Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AP28_LEIMU

TriTrypDb:

LmxM.12.1280

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	432	436	PF00656	0.599
CLV_C14_Caspase3-7	634	638	PF00656	0.643
CLV_NRD_NRD_1	1	3	PF00675	0.686
CLV_NRD_NRD_1	10	12	PF00675	0.632
CLV_NRD_NRD_1	118	120	PF00675	0.672
CLV_NRD_NRD_1	138	140	PF00675	0.684
CLV_NRD_NRD_1	190	192	PF00675	0.680
CLV_NRD_NRD_1	44	46	PF00675	0.703
CLV_NRD_NRD_1	609	611	PF00675	0.573
CLV_NRD_NRD_1	617	619	PF00675	0.485
CLV_NRD_NRD_1	87	89	PF00675	0.682
CLV_PCSK_FUR_1	116	120	PF00082	0.672
CLV_PCSK_FUR_1	615	619	PF00082	0.545
CLV_PCSK_KEX2_1	118	120	PF00082	0.660
CLV_PCSK_KEX2_1	138	140	PF00082	0.684
CLV_PCSK_KEX2_1	190	192	PF00082	0.764
CLV_PCSK_KEX2_1	44	46	PF00082	0.703
CLV_PCSK_KEX2_1	609	611	PF00082	0.590
CLV_PCSK_KEX2_1	615	617	PF00082	0.491
CLV_PCSK_KEX2_1	87	89	PF00082	0.682
CLV_PCSK_SKI1_1	488	492	PF00082	0.654
CLV_PCSK_SKI1_1	576	580	PF00082	0.707
CLV_PCSK_SKI1_1	82	86	PF00082	0.628
DEG_COP1_1	194	204	PF00400	0.561
DEG_Nend_UBRbox_1	1	4	PF02207	0.667
DEG_SCF_FBW7_1	346	352	PF00400	0.529
DEG_SCF_FBW7_1	577	583	PF00400	0.699
DEG_SPOP_SBC_1	142	146	PF00917	0.580
DEG_SPOP_SBC_1	173	177	PF00917	0.525
DOC_ANK_TNKS_1	244	251	PF00023	0.545
DOC_CKS1_1	219	224	PF01111	0.637
DOC_CKS1_1	346	351	PF01111	0.650
DOC_CKS1_1	36	41	PF01111	0.678
DOC_CKS1_1	406	411	PF01111	0.603
DOC_CKS1_1	446	451	PF01111	0.695
DOC_CKS1_1	577	582	PF01111	0.703
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.482
DOC_MAPK_DCC_7	198	206	PF00069	0.558
DOC_MAPK_gen_1	87	93	PF00069	0.682
DOC_MAPK_MEF2A_6	198	206	PF00069	0.558
DOC_PP2B_LxvP_1	283	286	PF13499	0.482
DOC_PP4_FxxP_1	452	455	PF00568	0.529
DOC_USP7_MATH_1	104	108	PF00917	0.689
DOC_USP7_MATH_1	120	124	PF00917	0.539
DOC_USP7_MATH_1	173	177	PF00917	0.564
DOC_USP7_MATH_1	31	35	PF00917	0.651
DOC_USP7_MATH_1	349	353	PF00917	0.532
DOC_USP7_MATH_1	509	513	PF00917	0.545
DOC_USP7_MATH_1	559	563	PF00917	0.662
DOC_USP7_MATH_1	568	572	PF00917	0.609
DOC_USP7_MATH_1	580	584	PF00917	0.668
DOC_USP7_MATH_1	587	591	PF00917	0.622
DOC_WW_Pin1_4	13	18	PF00397	0.707
DOC_WW_Pin1_4	162	167	PF00397	0.565
DOC_WW_Pin1_4	169	174	PF00397	0.609
DOC_WW_Pin1_4	204	209	PF00397	0.610
DOC_WW_Pin1_4	218	223	PF00397	0.480
DOC_WW_Pin1_4	262	267	PF00397	0.572
DOC_WW_Pin1_4	332	337	PF00397	0.708
DOC_WW_Pin1_4	345	350	PF00397	0.601
DOC_WW_Pin1_4	35	40	PF00397	0.682
DOC_WW_Pin1_4	396	401	PF00397	0.658
DOC_WW_Pin1_4	405	410	PF00397	0.602
DOC_WW_Pin1_4	445	450	PF00397	0.656
DOC_WW_Pin1_4	460	465	PF00397	0.550
DOC_WW_Pin1_4	478	483	PF00397	0.569
DOC_WW_Pin1_4	53	58	PF00397	0.531
DOC_WW_Pin1_4	542	547	PF00397	0.665
DOC_WW_Pin1_4	557	562	PF00397	0.576
DOC_WW_Pin1_4	576	581	PF00397	0.537
DOC_WW_Pin1_4	595	600	PF00397	0.502
LIG_14-3-3_CanoR_1	11	17	PF00244	0.567
LIG_14-3-3_CanoR_1	143	149	PF00244	0.563
LIG_14-3-3_CanoR_1	378	385	PF00244	0.535
LIG_14-3-3_CanoR_1	47	57	PF00244	0.653
LIG_14-3-3_CanoR_1	535	539	PF00244	0.618
LIG_14-3-3_CanoR_1	552	558	PF00244	0.536
LIG_14-3-3_CanoR_1	87	92	PF00244	0.681
LIG_BIR_III_2	435	439	PF00653	0.595
LIG_CSL_BTD_1	333	336	PF09270	0.636
LIG_FHA_1	104	110	PF00498	0.626
LIG_FHA_1	201	207	PF00498	0.653
LIG_FHA_1	325	331	PF00498	0.572
LIG_FHA_1	346	352	PF00498	0.678
LIG_FHA_1	406	412	PF00498	0.649
LIG_FHA_1	63	69	PF00498	0.630
LIG_FHA_1	88	94	PF00498	0.578
LIG_FHA_2	156	162	PF00498	0.621
LIG_FHA_2	275	281	PF00498	0.655
LIG_IRF3_LxIS_1	166	172	PF10401	0.559
LIG_LIR_Apic_2	168	173	PF02991	0.505
LIG_LIR_LC3C_4	280	285	PF02991	0.494
LIG_LYPXL_S_1	359	363	PF13949	0.528
LIG_LYPXL_yS_3	360	363	PF13949	0.646
LIG_MYND_1	489	493	PF01753	0.543
LIG_PDZ_Class_3	634	639	PF00595	0.650
LIG_PTB_Apo_2	354	361	PF02174	0.528
LIG_PTB_Phospho_1	354	360	PF10480	0.532
LIG_SH3_1	486	492	PF00018	0.547
LIG_SH3_1	574	580	PF00018	0.664
LIG_SH3_2	39	44	PF14604	0.684
LIG_SH3_3	14	20	PF00018	0.604
LIG_SH3_3	202	208	PF00018	0.614
LIG_SH3_3	216	222	PF00018	0.480
LIG_SH3_3	226	232	PF00018	0.672
LIG_SH3_3	288	294	PF00018	0.492
LIG_SH3_3	343	349	PF00018	0.644
LIG_SH3_3	355	361	PF00018	0.582
LIG_SH3_3	36	42	PF00018	0.679
LIG_SH3_3	403	409	PF00018	0.587
LIG_SH3_3	486	492	PF00018	0.547
LIG_SH3_3	54	60	PF00018	0.525
LIG_SH3_3	574	580	PF00018	0.664
LIG_SH3_3	90	96	PF00018	0.527
LIG_SH3_3	98	104	PF00018	0.506
LIG_SH3_4	82	89	PF00018	0.632
LIG_Sin3_3	281	288	PF02671	0.487
LIG_SUMO_SIM_anti_2	534	542	PF11976	0.509
LIG_SUMO_SIM_par_1	153	159	PF11976	0.530
LIG_SUMO_SIM_par_1	202	207	PF11976	0.608
LIG_TRAF2_1	225	228	PF00917	0.643
LIG_TRAF2_1	427	430	PF00917	0.549
MOD_CDC14_SPxK_1	560	563	PF00782	0.661
MOD_CDK_SPK_2	547	552	PF00069	0.554
MOD_CDK_SPK_2	561	566	PF00069	0.614
MOD_CDK_SPxK_1	460	466	PF00069	0.532
MOD_CDK_SPxK_1	557	563	PF00069	0.696
MOD_CK1_1	165	171	PF00069	0.661
MOD_CK1_1	172	178	PF00069	0.615
MOD_CK1_1	207	213	PF00069	0.601
MOD_CK1_1	320	326	PF00069	0.647
MOD_CK1_1	329	335	PF00069	0.600
MOD_CK1_1	347	353	PF00069	0.644
MOD_CK1_1	374	380	PF00069	0.639
MOD_CK1_1	428	434	PF00069	0.664
MOD_CK1_1	48	54	PF00069	0.687
MOD_CK1_1	501	507	PF00069	0.663
MOD_CK1_1	508	514	PF00069	0.685
MOD_CK1_1	547	553	PF00069	0.624
MOD_CK1_1	569	575	PF00069	0.716
MOD_CK1_1	58	64	PF00069	0.614
MOD_CK2_1	108	114	PF00069	0.696
MOD_CK2_1	155	161	PF00069	0.627
MOD_CK2_1	173	179	PF00069	0.502
MOD_CK2_1	267	273	PF00069	0.743
MOD_CK2_1	274	280	PF00069	0.663
MOD_CK2_1	396	402	PF00069	0.611
MOD_CK2_1	48	54	PF00069	0.616
MOD_DYRK1A_RPxSP_1	345	349	PF00069	0.531
MOD_GlcNHglycan	126	129	PF01048	0.681
MOD_GlcNHglycan	130	133	PF01048	0.700
MOD_GlcNHglycan	150	153	PF01048	0.631
MOD_GlcNHglycan	197	201	PF01048	0.660
MOD_GlcNHglycan	311	314	PF01048	0.587
MOD_GlcNHglycan	337	340	PF01048	0.537
MOD_GlcNHglycan	379	382	PF01048	0.573
MOD_GlcNHglycan	467	470	PF01048	0.672
MOD_GlcNHglycan	493	496	PF01048	0.675
MOD_GlcNHglycan	507	510	PF01048	0.607
MOD_GlcNHglycan	511	514	PF01048	0.573
MOD_GlcNHglycan	582	585	PF01048	0.649
MOD_GlcNHglycan	96	99	PF01048	0.653
MOD_GSK3_1	104	111	PF00069	0.586
MOD_GSK3_1	120	127	PF00069	0.662
MOD_GSK3_1	128	135	PF00069	0.602
MOD_GSK3_1	165	172	PF00069	0.678
MOD_GSK3_1	196	203	PF00069	0.775
MOD_GSK3_1	248	255	PF00069	0.665
MOD_GSK3_1	256	263	PF00069	0.601
MOD_GSK3_1	3	10	PF00069	0.639
MOD_GSK3_1	31	38	PF00069	0.655
MOD_GSK3_1	311	318	PF00069	0.689
MOD_GSK3_1	320	327	PF00069	0.625
MOD_GSK3_1	328	335	PF00069	0.607
MOD_GSK3_1	345	352	PF00069	0.523
MOD_GSK3_1	359	366	PF00069	0.632
MOD_GSK3_1	48	55	PF00069	0.591
MOD_GSK3_1	501	508	PF00069	0.622
MOD_GSK3_1	515	522	PF00069	0.579
MOD_GSK3_1	534	541	PF00069	0.556
MOD_GSK3_1	553	560	PF00069	0.547
MOD_GSK3_1	576	583	PF00069	0.620
MOD_GSK3_1	58	65	PF00069	0.613
MOD_GSK3_1	595	602	PF00069	0.493
MOD_N-GLC_1	324	329	PF02516	0.621
MOD_N-GLC_1	569	574	PF02516	0.717
MOD_N-GLC_1	630	635	PF02516	0.593
MOD_NEK2_1	196	201	PF00069	0.656
MOD_NEK2_1	260	265	PF00069	0.793
MOD_NEK2_1	311	316	PF00069	0.590
MOD_NEK2_1	317	322	PF00069	0.556
MOD_NEK2_1	363	368	PF00069	0.639
MOD_NEK2_1	379	384	PF00069	0.559
MOD_NEK2_1	465	470	PF00069	0.623
MOD_NEK2_1	593	598	PF00069	0.588
MOD_NEK2_1	78	83	PF00069	0.557
MOD_PIKK_1	425	431	PF00454	0.711
MOD_PIKK_1	48	54	PF00454	0.551
MOD_PIKK_1	501	507	PF00454	0.639
MOD_PKA_1	11	17	PF00069	0.604
MOD_PKA_1	2	8	PF00069	0.666
MOD_PKA_1	87	93	PF00069	0.518
MOD_PKA_2	10	16	PF00069	0.571
MOD_PKA_2	142	148	PF00069	0.671
MOD_PKA_2	344	350	PF00069	0.787
MOD_PKA_2	374	380	PF00069	0.584
MOD_PKA_2	419	425	PF00069	0.685
MOD_PKA_2	48	54	PF00069	0.616
MOD_PKA_2	505	511	PF00069	0.709
MOD_PKA_2	519	525	PF00069	0.571
MOD_PKA_2	534	540	PF00069	0.513
MOD_PKA_2	86	92	PF00069	0.702
MOD_PKB_1	45	53	PF00069	0.710
MOD_Plk_1	132	138	PF00069	0.600
MOD_Plk_1	196	202	PF00069	0.567
MOD_Plk_1	304	310	PF00069	0.686
MOD_Plk_1	630	636	PF00069	0.602
MOD_Plk_4	165	171	PF00069	0.596
MOD_Plk_4	200	206	PF00069	0.651
MOD_Plk_4	213	219	PF00069	0.536
MOD_Plk_4	329	335	PF00069	0.683
MOD_Plk_4	359	365	PF00069	0.679
MOD_Plk_4	519	525	PF00069	0.658
MOD_Plk_4	534	540	PF00069	0.513
MOD_ProDKin_1	13	19	PF00069	0.704
MOD_ProDKin_1	162	168	PF00069	0.567
MOD_ProDKin_1	169	175	PF00069	0.609
MOD_ProDKin_1	204	210	PF00069	0.607
MOD_ProDKin_1	218	224	PF00069	0.482
MOD_ProDKin_1	262	268	PF00069	0.574
MOD_ProDKin_1	332	338	PF00069	0.706
MOD_ProDKin_1	345	351	PF00069	0.603
MOD_ProDKin_1	35	41	PF00069	0.681
MOD_ProDKin_1	396	402	PF00069	0.658
MOD_ProDKin_1	405	411	PF00069	0.603
MOD_ProDKin_1	445	451	PF00069	0.656
MOD_ProDKin_1	460	466	PF00069	0.552
MOD_ProDKin_1	478	484	PF00069	0.571
MOD_ProDKin_1	53	59	PF00069	0.529
MOD_ProDKin_1	542	548	PF00069	0.663
MOD_ProDKin_1	557	563	PF00069	0.576
MOD_ProDKin_1	576	582	PF00069	0.528
MOD_ProDKin_1	595	601	PF00069	0.496
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.551
TRG_ENDOCYTIC_2	360	363	PF00928	0.646
TRG_ER_diArg_1	117	119	PF00400	0.665
TRG_ER_diArg_1	137	139	PF00400	0.697
TRG_ER_diArg_1	189	191	PF00400	0.769
TRG_ER_diArg_1	242	245	PF00400	0.555
TRG_ER_diArg_1	44	47	PF00400	0.702
TRG_ER_diArg_1	486	489	PF00400	0.763
TRG_ER_diArg_1	615	618	PF00400	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSA2	Leishmania donovani	76%	100%
E9AGJ0	Leishmania infantum	76%	100%
E9AIN8	Leishmania braziliensis	48%	97%
Q4QGG1	Leishmania major	77%	100%