Histone deacetylase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Histone deacetylase

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP29_LEIMU

TriTrypDb:

LmxM.12.1290

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	197	199	PF00675	0.567
CLV_NRD_NRD_1	55	57	PF00675	0.562
CLV_PCSK_FUR_1	195	199	PF00082	0.563
CLV_PCSK_KEX2_1	195	197	PF00082	0.558
CLV_PCSK_KEX2_1	200	202	PF00082	0.587
CLV_PCSK_KEX2_1	55	57	PF00082	0.478
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.583
CLV_PCSK_PC7_1	196	202	PF00082	0.559
CLV_PCSK_SKI1_1	56	60	PF00082	0.619
DEG_Nend_UBRbox_2	1	3	PF02207	0.716
DOC_PP1_RVXF_1	88	94	PF00149	0.455
DOC_PP4_FxxP_1	139	142	PF00568	0.632
DOC_WW_Pin1_4	1	6	PF00397	0.514
LIG_14-3-3_CanoR_1	90	94	PF00244	0.550
LIG_Actin_WH2_2	89	104	PF00022	0.435
LIG_EH1_1	158	166	PF00400	0.432
LIG_EVH1_2	123	127	PF00568	0.558
LIG_FHA_1	123	129	PF00498	0.609
LIG_FHA_1	138	144	PF00498	0.560
LIG_LIR_Apic_2	119	123	PF02991	0.494
LIG_LIR_Gen_1	92	101	PF02991	0.533
LIG_LIR_Nem_3	92	96	PF02991	0.528
LIG_SH2_CRK	115	119	PF00017	0.474
LIG_SH2_STAP1	31	35	PF00017	0.520
LIG_SH2_STAT5	117	120	PF00017	0.513
LIG_SH3_3	125	131	PF00018	0.548
LIG_SH3_5	113	117	PF00018	0.544
LIG_TRAF2_1	103	106	PF00917	0.543
MOD_CK1_1	166	172	PF00069	0.488
MOD_CK2_1	1	7	PF00069	0.513
MOD_CK2_1	154	160	PF00069	0.447
MOD_GlcNHglycan	132	135	PF01048	0.482
MOD_GlcNHglycan	21	24	PF01048	0.595
MOD_GlcNHglycan	27	30	PF01048	0.613
MOD_GlcNHglycan	31	34	PF01048	0.565
MOD_GlcNHglycan	76	79	PF01048	0.531
MOD_GSK3_1	25	32	PF00069	0.516
MOD_NEK2_1	185	190	PF00069	0.563
MOD_NEK2_1	59	64	PF00069	0.537
MOD_PKA_1	196	202	PF00069	0.615
MOD_PKA_2	14	20	PF00069	0.512
MOD_PKA_2	169	175	PF00069	0.432
MOD_PKA_2	185	191	PF00069	0.607
MOD_PKA_2	196	202	PF00069	0.498
MOD_PKA_2	89	95	PF00069	0.571
MOD_Plk_4	169	175	PF00069	0.382
MOD_ProDKin_1	1	7	PF00069	0.513
MOD_SUMO_rev_2	39	48	PF00179	0.590
TRG_DiLeu_BaEn_1	160	165	PF01217	0.556
TRG_ENDOCYTIC_2	115	118	PF00928	0.508
TRG_ER_diArg_1	148	151	PF00400	0.621
TRG_ER_diArg_1	195	198	PF00400	0.623
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILD1	Leptomonas seymouri	50%	92%
A0A3Q8ICR8	Leishmania donovani	77%	98%
E9AGJ1	Leishmania infantum	77%	98%
E9AIN7	Leishmania braziliensis	70%	100%
Q4QGG0	Leishmania major	81%	100%