SMP-LTD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative integral membrane protein conserved region (DUF2404), putative

Species:

Leishmania mexicana

UniProt:

E9AP17_LEIMU

TriTrypDb:

LmxM.12.1170

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AP17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP17

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006869	lipid transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0071702	organic substance transport	4	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0008289	lipid binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	664	668	PF00656	0.610
CLV_MEL_PAP_1	418	424	PF00089	0.344
CLV_NRD_NRD_1	194	196	PF00675	0.417
CLV_NRD_NRD_1	213	215	PF00675	0.311
CLV_NRD_NRD_1	272	274	PF00675	0.499
CLV_NRD_NRD_1	28	30	PF00675	0.393
CLV_NRD_NRD_1	300	302	PF00675	0.385
CLV_NRD_NRD_1	39	41	PF00675	0.400
CLV_NRD_NRD_1	43	45	PF00675	0.397
CLV_NRD_NRD_1	456	458	PF00675	0.415
CLV_PCSK_KEX2_1	194	196	PF00082	0.417
CLV_PCSK_KEX2_1	213	215	PF00082	0.287
CLV_PCSK_KEX2_1	272	274	PF00082	0.501
CLV_PCSK_KEX2_1	300	302	PF00082	0.385
CLV_PCSK_KEX2_1	544	546	PF00082	0.425
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.407
CLV_PCSK_SKI1_1	201	205	PF00082	0.339
CLV_PCSK_SKI1_1	338	342	PF00082	0.318
CLV_PCSK_SKI1_1	503	507	PF00082	0.456
CLV_PCSK_SKI1_1	550	554	PF00082	0.437
CLV_PCSK_SKI1_1	663	667	PF00082	0.401
CLV_PCSK_SKI1_1	85	89	PF00082	0.335
DOC_CKS1_1	311	316	PF01111	0.586
DOC_CKS1_1	557	562	PF01111	0.653
DOC_CYCLIN_RxL_1	300	313	PF00134	0.584
DOC_CYCLIN_RxL_1	500	509	PF00134	0.544
DOC_CYCLIN_RxL_1	660	670	PF00134	0.601
DOC_MAPK_DCC_7	427	436	PF00069	0.521
DOC_MAPK_gen_1	119	127	PF00069	0.447
DOC_MAPK_gen_1	371	378	PF00069	0.546
DOC_MAPK_gen_1	427	436	PF00069	0.521
DOC_MAPK_HePTP_8	410	422	PF00069	0.522
DOC_MAPK_HePTP_8	424	436	PF00069	0.477
DOC_MAPK_MEF2A_6	158	165	PF00069	0.606
DOC_MAPK_MEF2A_6	289	297	PF00069	0.548
DOC_MAPK_MEF2A_6	413	422	PF00069	0.523
DOC_MAPK_MEF2A_6	427	436	PF00069	0.482
DOC_MAPK_NFAT4_5	158	166	PF00069	0.610
DOC_MAPK_NFAT4_5	413	421	PF00069	0.553
DOC_PP1_RVXF_1	336	342	PF00149	0.512
DOC_PP1_RVXF_1	417	423	PF00149	0.549
DOC_PP1_RVXF_1	468	474	PF00149	0.575
DOC_PP1_RVXF_1	501	508	PF00149	0.541
DOC_PP1_RVXF_1	67	74	PF00149	0.550
DOC_PP4_FxxP_1	518	521	PF00568	0.568
DOC_SPAK_OSR1_1	421	425	PF12202	0.538
DOC_SPAK_OSR1_1	448	452	PF12202	0.531
DOC_USP7_MATH_1	123	127	PF00917	0.446
DOC_USP7_MATH_1	248	252	PF00917	0.655
DOC_USP7_MATH_1	254	258	PF00917	0.634
DOC_USP7_MATH_1	362	366	PF00917	0.599
DOC_USP7_MATH_1	396	400	PF00917	0.675
DOC_USP7_MATH_1	492	496	PF00917	0.581
DOC_USP7_MATH_1	672	676	PF00917	0.624
DOC_USP7_UBL2_3	356	360	PF12436	0.568
DOC_USP7_UBL2_3	41	45	PF12436	0.593
DOC_WW_Pin1_4	275	280	PF00397	0.708
DOC_WW_Pin1_4	310	315	PF00397	0.582
DOC_WW_Pin1_4	550	555	PF00397	0.819
DOC_WW_Pin1_4	556	561	PF00397	0.691
DOC_WW_Pin1_4	567	572	PF00397	0.691
DOC_WW_Pin1_4	598	603	PF00397	0.702
DOC_WW_Pin1_4	651	656	PF00397	0.712
LIG_14-3-3_CanoR_1	122	128	PF00244	0.589
LIG_14-3-3_CanoR_1	139	148	PF00244	0.607
LIG_14-3-3_CanoR_1	289	297	PF00244	0.437
LIG_14-3-3_CanoR_1	29	35	PF00244	0.573
LIG_14-3-3_CanoR_1	345	350	PF00244	0.548
LIG_14-3-3_CanoR_1	363	369	PF00244	0.545
LIG_14-3-3_CanoR_1	421	425	PF00244	0.553
LIG_14-3-3_CanoR_1	609	619	PF00244	0.622
LIG_14-3-3_CanoR_1	629	636	PF00244	0.821
LIG_APCC_ABBA_1	161	166	PF00400	0.601
LIG_APCC_ABBA_1	504	509	PF00400	0.632
LIG_APCC_ABBAyCdc20_2	373	379	PF00400	0.567
LIG_APCC_ABBAyCdc20_2	503	509	PF00400	0.634
LIG_BRCT_BRCA1_1	631	635	PF00533	0.714
LIG_CaM_NSCaTE_8	306	313	PF13499	0.589
LIG_deltaCOP1_diTrp_1	516	523	PF00928	0.592
LIG_FHA_1	16	22	PF00498	0.328
LIG_FHA_1	297	303	PF00498	0.569
LIG_FHA_1	472	478	PF00498	0.597
LIG_FHA_1	557	563	PF00498	0.657
LIG_FHA_1	611	617	PF00498	0.668
LIG_FHA_1	90	96	PF00498	0.546
LIG_FHA_2	101	107	PF00498	0.592
LIG_FHA_2	202	208	PF00498	0.630
LIG_FHA_2	346	352	PF00498	0.591
LIG_FHA_2	398	404	PF00498	0.607
LIG_GBD_Chelix_1	497	505	PF00786	0.326
LIG_LIR_Apic_2	516	521	PF02991	0.554
LIG_LIR_Gen_1	18	28	PF02991	0.374
LIG_LIR_Gen_1	288	298	PF02991	0.544
LIG_LIR_Gen_1	304	314	PF02991	0.523
LIG_LIR_Gen_1	316	327	PF02991	0.585
LIG_LIR_Gen_1	330	340	PF02991	0.558
LIG_LIR_Gen_1	405	416	PF02991	0.545
LIG_LIR_Gen_1	48	57	PF02991	0.619
LIG_LIR_Gen_1	534	543	PF02991	0.725
LIG_LIR_Nem_3	142	148	PF02991	0.620
LIG_LIR_Nem_3	18	23	PF02991	0.350
LIG_LIR_Nem_3	288	293	PF02991	0.537
LIG_LIR_Nem_3	304	309	PF02991	0.536
LIG_LIR_Nem_3	316	322	PF02991	0.591
LIG_LIR_Nem_3	330	335	PF02991	0.608
LIG_LIR_Nem_3	405	411	PF02991	0.546
LIG_LIR_Nem_3	423	429	PF02991	0.532
LIG_LIR_Nem_3	48	52	PF02991	0.612
LIG_LIR_Nem_3	517	523	PF02991	0.639
LIG_LIR_Nem_3	534	539	PF02991	0.727
LIG_MYND_1	560	564	PF01753	0.709
LIG_NRBOX	21	27	PF00104	0.195
LIG_NRBOX	348	354	PF00104	0.582
LIG_PCNA_yPIPBox_3	328	338	PF02747	0.562
LIG_Pex14_2	20	24	PF04695	0.423
LIG_REV1ctd_RIR_1	25	34	PF16727	0.305
LIG_SH2_CRK	11	15	PF00017	0.396
LIG_SH2_CRK	145	149	PF00017	0.600
LIG_SH2_NCK_1	536	540	PF00017	0.649
LIG_SH2_STAP1	536	540	PF00017	0.700
LIG_SH3_2	624	629	PF14604	0.735
LIG_SH3_3	390	396	PF00018	0.544
LIG_SH3_3	448	454	PF00018	0.509
LIG_SH3_3	461	467	PF00018	0.477
LIG_SH3_3	55	61	PF00018	0.617
LIG_SH3_3	551	557	PF00018	0.811
LIG_SH3_3	558	564	PF00018	0.723
LIG_SH3_3	571	577	PF00018	0.787
LIG_SH3_3	621	627	PF00018	0.739
LIG_SH3_3	638	644	PF00018	0.615
LIG_TYR_ITIM	424	429	PF00017	0.522
LIG_TYR_ITSM	141	148	PF00017	0.625
LIG_TYR_ITSM	532	539	PF00017	0.644
LIG_UBA3_1	21	30	PF00899	0.364
LIG_UBA3_1	434	439	PF00899	0.548
LIG_UBA3_1	490	496	PF00899	0.612
LIG_WW_3	623	627	PF00397	0.725
MOD_CDK_SPK_2	275	280	PF00069	0.607
MOD_CDK_SPxxK_3	556	563	PF00069	0.659
MOD_CK1_1	126	132	PF00069	0.571
MOD_CK1_1	288	294	PF00069	0.606
MOD_CK1_1	391	397	PF00069	0.579
MOD_CK1_1	579	585	PF00069	0.693
MOD_CK1_1	607	613	PF00069	0.720
MOD_CK1_1	614	620	PF00069	0.796
MOD_CK1_1	677	683	PF00069	0.654
MOD_CK2_1	201	207	PF00069	0.635
MOD_CK2_1	309	315	PF00069	0.574
MOD_Cter_Amidation	270	273	PF01082	0.443
MOD_GlcNHglycan	250	253	PF01048	0.582
MOD_GlcNHglycan	256	259	PF01048	0.620
MOD_GlcNHglycan	265	268	PF01048	0.507
MOD_GlcNHglycan	315	318	PF01048	0.336
MOD_GlcNHglycan	528	534	PF01048	0.593
MOD_GlcNHglycan	567	570	PF01048	0.623
MOD_GlcNHglycan	657	660	PF01048	0.533
MOD_GlcNHglycan	667	670	PF01048	0.578
MOD_GlcNHglycan	676	679	PF01048	0.404
MOD_GSK3_1	126	133	PF00069	0.637
MOD_GSK3_1	238	245	PF00069	0.714
MOD_GSK3_1	309	316	PF00069	0.598
MOD_GSK3_1	341	348	PF00069	0.543
MOD_GSK3_1	397	404	PF00069	0.582
MOD_GSK3_1	492	499	PF00069	0.539
MOD_GSK3_1	576	583	PF00069	0.689
MOD_GSK3_1	594	601	PF00069	0.775
MOD_GSK3_1	603	610	PF00069	0.714
MOD_GSK3_1	611	618	PF00069	0.732
MOD_GSK3_1	651	658	PF00069	0.720
MOD_GSK3_1	661	668	PF00069	0.709
MOD_GSK3_1	672	679	PF00069	0.622
MOD_N-GLC_1	139	144	PF02516	0.421
MOD_N-GLC_1	243	248	PF02516	0.410
MOD_N-GLC_1	391	396	PF02516	0.350
MOD_N-GLC_1	610	615	PF02516	0.413
MOD_NEK2_1	10	15	PF00069	0.195
MOD_NEK2_1	243	248	PF00069	0.744
MOD_NEK2_1	309	314	PF00069	0.618
MOD_NEK2_1	341	346	PF00069	0.543
MOD_NEK2_1	35	40	PF00069	0.556
MOD_NEK2_1	596	601	PF00069	0.634
MOD_NEK2_1	603	608	PF00069	0.626
MOD_NEK2_1	88	93	PF00069	0.540
MOD_PIKK_1	126	132	PF00454	0.555
MOD_PIKK_1	471	477	PF00454	0.558
MOD_PKA_2	130	136	PF00069	0.602
MOD_PKA_2	193	199	PF00069	0.601
MOD_PKA_2	248	254	PF00069	0.678
MOD_PKA_2	28	34	PF00069	0.563
MOD_PKA_2	288	294	PF00069	0.499
MOD_PKA_2	362	368	PF00069	0.582
MOD_PKA_2	420	426	PF00069	0.548
MOD_PKA_2	673	679	PF00069	0.824
MOD_PKB_1	137	145	PF00069	0.617
MOD_Plk_4	150	156	PF00069	0.553
MOD_Plk_4	16	22	PF00069	0.397
MOD_ProDKin_1	275	281	PF00069	0.705
MOD_ProDKin_1	310	316	PF00069	0.581
MOD_ProDKin_1	550	556	PF00069	0.819
MOD_ProDKin_1	567	573	PF00069	0.691
MOD_ProDKin_1	598	604	PF00069	0.702
MOD_ProDKin_1	651	657	PF00069	0.712
MOD_SUMO_for_1	62	65	PF00179	0.585
MOD_SUMO_rev_2	196	203	PF00179	0.576
MOD_SUMO_rev_2	351	357	PF00179	0.578
TRG_DiLeu_BaEn_4	282	288	PF01217	0.517
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.531
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.643
TRG_DiLeu_BaLyEn_6	599	604	PF01217	0.644
TRG_DiLeu_BaLyEn_6	647	652	PF01217	0.670
TRG_ENDOCYTIC_2	11	14	PF00928	0.324
TRG_ENDOCYTIC_2	145	148	PF00928	0.600
TRG_ENDOCYTIC_2	426	429	PF00928	0.552
TRG_ENDOCYTIC_2	536	539	PF00928	0.728
TRG_ER_diArg_1	194	197	PF00400	0.629
TRG_ER_diArg_1	212	214	PF00400	0.489
TRG_ER_diArg_1	300	302	PF00400	0.585
TRG_ER_diArg_1	446	449	PF00400	0.492
TRG_NLS_Bipartite_1	29	45	PF00514	0.575
TRG_NLS_MonoExtC_3	39	44	PF00514	0.548
TRG_NLS_MonoExtN_4	356	362	PF00514	0.580
TRG_NLS_MonoExtN_4	40	45	PF00514	0.492
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	663	667	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN3	Leptomonas seymouri	66%	94%
A0A3S5H6M5	Leishmania donovani	80%	98%
A4H6Z7	Leishmania braziliensis	63%	100%
C9ZI10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AGI1	Leishmania infantum	80%	98%
Q4QGH2	Leishmania major	78%	100%