nem_3	817	823	PF02991	0.436
LIG_LIR_Nem_3	886	892	PF02991	0.383
LIG_LIR_Nem_3	963	968	PF02991	0.573
LIG_NRBOX	157	163	PF00104	0.584
LIG_NRBOX	232	238	PF00104	0.568
LIG_NRBOX	503	509	PF00104	0.480
LIG_NRBOX	531	537	PF00104	0.480
LIG_NRBOX	719	725	PF00104	0.433
LIG_NRBOX	823	829	PF00104	0.436
LIG_PCNA_yPIPBox_3	583	597	PF02747	0.541
LIG_PDZ_Class_3	966	971	PF00595	0.577
LIG_Pex14_2	636	640	PF04695	0.471
LIG_PTAP_UEV_1	269	274	PF05743	0.641
LIG_REV1ctd_RIR_1	625	631	PF16727	0.497
LIG_RPA_C_Fungi	130	142	PF08784	0.435
LIG_RPA_C_Fungi	778	790	PF08784	0.548
LIG_SH2_CRK	16	20	PF00017	0.519
LIG_SH2_CRK	35	39	PF00017	0.516
LIG_SH2_CRK	820	824	PF00017	0.475
LIG_SH2_CRK	889	893	PF00017	0.408
LIG_SH2_NCK_1	260	264	PF00017	0.513
LIG_SH2_NCK_1	542	546	PF00017	0.402
LIG_SH2_SRC	260	263	PF00017	0.402
LIG_SH2_SRC	542	545	PF00017	0.480
LIG_SH2_SRC	812	815	PF00017	0.634
LIG_SH2_STAP1	318	322	PF00017	0.569
LIG_SH2_STAP1	542	546	PF00017	0.447
LIG_SH2_STAP1	669	673	PF00017	0.431
LIG_SH2_STAP1	713	717	PF00017	0.511
LIG_SH2_STAP1	807	811	PF00017	0.431
LIG_SH2_STAP1	820	824	PF00017	0.408
LIG_SH2_STAP1	889	893	PF00017	0.389
LIG_SH2_STAT3	587	590	PF00017	0.505
LIG_SH2_STAT3	695	698	PF00017	0.524
LIG_SH2_STAT5	190	193	PF00017	0.393
LIG_SH2_STAT5	264	267	PF00017	0.418
LIG_SH2_STAT5	347	350	PF00017	0.390
LIG_SH2_STAT5	404	407	PF00017	0.469
LIG_SH2_STAT5	460	463	PF00017	0.465
LIG_SH2_STAT5	587	590	PF00017	0.482
LIG_SH2_STAT5	679	682	PF00017	0.578
LIG_SH2_STAT5	695	698	PF00017	0.491
LIG_SH2_STAT5	763	766	PF00017	0.459
LIG_SH2_STAT5	820	823	PF00017	0.475
LIG_SH3_3	161	167	PF00018	0.544
LIG_SH3_3	214	220	PF00018	0.482
LIG_SH3_3	267	273	PF00018	0.548
LIG_SH3_3	276	282	PF00018	0.378
LIG_SH3_3	433	439	PF00018	0.614
LIG_SH3_3	473	479	PF00018	0.512
LIG_SH3_3	704	710	PF00018	0.601
LIG_SH3_3	854	860	PF00018	0.355
LIG_SUMO_SIM_anti_2	518	523	PF11976	0.354
LIG_SUMO_SIM_anti_2	838	846	PF11976	0.369
LIG_SUMO_SIM_par_1	159	165	PF11976	0.320
LIG_SUMO_SIM_par_1	532	537	PF11976	0.490
LIG_SUMO_SIM_par_1	689	694	PF11976	0.500
LIG_SUMO_SIM_par_1	88	94	PF11976	0.383
LIG_TRAF2_1	734	737	PF00917	0.652
LIG_Vh1_VBS_1	605	623	PF01044	0.498
LIG_WRC_WIRS_1	492	497	PF05994	0.424
MOD_CDC14_SPxK_1	727	730	PF00782	0.665
MOD_CDK_SPK_2	203	208	PF00069	0.592
MOD_CDK_SPK_2	683	688	PF00069	0.607
MOD_CDK_SPK_2	831	836	PF00069	0.592
MOD_CDK_SPxK_1	724	730	PF00069	0.624
MOD_CK1_1	107	113	PF00069	0.565
MOD_CK1_1	196	202	PF00069	0.537
MOD_CK1_1	209	215	PF00069	0.454
MOD_CK1_1	31	37	PF00069	0.411
MOD_CK1_1	413	419	PF00069	0.512
MOD_CK1_1	599	605	PF00069	0.580
MOD_CK1_1	609	615	PF00069	0.457
MOD_CK1_1	662	668	PF00069	0.448
MOD_CK1_1	900	906	PF00069	0.363
MOD_CK2_1	146	152	PF00069	0.443
MOD_CK2_1	282	288	PF00069	0.522
MOD_CK2_1	409	415	PF00069	0.531
MOD_CK2_1	551	557	PF00069	0.327
MOD_CK2_1	635	641	PF00069	0.513
MOD_CK2_1	675	681	PF00069	0.521
MOD_CK2_1	730	736	PF00069	0.537
MOD_CK2_1	944	950	PF00069	0.492
MOD_Cter_Amidation	185	188	PF01082	0.513
MOD_Cter_Amidation	84	87	PF01082	0.537
MOD_GlcNHglycan	107	110	PF01048	0.612
MOD_GlcNHglycan	208	211	PF01048	0.567
MOD_GlcNHglycan	270	273	PF01048	0.580
MOD_GlcNHglycan	471	474	PF01048	0.589
MOD_GlcNHglycan	58	61	PF01048	0.561
MOD_GlcNHglycan	601	604	PF01048	0.610
MOD_GlcNHglycan	606	609	PF01048	0.544
MOD_GlcNHglycan	654	657	PF01048	0.367
MOD_GlcNHglycan	663	667	PF01048	0.331
MOD_GlcNHglycan	669	672	PF01048	0.257
MOD_GlcNHglycan	758	761	PF01048	0.551
MOD_GlcNHglycan	885	888	PF01048	0.367
MOD_GlcNHglycan	889	892	PF01048	0.382
MOD_GSK3_1	193	200	PF00069	0.566
MOD_GSK3_1	264	271	PF00069	0.482
MOD_GSK3_1	30	37	PF00069	0.524
MOD_GSK3_1	409	416	PF00069	0.565
MOD_GSK3_1	595	602	PF00069	0.545
MOD_GSK3_1	604	611	PF00069	0.530
MOD_GSK3_1	616	623	PF00069	0.375
MOD_GSK3_1	677	684	PF00069	0.525
MOD_GSK3_1	724	731	PF00069	0.595
MOD_GSK3_1	814	821	PF00069	0.593
MOD_GSK3_1	831	838	PF00069	0.410
MOD_GSK3_1	883	890	PF00069	0.404
MOD_LATS_1	781	787	PF00433	0.587
MOD_N-GLC_1	56	61	PF02516	0.396
MOD_N-GLC_1	878	883	PF02516	0.434
MOD_N-GLC_2	512	514	PF02516	0.331
MOD_N-GLC_2	845	847	PF02516	0.408
MOD_NEK2_1	123	128	PF00069	0.431
MOD_NEK2_1	160	165	PF00069	0.570
MOD_NEK2_1	178	183	PF00069	0.503
MOD_NEK2_1	349	354	PF00069	0.529
MOD_NEK2_1	491	496	PF00069	0.474
MOD_NEK2_1	748	753	PF00069	0.398
MOD_NEK2_2	789	794	PF00069	0.411
MOD_NEK2_2	807	812	PF00069	0.440
MOD_PIKK_1	460	466	PF00454	0.544
MOD_PIKK_1	544	550	PF00454	0.480
MOD_PIKK_1	562	568	PF00454	0.451
MOD_PIKK_1	897	903	PF00454	0.285
MOD_PK_1	28	34	PF00069	0.426
MOD_PKA_1	146	152	PF00069	0.420
MOD_PKA_1	783	789	PF00069	0.521
MOD_PKA_2	146	152	PF00069	0.503
MOD_PKA_2	350	356	PF00069	0.508
MOD_PKA_2	835	841	PF00069	0.523
MOD_PKA_2	883	889	PF00069	0.389
MOD_PKA_2	905	911	PF00069	0.486
MOD_PKB_1	926	934	PF00069	0.480
MOD_Plk_1	115	121	PF00069	0.484
MOD_Plk_1	288	294	PF00069	0.641
MOD_Plk_1	409	415	PF00069	0.551
MOD_Plk_1	609	615	PF00069	0.514
MOD_Plk_1	802	808	PF00069	0.575
MOD_Plk_1	878	884	PF00069	0.434
MOD_Plk_2-3	410	416	PF00069	0.571
MOD_Plk_4	146	152	PF00069	0.467
MOD_Plk_4	173	179	PF00069	0.492
MOD_Plk_4	199	205	PF00069	0.637
MOD_Plk_4	445	451	PF00069	0.395
MOD_Plk_4	530	536	PF00069	0.442
MOD_Plk_4	61	67	PF00069	0.547
MOD_Plk_4	635	641	PF00069	0.529
MOD_Plk_4	642	648	PF00069	0.460
MOD_Plk_4	78	84	PF00069	0.537
MOD_Plk_4	867	873	PF00069	0.476
MOD_Plk_4	928	934	PF00069	0.408
MOD_ProDKin_1	203	209	PF00069	0.568
MOD_ProDKin_1	250	256	PF00069	0.538
MOD_ProDKin_1	332	338	PF00069	0.510
MOD_ProDKin_1	432	438	PF00069	0.627
MOD_ProDKin_1	683	689	PF00069	0.601
MOD_ProDKin_1	724	730	PF00069	0.593
MOD_ProDKin_1	749	755	PF00069	0.581
MOD_ProDKin_1	831	837	PF00069	0.577
MOD_SUMO_rev_2	44	49	PF00179	0.475
TRG_AP2beta_CARGO_1	694	704	PF09066	0.551
TRG_DiLeu_BaEn_4	736	742	PF01217	0.566
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.514
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.519
TRG_ENDOCYTIC_2	16	19	PF00928	0.467
TRG_ENDOCYTIC_2	299	302	PF00928	0.558
TRG_ENDOCYTIC_2	35	38	PF00928	0.333
TRG_ENDOCYTIC_2	637	640	PF00928	0.448
TRG_ENDOCYTIC_2	820	823	PF00928	0.550
TRG_ENDOCYTIC_2	889	892	PF00928	0.408
TRG_ENDOCYTIC_2	965	968	PF00928	0.577
TRG_ER_diArg_1	145	148	PF00400	0.536
TRG_ER_diArg_1	386	388	PF00400	0.382
TRG_ER_diArg_1	628	631	PF00400	0.454
TRG_ER_diArg_1	738	741	PF00400	0.466
TRG_ER_diArg_1	86	88	PF00400	0.523
TRG_ER_diArg_1	925	928	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	631	635	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	925	930	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT4	Leptomonas seymouri	52%	99%
A0A1X0NP42	Trypanosomatidae	28%	97%
A0A3R7M5A4	Trypanosoma rangeli	31%	99%
A0A3S7WSC2	Leishmania donovani	90%	100%
C9ZI46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	94%
E9AGJ5	Leishmania infantum	91%	100%
E9AIN3	Leishmania braziliensis	81%	100%
Q4QGF6	Leishmania major	89%	100%
V5BF34	Trypanosoma cruzi	32%	98%