N-ethylmaleimide reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

n-ethylmaleimide reductase-like protein

Species:

Leishmania mexicana

UniProt:

E9AP14_LEIMU

TriTrypDb:

LmxM.12.1140

Length:

819

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

E9AP14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP14

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0010181	FMN binding	4	6
GO:0016491	oxidoreductase activity	2	6
GO:0032553	ribonucleotide binding	3	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.634
CLV_C14_Caspase3-7	391	395	PF00656	0.634
CLV_C14_Caspase3-7	633	637	PF00656	0.532
CLV_C14_Caspase3-7	688	692	PF00656	0.532
CLV_MEL_PAP_1	647	653	PF00089	0.301
CLV_NRD_NRD_1	257	259	PF00675	0.232
CLV_NRD_NRD_1	272	274	PF00675	0.279
CLV_NRD_NRD_1	298	300	PF00675	0.332
CLV_NRD_NRD_1	397	399	PF00675	0.641
CLV_NRD_NRD_1	460	462	PF00675	0.332

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8C3	Leishmania donovani	89%	99%
A4H6Z4	Leishmania braziliensis	80%	100%
E9AGH8	Leishmania infantum	89%	99%
Q4QGH5	Leishmania major	89%	100%

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