CSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP18_LEIMU

TriTrypDb:

LmxM.12.1180

Length:

866

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.640
CLV_C14_Caspase3-7	126	130	PF00656	0.661
CLV_C14_Caspase3-7	171	175	PF00656	0.550
CLV_C14_Caspase3-7	465	469	PF00656	0.546
CLV_C14_Caspase3-7	473	477	PF00656	0.613
CLV_C14_Caspase3-7	492	496	PF00656	0.789
CLV_C14_Caspase3-7	778	782	PF00656	0.445
CLV_NRD_NRD_1	167	169	PF00675	0.601
CLV_NRD_NRD_1	185	187	PF00675	0.599
CLV_NRD_NRD_1	77	79	PF00675	0.680
CLV_NRD_NRD_1	810	812	PF00675	0.637
CLV_NRD_NRD_1	843	845	PF00675	0.589
CLV_PCSK_KEX2_1	167	169	PF00082	0.718
CLV_PCSK_KEX2_1	184	186	PF00082	0.592
CLV_PCSK_KEX2_1	750	752	PF00082	0.436
CLV_PCSK_KEX2_1	77	79	PF00082	0.680
CLV_PCSK_KEX2_1	809	811	PF00082	0.670
CLV_PCSK_KEX2_1	845	847	PF00082	0.571
CLV_PCSK_PC1ET2_1	750	752	PF00082	0.512
CLV_PCSK_PC1ET2_1	845	847	PF00082	0.571
CLV_PCSK_SKI1_1	211	215	PF00082	0.610
CLV_PCSK_SKI1_1	439	443	PF00082	0.348
CLV_PCSK_SKI1_1	524	528	PF00082	0.548
CLV_PCSK_SKI1_1	78	82	PF00082	0.662
CLV_PCSK_SKI1_1	8	12	PF00082	0.484
CLV_PCSK_SKI1_1	845	849	PF00082	0.668
CLV_PCSK_SKI1_1	98	102	PF00082	0.480
DEG_SCF_FBW7_2	776	783	PF00400	0.296
DEG_SCF_SKP2-CKS1_1	474	481	PF00560	0.503
DEG_SCF_TRCP1_1	816	822	PF00400	0.501
DEG_SPOP_SBC_1	667	671	PF00917	0.682
DOC_ANK_TNKS_1	184	191	PF00023	0.534
DOC_CKS1_1	777	782	PF01111	0.342
DOC_CYCLIN_RxL_1	75	84	PF00134	0.666
DOC_CYCLIN_yClb1_LxF_4	794	800	PF00134	0.604
DOC_CYCLIN_yCln2_LP_2	368	374	PF00134	0.675
DOC_CYCLIN_yCln2_LP_2	392	395	PF00134	0.481
DOC_MAPK_gen_1	750	759	PF00069	0.413
DOC_MAPK_MEF2A_6	626	635	PF00069	0.455
DOC_PP2B_LxvP_1	101	104	PF13499	0.492
DOC_PP2B_LxvP_1	392	395	PF13499	0.481
DOC_PP2B_LxvP_1	633	636	PF13499	0.414
DOC_PP2B_LxvP_1	665	668	PF13499	0.529
DOC_PP4_FxxP_1	238	241	PF00568	0.524
DOC_PP4_FxxP_1	416	419	PF00568	0.376
DOC_USP7_MATH_1	104	108	PF00917	0.612
DOC_USP7_MATH_1	149	153	PF00917	0.631
DOC_USP7_MATH_1	317	321	PF00917	0.766
DOC_USP7_MATH_1	335	339	PF00917	0.504
DOC_USP7_MATH_1	466	470	PF00917	0.651
DOC_USP7_MATH_1	502	506	PF00917	0.551
DOC_USP7_MATH_1	61	65	PF00917	0.646
DOC_USP7_MATH_1	668	672	PF00917	0.683
DOC_USP7_MATH_1	686	690	PF00917	0.637
DOC_USP7_MATH_1	833	837	PF00917	0.659
DOC_USP7_UBL2_3	211	215	PF12436	0.497
DOC_USP7_UBL2_3	4	8	PF12436	0.564
DOC_WW_Pin1_4	136	141	PF00397	0.817
DOC_WW_Pin1_4	321	326	PF00397	0.632
DOC_WW_Pin1_4	415	420	PF00397	0.561
DOC_WW_Pin1_4	468	473	PF00397	0.712
DOC_WW_Pin1_4	475	480	PF00397	0.552
DOC_WW_Pin1_4	505	510	PF00397	0.616
DOC_WW_Pin1_4	726	731	PF00397	0.651
DOC_WW_Pin1_4	776	781	PF00397	0.337
LIG_14-3-3_CanoR_1	601	605	PF00244	0.440
LIG_Actin_WH2_2	433	450	PF00022	0.443
LIG_Actin_WH2_2	581	599	PF00022	0.485
LIG_APCC_ABBA_1	855	860	PF00400	0.604
LIG_BIR_III_2	252	256	PF00653	0.577
LIG_deltaCOP1_diTrp_1	638	646	PF00928	0.392
LIG_FHA_1	123	129	PF00498	0.514
LIG_FHA_1	299	305	PF00498	0.661
LIG_FHA_1	428	434	PF00498	0.355
LIG_FHA_1	540	546	PF00498	0.535
LIG_FHA_1	578	584	PF00498	0.471
LIG_FHA_1	699	705	PF00498	0.390
LIG_FHA_1	727	733	PF00498	0.571
LIG_FHA_1	87	93	PF00498	0.662
LIG_FHA_2	191	197	PF00498	0.714
LIG_FHA_2	383	389	PF00498	0.475
LIG_FHA_2	490	496	PF00498	0.727
LIG_FHA_2	559	565	PF00498	0.534
LIG_FHA_2	776	782	PF00498	0.383
LIG_FHA_2	789	795	PF00498	0.483
LIG_Integrin_isoDGR_2	616	618	PF01839	0.565
LIG_LIR_Apic_2	237	241	PF02991	0.522
LIG_LIR_Apic_2	638	644	PF02991	0.468
LIG_LIR_Gen_1	12	23	PF02991	0.487
LIG_LIR_Gen_1	436	445	PF02991	0.425
LIG_LIR_Gen_1	738	749	PF02991	0.297
LIG_LIR_Nem_3	12	18	PF02991	0.469
LIG_LIR_Nem_3	164	169	PF02991	0.687
LIG_LIR_Nem_3	436	440	PF02991	0.351
LIG_LIR_Nem_3	640	645	PF02991	0.409
LIG_LYPXL_yS_3	863	866	PF13949	0.609
LIG_MYND_1	663	667	PF01753	0.507
LIG_PALB2_WD40_1	637	645	PF16756	0.468
LIG_Pex14_2	11	15	PF04695	0.506
LIG_Pex14_2	642	646	PF04695	0.405
LIG_SH2_NCK_1	150	154	PF00017	0.613
LIG_SH2_NCK_1	351	355	PF00017	0.485
LIG_SH2_SRC	735	738	PF00017	0.401
LIG_SH2_STAP1	735	739	PF00017	0.396
LIG_SH2_STAT5	150	153	PF00017	0.646
LIG_SH2_STAT5	351	354	PF00017	0.502
LIG_SH2_STAT5	401	404	PF00017	0.457
LIG_SH2_STAT5	446	449	PF00017	0.591
LIG_SH2_STAT5	700	703	PF00017	0.422
LIG_SH2_STAT5	715	718	PF00017	0.482
LIG_SH2_STAT5	772	775	PF00017	0.471
LIG_SH3_3	449	455	PF00018	0.489
LIG_SH3_3	501	507	PF00018	0.601
LIG_SH3_3	641	647	PF00018	0.415
LIG_SH3_3	660	666	PF00018	0.737
LIG_SUMO_SIM_anti_2	388	394	PF11976	0.433
LIG_TRAF2_1	225	228	PF00917	0.486
LIG_TRAF2_1	562	565	PF00917	0.527
LIG_WRC_WIRS_1	687	692	PF05994	0.487
LIG_WW_1	147	150	PF00397	0.695
LIG_WW_2	663	666	PF00397	0.510
MOD_CDK_SPxK_1	475	481	PF00069	0.503
MOD_CK1_1	139	145	PF00069	0.699
MOD_CK1_1	152	158	PF00069	0.564
MOD_CK1_1	467	473	PF00069	0.607
MOD_CK1_1	505	511	PF00069	0.611
MOD_CK1_1	574	580	PF00069	0.478
MOD_CK1_1	64	70	PF00069	0.558
MOD_CK1_1	669	675	PF00069	0.696
MOD_CK1_1	689	695	PF00069	0.705
MOD_CK1_1	721	727	PF00069	0.561
MOD_CK1_1	96	102	PF00069	0.605
MOD_CK2_1	190	196	PF00069	0.712
MOD_CK2_1	27	33	PF00069	0.510
MOD_CK2_1	270	276	PF00069	0.701
MOD_CK2_1	382	388	PF00069	0.492
MOD_CK2_1	42	48	PF00069	0.448
MOD_CK2_1	558	564	PF00069	0.545
MOD_CK2_1	668	674	PF00069	0.648
MOD_CK2_1	679	685	PF00069	0.596
MOD_CK2_1	788	794	PF00069	0.460
MOD_GlcNHglycan	105	109	PF01048	0.565
MOD_GlcNHglycan	141	144	PF01048	0.727
MOD_GlcNHglycan	151	154	PF01048	0.644
MOD_GlcNHglycan	176	179	PF01048	0.614
MOD_GlcNHglycan	272	275	PF01048	0.689
MOD_GlcNHglycan	279	282	PF01048	0.657
MOD_GlcNHglycan	315	318	PF01048	0.674
MOD_GlcNHglycan	319	322	PF01048	0.654
MOD_GlcNHglycan	352	355	PF01048	0.779
MOD_GlcNHglycan	360	363	PF01048	0.632
MOD_GlcNHglycan	448	451	PF01048	0.423
MOD_GlcNHglycan	472	475	PF01048	0.782
MOD_GlcNHglycan	489	492	PF01048	0.631
MOD_GlcNHglycan	504	507	PF01048	0.532
MOD_GlcNHglycan	54	57	PF01048	0.711
MOD_GlcNHglycan	577	580	PF01048	0.497
MOD_GlcNHglycan	654	657	PF01048	0.710
MOD_GlcNHglycan	66	69	PF01048	0.615
MOD_GlcNHglycan	671	674	PF01048	0.750
MOD_GlcNHglycan	722	726	PF01048	0.604
MOD_GlcNHglycan	814	819	PF01048	0.638
MOD_GlcNHglycan	821	824	PF01048	0.781
MOD_GlcNHglycan	835	838	PF01048	0.528
MOD_GlcNHglycan	98	101	PF01048	0.541
MOD_GSK3_1	135	142	PF00069	0.711
MOD_GSK3_1	148	155	PF00069	0.679
MOD_GSK3_1	23	30	PF00069	0.524
MOD_GSK3_1	285	292	PF00069	0.764
MOD_GSK3_1	294	301	PF00069	0.629
MOD_GSK3_1	313	320	PF00069	0.476
MOD_GSK3_1	429	436	PF00069	0.415
MOD_GSK3_1	43	50	PF00069	0.599
MOD_GSK3_1	464	471	PF00069	0.688
MOD_GSK3_1	554	561	PF00069	0.526
MOD_GSK3_1	564	571	PF00069	0.413
MOD_GSK3_1	600	607	PF00069	0.432
MOD_GSK3_1	66	73	PF00069	0.537
MOD_GSK3_1	686	693	PF00069	0.700
MOD_GSK3_1	759	766	PF00069	0.404
MOD_GSK3_1	772	779	PF00069	0.382
MOD_GSK3_1	92	99	PF00069	0.602
MOD_N-GLC_1	496	501	PF02516	0.605
MOD_N-GLC_1	61	66	PF02516	0.611
MOD_N-GLC_1	788	793	PF02516	0.623
MOD_N-GLC_1	96	101	PF02516	0.501
MOD_NEK2_1	23	28	PF00069	0.655
MOD_NEK2_1	42	47	PF00069	0.636
MOD_NEK2_1	435	440	PF00069	0.343
MOD_NEK2_1	539	544	PF00069	0.481
MOD_NEK2_1	575	580	PF00069	0.474
MOD_NEK2_1	604	609	PF00069	0.436
MOD_NEK2_1	637	642	PF00069	0.445
MOD_NEK2_1	690	695	PF00069	0.590
MOD_NEK2_1	759	764	PF00069	0.578
MOD_NEK2_2	161	166	PF00069	0.483
MOD_PKA_2	554	560	PF00069	0.527
MOD_PKA_2	600	606	PF00069	0.520
MOD_PKA_2	698	704	PF00069	0.518
MOD_PKA_2	753	759	PF00069	0.411
MOD_PKA_2	93	99	PF00069	0.627
MOD_PKB_1	522	530	PF00069	0.480
MOD_Plk_1	275	281	PF00069	0.628
MOD_Plk_1	285	291	PF00069	0.559
MOD_Plk_1	496	502	PF00069	0.584
MOD_Plk_1	564	570	PF00069	0.326
MOD_Plk_1	637	643	PF00069	0.398
MOD_Plk_1	788	794	PF00069	0.488
MOD_Plk_1	96	102	PF00069	0.501
MOD_Plk_2-3	564	570	PF00069	0.326
MOD_Plk_2-3	788	794	PF00069	0.460
MOD_Plk_4	161	167	PF00069	0.579
MOD_Plk_4	571	577	PF00069	0.489
MOD_Plk_4	600	606	PF00069	0.465
MOD_Plk_4	637	643	PF00069	0.417
MOD_Plk_4	735	741	PF00069	0.413
MOD_Plk_4	772	778	PF00069	0.385
MOD_Plk_4	81	87	PF00069	0.471
MOD_ProDKin_1	136	142	PF00069	0.819
MOD_ProDKin_1	321	327	PF00069	0.632
MOD_ProDKin_1	415	421	PF00069	0.567
MOD_ProDKin_1	468	474	PF00069	0.713
MOD_ProDKin_1	475	481	PF00069	0.554
MOD_ProDKin_1	505	511	PF00069	0.618
MOD_ProDKin_1	726	732	PF00069	0.635
MOD_ProDKin_1	776	782	PF00069	0.340
MOD_SUMO_for_1	31	34	PF00179	0.583
MOD_SUMO_rev_2	838	847	PF00179	0.653
TRG_DiLeu_BaEn_1	388	393	PF01217	0.434
TRG_DiLeu_BaEn_1	851	856	PF01217	0.598
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.673
TRG_DiLeu_BaLyEn_6	579	584	PF01217	0.417
TRG_DiLeu_BaLyEn_6	615	620	PF01217	0.543
TRG_ENDOCYTIC_2	863	866	PF00928	0.533
TRG_ER_diArg_1	166	168	PF00400	0.606
TRG_ER_diArg_1	184	186	PF00400	0.605
TRG_ER_diArg_1	76	78	PF00400	0.688
TRG_ER_diArg_1	809	811	PF00400	0.688
TRG_NLS_MonoExtN_4	844	849	PF00514	0.553
TRG_Pf-PMV_PEXEL_1	582	587	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	618	623	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IHU8	Leishmania donovani	82%	99%
A4H6Z8	Leishmania braziliensis	69%	100%
C9ZI14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AGI2	Leishmania infantum	83%	99%
Q4QGH1	Leishmania major	82%	100%