J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AP11_LEIMU

TriTrypDb:

LmxM.12.1110

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AP11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP11

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0035966	response to topologically incorrect protein	3	1
GO:0035967	cellular response to topologically incorrect protein	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051084	'de novo' post-translational protein folding	4	1
GO:0051085	chaperone cofactor-dependent protein refolding	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0051788	response to misfolded protein	4	1
GO:0061077	chaperone-mediated protein folding	3	1
GO:0070887	cellular response to chemical stimulus	3	1
GO:0071218	cellular response to misfolded protein	5	1
GO:0071310	cellular response to organic substance	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030544	Hsp70 protein binding	4	1
GO:0031072	heat shock protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.520
CLV_C14_Caspase3-7	410	414	PF00656	0.632
CLV_NRD_NRD_1	132	134	PF00675	0.672
CLV_NRD_NRD_1	175	177	PF00675	0.533
CLV_NRD_NRD_1	24	26	PF00675	0.360
CLV_NRD_NRD_1	306	308	PF00675	0.685
CLV_NRD_NRD_1	59	61	PF00675	0.376
CLV_PCSK_FUR_1	173	177	PF00082	0.527
CLV_PCSK_KEX2_1	132	134	PF00082	0.672
CLV_PCSK_KEX2_1	175	177	PF00082	0.533
CLV_PCSK_KEX2_1	21	23	PF00082	0.308
CLV_PCSK_KEX2_1	280	282	PF00082	0.533
CLV_PCSK_KEX2_1	306	308	PF00082	0.685
CLV_PCSK_KEX2_1	58	60	PF00082	0.308
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.259
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.533
CLV_PCSK_SKI1_1	26	30	PF00082	0.312
DEG_APCC_DBOX_1	580	588	PF00400	0.454
DEG_SPOP_SBC_1	588	592	PF00917	0.587
DOC_ANK_TNKS_1	145	152	PF00023	0.594
DOC_CKS1_1	229	234	PF01111	0.491
DOC_CYCLIN_RxL_1	4	12	PF00134	0.292
DOC_MAPK_gen_1	21	31	PF00069	0.308
DOC_MAPK_gen_1	296	304	PF00069	0.551
DOC_MAPK_gen_1	331	340	PF00069	0.541
DOC_MAPK_MEF2A_6	22	31	PF00069	0.211
DOC_PP4_FxxP_1	103	106	PF00568	0.611
DOC_PP4_FxxP_1	189	192	PF00568	0.628
DOC_PP4_FxxP_1	212	215	PF00568	0.498
DOC_PP4_FxxP_1	460	463	PF00568	0.600
DOC_USP7_MATH_1	339	343	PF00917	0.640
DOC_USP7_MATH_1	344	348	PF00917	0.607
DOC_USP7_MATH_1	433	437	PF00917	0.530
DOC_USP7_MATH_1	503	507	PF00917	0.467
DOC_USP7_MATH_1	593	597	PF00917	0.630
DOC_USP7_MATH_1	619	623	PF00917	0.551
DOC_USP7_MATH_1	69	73	PF00917	0.668
DOC_USP7_MATH_1	74	78	PF00917	0.475
DOC_USP7_MATH_1	94	98	PF00917	0.691
DOC_WW_Pin1_4	104	109	PF00397	0.574
DOC_WW_Pin1_4	201	206	PF00397	0.663
DOC_WW_Pin1_4	211	216	PF00397	0.499
DOC_WW_Pin1_4	228	233	PF00397	0.472
DOC_WW_Pin1_4	243	248	PF00397	0.530
DOC_WW_Pin1_4	405	410	PF00397	0.597
DOC_WW_Pin1_4	493	498	PF00397	0.572
DOC_WW_Pin1_4	72	77	PF00397	0.573
LIG_14-3-3_CanoR_1	181	189	PF00244	0.608
LIG_14-3-3_CanoR_1	220	224	PF00244	0.688
LIG_14-3-3_CanoR_1	322	327	PF00244	0.658
LIG_14-3-3_CanoR_1	350	359	PF00244	0.588
LIG_14-3-3_CanoR_1	4	10	PF00244	0.359
LIG_14-3-3_CanoR_1	484	493	PF00244	0.437
LIG_14-3-3_CanoR_1	581	585	PF00244	0.446
LIG_14-3-3_CanoR_1	615	619	PF00244	0.712
LIG_APCC_ABBA_1	29	34	PF00400	0.309
LIG_BIR_III_2	451	455	PF00653	0.504
LIG_BRCT_BRCA1_1	203	207	PF00533	0.696
LIG_BRCT_BRCA1_1	208	212	PF00533	0.654
LIG_CSL_BTD_1	244	247	PF09270	0.512
LIG_eIF4E_1	24	30	PF01652	0.308
LIG_EVH1_1	584	588	PF00568	0.479
LIG_FHA_1	151	157	PF00498	0.659
LIG_FHA_1	224	230	PF00498	0.505
LIG_FHA_1	333	339	PF00498	0.703
LIG_FHA_1	6	12	PF00498	0.379
LIG_FHA_2	111	117	PF00498	0.595
LIG_FHA_2	316	322	PF00498	0.530
LIG_FHA_2	368	374	PF00498	0.660
LIG_GBD_Chelix_1	516	524	PF00786	0.399
LIG_LIR_Apic_2	188	192	PF02991	0.628
LIG_LIR_Apic_2	209	215	PF02991	0.504
LIG_LIR_Apic_2	323	329	PF02991	0.566
LIG_LIR_Apic_2	458	463	PF02991	0.537
LIG_LIR_Nem_3	3	9	PF02991	0.308
LIG_LIR_Nem_3	627	633	PF02991	0.556
LIG_MYND_1	585	589	PF01753	0.484
LIG_Rb_LxCxE_1	637	646	PF01857	0.458
LIG_SH2_CRK	6	10	PF00017	0.308
LIG_SH2_CRK	630	634	PF00017	0.478
LIG_SH2_NCK_1	326	330	PF00017	0.528
LIG_SH2_SRC	50	53	PF00017	0.379
LIG_SH2_STAP1	50	54	PF00017	0.308
LIG_SH2_STAT5	495	498	PF00017	0.617
LIG_SH2_STAT5	511	514	PF00017	0.340
LIG_SH2_STAT5	551	554	PF00017	0.409
LIG_SH2_STAT5	564	567	PF00017	0.331
LIG_SH3_3	190	196	PF00018	0.633
LIG_SH3_3	403	409	PF00018	0.599
LIG_SH3_3	582	588	PF00018	0.563
LIG_SH3_3	630	636	PF00018	0.513
LIG_SH3_3	77	83	PF00018	0.614
LIG_SH3_3	98	104	PF00018	0.630
LIG_TRAF2_1	334	337	PF00917	0.591
LIG_WW_2	585	588	PF00397	0.486
MOD_CK1_1	161	167	PF00069	0.587
MOD_CK1_1	208	214	PF00069	0.679
MOD_CK1_1	228	234	PF00069	0.667
MOD_CK1_1	312	318	PF00069	0.597
MOD_CK1_1	367	373	PF00069	0.573
MOD_CK1_1	415	421	PF00069	0.663
MOD_CK1_1	444	450	PF00069	0.510
MOD_CK1_1	566	572	PF00069	0.511
MOD_CK1_1	609	615	PF00069	0.546
MOD_CK1_1	617	623	PF00069	0.554
MOD_CK1_1	637	643	PF00069	0.593
MOD_CK1_1	72	78	PF00069	0.619
MOD_CK2_1	110	116	PF00069	0.628
MOD_CK2_1	182	188	PF00069	0.581
MOD_CK2_1	245	251	PF00069	0.766
MOD_CK2_1	315	321	PF00069	0.642
MOD_CK2_1	365	371	PF00069	0.684
MOD_CK2_1	503	509	PF00069	0.444
MOD_CK2_1	512	518	PF00069	0.426
MOD_CK2_1	555	561	PF00069	0.395
MOD_CK2_1	594	600	PF00069	0.781
MOD_CK2_1	637	643	PF00069	0.537
MOD_GlcNHglycan	141	145	PF01048	0.706
MOD_GlcNHglycan	184	187	PF01048	0.765
MOD_GlcNHglycan	188	192	PF01048	0.616
MOD_GlcNHglycan	199	202	PF01048	0.673
MOD_GlcNHglycan	248	251	PF01048	0.613
MOD_GlcNHglycan	291	294	PF01048	0.564
MOD_GlcNHglycan	310	314	PF01048	0.663
MOD_GlcNHglycan	346	349	PF01048	0.565
MOD_GlcNHglycan	413	417	PF01048	0.709
MOD_GlcNHglycan	427	430	PF01048	0.564
MOD_GlcNHglycan	433	436	PF01048	0.493
MOD_GlcNHglycan	457	460	PF01048	0.687
MOD_GlcNHglycan	541	544	PF01048	0.452
MOD_GlcNHglycan	565	568	PF01048	0.430
MOD_GlcNHglycan	608	611	PF01048	0.533
MOD_GlcNHglycan	621	624	PF01048	0.680
MOD_GlcNHglycan	71	74	PF01048	0.538
MOD_GlcNHglycan	96	99	PF01048	0.551
MOD_GSK3_1	197	204	PF00069	0.697
MOD_GSK3_1	207	214	PF00069	0.693
MOD_GSK3_1	219	226	PF00069	0.603
MOD_GSK3_1	280	287	PF00069	0.626
MOD_GSK3_1	350	357	PF00069	0.628
MOD_GSK3_1	358	365	PF00069	0.636
MOD_GSK3_1	439	446	PF00069	0.620
MOD_GSK3_1	535	542	PF00069	0.386
MOD_GSK3_1	587	594	PF00069	0.685
MOD_GSK3_1	601	608	PF00069	0.555
MOD_GSK3_1	614	621	PF00069	0.497
MOD_GSK3_1	68	75	PF00069	0.654
MOD_N-GLC_2	160	162	PF02516	0.665
MOD_NEK2_1	118	123	PF00069	0.682
MOD_NEK2_1	207	212	PF00069	0.655
MOD_NEK2_1	359	364	PF00069	0.711
MOD_NEK2_1	439	444	PF00069	0.608
MOD_NEK2_1	480	485	PF00069	0.345
MOD_NEK2_1	512	517	PF00069	0.494
MOD_NEK2_1	552	557	PF00069	0.480
MOD_NEK2_1	579	584	PF00069	0.423
MOD_NEK2_1	618	623	PF00069	0.649
MOD_PIKK_1	214	220	PF00454	0.691
MOD_PK_1	280	286	PF00069	0.532
MOD_PK_1	634	640	PF00069	0.530
MOD_PKA_1	280	286	PF00069	0.532
MOD_PKA_2	219	225	PF00069	0.706
MOD_PKA_2	280	286	PF00069	0.596
MOD_PKA_2	289	295	PF00069	0.557
MOD_PKA_2	315	321	PF00069	0.524
MOD_PKA_2	332	338	PF00069	0.528
MOD_PKA_2	389	395	PF00069	0.538
MOD_PKA_2	530	536	PF00069	0.522
MOD_PKA_2	580	586	PF00069	0.444
MOD_PKA_2	614	620	PF00069	0.693
MOD_Plk_1	392	398	PF00069	0.548
MOD_Plk_1	480	486	PF00069	0.349
MOD_Plk_1	579	585	PF00069	0.422
MOD_Plk_2-3	251	257	PF00069	0.696
MOD_Plk_2-3	462	468	PF00069	0.516
MOD_Plk_4	219	225	PF00069	0.565
MOD_Plk_4	594	600	PF00069	0.506
MOD_Plk_4	634	640	PF00069	0.498
MOD_ProDKin_1	104	110	PF00069	0.572
MOD_ProDKin_1	201	207	PF00069	0.664
MOD_ProDKin_1	211	217	PF00069	0.497
MOD_ProDKin_1	228	234	PF00069	0.472
MOD_ProDKin_1	243	249	PF00069	0.530
MOD_ProDKin_1	405	411	PF00069	0.600
MOD_ProDKin_1	493	499	PF00069	0.571
MOD_ProDKin_1	72	78	PF00069	0.573
MOD_SUMO_rev_2	17	23	PF00179	0.262
MOD_SUMO_rev_2	251	260	PF00179	0.527
TRG_ENDOCYTIC_2	24	27	PF00928	0.193
TRG_ENDOCYTIC_2	6	9	PF00928	0.312
TRG_ENDOCYTIC_2	630	633	PF00928	0.551
TRG_ER_diArg_1	174	176	PF00400	0.522
TRG_ER_diArg_1	306	308	PF00400	0.679
TRG_ER_diArg_1	331	334	PF00400	0.544
TRG_ER_diArg_1	58	60	PF00400	0.403
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC79	Leptomonas seymouri	37%	100%
A0A3S7WS81	Leishmania donovani	78%	100%
A4H6Z1	Leishmania braziliensis	61%	100%
E9AGH2	Leishmania infantum	78%	100%
Q4QGH8	Leishmania major	75%	100%