RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AP24_LEIMU

TriTrypDb:

LmxM.12.1240

Length:

868

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP24

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.502
CLV_C14_Caspase3-7	397	401	PF00656	0.484
CLV_MEL_PAP_1	391	397	PF00089	0.442
CLV_NRD_NRD_1	127	129	PF00675	0.558
CLV_NRD_NRD_1	135	137	PF00675	0.565
CLV_NRD_NRD_1	323	325	PF00675	0.459
CLV_NRD_NRD_1	345	347	PF00675	0.447
CLV_NRD_NRD_1	393	395	PF00675	0.561
CLV_NRD_NRD_1	439	441	PF00675	0.560
CLV_NRD_NRD_1	490	492	PF00675	0.489
CLV_NRD_NRD_1	496	498	PF00675	0.450
CLV_NRD_NRD_1	5	7	PF00675	0.618
CLV_NRD_NRD_1	536	538	PF00675	0.389
CLV_NRD_NRD_1	586	588	PF00675	0.478
CLV_NRD_NRD_1	758	760	PF00675	0.221
CLV_NRD_NRD_1	818	820	PF00675	0.442
CLV_PCSK_KEX2_1	127	129	PF00082	0.558
CLV_PCSK_KEX2_1	134	136	PF00082	0.566
CLV_PCSK_KEX2_1	269	271	PF00082	0.484
CLV_PCSK_KEX2_1	323	325	PF00082	0.459
CLV_PCSK_KEX2_1	345	347	PF00082	0.443
CLV_PCSK_KEX2_1	393	395	PF00082	0.561
CLV_PCSK_KEX2_1	441	443	PF00082	0.552
CLV_PCSK_KEX2_1	490	492	PF00082	0.489
CLV_PCSK_KEX2_1	496	498	PF00082	0.450
CLV_PCSK_KEX2_1	5	7	PF00082	0.618
CLV_PCSK_KEX2_1	536	538	PF00082	0.389
CLV_PCSK_KEX2_1	758	760	PF00082	0.221
CLV_PCSK_KEX2_1	818	820	PF00082	0.442
CLV_PCSK_KEX2_1	857	859	PF00082	0.639
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.467
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.449
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.552
CLV_PCSK_PC1ET2_1	857	859	PF00082	0.639
CLV_PCSK_PC7_1	130	136	PF00082	0.439
CLV_PCSK_PC7_1	319	325	PF00082	0.462
CLV_PCSK_SKI1_1	145	149	PF00082	0.432
CLV_PCSK_SKI1_1	201	205	PF00082	0.566
CLV_PCSK_SKI1_1	323	327	PF00082	0.465
CLV_PCSK_SKI1_1	345	349	PF00082	0.546
CLV_PCSK_SKI1_1	353	357	PF00082	0.444
CLV_PCSK_SKI1_1	524	528	PF00082	0.412
CLV_PCSK_SKI1_1	539	543	PF00082	0.534
CLV_PCSK_SKI1_1	578	582	PF00082	0.524
CLV_PCSK_SKI1_1	625	629	PF00082	0.573
CLV_PCSK_SKI1_1	642	646	PF00082	0.401
DEG_APCC_DBOX_1	439	447	PF00400	0.554
DEG_APCC_DBOX_1	83	91	PF00400	0.599
DOC_MAPK_gen_1	81	91	PF00069	0.604
DOC_MAPK_gen_1	856	864	PF00069	0.498
DOC_MAPK_MEF2A_6	84	92	PF00069	0.601
DOC_MAPK_MEF2A_6	856	864	PF00069	0.498
DOC_MAPK_RevD_3	482	497	PF00069	0.371
DOC_PP1_RVXF_1	344	351	PF00149	0.411
DOC_PP1_RVXF_1	403	410	PF00149	0.533
DOC_PP1_RVXF_1	671	678	PF00149	0.412
DOC_USP7_MATH_1	179	183	PF00917	0.474
DOC_USP7_MATH_1	261	265	PF00917	0.545
DOC_USP7_MATH_1	379	383	PF00917	0.563
DOC_USP7_MATH_1	580	584	PF00917	0.415
DOC_USP7_MATH_1	743	747	PF00917	0.489
DOC_USP7_MATH_1	795	799	PF00917	0.616
DOC_USP7_MATH_1	823	827	PF00917	0.457
DOC_USP7_UBL2_3	852	856	PF12436	0.526
DOC_WW_Pin1_4	68	73	PF00397	0.630
DOC_WW_Pin1_4	79	84	PF00397	0.505
LIG_14-3-3_CanoR_1	164	170	PF00244	0.396
LIG_14-3-3_CanoR_1	191	200	PF00244	0.506
LIG_14-3-3_CanoR_1	381	385	PF00244	0.522
LIG_14-3-3_CanoR_1	428	437	PF00244	0.443
LIG_14-3-3_CanoR_1	5	11	PF00244	0.624
LIG_14-3-3_CanoR_1	536	542	PF00244	0.505
LIG_14-3-3_CanoR_1	548	557	PF00244	0.427
LIG_14-3-3_CanoR_1	701	707	PF00244	0.480
LIG_14-3-3_CanoR_1	780	785	PF00244	0.500
LIG_14-3-3_CanoR_1	818	823	PF00244	0.525
LIG_Actin_WH2_2	185	203	PF00022	0.386
LIG_Actin_WH2_2	275	290	PF00022	0.512
LIG_BIR_III_4	803	807	PF00653	0.448
LIG_deltaCOP1_diTrp_1	535	542	PF00928	0.387
LIG_eIF4E_1	770	776	PF01652	0.385
LIG_FHA_1	100	106	PF00498	0.663
LIG_FHA_1	146	152	PF00498	0.538
LIG_FHA_1	274	280	PF00498	0.572
LIG_FHA_1	327	333	PF00498	0.402
LIG_FHA_1	385	391	PF00498	0.551
LIG_FHA_1	418	424	PF00498	0.508
LIG_FHA_1	496	502	PF00498	0.441
LIG_FHA_1	588	594	PF00498	0.617
LIG_FHA_1	605	611	PF00498	0.428
LIG_FHA_1	812	818	PF00498	0.593
LIG_FHA_2	276	282	PF00498	0.575
LIG_FHA_2	302	308	PF00498	0.495
LIG_FHA_2	538	544	PF00498	0.509
LIG_FHA_2	717	723	PF00498	0.514
LIG_FHA_2	837	843	PF00498	0.473
LIG_LIR_Apic_2	755	760	PF02991	0.465
LIG_LIR_Gen_1	167	176	PF02991	0.508
LIG_LIR_Gen_1	635	644	PF02991	0.557
LIG_LIR_LC3C_4	86	90	PF02991	0.354
LIG_LIR_Nem_3	635	639	PF02991	0.552
LIG_LIR_Nem_3	722	726	PF02991	0.619
LIG_NRBOX	859	865	PF00104	0.456
LIG_PCNA_yPIPBox_3	181	193	PF02747	0.422
LIG_Pex14_1	538	542	PF04695	0.392
LIG_Rb_LxCxE_1	826	842	PF01857	0.444
LIG_RPA_C_Fungi	492	504	PF08784	0.470
LIG_SH2_CRK	757	761	PF00017	0.385
LIG_SH2_STAP1	572	576	PF00017	0.517
LIG_SH2_STAT3	572	575	PF00017	0.519
LIG_SH2_STAT5	297	300	PF00017	0.557
LIG_SH2_STAT5	770	773	PF00017	0.527
LIG_SH3_3	12	18	PF00018	0.575
LIG_SH3_3	25	31	PF00018	0.647
LIG_SH3_3	69	75	PF00018	0.509
LIG_SH3_3	838	844	PF00018	0.439
LIG_Sin3_3	85	92	PF02671	0.360
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.517
LIG_SUMO_SIM_anti_2	59	65	PF11976	0.596
LIG_SUMO_SIM_anti_2	859	864	PF11976	0.517
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.489
LIG_TRAF2_1	304	307	PF00917	0.524
LIG_TRAF2_1	336	339	PF00917	0.570
LIG_TRAF2_1	362	365	PF00917	0.441
LIG_TRAF2_1	544	547	PF00917	0.458
LIG_TRAF2_1	67	70	PF00917	0.523
LIG_TRAF2_1	691	694	PF00917	0.479
LIG_TRAF2_1	708	711	PF00917	0.421
LIG_UBA3_1	845	852	PF00899	0.442
LIG_WW_2	28	31	PF00397	0.617
MOD_CDK_SPK_2	79	84	PF00069	0.535
MOD_CK1_1	275	281	PF00069	0.571
MOD_CK1_1	525	531	PF00069	0.450
MOD_CK1_1	783	789	PF00069	0.548
MOD_CK1_1	790	796	PF00069	0.592
MOD_CK2_1	224	230	PF00069	0.517
MOD_CK2_1	275	281	PF00069	0.571
MOD_CK2_1	301	307	PF00069	0.490
MOD_CK2_1	379	385	PF00069	0.522
MOD_CK2_1	413	419	PF00069	0.607
MOD_CK2_1	529	535	PF00069	0.441
MOD_CK2_1	537	543	PF00069	0.503
MOD_CK2_1	64	70	PF00069	0.527
MOD_CK2_1	739	745	PF00069	0.482
MOD_CK2_1	795	801	PF00069	0.656
MOD_CK2_1	836	842	PF00069	0.479
MOD_Cter_Amidation	343	346	PF01082	0.407
MOD_GlcNHglycan	115	118	PF01048	0.597
MOD_GlcNHglycan	216	219	PF01048	0.520
MOD_GlcNHglycan	41	44	PF01048	0.625
MOD_GlcNHglycan	524	527	PF01048	0.531
MOD_GlcNHglycan	552	555	PF01048	0.377
MOD_GlcNHglycan	58	61	PF01048	0.548
MOD_GlcNHglycan	741	744	PF01048	0.455
MOD_GlcNHglycan	745	748	PF01048	0.409
MOD_GlcNHglycan	792	795	PF01048	0.604
MOD_GlcNHglycan	820	823	PF01048	0.447
MOD_GSK3_1	268	275	PF00069	0.531
MOD_GSK3_1	380	387	PF00069	0.551
MOD_GSK3_1	389	396	PF00069	0.459
MOD_GSK3_1	39	46	PF00069	0.568
MOD_GSK3_1	409	416	PF00069	0.398
MOD_GSK3_1	525	532	PF00069	0.393
MOD_GSK3_1	64	71	PF00069	0.610
MOD_GSK3_1	739	746	PF00069	0.454
MOD_GSK3_1	776	783	PF00069	0.418
MOD_GSK3_1	786	793	PF00069	0.546
MOD_GSK3_1	831	838	PF00069	0.472
MOD_LATS_1	585	591	PF00433	0.602
MOD_LATS_1	778	784	PF00433	0.446
MOD_N-GLC_1	179	184	PF02516	0.435
MOD_N-GLC_1	780	785	PF02516	0.456
MOD_NEK2_1	192	197	PF00069	0.507
MOD_NEK2_1	214	219	PF00069	0.505
MOD_NEK2_1	326	331	PF00069	0.420
MOD_NEK2_1	417	422	PF00069	0.479
MOD_NEK2_1	446	451	PF00069	0.548
MOD_NEK2_1	64	69	PF00069	0.601
MOD_NEK2_1	716	721	PF00069	0.511
MOD_NEK2_1	776	781	PF00069	0.311
MOD_NEK2_1	811	816	PF00069	0.488
MOD_NEK2_2	823	828	PF00069	0.404
MOD_PIKK_1	209	215	PF00454	0.556
MOD_PIKK_1	229	235	PF00454	0.370
MOD_PIKK_1	446	452	PF00454	0.551
MOD_PIKK_1	529	535	PF00454	0.369
MOD_PIKK_1	542	548	PF00454	0.381
MOD_PIKK_1	587	593	PF00454	0.609
MOD_PIKK_1	716	722	PF00454	0.512
MOD_PIKK_1	96	102	PF00454	0.525
MOD_PK_1	101	107	PF00069	0.536
MOD_PKA_1	393	399	PF00069	0.518
MOD_PKA_1	5	11	PF00069	0.624
MOD_PKA_1	587	593	PF00069	0.447
MOD_PKA_1	818	824	PF00069	0.405
MOD_PKA_1	856	862	PF00069	0.498
MOD_PKA_2	113	119	PF00069	0.542
MOD_PKA_2	287	293	PF00069	0.496
MOD_PKA_2	334	340	PF00069	0.526
MOD_PKA_2	380	386	PF00069	0.524
MOD_PKA_2	393	399	PF00069	0.426
MOD_PKA_2	495	501	PF00069	0.506
MOD_PKA_2	5	11	PF00069	0.624
MOD_PKA_2	64	70	PF00069	0.574
MOD_PKA_2	700	706	PF00069	0.484
MOD_PKA_2	776	782	PF00069	0.254
MOD_PKA_2	818	824	PF00069	0.405
MOD_PKB_1	780	788	PF00069	0.410
MOD_Plk_1	209	215	PF00069	0.392
MOD_Plk_1	36	42	PF00069	0.503
MOD_Plk_1	413	419	PF00069	0.607
MOD_Plk_1	780	786	PF00069	0.504
MOD_Plk_1	811	817	PF00069	0.502
MOD_Plk_4	150	156	PF00069	0.521
MOD_Plk_4	275	281	PF00069	0.516
MOD_Plk_4	650	656	PF00069	0.383
MOD_Plk_4	787	793	PF00069	0.512
MOD_Plk_4	823	829	PF00069	0.484
MOD_Plk_4	836	842	PF00069	0.539
MOD_ProDKin_1	68	74	PF00069	0.626
MOD_ProDKin_1	79	85	PF00069	0.502
MOD_SUMO_for_1	170	173	PF00179	0.391
MOD_SUMO_for_1	640	643	PF00179	0.402
TRG_DiLeu_BaEn_1	263	268	PF01217	0.448
TRG_DiLeu_BaEn_1	364	369	PF01217	0.436
TRG_DiLeu_BaEn_4	364	370	PF01217	0.437
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.565
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.504
TRG_ER_diArg_1	126	128	PF00400	0.554
TRG_ER_diArg_1	135	137	PF00400	0.556
TRG_ER_diArg_1	322	324	PF00400	0.543
TRG_ER_diArg_1	330	333	PF00400	0.505
TRG_ER_diArg_1	345	347	PF00400	0.446
TRG_ER_diArg_1	393	395	PF00400	0.561
TRG_ER_diArg_1	440	443	PF00400	0.557
TRG_ER_diArg_1	490	492	PF00400	0.486
TRG_ER_diArg_1	536	538	PF00400	0.389
TRG_ER_diArg_1	564	567	PF00400	0.441
TRG_ER_diArg_1	757	759	PF00400	0.221
TRG_ER_diArg_1	817	819	PF00400	0.412
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSB7	Leishmania donovani	81%	100%
A4H704	Leishmania braziliensis	64%	99%
E9AGI6	Leishmania infantum	81%	100%
Q4QGG5	Leishmania major	81%	100%