Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP06_LEIMU

TriTrypDb:

LmxM.12.0867

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 23
NetGPI	no	yes: 0, no: 24

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.596
CLV_C14_Caspase3-7	365	369	PF00656	0.721
CLV_NRD_NRD_1	229	231	PF00675	0.607
CLV_NRD_NRD_1	307	309	PF00675	0.789
CLV_NRD_NRD_1	318	320	PF00675	0.697
CLV_NRD_NRD_1	394	396	PF00675	0.656
CLV_PCSK_KEX2_1	229	231	PF00082	0.607
CLV_PCSK_KEX2_1	243	245	PF00082	0.624
CLV_PCSK_KEX2_1	307	309	PF00082	0.740
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.624
CLV_PCSK_SKI1_1	395	399	PF00082	0.676
CLV_Separin_Metazoa	226	230	PF03568	0.604
DEG_Nend_Nbox_1	1	3	PF02207	0.644
DOC_CYCLIN_RxL_1	392	402	PF00134	0.684
DOC_MAPK_gen_1	319	327	PF00069	0.733
DOC_MAPK_gen_1	34	44	PF00069	0.575
DOC_MAPK_gen_1	8	18	PF00069	0.659
DOC_MAPK_MEF2A_6	11	18	PF00069	0.610
DOC_PP4_FxxP_1	148	151	PF00568	0.576
DOC_USP7_MATH_1	426	430	PF00917	0.711
DOC_WW_Pin1_4	10	15	PF00397	0.576
DOC_WW_Pin1_4	103	108	PF00397	0.579
DOC_WW_Pin1_4	352	357	PF00397	0.670
DOC_WW_Pin1_4	431	436	PF00397	0.601
DOC_WW_Pin1_4	61	66	PF00397	0.573
LIG_14-3-3_CanoR_1	171	177	PF00244	0.530
LIG_14-3-3_CanoR_1	219	227	PF00244	0.465
LIG_14-3-3_CanoR_1	312	321	PF00244	0.516
LIG_14-3-3_CanoR_1	431	435	PF00244	0.766
LIG_BRCT_BRCA1_1	6	10	PF00533	0.653
LIG_deltaCOP1_diTrp_1	310	315	PF00928	0.643
LIG_EVH1_1	148	152	PF00568	0.576
LIG_EVH1_2	29	33	PF00568	0.497
LIG_FHA_1	11	17	PF00498	0.634
LIG_FHA_1	243	249	PF00498	0.614
LIG_FHA_2	328	334	PF00498	0.578
LIG_FHA_2	399	405	PF00498	0.690
LIG_FHA_2	55	61	PF00498	0.406
LIG_LIR_Apic_2	146	151	PF02991	0.587
LIG_LIR_Apic_2	250	255	PF02991	0.645
LIG_LIR_Apic_2	299	303	PF02991	0.645
LIG_LIR_Apic_2	59	65	PF02991	0.563
LIG_LIR_Apic_2	93	97	PF02991	0.596
LIG_LIR_Gen_1	175	181	PF02991	0.743
LIG_LIR_Gen_1	236	247	PF02991	0.605
LIG_LIR_Gen_1	289	300	PF02991	0.599
LIG_LIR_Nem_3	182	188	PF02991	0.562
LIG_LIR_Nem_3	236	242	PF02991	0.637
LIG_LIR_Nem_3	289	295	PF02991	0.592
LIG_LIR_Nem_3	31	36	PF02991	0.626
LIG_LIR_Nem_3	310	314	PF02991	0.644
LIG_LIR_Nem_3	85	90	PF02991	0.580
LIG_PCNA_PIPBox_1	116	125	PF02747	0.654
LIG_Pex14_2	327	331	PF04695	0.723
LIG_SH2_CRK	292	296	PF00017	0.622
LIG_SH2_CRK	87	91	PF00017	0.581
LIG_SH2_NCK_1	292	296	PF00017	0.651
LIG_SH2_PTP2	300	303	PF00017	0.645
LIG_SH2_SRC	300	303	PF00017	0.665
LIG_SH2_SRC	364	367	PF00017	0.699
LIG_SH2_STAP1	174	178	PF00017	0.524
LIG_SH2_STAT3	210	213	PF00017	0.751
LIG_SH2_STAT3	70	73	PF00017	0.569
LIG_SH2_STAT5	300	303	PF00017	0.645
LIG_SH2_STAT5	56	59	PF00017	0.465
LIG_SH2_STAT5	70	73	PF00017	0.596
LIG_SH2_STAT5	94	97	PF00017	0.599
LIG_SH3_1	420	426	PF00018	0.753
LIG_SH3_3	135	141	PF00018	0.596
LIG_SH3_3	146	152	PF00018	0.583
LIG_SH3_3	186	192	PF00018	0.596
LIG_SH3_3	245	251	PF00018	0.634
LIG_SH3_3	318	324	PF00018	0.459
LIG_SH3_3	342	348	PF00018	0.650
LIG_SH3_3	402	408	PF00018	0.697
LIG_SH3_3	420	426	PF00018	0.746
LIG_TRAF2_1	20	23	PF00917	0.651
LIG_TRAF2_1	221	224	PF00917	0.675
LIG_TRAF2_1	247	250	PF00917	0.737
LIG_TRAF2_1	65	68	PF00917	0.666
LIG_UBA3_1	130	134	PF00899	0.557
LIG_WW_2	425	428	PF00397	0.831
MOD_CDC14_SPxK_1	106	109	PF00782	0.562
MOD_CDK_SPK_2	352	357	PF00069	0.670
MOD_CDK_SPxK_1	103	109	PF00069	0.574
MOD_CDK_SPxxK_3	10	17	PF00069	0.603
MOD_CK1_1	429	435	PF00069	0.814
MOD_CK2_1	158	164	PF00069	0.571
MOD_CK2_1	218	224	PF00069	0.474
MOD_CK2_1	383	389	PF00069	0.565
MOD_CK2_1	398	404	PF00069	0.613
MOD_CK2_1	54	60	PF00069	0.402
MOD_Cter_Amidation	305	308	PF01082	0.739
MOD_Cter_Amidation	317	320	PF01082	0.716
MOD_DYRK1A_RPxSP_1	431	435	PF00069	0.522
MOD_GlcNHglycan	23	29	PF01048	0.751
MOD_GlcNHglycan	316	319	PF01048	0.715
MOD_GlcNHglycan	368	371	PF01048	0.478
MOD_GlcNHglycan	400	404	PF01048	0.664
MOD_GlcNHglycan	405	408	PF01048	0.650
MOD_GlcNHglycan	428	431	PF01048	0.790
MOD_GlcNHglycan	84	87	PF01048	0.567
MOD_GSK3_1	24	31	PF00069	0.785
MOD_GSK3_1	399	406	PF00069	0.695
MOD_GSK3_1	426	433	PF00069	0.612
MOD_GSK3_1	99	106	PF00069	0.578
MOD_N-GLC_1	103	108	PF02516	0.453
MOD_NEK2_1	314	319	PF00069	0.633
MOD_NEK2_1	327	332	PF00069	0.574
MOD_NEK2_1	398	403	PF00069	0.626
MOD_NEK2_1	99	104	PF00069	0.597
MOD_PKA_2	172	178	PF00069	0.438
MOD_PKA_2	218	224	PF00069	0.474
MOD_PKA_2	430	436	PF00069	0.741
MOD_Plk_1	158	164	PF00069	0.585
MOD_Plk_1	383	389	PF00069	0.538
MOD_ProDKin_1	10	16	PF00069	0.580
MOD_ProDKin_1	103	109	PF00069	0.574
MOD_ProDKin_1	352	358	PF00069	0.668
MOD_ProDKin_1	431	437	PF00069	0.598
MOD_ProDKin_1	61	67	PF00069	0.577
TRG_DiLeu_BaEn_4	223	229	PF01217	0.462
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.611
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.589
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.603
TRG_ENDOCYTIC_2	176	179	PF00928	0.585
TRG_ENDOCYTIC_2	292	295	PF00928	0.608
TRG_ENDOCYTIC_2	87	90	PF00928	0.578
TRG_ER_diArg_1	228	230	PF00400	0.607
TRG_ER_diArg_1	258	261	PF00400	0.736
TRG_ER_diArg_1	48	51	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	395	400	PF00026	0.685
TRG_PTS2	1	48	PF00400	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T4	Leptomonas seymouri	84%	99%
A0A0S4IRN8	Bodo saltans	76%	100%
A0A1X0NP12	Trypanosomatidae	76%	100%
A0A381ME06	Leishmania infantum	94%	100%
A0A3Q8IHT5	Leishmania donovani	94%	100%
A0A3S7WS51	Leishmania donovani	94%	100%
A4H6Y7	Leishmania braziliensis	86%	100%
C9ZHZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9AGG3	Leishmania infantum	94%	100%
E9AGG8	Leishmania infantum	94%	100%
Q4QGI1	Leishmania major	93%	100%
Q4QGI3	Leishmania major	91%	100%
Q4QGJ1	Leishmania major	95%	100%
Q4QGJ3	Leishmania major	92%	100%
Q4QGJ5	Leishmania major	91%	100%
Q4QGJ8	Leishmania major	92%	100%
Q4QGK3	Leishmania major	92%	100%
Q4QGK5	Leishmania major	92%	100%
Q4QGK7	Leishmania major	93%	100%
Q4QGL3	Leishmania major	92%	100%
Q4QGL6	Leishmania major	91%	100%
Q4QGM0	Leishmania major	91%	100%
V5BF60	Trypanosoma cruzi	77%	89%