CLASP_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AP20_LEIMU

TriTrypDb:

LmxM.12.1200

Length:

540

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.560
CLV_C14_Caspase3-7	287	291	PF00656	0.528
CLV_C14_Caspase3-7	365	369	PF00656	0.557
CLV_C14_Caspase3-7	48	52	PF00656	0.634
CLV_C14_Caspase3-7	481	485	PF00656	0.540
CLV_NRD_NRD_1	211	213	PF00675	0.661
CLV_NRD_NRD_1	216	218	PF00675	0.552
CLV_NRD_NRD_1	253	255	PF00675	0.506
CLV_NRD_NRD_1	450	452	PF00675	0.648
CLV_NRD_NRD_1	96	98	PF00675	0.747
CLV_PCSK_FUR_1	251	255	PF00082	0.462
CLV_PCSK_KEX2_1	211	213	PF00082	0.600
CLV_PCSK_KEX2_1	216	218	PF00082	0.570
CLV_PCSK_KEX2_1	253	255	PF00082	0.572
CLV_PCSK_KEX2_1	450	452	PF00082	0.645
CLV_PCSK_KEX2_1	96	98	PF00082	0.704
CLV_PCSK_PC7_1	212	218	PF00082	0.539
CLV_PCSK_SKI1_1	116	120	PF00082	0.554
CLV_PCSK_SKI1_1	191	195	PF00082	0.565
CLV_PCSK_SKI1_1	352	356	PF00082	0.447
CLV_PCSK_SKI1_1	418	422	PF00082	0.684
CLV_PCSK_SKI1_1	423	427	PF00082	0.662
CLV_PCSK_SKI1_1	455	459	PF00082	0.798
CLV_PCSK_SKI1_1	97	101	PF00082	0.603
DEG_APCC_DBOX_1	95	103	PF00400	0.745
DOC_CKS1_1	194	199	PF01111	0.626
DOC_CKS1_1	312	317	PF01111	0.579
DOC_CYCLIN_RxL_1	187	196	PF00134	0.549
DOC_CYCLIN_RxL_1	76	87	PF00134	0.760
DOC_CYCLIN_RxL_1	93	104	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.628
DOC_MAPK_gen_1	226	234	PF00069	0.654
DOC_MAPK_gen_1	93	102	PF00069	0.724
DOC_PP2B_LxvP_1	198	201	PF13499	0.711
DOC_PP2B_LxvP_1	411	414	PF13499	0.680
DOC_PP4_FxxP_1	312	315	PF00568	0.507
DOC_USP7_MATH_1	281	285	PF00917	0.495
DOC_USP7_MATH_1	478	482	PF00917	0.648
DOC_USP7_MATH_2	151	157	PF00917	0.488
DOC_USP7_UBL2_3	444	448	PF12436	0.675
DOC_WW_Pin1_4	17	22	PF00397	0.693
DOC_WW_Pin1_4	193	198	PF00397	0.614
DOC_WW_Pin1_4	311	316	PF00397	0.605
DOC_WW_Pin1_4	434	439	PF00397	0.614
DOC_WW_Pin1_4	505	510	PF00397	0.750
LIG_14-3-3_CanoR_1	321	330	PF00244	0.528
LIG_14-3-3_CanoR_1	407	412	PF00244	0.846
LIG_14-3-3_CanoR_1	423	428	PF00244	0.617
LIG_14-3-3_CanoR_1	430	438	PF00244	0.645
LIG_14-3-3_CanoR_1	455	463	PF00244	0.523
LIG_14-3-3_CanoR_1	495	502	PF00244	0.666
LIG_14-3-3_CanoR_1	6	15	PF00244	0.613
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_BIR_III_2	460	464	PF00653	0.556
LIG_BRCT_BRCA1_1	146	150	PF00533	0.565
LIG_BRCT_BRCA1_1	521	525	PF00533	0.505
LIG_deltaCOP1_diTrp_1	246	256	PF00928	0.567
LIG_FHA_1	152	158	PF00498	0.582
LIG_FHA_1	359	365	PF00498	0.591
LIG_FHA_1	406	412	PF00498	0.651
LIG_FHA_1	457	463	PF00498	0.615
LIG_FHA_1	62	68	PF00498	0.616
LIG_FHA_1	76	82	PF00498	0.531
LIG_FHA_2	14	20	PF00498	0.619
LIG_FHA_2	173	179	PF00498	0.492
LIG_FHA_2	219	225	PF00498	0.693
LIG_Integrin_isoDGR_2	114	116	PF01839	0.504
LIG_LIR_Apic_2	309	315	PF02991	0.537
LIG_LIR_Apic_2	318	323	PF02991	0.570
LIG_LIR_Gen_1	233	242	PF02991	0.591
LIG_LIR_Gen_1	324	335	PF02991	0.527
LIG_LIR_Nem_3	233	237	PF02991	0.665
LIG_LIR_Nem_3	257	263	PF02991	0.566
LIG_LIR_Nem_3	324	330	PF02991	0.538
LIG_LIR_Nem_3	78	83	PF02991	0.595
LIG_Pex14_1	252	256	PF04695	0.582
LIG_Pex14_2	312	316	PF04695	0.513
LIG_REV1ctd_RIR_1	336	345	PF16727	0.638
LIG_SH2_GRB2like	41	44	PF00017	0.602
LIG_SH2_STAP1	260	264	PF00017	0.460
LIG_SH2_STAP1	41	45	PF00017	0.565
LIG_SH2_STAP1	416	420	PF00017	0.611
LIG_SH2_STAT5	255	258	PF00017	0.580
LIG_SH2_STAT5	263	266	PF00017	0.543
LIG_SH2_STAT5	332	335	PF00017	0.553
LIG_SH2_STAT5	349	352	PF00017	0.559
LIG_SH2_STAT5	359	362	PF00017	0.572
LIG_SH3_3	194	200	PF00018	0.628
LIG_SH3_3	396	402	PF00018	0.597
LIG_SH3_3	443	449	PF00018	0.546
LIG_SUMO_SIM_par_1	241	247	PF11976	0.581
LIG_SUMO_SIM_par_1	439	445	PF11976	0.556
LIG_SUMO_SIM_par_1	72	78	PF11976	0.494
LIG_SUMO_SIM_par_1	98	104	PF11976	0.562
LIG_TRAF2_1	171	174	PF00917	0.605
LIG_TRAF2_1	387	390	PF00917	0.640
LIG_TRAF2_1	403	406	PF00917	0.683
MOD_CDC14_SPxK_1	508	511	PF00782	0.608
MOD_CDK_SPxK_1	193	199	PF00069	0.695
MOD_CDK_SPxK_1	505	511	PF00069	0.687
MOD_CK1_1	124	130	PF00069	0.607
MOD_CK1_1	168	174	PF00069	0.466
MOD_CK1_1	22	28	PF00069	0.618
MOD_CK1_1	33	39	PF00069	0.712
MOD_CK1_1	442	448	PF00069	0.640
MOD_CK1_1	505	511	PF00069	0.615
MOD_CK1_1	52	58	PF00069	0.721
MOD_CK1_1	7	13	PF00069	0.597
MOD_CK1_1	84	90	PF00069	0.563
MOD_CK2_1	161	167	PF00069	0.598
MOD_CK2_1	168	174	PF00069	0.552
MOD_CK2_1	218	224	PF00069	0.549
MOD_CK2_1	281	287	PF00069	0.537
MOD_CK2_1	384	390	PF00069	0.678
MOD_CMANNOS	249	252	PF00535	0.560
MOD_Cter_Amidation	214	217	PF01082	0.540
MOD_GlcNHglycan	144	147	PF01048	0.469
MOD_GlcNHglycan	170	173	PF01048	0.645
MOD_GlcNHglycan	32	35	PF01048	0.647
MOD_GlcNHglycan	324	327	PF01048	0.549
MOD_GlcNHglycan	45	48	PF01048	0.658
MOD_GlcNHglycan	479	483	PF01048	0.574
MOD_GlcNHglycan	504	507	PF01048	0.627
MOD_GlcNHglycan	88	91	PF01048	0.569
MOD_GSK3_1	117	124	PF00069	0.565
MOD_GSK3_1	13	20	PF00069	0.634
MOD_GSK3_1	161	168	PF00069	0.596
MOD_GSK3_1	172	179	PF00069	0.600
MOD_GSK3_1	33	40	PF00069	0.649
MOD_GSK3_1	339	346	PF00069	0.570
MOD_GSK3_1	4	11	PF00069	0.593
MOD_GSK3_1	401	408	PF00069	0.659
MOD_GSK3_1	430	437	PF00069	0.701
MOD_GSK3_1	45	52	PF00069	0.698
MOD_GSK3_1	478	485	PF00069	0.680
MOD_GSK3_1	515	522	PF00069	0.611
MOD_GSK3_1	82	89	PF00069	0.582
MOD_LATS_1	319	325	PF00433	0.468
MOD_N-GLC_1	176	181	PF02516	0.487
MOD_N-GLC_2	137	139	PF02516	0.580
MOD_NEK2_1	121	126	PF00069	0.595
MOD_NEK2_1	144	149	PF00069	0.747
MOD_NEK2_1	24	29	PF00069	0.564
MOD_NEK2_1	45	50	PF00069	0.635
MOD_NEK2_1	502	507	PF00069	0.714
MOD_NEK2_1	75	80	PF00069	0.588
MOD_NEK2_1	81	86	PF00069	0.577
MOD_NEK2_2	158	163	PF00069	0.499
MOD_NEK2_2	176	181	PF00069	0.487
MOD_PIKK_1	121	127	PF00454	0.735
MOD_PIKK_1	33	39	PF00454	0.608
MOD_PIKK_1	418	424	PF00454	0.658
MOD_PKA_2	30	36	PF00069	0.654
MOD_PKA_2	429	435	PF00069	0.665
MOD_PKA_2	43	49	PF00069	0.669
MOD_PKA_2	466	472	PF00069	0.729
MOD_PKA_2	482	488	PF00069	0.753
MOD_PKA_2	494	500	PF00069	0.653
MOD_PKB_1	428	436	PF00069	0.549
MOD_Plk_1	176	182	PF00069	0.487
MOD_Plk_1	343	349	PF00069	0.576
MOD_Plk_1	486	492	PF00069	0.633
MOD_Plk_1	530	536	PF00069	0.528
MOD_Plk_2-3	233	239	PF00069	0.593
MOD_Plk_4	144	150	PF00069	0.585
MOD_Plk_4	176	182	PF00069	0.565
MOD_Plk_4	19	25	PF00069	0.603
MOD_Plk_4	436	442	PF00069	0.788
MOD_Plk_4	45	51	PF00069	0.641
MOD_ProDKin_1	17	23	PF00069	0.694
MOD_ProDKin_1	193	199	PF00069	0.619
MOD_ProDKin_1	311	317	PF00069	0.599
MOD_ProDKin_1	434	440	PF00069	0.617
MOD_ProDKin_1	505	511	PF00069	0.748
MOD_SUMO_for_1	227	230	PF00179	0.660
MOD_SUMO_for_1	473	476	PF00179	0.507
MOD_SUMO_rev_2	219	227	PF00179	0.675
MOD_SUMO_rev_2	283	291	PF00179	0.512
TRG_DiLeu_BaEn_2	229	235	PF01217	0.616
TRG_ENDOCYTIC_2	327	330	PF00928	0.559
TRG_ENDOCYTIC_2	332	335	PF00928	0.553
TRG_ER_diArg_1	210	212	PF00400	0.529
TRG_ER_diArg_1	252	254	PF00400	0.495
TRG_ER_diArg_1	427	430	PF00400	0.675
TRG_ER_diArg_1	449	451	PF00400	0.648
TRG_ER_diArg_1	95	97	PF00400	0.759
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY24	Leptomonas seymouri	45%	94%
A0A3Q8I9I2	Leishmania donovani	75%	96%
A4H700	Leishmania braziliensis	50%	95%
E9AGI4	Leishmania infantum	75%	100%
Q4QGG9	Leishmania major	74%	100%