N-ethylmaleimide reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

n-ethylmaleimide reductase-like protein

Species:

Leishmania mexicana

UniProt:

E9AP14_LEIMU

TriTrypDb:

LmxM.12.1140

Length:

819

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AP14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP14

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0010181	FMN binding	4	6
GO:0016491	oxidoreductase activity	2	6
GO:0032553	ribonucleotide binding	3	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.634
CLV_C14_Caspase3-7	391	395	PF00656	0.634
CLV_C14_Caspase3-7	633	637	PF00656	0.532
CLV_C14_Caspase3-7	688	692	PF00656	0.532
CLV_MEL_PAP_1	647	653	PF00089	0.301
CLV_NRD_NRD_1	257	259	PF00675	0.232
CLV_NRD_NRD_1	272	274	PF00675	0.279
CLV_NRD_NRD_1	298	300	PF00675	0.332
CLV_NRD_NRD_1	397	399	PF00675	0.641
CLV_NRD_NRD_1	460	462	PF00675	0.332
CLV_NRD_NRD_1	496	498	PF00675	0.301
CLV_NRD_NRD_1	609	611	PF00675	0.330
CLV_NRD_NRD_1	645	647	PF00675	0.332
CLV_NRD_NRD_1	678	680	PF00675	0.332
CLV_NRD_NRD_1	785	787	PF00675	0.523
CLV_PCSK_KEX2_1	257	259	PF00082	0.223
CLV_PCSK_KEX2_1	298	300	PF00082	0.332
CLV_PCSK_KEX2_1	397	399	PF00082	0.641
CLV_PCSK_KEX2_1	460	462	PF00082	0.332
CLV_PCSK_KEX2_1	644	646	PF00082	0.332
CLV_PCSK_KEX2_1	727	729	PF00082	0.332
CLV_PCSK_KEX2_1	785	787	PF00082	0.368
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.332
CLV_PCSK_SKI1_1	172	176	PF00082	0.332
CLV_PCSK_SKI1_1	223	227	PF00082	0.434
CLV_PCSK_SKI1_1	274	278	PF00082	0.293
CLV_PCSK_SKI1_1	344	348	PF00082	0.332
CLV_PCSK_SKI1_1	497	501	PF00082	0.332
CLV_PCSK_SKI1_1	658	662	PF00082	0.332
CLV_PCSK_SKI1_1	704	708	PF00082	0.301
CLV_PCSK_SKI1_1	91	95	PF00082	0.434
CLV_Separin_Metazoa	564	568	PF03568	0.501
DEG_APCC_DBOX_1	222	230	PF00400	0.532
DEG_COP1_1	39	46	PF00400	0.634
DEG_SCF_FBW7_1	243	250	PF00400	0.532
DOC_ANK_TNKS_1	285	292	PF00023	0.532
DOC_CYCLIN_RxL_1	220	230	PF00134	0.634
DOC_MAPK_gen_1	221	228	PF00069	0.547
DOC_MAPK_gen_1	237	245	PF00069	0.523
DOC_MAPK_gen_1	273	280	PF00069	0.493
DOC_MAPK_gen_1	460	468	PF00069	0.532
DOC_MAPK_gen_1	572	581	PF00069	0.532
DOC_MAPK_gen_1	644	651	PF00069	0.532
DOC_MAPK_gen_1	679	686	PF00069	0.532
DOC_MAPK_MEF2A_6	237	245	PF00069	0.543
DOC_MAPK_MEF2A_6	572	581	PF00069	0.532
DOC_MAPK_MEF2A_6	644	651	PF00069	0.532
DOC_PP1_RVXF_1	271	278	PF00149	0.634
DOC_PP1_RVXF_1	570	576	PF00149	0.532
DOC_PP1_SILK_1	700	705	PF00149	0.454
DOC_PP4_FxxP_1	378	381	PF00568	0.636
DOC_PP4_FxxP_1	694	697	PF00568	0.415
DOC_USP7_MATH_1	161	165	PF00917	0.518
DOC_USP7_MATH_1	170	174	PF00917	0.487
DOC_USP7_MATH_1	354	358	PF00917	0.457
DOC_USP7_MATH_1	687	691	PF00917	0.532
DOC_USP7_MATH_1	793	797	PF00917	0.566
DOC_USP7_UBL2_3	408	412	PF12436	0.501
DOC_USP7_UBL2_3	574	578	PF12436	0.501
DOC_WW_Pin1_4	113	118	PF00397	0.532
DOC_WW_Pin1_4	243	248	PF00397	0.634
DOC_WW_Pin1_4	620	625	PF00397	0.532
DOC_WW_Pin1_4	649	654	PF00397	0.532
DOC_WW_Pin1_4	809	814	PF00397	0.599
LIG_14-3-3_CanoR_1	113	117	PF00244	0.634
LIG_14-3-3_CanoR_1	298	302	PF00244	0.532
LIG_14-3-3_CanoR_1	397	401	PF00244	0.592
LIG_14-3-3_CanoR_1	403	408	PF00244	0.608
LIG_14-3-3_CanoR_1	460	465	PF00244	0.532
LIG_14-3-3_CanoR_1	477	482	PF00244	0.419
LIG_14-3-3_CanoR_1	519	523	PF00244	0.501
LIG_14-3-3_CanoR_1	540	549	PF00244	0.415
LIG_14-3-3_CanoR_1	55	59	PF00244	0.634
LIG_14-3-3_CanoR_1	567	575	PF00244	0.501
LIG_Actin_WH2_2	561	576	PF00022	0.529
LIG_BIR_II_1	1	5	PF00653	0.763
LIG_BIR_III_2	776	780	PF00653	0.330
LIG_BRCT_BRCA1_1	356	360	PF00533	0.446
LIG_CaMK_CASK_1	294	299	PF00069	0.532
LIG_deltaCOP1_diTrp_1	294	301	PF00928	0.532
LIG_FHA_1	261	267	PF00498	0.634
LIG_FHA_1	498	504	PF00498	0.532
LIG_FHA_1	537	543	PF00498	0.521
LIG_FHA_1	61	67	PF00498	0.532
LIG_FHA_1	92	98	PF00498	0.634
LIG_FHA_2	161	167	PF00498	0.564
LIG_FHA_2	244	250	PF00498	0.532
LIG_FHA_2	613	619	PF00498	0.532
LIG_FHA_2	661	667	PF00498	0.532
LIG_FHA_2	778	784	PF00498	0.436
LIG_FHA_2	90	96	PF00498	0.485
LIG_Integrin_RGD_1	282	284	PF01839	0.426
LIG_LIR_Apic_2	691	697	PF02991	0.532
LIG_LIR_Gen_1	780	788	PF02991	0.460
LIG_LIR_Nem_3	340	346	PF02991	0.542
LIG_LIR_Nem_3	364	370	PF02991	0.602
LIG_LIR_Nem_3	463	467	PF02991	0.530
LIG_LIR_Nem_3	772	778	PF02991	0.505
LIG_LIR_Nem_3	780	784	PF02991	0.422
LIG_LIR_Nem_3	88	93	PF02991	0.578
LIG_PTB_Apo_2	345	352	PF02174	0.559
LIG_RPA_C_Fungi	455	467	PF08784	0.385
LIG_RPA_C_Fungi	789	801	PF08784	0.462
LIG_SH2_CRK	416	420	PF00017	0.323
LIG_SH2_CRK	464	468	PF00017	0.385
LIG_SH2_CRK	511	515	PF00017	0.385
LIG_SH2_CRK	683	687	PF00017	0.295
LIG_SH2_CRK	695	699	PF00017	0.364
LIG_SH2_SRC	77	80	PF00017	0.385
LIG_SH2_STAP1	10	14	PF00017	0.514
LIG_SH2_STAP1	155	159	PF00017	0.250
LIG_SH2_STAP1	458	462	PF00017	0.320
LIG_SH2_STAP1	52	56	PF00017	0.363
LIG_SH2_STAP1	803	807	PF00017	0.448
LIG_SH2_STAT3	265	268	PF00017	0.342
LIG_SH2_STAT5	10	13	PF00017	0.473
LIG_SH2_STAT5	197	200	PF00017	0.527
LIG_SH2_STAT5	265	268	PF00017	0.517
LIG_SH2_STAT5	367	370	PF00017	0.551
LIG_SH2_STAT5	416	419	PF00017	0.495
LIG_SH2_STAT5	481	484	PF00017	0.385
LIG_SH2_STAT5	511	514	PF00017	0.385
LIG_SH2_STAT5	580	583	PF00017	0.385
LIG_SH2_STAT5	603	606	PF00017	0.385
LIG_SH2_STAT5	693	696	PF00017	0.303
LIG_SH3_3	124	130	PF00018	0.385
LIG_SH3_3	16	22	PF00018	0.446
LIG_SH3_3	26	32	PF00018	0.429
LIG_SH3_3	369	375	PF00018	0.575
LIG_SH3_3	416	422	PF00018	0.489
LIG_SH3_3	432	438	PF00018	0.237
LIG_SH3_3	756	762	PF00018	0.504
LIG_SUMO_SIM_par_1	224	230	PF11976	0.385
LIG_TRAF2_2	440	445	PF00917	0.385
LIG_TYR_ITIM	509	514	PF00017	0.385
LIG_TYR_ITIM	681	686	PF00017	0.385
LIG_WRC_WIRS_1	171	176	PF05994	0.320
LIG_WRC_WIRS_1	199	204	PF05994	0.385
LIG_WRC_WIRS_1	248	253	PF05994	0.527
MOD_CDK_SPxxK_3	620	627	PF00069	0.385
MOD_CK1_1	396	402	PF00069	0.555
MOD_CK1_1	54	60	PF00069	0.385
MOD_CK1_1	796	802	PF00069	0.428
MOD_CK1_1	805	811	PF00069	0.503
MOD_CK2_1	160	166	PF00069	0.396
MOD_CK2_1	718	724	PF00069	0.385
MOD_CK2_1	777	783	PF00069	0.439
MOD_CK2_1	89	95	PF00069	0.320
MOD_Cter_Amidation	642	645	PF01082	0.385
MOD_DYRK1A_RPxSP_1	113	117	PF00069	0.385
MOD_GlcNHglycan	121	124	PF01048	0.385
MOD_GlcNHglycan	130	133	PF01048	0.454
MOD_GlcNHglycan	163	166	PF01048	0.342
MOD_GlcNHglycan	2	5	PF01048	0.757
MOD_GlcNHglycan	291	294	PF01048	0.325
MOD_GlcNHglycan	542	545	PF01048	0.352
MOD_GlcNHglycan	568	571	PF01048	0.385
MOD_GlcNHglycan	687	690	PF01048	0.385
MOD_GlcNHglycan	72	75	PF01048	0.393
MOD_GlcNHglycan	795	798	PF01048	0.567
MOD_GlcNHglycan	82	85	PF01048	0.295
MOD_GSK3_1	243	250	PF00069	0.527
MOD_GSK3_1	354	361	PF00069	0.572
MOD_GSK3_1	384	391	PF00069	0.639
MOD_GSK3_1	392	399	PF00069	0.593
MOD_GSK3_1	536	543	PF00069	0.361
MOD_GSK3_1	801	808	PF00069	0.517
MOD_N-GLC_1	118	123	PF02516	0.385
MOD_N-GLC_1	219	224	PF02516	0.385
MOD_N-GLC_1	376	381	PF02516	0.459
MOD_N-GLC_1	70	75	PF02516	0.331
MOD_N-GLC_1	718	723	PF02516	0.385
MOD_N-GLC_1	808	813	PF02516	0.537
MOD_NEK2_1	198	203	PF00069	0.499
MOD_NEK2_1	384	389	PF00069	0.565
MOD_NEK2_2	426	431	PF00069	0.385
MOD_PIKK_1	153	159	PF00454	0.300
MOD_PIKK_1	417	423	PF00454	0.481
MOD_PKA_1	460	466	PF00069	0.385
MOD_PKA_1	497	503	PF00069	0.342
MOD_PKA_1	610	616	PF00069	0.385
MOD_PKA_2	112	118	PF00069	0.527
MOD_PKA_2	297	303	PF00069	0.385
MOD_PKA_2	361	367	PF00069	0.487
MOD_PKA_2	396	402	PF00069	0.678
MOD_PKA_2	460	466	PF00069	0.382
MOD_PKA_2	518	524	PF00069	0.342
MOD_PKA_2	54	60	PF00069	0.527
MOD_PKA_2	566	572	PF00069	0.342
MOD_PKA_2	793	799	PF00069	0.569
MOD_Plk_1	219	225	PF00069	0.385
MOD_Plk_1	354	360	PF00069	0.449
MOD_Plk_1	718	724	PF00069	0.382
MOD_Plk_2-3	718	724	PF00069	0.385
MOD_Plk_4	198	204	PF00069	0.385
MOD_Plk_4	261	267	PF00069	0.287
MOD_Plk_4	355	361	PF00069	0.633
MOD_Plk_4	477	483	PF00069	0.385
MOD_Plk_4	698	704	PF00069	0.320
MOD_Plk_4	763	769	PF00069	0.528
MOD_ProDKin_1	113	119	PF00069	0.385
MOD_ProDKin_1	243	249	PF00069	0.527
MOD_ProDKin_1	620	626	PF00069	0.385
MOD_ProDKin_1	649	655	PF00069	0.385
MOD_ProDKin_1	809	815	PF00069	0.601
MOD_SUMO_rev_2	147	152	PF00179	0.385
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.385
TRG_DiLeu_BaLyEn_6	626	631	PF01217	0.385
TRG_ENDOCYTIC_2	10	13	PF00928	0.517
TRG_ENDOCYTIC_2	311	314	PF00928	0.336
TRG_ENDOCYTIC_2	416	419	PF00928	0.495
TRG_ENDOCYTIC_2	464	467	PF00928	0.385
TRG_ENDOCYTIC_2	511	514	PF00928	0.385
TRG_ENDOCYTIC_2	683	686	PF00928	0.385
TRG_ENDOCYTIC_2	695	698	PF00928	0.274
TRG_ENDOCYTIC_2	72	75	PF00928	0.527
TRG_ENDOCYTIC_2	781	784	PF00928	0.497
TRG_ER_diArg_1	221	224	PF00400	0.527
TRG_ER_diArg_1	257	259	PF00400	0.232
TRG_ER_diArg_1	297	299	PF00400	0.385
TRG_ER_diArg_1	440	443	PF00400	0.385
TRG_ER_diArg_1	627	630	PF00400	0.346
TRG_ER_diArg_1	644	646	PF00400	0.227
TRG_ER_diArg_1	784	786	PF00400	0.363
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	398	402	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	629	633	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8C3	Leishmania donovani	89%	99%
A4H6Z4	Leishmania braziliensis	80%	100%
E9AGH8	Leishmania infantum	89%	99%
Q4QGH5	Leishmania major	89%	100%