NADH:flavin oxidoreductase/NADH oxidase,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH:flavin oxidoreductase/NADH oxidase, putative

Species:

Leishmania mexicana

UniProt:

E9AP13_LEIMU

TriTrypDb:

LmxM.12.1130

Length:

384

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0110165	cellular anatomical entity	1	10
GO:0005829	cytosol	2	1

Expansion

Sequence features

E9AP13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP13

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0010181	FMN binding	4	10
GO:0016491	oxidoreductase activity	2	10
GO:0032553	ribonucleotide binding	3	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016657	oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.552
CLV_C14_Caspase3-7	353	357	PF00656	0.321
CLV_NRD_NRD_1	266	268	PF00675	0.311
CLV_PCSK_SKI1_1	13	17	PF00082	0.270
CLV_PCSK_SKI1_1	217	221	PF00082	0.366
CLV_PCSK_SKI1_1	268	272	PF00082	0.300
CLV_PCSK_SKI1_1	89	93	PF00082	0.339
DEG_COP1_1	37	44	PF00400	0.523
DOC_CYCLIN_RxL_1	214	224	PF00134	0.552
DOC_MAPK_gen_1	232	239	PF00069	0.523
DOC_MAPK_gen_1	267	274	PF00069	0.434
DOC_MAPK_MEF2A_6	232	239	PF00069	0.523
DOC_MAPK_MEF2A_6	53	60	PF00069	0.552
DOC_MAPK_NFAT4_5	53	61	PF00069	0.552
DOC_PP1_RVXF_1	265	272	PF00149	0.552
DOC_PP4_FxxP_1	364	367	PF00568	0.340
DOC_USP7_MATH_1	241	245	PF00917	0.518
DOC_USP7_MATH_1	373	377	PF00917	0.658
DOC_WW_Pin1_4	237	242	PF00397	0.469
LIG_14-3-3_CanoR_1	111	115	PF00244	0.535
LIG_14-3-3_CanoR_1	258	266	PF00244	0.465
LIG_14-3-3_CanoR_1	53	57	PF00244	0.469
LIG_Actin_WH2_2	223	240	PF00022	0.469
LIG_Actin_WH2_2	253	269	PF00022	0.446
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_BRCT_BRCA1_1	22	26	PF00533	0.497
LIG_FHA_1	255	261	PF00498	0.469
LIG_FHA_1	323	329	PF00498	0.564
LIG_FHA_1	90	96	PF00498	0.567
LIG_FHA_2	131	137	PF00498	0.613
LIG_FHA_2	155	161	PF00498	0.422
LIG_FHA_2	351	357	PF00498	0.448
LIG_IRF3_LxIS_1	235	240	PF10401	0.486
LIG_LIR_Apic_2	361	367	PF02991	0.322
LIG_LIR_Gen_1	361	367	PF02991	0.340
LIG_LIR_Nem_3	278	282	PF02991	0.488
LIG_LIR_Nem_3	292	297	PF02991	0.496
LIG_LIR_Nem_3	356	362	PF02991	0.454
LIG_LIR_Nem_3	86	91	PF02991	0.513
LIG_SH2_NCK_1	168	172	PF00017	0.552
LIG_SH2_STAP1	168	172	PF00017	0.552
LIG_SH2_STAP1	50	54	PF00017	0.486
LIG_SH2_STAP1	70	74	PF00017	0.537
LIG_SH2_STAT5	140	143	PF00017	0.431
LIG_SH2_STAT5	191	194	PF00017	0.469
LIG_SH2_STAT5	259	262	PF00017	0.502
LIG_SH2_STAT5	352	355	PF00017	0.433
LIG_SH2_STAT5	362	365	PF00017	0.411
LIG_SH3_3	369	375	PF00018	0.610
LIG_TRAF2_1	157	160	PF00917	0.556
LIG_TRAF2_1	290	293	PF00917	0.596
LIG_UBA3_1	219	228	PF00899	0.493
LIG_WRC_WIRS_1	242	247	PF05994	0.523
MOD_CK1_1	2	8	PF00069	0.485
MOD_CK2_1	130	136	PF00069	0.613
MOD_CK2_1	154	160	PF00069	0.433
MOD_Cter_Amidation	144	147	PF01082	0.194
MOD_GlcNHglycan	127	130	PF01048	0.283
MOD_GlcNHglycan	2	5	PF01048	0.578
MOD_GlcNHglycan	314	317	PF01048	0.323
MOD_GlcNHglycan	375	378	PF01048	0.618
MOD_GlcNHglycan	70	73	PF01048	0.272
MOD_GSK3_1	109	116	PF00069	0.497
MOD_GSK3_1	198	205	PF00069	0.520
MOD_GSK3_1	237	244	PF00069	0.486
MOD_GSK3_1	347	354	PF00069	0.480
MOD_GSK3_1	48	55	PF00069	0.537
MOD_NEK2_1	167	172	PF00069	0.490
MOD_NEK2_1	196	201	PF00069	0.479
MOD_PIKK_1	259	265	PF00454	0.598
MOD_PIKK_1	61	67	PF00454	0.523
MOD_PKA_1	89	95	PF00069	0.552
MOD_PKA_2	110	116	PF00069	0.558
MOD_PKA_2	52	58	PF00069	0.512
MOD_Plk_1	61	67	PF00069	0.469
MOD_Plk_4	347	353	PF00069	0.542
MOD_ProDKin_1	237	243	PF00069	0.469
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.334
TRG_ENDOCYTIC_2	294	297	PF00928	0.486
TRG_ENDOCYTIC_2	362	365	PF00928	0.540
TRG_ENDOCYTIC_2	70	73	PF00928	0.469
TRG_ER_diArg_1	215	218	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2A2	Leptomonas seymouri	68%	100%
A0A0N0P2S0	Leptomonas seymouri	32%	100%
A0A0N1HZB3	Leptomonas seymouri	39%	68%
A0A0S4IVY9	Bodo saltans	34%	100%
A0A0S4IYW9	Bodo saltans	40%	100%
A0A0S4JST7	Bodo saltans	28%	68%
A0A1D8PPK1	Candida albicans (strain SC5314 / ATCC MYA-2876)	33%	94%
A0A1U8QTA2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	39%	99%
A0A1X0P653	Trypanosomatidae	48%	100%
A0A3Q8ICQ9	Leishmania donovani	88%	100%
A0A422NKC3	Trypanosoma rangeli	46%	100%
A0A482NAR8	Talaromyces variabilis	29%	95%
A2TBU0	Epichloe festucae var. lolii	35%	100%
A4H6Z3	Leishmania braziliensis	80%	100%
A4IQK7	Geobacillus thermodenitrificans (strain NG80-2)	31%	100%
A8C7R3	Claviceps fusiformis	32%	100%
B8N8Q9	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	30%	93%
B8NWW6	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	37%	100%
B9FFD2	Oryza sativa subsp. japonica	41%	95%
B9FFD3	Oryza sativa subsp. japonica	39%	100%
B9FSC8	Oryza sativa subsp. japonica	39%	100%
C5H429	Artemisia annua	39%	99%
E9AGH7	Leishmania infantum	89%	100%
I1RV17	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	93%
M1W0Y0	Claviceps purpurea (strain 20.1)	32%	100%
P0DI08	Arabidopsis thaliana	40%	100%
P0DI09	Arabidopsis thaliana	40%	100%
P0DN73	Streptococcus pyogenes serotype M5 (strain Manfredo)	28%	96%
P40952	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	32%	96%
P41816	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	96%
P43084	Candida albicans	33%	94%
P54524	Bacillus subtilis (strain 168)	34%	100%
P77258	Escherichia coli (strain K12)	39%	100%
Q02899	Saccharomyces pastorianus	34%	96%
Q03558	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	96%
Q09670	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q09671	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	98%
Q0E0C6	Oryza sativa subsp. japonica	38%	95%
Q4QGH6	Leishmania major	87%	100%
Q4WZ70	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	36%	100%
Q5KXG9	Geobacillus kaustophilus (strain HTA426)	32%	100%
Q69TH4	Oryza sativa subsp. japonica	40%	100%
Q69TH6	Oryza sativa subsp. japonica	41%	100%
Q69TH8	Oryza sativa subsp. japonica	38%	100%
Q69TI0	Oryza sativa subsp. japonica	41%	100%
Q69TI2	Oryza sativa subsp. japonica	39%	98%
Q6Z965	Oryza sativa subsp. japonica	41%	97%
Q6ZXC1	Claviceps purpurea	33%	100%
Q84QK0	Oryza sativa subsp. japonica	40%	100%
Q8GYA3	Arabidopsis thaliana	37%	100%
Q8GYB8	Arabidopsis thaliana	38%	100%
Q8LAH7	Arabidopsis thaliana	39%	100%
Q9FEW9	Solanum lycopersicum	39%	97%
Q9FEX0	Solanum lycopersicum	34%	100%
Q9FUP0	Arabidopsis thaliana	40%	98%
Q9XG54	Solanum lycopersicum	39%	100%
V5BT91	Trypanosoma cruzi	46%	100%
W6Q2D7	Penicillium roqueforti (strain FM164)	39%	100%
W6Q9S9	Penicillium roqueforti (strain FM164)	38%	100%