RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP26_LEIMU

TriTrypDb:

LmxM.12.1260

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 5
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP26

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.776
CLV_NRD_NRD_1	152	154	PF00675	0.627
CLV_NRD_NRD_1	156	158	PF00675	0.601
CLV_NRD_NRD_1	160	162	PF00675	0.601
CLV_NRD_NRD_1	336	338	PF00675	0.485
CLV_NRD_NRD_1	411	413	PF00675	0.776
CLV_NRD_NRD_1	421	423	PF00675	0.680
CLV_PCSK_KEX2_1	151	153	PF00082	0.640
CLV_PCSK_KEX2_1	156	158	PF00082	0.598
CLV_PCSK_KEX2_1	160	162	PF00082	0.597
CLV_PCSK_KEX2_1	336	338	PF00082	0.485
CLV_PCSK_KEX2_1	388	390	PF00082	0.559
CLV_PCSK_KEX2_1	411	413	PF00082	0.770
CLV_PCSK_KEX2_1	420	422	PF00082	0.657
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.469
CLV_PCSK_PC7_1	152	158	PF00082	0.653
CLV_PCSK_PC7_1	416	422	PF00082	0.554
CLV_PCSK_SKI1_1	128	132	PF00082	0.675
CLV_PCSK_SKI1_1	20	24	PF00082	0.543
CLV_PCSK_SKI1_1	389	393	PF00082	0.528
CLV_PCSK_SKI1_1	411	415	PF00082	0.764
DEG_Nend_Nbox_1	1	3	PF02207	0.698
DEG_SPOP_SBC_1	145	149	PF00917	0.628
DOC_ANK_TNKS_1	271	278	PF00023	0.409
DOC_CYCLIN_yCln2_LP_2	391	397	PF00134	0.476
DOC_MAPK_gen_1	326	335	PF00069	0.367
DOC_MAPK_gen_1	388	395	PF00069	0.536
DOC_MAPK_JIP1_4	389	395	PF00069	0.487
DOC_MAPK_MEF2A_6	20	29	PF00069	0.456
DOC_MAPK_MEF2A_6	388	395	PF00069	0.565
DOC_PP2B_LxvP_1	391	394	PF13499	0.479
DOC_PP2B_PxIxI_1	305	311	PF00149	0.389
DOC_USP7_MATH_1	145	149	PF00917	0.638
DOC_USP7_MATH_1	183	187	PF00917	0.596
DOC_USP7_MATH_1	249	253	PF00917	0.474
DOC_USP7_MATH_1	36	40	PF00917	0.508
DOC_USP7_MATH_1	430	434	PF00917	0.675
DOC_WW_Pin1_4	240	245	PF00397	0.400
DOC_WW_Pin1_4	393	398	PF00397	0.541
LIG_14-3-3_CanoR_1	82	88	PF00244	0.565
LIG_BRCT_BRCA1_1	203	207	PF00533	0.469
LIG_DCNL_PONY_1	1	4	PF03556	0.697
LIG_FHA_1	133	139	PF00498	0.784
LIG_FHA_1	173	179	PF00498	0.608
LIG_FHA_1	292	298	PF00498	0.379
LIG_FHA_1	408	414	PF00498	0.475
LIG_FHA_1	432	438	PF00498	0.483
LIG_FHA_2	114	120	PF00498	0.647
LIG_FHA_2	317	323	PF00498	0.649
LIG_LIR_Gen_1	17	26	PF02991	0.475
LIG_LIR_Gen_1	191	200	PF02991	0.421
LIG_LIR_Gen_1	204	215	PF02991	0.431
LIG_LIR_Gen_1	216	225	PF02991	0.473
LIG_LIR_Gen_1	39	48	PF02991	0.646
LIG_LIR_Gen_1	62	70	PF02991	0.496
LIG_LIR_LC3C_4	359	364	PF02991	0.256
LIG_LIR_LC3C_4	396	400	PF02991	0.439
LIG_LIR_Nem_3	17	21	PF02991	0.501
LIG_LIR_Nem_3	204	210	PF02991	0.467
LIG_LIR_Nem_3	211	217	PF02991	0.396
LIG_LIR_Nem_3	39	44	PF02991	0.639
LIG_Pex14_1	374	378	PF04695	0.353
LIG_RPA_C_Fungi	332	344	PF08784	0.391
LIG_SH2_CRK	279	283	PF00017	0.332
LIG_SH2_SRC	366	369	PF00017	0.355
LIG_SH2_STAP1	18	22	PF00017	0.416
LIG_SH2_STAP1	236	240	PF00017	0.462
LIG_SH2_STAP1	279	283	PF00017	0.381
LIG_SH2_STAT3	368	371	PF00017	0.371
LIG_SH2_STAT3	378	381	PF00017	0.387
LIG_SH2_STAT5	225	228	PF00017	0.423
LIG_SH2_STAT5	334	337	PF00017	0.358
LIG_SH2_STAT5	366	369	PF00017	0.384
LIG_SH3_1	10	16	PF00018	0.632
LIG_SH3_3	10	16	PF00018	0.634
LIG_SH3_3	229	235	PF00018	0.541
LIG_SH3_3	391	397	PF00018	0.498
LIG_SH3_3	96	102	PF00018	0.602
LIG_SUMO_SIM_par_1	27	34	PF11976	0.557
LIG_SUMO_SIM_par_1	396	403	PF11976	0.376
LIG_TRAF2_1	70	73	PF00917	0.484
LIG_WRC_WIRS_1	60	65	PF05994	0.532
MOD_CDK_SPK_2	240	245	PF00069	0.460
MOD_CK1_1	143	149	PF00069	0.731
MOD_CK1_1	167	173	PF00069	0.575
MOD_CK1_1	201	207	PF00069	0.521
MOD_CK1_1	252	258	PF00069	0.389
MOD_CK1_1	39	45	PF00069	0.640
MOD_CK1_1	407	413	PF00069	0.677
MOD_CK1_1	52	58	PF00069	0.610
MOD_CK2_1	106	112	PF00069	0.646
MOD_CK2_1	113	119	PF00069	0.623
MOD_Cter_Amidation	386	389	PF01082	0.434
MOD_Cter_Amidation	418	421	PF01082	0.599
MOD_GlcNHglycan	108	111	PF01048	0.665
MOD_GlcNHglycan	161	164	PF01048	0.665
MOD_GlcNHglycan	178	181	PF01048	0.643
MOD_GlcNHglycan	382	385	PF01048	0.372
MOD_GlcNHglycan	401	405	PF01048	0.494
MOD_GlcNHglycan	406	409	PF01048	0.587
MOD_GlcNHglycan	51	54	PF01048	0.626
MOD_GlcNHglycan	78	81	PF01048	0.494
MOD_GSK3_1	100	107	PF00069	0.773
MOD_GSK3_1	111	118	PF00069	0.657
MOD_GSK3_1	120	127	PF00069	0.722
MOD_GSK3_1	128	135	PF00069	0.528
MOD_GSK3_1	139	146	PF00069	0.697
MOD_GSK3_1	159	166	PF00069	0.602
MOD_GSK3_1	168	175	PF00069	0.550
MOD_GSK3_1	248	255	PF00069	0.390
MOD_GSK3_1	39	46	PF00069	0.587
MOD_GSK3_1	400	407	PF00069	0.577
MOD_GSK3_1	426	433	PF00069	0.699
MOD_GSK3_1	83	90	PF00069	0.588
MOD_LATS_1	113	119	PF00433	0.699
MOD_NEK2_1	126	131	PF00069	0.676
MOD_NEK2_1	178	183	PF00069	0.625
MOD_NEK2_1	198	203	PF00069	0.490
MOD_NEK2_1	248	253	PF00069	0.391
MOD_NEK2_1	27	32	PF00069	0.562
MOD_NEK2_1	83	88	PF00069	0.608
MOD_NEK2_2	329	334	PF00069	0.431
MOD_PIKK_1	178	184	PF00454	0.521
MOD_PIKK_1	188	194	PF00454	0.418
MOD_PIKK_1	36	42	PF00454	0.604
MOD_PIKK_1	83	89	PF00454	0.545
MOD_PKA_1	411	417	PF00069	0.798
MOD_PKA_2	159	165	PF00069	0.696
MOD_PKA_2	252	258	PF00069	0.518
MOD_PKA_2	266	272	PF00069	0.276
MOD_PKA_2	411	417	PF00069	0.730
MOD_Plk_1	16	22	PF00069	0.577
MOD_Plk_1	426	432	PF00069	0.576
MOD_Plk_2-3	354	360	PF00069	0.488
MOD_Plk_4	164	170	PF00069	0.475
MOD_Plk_4	27	33	PF00069	0.552
MOD_Plk_4	293	299	PF00069	0.369
MOD_Plk_4	329	335	PF00069	0.370
MOD_Plk_4	43	49	PF00069	0.560
MOD_ProDKin_1	240	246	PF00069	0.398
MOD_ProDKin_1	393	399	PF00069	0.540
TRG_DiLeu_BaEn_1	338	343	PF01217	0.407
TRG_DiLeu_BaEn_2	16	22	PF01217	0.574
TRG_ENDOCYTIC_2	18	21	PF00928	0.423
TRG_ENDOCYTIC_2	217	220	PF00928	0.436
TRG_ENDOCYTIC_2	279	282	PF00928	0.321
TRG_ER_diArg_1	151	153	PF00400	0.632
TRG_ER_diArg_1	271	274	PF00400	0.526
TRG_ER_diArg_1	335	337	PF00400	0.458
TRG_ER_diArg_1	411	413	PF00400	0.759
TRG_ER_diArg_1	420	422	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W8	Leptomonas seymouri	55%	97%
A0A3R7L7Q9	Trypanosoma rangeli	35%	98%
A0A3S7WS83	Leishmania donovani	89%	100%
A4H706	Leishmania braziliensis	73%	100%
E9AGI8	Leishmania infantum	89%	100%
Q4QGG3	Leishmania major	89%	100%
V5DFZ8	Trypanosoma cruzi	35%	99%