Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AP09_LEIMU

TriTrypDb:

LmxM.12.0905

Length:

267

Annotations

LeishMANIAdb annotations

This is a highly disordered Cys-rich prote8in with spurious hydrophobic segments. Very low conservation.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP09

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0051536	iron-sulfur cluster binding	3	2
GO:0051537	2 iron, 2 sulfur cluster binding	4	2
GO:0051540	metal cluster binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.721
CLV_NRD_NRD_1	110	112	PF00675	0.804
CLV_NRD_NRD_1	145	147	PF00675	0.740
CLV_NRD_NRD_1	183	185	PF00675	0.736
CLV_NRD_NRD_1	248	250	PF00675	0.667
CLV_NRD_NRD_1	254	256	PF00675	0.611
CLV_NRD_NRD_1	257	259	PF00675	0.572
CLV_NRD_NRD_1	31	33	PF00675	0.696
CLV_NRD_NRD_1	64	66	PF00675	0.655
CLV_PCSK_FUR_1	108	112	PF00082	0.689
CLV_PCSK_FUR_1	255	259	PF00082	0.678
CLV_PCSK_KEX2_1	110	112	PF00082	0.804
CLV_PCSK_KEX2_1	145	147	PF00082	0.740
CLV_PCSK_KEX2_1	183	185	PF00082	0.736
CLV_PCSK_KEX2_1	248	250	PF00082	0.667
CLV_PCSK_KEX2_1	254	256	PF00082	0.611
CLV_PCSK_KEX2_1	257	259	PF00082	0.572
CLV_PCSK_KEX2_1	31	33	PF00082	0.696
CLV_PCSK_KEX2_1	64	66	PF00082	0.655
CLV_PCSK_PC7_1	60	66	PF00082	0.663
CLV_PCSK_SKI1_1	64	68	PF00082	0.587
CLV_Separin_Metazoa	245	249	PF03568	0.658
DEG_APCC_DBOX_1	63	71	PF00400	0.590
DEG_Nend_UBRbox_1	1	4	PF02207	0.706
DOC_CYCLIN_RxL_1	60	73	PF00134	0.664
DOC_MAPK_gen_1	64	72	PF00069	0.661
DOC_PP4_FxxP_1	153	156	PF00568	0.673
DOC_WW_Pin1_4	101	106	PF00397	0.678
DOC_WW_Pin1_4	92	97	PF00397	0.696
LIG_14-3-3_CanoR_1	190	198	PF00244	0.684
LIG_14-3-3_CanoR_1	207	211	PF00244	0.502
LIG_14-3-3_CanoR_1	257	266	PF00244	0.684
LIG_14-3-3_CanoR_1	54	63	PF00244	0.684
LIG_14-3-3_CanoR_1	64	70	PF00244	0.529
LIG_DLG_GKlike_1	65	72	PF00625	0.661
LIG_FHA_2	128	134	PF00498	0.835
LIG_FHA_2	212	218	PF00498	0.725
LIG_NRBOX	65	71	PF00104	0.658
LIG_PDZ_Class_1	262	267	PF00595	0.688
LIG_SH3_2	156	161	PF14604	0.794
LIG_SH3_3	153	159	PF00018	0.773
LIG_SH3_3	205	211	PF00018	0.702
LIG_SH3_3	3	9	PF00018	0.800
LIG_SH3_3	76	82	PF00018	0.787
LIG_SH3_CIN85_PxpxPR_1	140	145	PF14604	0.707
LIG_SUMO_SIM_par_1	68	73	PF11976	0.749
LIG_WW_3	78	82	PF00397	0.769
MOD_CDK_SPxxK_3	101	108	PF00069	0.682
MOD_CK1_1	154	160	PF00069	0.759
MOD_Cter_Amidation	29	32	PF01082	0.690
MOD_GlcNHglycan	148	151	PF01048	0.679
MOD_GlcNHglycan	153	156	PF01048	0.615
MOD_GlcNHglycan	192	195	PF01048	0.656
MOD_GlcNHglycan	227	230	PF01048	0.680
MOD_GlcNHglycan	259	262	PF01048	0.680
MOD_GlcNHglycan	41	44	PF01048	0.704
MOD_GSK3_1	253	260	PF00069	0.681
MOD_NEK2_1	203	208	PF00069	0.707
MOD_NEK2_1	253	258	PF00069	0.682
MOD_NEK2_1	70	75	PF00069	0.758
MOD_NEK2_1	98	103	PF00069	0.694
MOD_NEK2_2	262	267	PF00069	0.688
MOD_OFUCOSY	117	122	PF10250	0.674
MOD_PKA_1	257	263	PF00069	0.681
MOD_PKA_2	189	195	PF00069	0.681
MOD_PKA_2	206	212	PF00069	0.508
MOD_PKA_2	253	259	PF00069	0.680
MOD_PKA_2	44	50	PF00069	0.695
MOD_PKA_2	55	61	PF00069	0.549
MOD_PKB_1	255	263	PF00069	0.681
MOD_PKB_1	48	56	PF00069	0.694
MOD_Plk_4	34	40	PF00069	0.599
MOD_Plk_4	65	71	PF00069	0.658
MOD_ProDKin_1	101	107	PF00069	0.679
MOD_ProDKin_1	92	98	PF00069	0.698
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.765
TRG_ER_diArg_1	108	111	PF00400	0.795
TRG_ER_diArg_1	144	146	PF00400	0.707
TRG_ER_diArg_1	247	249	PF00400	0.665
TRG_ER_diArg_1	253	255	PF00400	0.614
TRG_ER_diArg_1	63	65	PF00400	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AGG6	Leishmania infantum	37%	100%