SNARE associated Golgi protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SNARE associated Golgi protein, putative

Species:

Leishmania mexicana

UniProt:

E9AP23_LEIMU

TriTrypDb:

LmxM.12.1230

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AP23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.484
CLV_MEL_PAP_1	251	257	PF00089	0.453
CLV_NRD_NRD_1	299	301	PF00675	0.472
CLV_NRD_NRD_1	79	81	PF00675	0.299
CLV_PCSK_KEX2_1	268	270	PF00082	0.687
CLV_PCSK_KEX2_1	79	81	PF00082	0.299
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.687
CLV_PCSK_SKI1_1	189	193	PF00082	0.280
CLV_PCSK_SKI1_1	269	273	PF00082	0.506
CLV_PCSK_SKI1_1	294	298	PF00082	0.397
CLV_PCSK_SKI1_1	32	36	PF00082	0.604
CLV_PCSK_SKI1_1	52	56	PF00082	0.494
DEG_APCC_DBOX_1	51	59	PF00400	0.362
DEG_SCF_FBW7_1	270	276	PF00400	0.451
DOC_CKS1_1	270	275	PF01111	0.418
DOC_MAPK_gen_1	49	59	PF00069	0.365
DOC_MAPK_HePTP_8	29	41	PF00069	0.264
DOC_MAPK_MEF2A_6	202	211	PF00069	0.494
DOC_MAPK_MEF2A_6	32	41	PF00069	0.320
DOC_MAPK_MEF2A_6	52	61	PF00069	0.259
DOC_PP2B_LxvP_1	150	153	PF13499	0.347
DOC_PP2B_LxvP_1	230	233	PF13499	0.451
DOC_PP2B_LxvP_1	4	7	PF13499	0.336
DOC_PP4_FxxP_1	130	133	PF00568	0.379
DOC_USP7_MATH_1	318	322	PF00917	0.623
DOC_USP7_UBL2_3	103	107	PF12436	0.552
DOC_WW_Pin1_4	2	7	PF00397	0.401
DOC_WW_Pin1_4	212	217	PF00397	0.463
DOC_WW_Pin1_4	224	229	PF00397	0.453
DOC_WW_Pin1_4	269	274	PF00397	0.305
LIG_14-3-3_CanoR_1	195	205	PF00244	0.538
LIG_14-3-3_CanoR_1	312	317	PF00244	0.653
LIG_Actin_WH2_2	77	95	PF00022	0.553
LIG_BIR_II_1	1	5	PF00653	0.431
LIG_FHA_1	127	133	PF00498	0.348
LIG_FHA_1	173	179	PF00498	0.533
LIG_FHA_1	213	219	PF00498	0.442
LIG_FHA_1	274	280	PF00498	0.348
LIG_FHA_1	72	78	PF00498	0.326
LIG_FHA_2	270	276	PF00498	0.369
LIG_LIR_Apic_2	129	133	PF02991	0.374
LIG_LIR_Gen_1	121	132	PF02991	0.306
LIG_LIR_Gen_1	204	214	PF02991	0.454
LIG_LIR_Gen_1	249	258	PF02991	0.253
LIG_LIR_Gen_1	272	281	PF02991	0.306
LIG_LIR_Gen_1	311	318	PF02991	0.626
LIG_LIR_Gen_1	72	81	PF02991	0.402
LIG_LIR_Nem_3	121	127	PF02991	0.315
LIG_LIR_Nem_3	204	209	PF02991	0.443
LIG_LIR_Nem_3	249	253	PF02991	0.264
LIG_LIR_Nem_3	272	277	PF02991	0.296
LIG_LIR_Nem_3	311	316	PF02991	0.703
LIG_LIR_Nem_3	63	69	PF02991	0.381
LIG_LIR_Nem_3	72	78	PF02991	0.380
LIG_NRBOX	64	70	PF00104	0.276
LIG_PCNA_PIPBox_1	161	170	PF02747	0.276
LIG_Pex14_1	114	118	PF04695	0.431
LIG_Pex14_2	62	66	PF04695	0.335
LIG_PTAP_UEV_1	6	11	PF05743	0.291
LIG_Rb_pABgroove_1	15	23	PF01858	0.315
LIG_SH2_CRK	154	158	PF00017	0.270
LIG_SH2_STAT5	124	127	PF00017	0.301
LIG_SH2_STAT5	154	157	PF00017	0.319
LIG_SH2_STAT5	208	211	PF00017	0.453
LIG_SH2_STAT5	250	253	PF00017	0.253
LIG_SH2_STAT5	70	73	PF00017	0.313
LIG_SH3_1	213	219	PF00018	0.453
LIG_SH3_3	213	219	PF00018	0.453
LIG_SH3_3	320	326	PF00018	0.693
LIG_SH3_3	4	10	PF00018	0.354
LIG_SH3_3	44	50	PF00018	0.414
LIG_SH3_3	54	60	PF00018	0.266
LIG_Sin3_3	31	38	PF02671	0.266
LIG_SUMO_SIM_anti_2	15	25	PF11976	0.311
LIG_SUMO_SIM_par_1	275	282	PF11976	0.421
LIG_SUMO_SIM_par_1	8	16	PF11976	0.281
LIG_TYR_ITIM	152	157	PF00017	0.266
LIG_WRC_WIRS_1	127	132	PF05994	0.379
LIG_WRC_WIRS_1	234	239	PF05994	0.397
MOD_CK1_1	12	18	PF00069	0.428
MOD_CK1_1	196	202	PF00069	0.501
MOD_CK1_1	2	8	PF00069	0.495
MOD_CK1_1	24	30	PF00069	0.378
MOD_CK1_1	314	320	PF00069	0.711
MOD_CK1_1	91	97	PF00069	0.478
MOD_CK2_1	173	179	PF00069	0.533
MOD_GlcNHglycan	1	4	PF01048	0.725
MOD_GlcNHglycan	25	29	PF01048	0.617
MOD_GlcNHglycan	260	263	PF01048	0.618
MOD_GlcNHglycan	304	307	PF01048	0.471
MOD_GlcNHglycan	308	311	PF01048	0.462
MOD_GlcNHglycan	320	323	PF01048	0.410
MOD_GlcNHglycan	7	10	PF01048	0.640
MOD_GlcNHglycan	93	96	PF01048	0.367
MOD_GSK3_1	119	126	PF00069	0.455
MOD_GSK3_1	153	160	PF00069	0.310
MOD_GSK3_1	189	196	PF00069	0.528
MOD_GSK3_1	20	27	PF00069	0.301
MOD_GSK3_1	254	261	PF00069	0.284
MOD_GSK3_1	269	276	PF00069	0.217
MOD_GSK3_1	302	309	PF00069	0.613
MOD_GSK3_1	312	319	PF00069	0.658
MOD_GSK3_1	5	12	PF00069	0.412
MOD_GSK3_1	69	76	PF00069	0.397
MOD_GSK3_1	87	94	PF00069	0.583
MOD_NEK2_1	118	123	PF00069	0.334
MOD_NEK2_1	13	18	PF00069	0.447
MOD_NEK2_1	157	162	PF00069	0.283
MOD_NEK2_1	167	172	PF00069	0.314
MOD_NEK2_1	258	263	PF00069	0.430
MOD_NEK2_1	279	284	PF00069	0.378
MOD_NEK2_1	316	321	PF00069	0.626
MOD_NEK2_1	69	74	PF00069	0.285
MOD_NEK2_2	73	78	PF00069	0.405
MOD_PIKK_1	193	199	PF00454	0.523
MOD_PKA_1	294	300	PF00069	0.596
MOD_PKA_2	311	317	PF00069	0.725
MOD_Plk_1	24	30	PF00069	0.319
MOD_Plk_1	87	93	PF00069	0.577
MOD_Plk_4	119	125	PF00069	0.356
MOD_Plk_4	132	138	PF00069	0.269
MOD_Plk_4	145	151	PF00069	0.243
MOD_Plk_4	153	159	PF00069	0.330
MOD_Plk_4	173	179	PF00069	0.479
MOD_Plk_4	238	244	PF00069	0.305
MOD_Plk_4	246	252	PF00069	0.308
MOD_Plk_4	273	279	PF00069	0.321
MOD_ProDKin_1	2	8	PF00069	0.398
MOD_ProDKin_1	212	218	PF00069	0.463
MOD_ProDKin_1	224	230	PF00069	0.453
MOD_ProDKin_1	269	275	PF00069	0.305
MOD_SUMO_for_1	85	88	PF00179	0.454
MOD_SUMO_rev_2	261	270	PF00179	0.495
TRG_AP2beta_CARGO_1	204	213	PF09066	0.453
TRG_ENDOCYTIC_2	113	116	PF00928	0.529
TRG_ENDOCYTIC_2	124	127	PF00928	0.243
TRG_ENDOCYTIC_2	154	157	PF00928	0.321
TRG_ENDOCYTIC_2	208	211	PF00928	0.453
TRG_ENDOCYTIC_2	250	253	PF00928	0.253
TRG_ER_diArg_1	78	80	PF00400	0.509
TRG_NLS_MonoExtN_4	291	297	PF00514	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZM9	Leptomonas seymouri	73%	100%
A0A1X0NMH8	Trypanosomatidae	60%	100%
A0A3Q8I9D7	Leishmania donovani	92%	100%
A0A422NV37	Trypanosoma rangeli	56%	100%
A4H703	Leishmania braziliensis	80%	100%
A4II98	Xenopus tropicalis	29%	100%
C9ZI22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AGI5	Leishmania infantum	92%	100%
O62126	Caenorhabditis elegans	29%	100%
Q08D99	Bos taurus	30%	100%
Q4QGG6	Leishmania major	84%	100%
Q5BJD5	Homo sapiens	29%	100%
Q5RBZ8	Pongo abelii	30%	100%
Q5ZIL6	Gallus gallus	31%	100%
Q96HV5	Homo sapiens	30%	100%
Q9D8U2	Mus musculus	29%	100%
Q9VX39	Drosophila melanogaster	30%	100%
V5BJQ3	Trypanosoma cruzi	57%	100%