RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative integral membrane protein conserved region (DUF2404), putative

Species:

Leishmania mexicana

UniProt:

E9AP16_LEIMU

TriTrypDb:

LmxM.12.1160

Length:

943

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AP16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP16

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006869	lipid transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0071702	organic substance transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0008289	lipid binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.630
CLV_C14_Caspase3-7	343	347	PF00656	0.696
CLV_C14_Caspase3-7	375	379	PF00656	0.750
CLV_C14_Caspase3-7	395	399	PF00656	0.684
CLV_C14_Caspase3-7	764	768	PF00656	0.799
CLV_NRD_NRD_1	408	410	PF00675	0.532
CLV_NRD_NRD_1	499	501	PF00675	0.356
CLV_NRD_NRD_1	720	722	PF00675	0.458
CLV_PCSK_KEX2_1	408	410	PF00082	0.524
CLV_PCSK_KEX2_1	720	722	PF00082	0.477
CLV_PCSK_KEX2_1	909	911	PF00082	0.538
CLV_PCSK_PC1ET2_1	909	911	PF00082	0.538
CLV_PCSK_SKI1_1	199	203	PF00082	0.546
CLV_PCSK_SKI1_1	322	326	PF00082	0.436
CLV_PCSK_SKI1_1	463	467	PF00082	0.454
CLV_PCSK_SKI1_1	480	484	PF00082	0.300
CLV_PCSK_SKI1_1	567	571	PF00082	0.325
CLV_PCSK_SKI1_1	627	631	PF00082	0.408
CLV_PCSK_SKI1_1	632	636	PF00082	0.351
CLV_PCSK_SKI1_1	689	693	PF00082	0.394
CLV_PCSK_SKI1_1	91	95	PF00082	0.390
CLV_PCSK_SKI1_1	910	914	PF00082	0.490
CLV_PCSK_SKI1_1	918	922	PF00082	0.404
CLV_PCSK_SKI1_1	929	933	PF00082	0.391
DEG_APCC_DBOX_1	499	507	PF00400	0.548
DEG_APCC_DBOX_1	626	634	PF00400	0.503
DEG_APCC_DBOX_1	765	773	PF00400	0.799
DEG_MDM2_SWIB_1	7	15	PF02201	0.331
DEG_SCF_FBW7_1	733	739	PF00400	0.771
DEG_SPOP_SBC_1	353	357	PF00917	0.695
DOC_CDC14_PxL_1	634	642	PF14671	0.544
DOC_CKS1_1	733	738	PF01111	0.773
DOC_CYCLIN_yClb5_NLxxxL_5	918	924	PF00134	0.688
DOC_MAPK_DCC_7	632	642	PF00069	0.471
DOC_MAPK_gen_1	500	508	PF00069	0.635
DOC_MAPK_gen_1	918	926	PF00069	0.624
DOC_MAPK_MEF2A_6	611	619	PF00069	0.542
DOC_PP1_RVXF_1	310	317	PF00149	0.563
DOC_PP2B_LxvP_1	791	794	PF13499	0.631
DOC_PP4_FxxP_1	194	197	PF00568	0.522
DOC_PP4_FxxP_1	664	667	PF00568	0.576
DOC_USP7_MATH_1	142	146	PF00917	0.697
DOC_USP7_MATH_1	228	232	PF00917	0.798
DOC_USP7_MATH_1	235	239	PF00917	0.740
DOC_USP7_MATH_1	288	292	PF00917	0.782
DOC_USP7_MATH_1	295	299	PF00917	0.672
DOC_USP7_MATH_1	332	336	PF00917	0.670
DOC_USP7_MATH_1	539	543	PF00917	0.566
DOC_USP7_MATH_1	665	669	PF00917	0.594
DOC_USP7_MATH_1	673	677	PF00917	0.633
DOC_USP7_MATH_1	736	740	PF00917	0.658
DOC_USP7_MATH_1	778	782	PF00917	0.788
DOC_USP7_MATH_1	812	816	PF00917	0.716
DOC_USP7_MATH_1	872	876	PF00917	0.782
DOC_USP7_UBL2_3	229	233	PF12436	0.704
DOC_USP7_UBL2_3	921	925	PF12436	0.628
DOC_WW_Pin1_4	231	236	PF00397	0.712
DOC_WW_Pin1_4	326	331	PF00397	0.770
DOC_WW_Pin1_4	364	369	PF00397	0.758
DOC_WW_Pin1_4	669	674	PF00397	0.614
DOC_WW_Pin1_4	729	734	PF00397	0.735
DOC_WW_Pin1_4	744	749	PF00397	0.656
DOC_WW_Pin1_4	83	88	PF00397	0.690
DOC_WW_Pin1_4	836	841	PF00397	0.798
LIG_14-3-3_CanoR_1	415	422	PF00244	0.661
LIG_14-3-3_CanoR_1	447	452	PF00244	0.554
LIG_14-3-3_CanoR_1	540	547	PF00244	0.635
LIG_14-3-3_CanoR_1	567	573	PF00244	0.613
LIG_14-3-3_CanoR_1	632	640	PF00244	0.562
LIG_14-3-3_CanoR_1	738	742	PF00244	0.706
LIG_14-3-3_CanoR_1	782	792	PF00244	0.636
LIG_14-3-3_CanoR_1	910	920	PF00244	0.617
LIG_APCC_ABBA_1	650	655	PF00400	0.538
LIG_APCC_ABBA_1	657	662	PF00400	0.559
LIG_APCC_ABBAyCdc20_2	649	655	PF00400	0.538
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_BRCT_BRCA1_1	161	165	PF00533	0.768
LIG_BRCT_BRCA1_1	350	354	PF00533	0.694
LIG_BRCT_BRCA1_1	478	482	PF00533	0.526
LIG_BRCT_BRCA1_1	562	566	PF00533	0.509
LIG_BRCT_BRCA1_1	601	605	PF00533	0.564
LIG_Clathr_ClatBox_1	117	121	PF01394	0.616
LIG_Clathr_ClatBox_1	586	590	PF01394	0.517
LIG_CSL_BTD_1	856	859	PF09270	0.716
LIG_deltaCOP1_diTrp_1	854	864	PF00928	0.628
LIG_FHA_1	198	204	PF00498	0.583
LIG_FHA_1	24	30	PF00498	0.501
LIG_FHA_1	255	261	PF00498	0.669
LIG_FHA_1	308	314	PF00498	0.630
LIG_FHA_1	372	378	PF00498	0.790
LIG_FHA_1	590	596	PF00498	0.526
LIG_FHA_1	60	66	PF00498	0.587
LIG_FHA_1	643	649	PF00498	0.523
LIG_FHA_1	821	827	PF00498	0.687
LIG_FHA_2	170	176	PF00498	0.610
LIG_FHA_2	185	191	PF00498	0.587
LIG_FHA_2	241	247	PF00498	0.629
LIG_FHA_2	261	267	PF00498	0.772
LIG_FHA_2	341	347	PF00498	0.699
LIG_FHA_2	393	399	PF00498	0.770
LIG_FHA_2	402	408	PF00498	0.598
LIG_FHA_2	492	498	PF00498	0.626
LIG_FHA_2	72	78	PF00498	0.581
LIG_GBD_Chelix_1	15	23	PF00786	0.258
LIG_LIR_Apic_2	102	106	PF02991	0.636
LIG_LIR_Apic_2	662	667	PF02991	0.576
LIG_LIR_Apic_2	861	867	PF02991	0.616
LIG_LIR_Gen_1	126	133	PF02991	0.558
LIG_LIR_Gen_1	431	439	PF02991	0.608
LIG_LIR_Gen_1	446	455	PF02991	0.485
LIG_LIR_Gen_1	550	555	PF02991	0.515
LIG_LIR_Gen_1	675	685	PF02991	0.710
LIG_LIR_Nem_3	126	131	PF02991	0.540
LIG_LIR_Nem_3	431	435	PF02991	0.621
LIG_LIR_Nem_3	446	451	PF02991	0.493
LIG_LIR_Nem_3	459	464	PF02991	0.575
LIG_LIR_Nem_3	550	554	PF02991	0.554
LIG_LIR_Nem_3	563	568	PF02991	0.467
LIG_LIR_Nem_3	571	575	PF02991	0.576
LIG_LIR_Nem_3	67	71	PF02991	0.641
LIG_LIR_Nem_3	675	680	PF02991	0.706
LIG_MLH1_MIPbox_1	161	165	PF16413	0.768
LIG_MLH1_MIPbox_1	478	482	PF16413	0.526
LIG_MLH1_MIPbox_1	562	566	PF16413	0.509
LIG_MYND_1	840	844	PF01753	0.784
LIG_NRBOX	520	526	PF00104	0.611
LIG_NRBOX	919	925	PF00104	0.691
LIG_PCNA_PIPBox_1	644	653	PF02747	0.494
LIG_Pex14_2	477	481	PF04695	0.530
LIG_Pex14_2	7	11	PF04695	0.331
LIG_REV1ctd_RIR_1	162	168	PF16727	0.762
LIG_REV1ctd_RIR_1	563	571	PF16727	0.516
LIG_REV1ctd_RIR_1	66	74	PF16727	0.682
LIG_RPA_C_Fungi	825	837	PF08784	0.661
LIG_SH2_CRK	128	132	PF00017	0.548
LIG_SH2_CRK	572	576	PF00017	0.543
LIG_SH2_NCK_1	742	746	PF00017	0.513
LIG_SH2_STAP1	464	468	PF00017	0.615
LIG_SH2_STAT5	48	51	PF00017	0.494
LIG_SH2_STAT5	572	575	PF00017	0.539
LIG_SH2_STAT5	651	654	PF00017	0.392
LIG_SH3_1	730	736	PF00018	0.514
LIG_SH3_1	837	843	PF00018	0.760
LIG_SH3_2	733	738	PF14604	0.627
LIG_SH3_3	282	288	PF00018	0.535
LIG_SH3_3	533	539	PF00018	0.416
LIG_SH3_3	667	673	PF00018	0.471
LIG_SH3_3	730	736	PF00018	0.637
LIG_SH3_3	786	792	PF00018	0.541
LIG_SH3_3	837	843	PF00018	0.760
LIG_SUMO_SIM_anti_2	494	500	PF11976	0.538
LIG_SUMO_SIM_anti_2	639	645	PF11976	0.279
LIG_SUMO_SIM_par_1	115	121	PF11976	0.511
LIG_SUMO_SIM_par_1	585	590	PF11976	0.371
LIG_TYR_ITIM	570	575	PF00017	0.527
LIG_UBA3_1	45	51	PF00899	0.402
LIG_UBA3_1	451	456	PF00899	0.528
LIG_UBA3_1	495	501	PF00899	0.411
LIG_UBA3_1	643	649	PF00899	0.335
LIG_WRC_WIRS_1	474	479	PF05994	0.395
LIG_WRC_WIRS_1	65	70	PF05994	0.488
MOD_CDC14_SPxK_1	86	89	PF00782	0.692
MOD_CDK_SPK_2	669	674	PF00069	0.490
MOD_CDK_SPxK_1	732	738	PF00069	0.734
MOD_CDK_SPxK_1	83	89	PF00069	0.696
MOD_CK1_1	143	149	PF00069	0.764
MOD_CK1_1	231	237	PF00069	0.628
MOD_CK1_1	265	271	PF00069	0.809
MOD_CK1_1	276	282	PF00069	0.631
MOD_CK1_1	291	297	PF00069	0.592
MOD_CK1_1	307	313	PF00069	0.588
MOD_CK1_1	373	379	PF00069	0.751
MOD_CK1_1	381	387	PF00069	0.613
MOD_CK1_1	534	540	PF00069	0.447
MOD_CK1_1	701	707	PF00069	0.762
MOD_CK1_1	732	738	PF00069	0.730
MOD_CK1_1	740	746	PF00069	0.629
MOD_CK1_1	749	755	PF00069	0.614
MOD_CK1_1	757	763	PF00069	0.558
MOD_CK1_1	796	802	PF00069	0.644
MOD_CK1_1	805	811	PF00069	0.539
MOD_CK1_1	873	879	PF00069	0.508
MOD_CK1_1	904	910	PF00069	0.593
MOD_CK1_1	911	917	PF00069	0.541
MOD_CK2_1	169	175	PF00069	0.517
MOD_CK2_1	184	190	PF00069	0.474
MOD_CK2_1	218	224	PF00069	0.757
MOD_CK2_1	260	266	PF00069	0.770
MOD_CK2_1	401	407	PF00069	0.460
MOD_CK2_1	491	497	PF00069	0.518
MOD_GlcNHglycan	12	15	PF01048	0.391
MOD_GlcNHglycan	135	138	PF01048	0.614
MOD_GlcNHglycan	142	145	PF01048	0.588
MOD_GlcNHglycan	220	223	PF01048	0.726
MOD_GlcNHglycan	226	229	PF01048	0.643
MOD_GlcNHglycan	237	240	PF01048	0.491
MOD_GlcNHglycan	250	254	PF01048	0.670
MOD_GlcNHglycan	269	272	PF01048	0.584
MOD_GlcNHglycan	282	285	PF01048	0.612
MOD_GlcNHglycan	34	37	PF01048	0.454
MOD_GlcNHglycan	350	353	PF01048	0.614
MOD_GlcNHglycan	452	455	PF01048	0.405
MOD_GlcNHglycan	491	494	PF01048	0.290
MOD_GlcNHglycan	541	544	PF01048	0.437
MOD_GlcNHglycan	624	627	PF01048	0.508
MOD_GlcNHglycan	694	697	PF01048	0.673
MOD_GlcNHglycan	703	706	PF01048	0.615
MOD_GlcNHglycan	727	730	PF01048	0.679
MOD_GlcNHglycan	785	788	PF01048	0.755
MOD_GlcNHglycan	795	798	PF01048	0.709
MOD_GlcNHglycan	881	884	PF01048	0.552
MOD_GlcNHglycan	903	906	PF01048	0.582
MOD_GlcNHglycan	913	916	PF01048	0.533
MOD_GlcNHglycan	95	98	PF01048	0.411
MOD_GSK3_1	131	138	PF00069	0.642
MOD_GSK3_1	140	147	PF00069	0.600
MOD_GSK3_1	164	171	PF00069	0.627
MOD_GSK3_1	224	231	PF00069	0.683
MOD_GSK3_1	260	267	PF00069	0.693
MOD_GSK3_1	272	279	PF00069	0.597
MOD_GSK3_1	291	298	PF00069	0.730
MOD_GSK3_1	332	339	PF00069	0.683
MOD_GSK3_1	348	355	PF00069	0.601
MOD_GSK3_1	378	385	PF00069	0.788
MOD_GSK3_1	55	62	PF00069	0.469
MOD_GSK3_1	589	596	PF00069	0.383
MOD_GSK3_1	638	645	PF00069	0.400
MOD_GSK3_1	665	672	PF00069	0.509
MOD_GSK3_1	701	708	PF00069	0.625
MOD_GSK3_1	725	732	PF00069	0.781
MOD_GSK3_1	736	743	PF00069	0.773
MOD_GSK3_1	746	753	PF00069	0.591
MOD_GSK3_1	773	780	PF00069	0.581
MOD_GSK3_1	796	803	PF00069	0.719
MOD_GSK3_1	826	833	PF00069	0.716
MOD_GSK3_1	866	873	PF00069	0.605
MOD_GSK3_1	890	897	PF00069	0.654
MOD_GSK3_1	904	911	PF00069	0.685
MOD_GSK3_1	932	939	PF00069	0.729
MOD_N-GLC_1	184	189	PF02516	0.595
MOD_N-GLC_1	340	345	PF02516	0.750
MOD_N-GLC_1	60	65	PF02516	0.467
MOD_N-GLC_1	709	714	PF02516	0.530
MOD_N-GLC_1	783	788	PF02516	0.536
MOD_N-GLC_1	812	817	PF02516	0.736
MOD_N-GLC_1	870	875	PF02516	0.676
MOD_N-GLC_1	891	896	PF02516	0.721
MOD_N-GLC_2	38	40	PF02516	0.383
MOD_NEK2_1	133	138	PF00069	0.560
MOD_NEK2_1	164	169	PF00069	0.713
MOD_NEK2_1	183	188	PF00069	0.491
MOD_NEK2_1	249	254	PF00069	0.717
MOD_NEK2_1	260	265	PF00069	0.584
MOD_NEK2_1	280	285	PF00069	0.545
MOD_NEK2_1	32	37	PF00069	0.517
MOD_NEK2_1	324	329	PF00069	0.562
MOD_NEK2_1	354	359	PF00069	0.666
MOD_NEK2_1	491	496	PF00069	0.549
MOD_NEK2_1	525	530	PF00069	0.412
MOD_NEK2_1	568	573	PF00069	0.503
MOD_NEK2_1	589	594	PF00069	0.377
MOD_NEK2_1	71	76	PF00069	0.541
MOD_NEK2_1	750	755	PF00069	0.750
MOD_NEK2_1	826	831	PF00069	0.717
MOD_NEK2_1	879	884	PF00069	0.726
MOD_NEK2_1	888	893	PF00069	0.610
MOD_NEK2_2	560	565	PF00069	0.257
MOD_NEK2_2	737	742	PF00069	0.518
MOD_OFUCOSY	890	895	PF10250	0.725
MOD_PIKK_1	525	531	PF00454	0.398
MOD_PIKK_1	709	715	PF00454	0.530
MOD_PIKK_1	773	779	PF00454	0.536
MOD_PIKK_1	830	836	PF00454	0.768
MOD_PIKK_1	845	851	PF00454	0.504
MOD_PK_1	908	914	PF00069	0.541
MOD_PKA_1	908	914	PF00069	0.665
MOD_PKA_2	159	165	PF00069	0.619
MOD_PKA_2	371	377	PF00069	0.678
MOD_PKA_2	379	385	PF00069	0.587
MOD_PKA_2	539	545	PF00069	0.595
MOD_PKA_2	698	704	PF00069	0.620
MOD_PKA_2	719	725	PF00069	0.666
MOD_PKA_2	737	743	PF00069	0.490
MOD_PKA_2	753	759	PF00069	0.566
MOD_PKA_2	765	771	PF00069	0.742
MOD_PKA_2	845	851	PF00069	0.714
MOD_PKA_2	932	938	PF00069	0.707
MOD_Plk_1	184	190	PF00069	0.590
MOD_Plk_1	260	266	PF00069	0.750
MOD_Plk_1	340	346	PF00069	0.751
MOD_Plk_1	392	398	PF00069	0.660
MOD_Plk_1	589	595	PF00069	0.375
MOD_Plk_1	59	65	PF00069	0.464
MOD_Plk_1	638	644	PF00069	0.282
MOD_Plk_1	812	818	PF00069	0.633
MOD_Plk_1	853	859	PF00069	0.655
MOD_Plk_1	870	876	PF00069	0.620
MOD_Plk_2-3	392	398	PF00069	0.731
MOD_Plk_4	123	129	PF00069	0.402
MOD_Plk_4	169	175	PF00069	0.601
MOD_Plk_4	184	190	PF00069	0.586
MOD_Plk_4	304	310	PF00069	0.694
MOD_Plk_4	44	50	PF00069	0.686
MOD_Plk_4	447	453	PF00069	0.424
MOD_Plk_4	473	479	PF00069	0.403
MOD_Plk_4	491	497	PF00069	0.402
MOD_Plk_4	560	566	PF00069	0.520
MOD_Plk_4	60	66	PF00069	0.470
MOD_Plk_4	638	644	PF00069	0.341
MOD_Plk_4	665	671	PF00069	0.495
MOD_Plk_4	737	743	PF00069	0.514
MOD_Plk_4	853	859	PF00069	0.760
MOD_Plk_4	99	105	PF00069	0.399
MOD_ProDKin_1	231	237	PF00069	0.645
MOD_ProDKin_1	326	332	PF00069	0.731
MOD_ProDKin_1	364	370	PF00069	0.711
MOD_ProDKin_1	669	675	PF00069	0.512
MOD_ProDKin_1	729	735	PF00069	0.674
MOD_ProDKin_1	744	750	PF00069	0.570
MOD_ProDKin_1	83	89	PF00069	0.613
MOD_ProDKin_1	836	842	PF00069	0.766
MOD_SUMO_for_1	437	440	PF00179	0.507
MOD_SUMO_rev_2	155	165	PF00179	0.727
MOD_SUMO_rev_2	708	718	PF00179	0.759
TRG_DiLeu_BaEn_2	2	8	PF01217	0.344
TRG_ENDOCYTIC_2	128	131	PF00928	0.534
TRG_ENDOCYTIC_2	572	575	PF00928	0.539
TRG_ENDOCYTIC_2	9	12	PF00928	0.331
TRG_ER_diArg_1	680	683	PF00400	0.546
TRG_ER_diLys_1	940	943	PF00400	0.763
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	513	518	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILD4	Leptomonas seymouri	49%	100%
A0A3S7WS71	Leishmania donovani	82%	100%
E9AGI0	Leishmania infantum	83%	100%
Q4QGH3	Leishmania major	79%	100%