LeishMANIAdb
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Promastigote surface antigen protein PSA

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Promastigote surface antigen protein PSA
Gene product:
promastigote surface antigen protein PSA
Species:
Leishmania mexicana
UniProt:
E9AP05_LEIMU
TriTrypDb:
LmxM.12.1090
Length:
514

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 160
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 71, no: 14
NetGPI no yes: 0, no: 85
Cellular components
Term Name Level Count
GO:0005929 cilium 4 86
GO:0042995 cell projection 2 86
GO:0043226 organelle 2 86
GO:0043227 membrane-bounded organelle 3 86
GO:0110165 cellular anatomical entity 1 86
GO:0120025 plasma membrane bounded cell projection 3 86
GO:0016020 membrane 2 34
GO:0005886 plasma membrane 3 7

Expansion

Sequence features

E9AP05
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP05

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 124 128 PF00656 0.544
CLV_NRD_NRD_1 311 313 PF00675 0.295
CLV_NRD_NRD_1 6 8 PF00675 0.766
CLV_PCSK_KEX2_1 311 313 PF00082 0.286
CLV_PCSK_KEX2_1 6 8 PF00082 0.766
CLV_PCSK_SKI1_1 131 135 PF00082 0.236
CLV_PCSK_SKI1_1 185 189 PF00082 0.454
CLV_PCSK_SKI1_1 231 235 PF00082 0.590
CLV_PCSK_SKI1_1 279 283 PF00082 0.284
CLV_PCSK_SKI1_1 327 331 PF00082 0.429
CLV_PCSK_SKI1_1 351 355 PF00082 0.519
CLV_PCSK_SKI1_1 7 11 PF00082 0.752
DEG_SPOP_SBC_1 499 503 PF00917 0.476
DOC_AGCK_PIF_2 69 74 PF00069 0.333
DOC_CYCLIN_RxL_1 185 197 PF00134 0.351
DOC_CYCLIN_RxL_1 399 409 PF00134 0.245
DOC_CYCLIN_yCln2_LP_2 10 16 PF00134 0.695
DOC_MAPK_gen_1 469 477 PF00069 0.588
DOC_MAPK_MEF2A_6 351 360 PF00069 0.360
DOC_MAPK_MEF2A_6 469 477 PF00069 0.517
DOC_MAPK_MEF2A_6 482 489 PF00069 0.369
DOC_MAPK_NFAT4_5 482 490 PF00069 0.299
DOC_PP1_RVXF_1 301 308 PF00149 0.360
DOC_PP2B_LxvP_1 10 13 PF13499 0.688
DOC_USP7_MATH_1 204 208 PF00917 0.482
DOC_USP7_MATH_1 33 37 PF00917 0.454
DOC_USP7_MATH_1 394 398 PF00917 0.445
DOC_USP7_MATH_1 505 509 PF00917 0.558
DOC_USP7_MATH_1 59 63 PF00917 0.439
DOC_USP7_MATH_2 175 181 PF00917 0.515
DOC_USP7_MATH_2 344 350 PF00917 0.291
DOC_USP7_MATH_2 368 374 PF00917 0.262
DOC_USP7_UBL2_3 465 469 PF12436 0.282
LIG_14-3-3_CanoR_1 258 263 PF00244 0.330
LIG_14-3-3_CanoR_1 311 319 PF00244 0.432
LIG_14-3-3_CanoR_1 321 327 PF00244 0.368
LIG_14-3-3_CanoR_1 359 367 PF00244 0.589
LIG_14-3-3_CanoR_1 450 455 PF00244 0.501
LIG_14-3-3_CanoR_1 504 512 PF00244 0.575
LIG_Actin_WH2_2 298 313 PF00022 0.526
LIG_Actin_WH2_2 346 361 PF00022 0.509
LIG_BIR_II_1 1 5 PF00653 0.702
LIG_BRCT_BRCA1_1 264 268 PF00533 0.527
LIG_BRCT_BRCA1_1 303 307 PF00533 0.482
LIG_BRCT_BRCA1_1 70 74 PF00533 0.566
LIG_FHA_1 169 175 PF00498 0.500
LIG_FHA_1 184 190 PF00498 0.353
LIG_FHA_1 218 224 PF00498 0.471
LIG_FHA_1 242 248 PF00498 0.395
LIG_FHA_1 281 287 PF00498 0.404
LIG_FHA_1 328 334 PF00498 0.362
LIG_FHA_1 401 407 PF00498 0.375
LIG_FHA_1 44 50 PF00498 0.556
LIG_FHA_1 74 80 PF00498 0.353
LIG_FHA_2 108 114 PF00498 0.445
LIG_FHA_2 122 128 PF00498 0.555
LIG_FHA_2 421 427 PF00498 0.440
LIG_FHA_2 63 69 PF00498 0.510
LIG_FHA_2 92 98 PF00498 0.534
LIG_LIR_Gen_1 103 112 PF02991 0.456
LIG_LIR_Gen_1 201 208 PF02991 0.414
LIG_LIR_Gen_1 249 259 PF02991 0.305
LIG_LIR_Gen_1 297 307 PF02991 0.314
LIG_LIR_Gen_1 346 355 PF02991 0.254
LIG_LIR_Gen_1 370 379 PF02991 0.523
LIG_LIR_Gen_1 441 451 PF02991 0.481
LIG_LIR_Gen_1 71 79 PF02991 0.572
LIG_LIR_Nem_3 103 107 PF02991 0.522
LIG_LIR_Nem_3 127 132 PF02991 0.509
LIG_LIR_Nem_3 234 240 PF02991 0.413
LIG_LIR_Nem_3 265 271 PF02991 0.328
LIG_LIR_Nem_3 304 310 PF02991 0.336
LIG_LIR_Nem_3 346 350 PF02991 0.250
LIG_LIR_Nem_3 441 446 PF02991 0.459
LIG_LIR_Nem_3 71 75 PF02991 0.420
LIG_NRBOX 183 189 PF00104 0.529
LIG_PCNA_PIPBox_1 156 165 PF02747 0.501
LIG_PCNA_PIPBox_1 230 239 PF02747 0.422
LIG_SH2_CRK 104 108 PF00017 0.543
LIG_SH2_CRK 240 244 PF00017 0.310
LIG_SH2_CRK 384 388 PF00017 0.511
LIG_SH2_GRB2like 104 107 PF00017 0.529
LIG_SH2_NCK_1 240 244 PF00017 0.239
LIG_SH2_NCK_1 384 388 PF00017 0.256
LIG_SH2_STAP1 104 108 PF00017 0.522
LIG_SH2_STAT5 104 107 PF00017 0.503
LIG_SH2_STAT5 309 312 PF00017 0.355
LIG_SH2_STAT5 91 94 PF00017 0.558
LIG_SH3_3 93 99 PF00018 0.549
LIG_SUMO_SIM_anti_2 328 333 PF11976 0.455
LIG_SUMO_SIM_anti_2 352 357 PF11976 0.452
LIG_SUMO_SIM_anti_2 375 381 PF11976 0.515
LIG_SUMO_SIM_anti_2 423 429 PF11976 0.335
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.462
LIG_SUMO_SIM_par_1 131 137 PF11976 0.521
LIG_SUMO_SIM_par_1 450 455 PF11976 0.314
LIG_SxIP_EBH_1 439 450 PF03271 0.250
LIG_TYR_ITIM 102 107 PF00017 0.570
LIG_TYR_ITIM 238 243 PF00017 0.498
LIG_TYR_ITIM 382 387 PF00017 0.563
LIG_UBA3_1 331 338 PF00899 0.502
MOD_CK1_1 154 160 PF00069 0.479
MOD_CK1_1 207 213 PF00069 0.453
MOD_CK1_1 229 235 PF00069 0.380
MOD_CK1_1 241 247 PF00069 0.405
MOD_CK1_1 277 283 PF00069 0.517
MOD_CK1_1 301 307 PF00069 0.336
MOD_CK1_1 325 331 PF00069 0.402
MOD_CK1_1 349 355 PF00069 0.321
MOD_CK1_1 36 42 PF00069 0.491
MOD_CK1_1 372 378 PF00069 0.544
MOD_CK1_1 385 391 PF00069 0.447
MOD_CK1_1 396 402 PF00069 0.492
MOD_CK1_1 420 426 PF00069 0.389
MOD_CK1_1 441 447 PF00069 0.408
MOD_CK1_1 455 461 PF00069 0.314
MOD_CK1_1 62 68 PF00069 0.362
MOD_CK2_1 177 183 PF00069 0.303
MOD_CK2_1 420 426 PF00069 0.566
MOD_CK2_1 91 97 PF00069 0.553
MOD_GlcNHglycan 121 124 PF01048 0.517
MOD_GlcNHglycan 140 143 PF01048 0.482
MOD_GlcNHglycan 145 148 PF01048 0.466
MOD_GlcNHglycan 194 197 PF01048 0.500
MOD_GlcNHglycan 25 28 PF01048 0.681
MOD_GlcNHglycan 291 294 PF01048 0.371
MOD_GlcNHglycan 315 318 PF01048 0.431
MOD_GlcNHglycan 339 342 PF01048 0.411
MOD_GlcNHglycan 363 366 PF01048 0.593
MOD_GlcNHglycan 387 390 PF01048 0.465
MOD_GlcNHglycan 411 414 PF01048 0.496
MOD_GlcNHglycan 419 422 PF01048 0.438
MOD_GlcNHglycan 454 457 PF01048 0.496
MOD_GlcNHglycan 507 510 PF01048 0.593
MOD_GlcNHglycan 99 102 PF01048 0.360
MOD_GSK3_1 121 128 PF00069 0.529
MOD_GSK3_1 207 214 PF00069 0.472
MOD_GSK3_1 225 232 PF00069 0.384
MOD_GSK3_1 246 253 PF00069 0.379
MOD_GSK3_1 258 265 PF00069 0.407
MOD_GSK3_1 273 280 PF00069 0.509
MOD_GSK3_1 294 301 PF00069 0.374
MOD_GSK3_1 32 39 PF00069 0.606
MOD_GSK3_1 321 328 PF00069 0.376
MOD_GSK3_1 345 352 PF00069 0.328
MOD_GSK3_1 354 361 PF00069 0.337
MOD_GSK3_1 393 400 PF00069 0.488
MOD_GSK3_1 417 424 PF00069 0.416
MOD_GSK3_1 438 445 PF00069 0.362
MOD_GSK3_1 60 67 PF00069 0.305
MOD_GSK3_1 73 80 PF00069 0.422
MOD_N-GLC_1 143 148 PF02516 0.382
MOD_N-GLC_1 238 243 PF02516 0.389
MOD_N-GLC_1 77 82 PF02516 0.375
MOD_N-GLC_2 490 492 PF02516 0.589
MOD_NEK2_1 121 126 PF00069 0.495
MOD_NEK2_1 138 143 PF00069 0.407
MOD_NEK2_1 192 197 PF00069 0.461
MOD_NEK2_1 21 26 PF00069 0.531
MOD_NEK2_1 211 216 PF00069 0.335
MOD_NEK2_1 286 291 PF00069 0.362
MOD_NEK2_1 310 315 PF00069 0.423
MOD_NEK2_1 334 339 PF00069 0.496
MOD_NEK2_1 358 363 PF00069 0.556
MOD_NEK2_1 382 387 PF00069 0.413
MOD_NEK2_1 406 411 PF00069 0.447
MOD_NEK2_1 60 65 PF00069 0.344
MOD_NEK2_2 226 231 PF00069 0.575
MOD_OFUCOSY 70 77 PF10250 0.404
MOD_PIKK_1 246 252 PF00454 0.259
MOD_PIKK_1 262 268 PF00454 0.314
MOD_PIKK_1 286 292 PF00454 0.419
MOD_PIKK_1 294 300 PF00454 0.339
MOD_PIKK_1 310 316 PF00454 0.388
MOD_PIKK_1 358 364 PF00454 0.301
MOD_PIKK_1 382 388 PF00454 0.536
MOD_PK_1 258 264 PF00069 0.390
MOD_PKA_2 168 174 PF00069 0.462
MOD_PKA_2 310 316 PF00069 0.482
MOD_PKA_2 358 364 PF00069 0.293
MOD_Plk_1 136 142 PF00069 0.298
MOD_Plk_1 238 244 PF00069 0.418
MOD_Plk_1 345 351 PF00069 0.284
MOD_Plk_1 369 375 PF00069 0.552
MOD_Plk_2-3 177 183 PF00069 0.362
MOD_Plk_2-3 68 74 PF00069 0.537
MOD_Plk_4 238 244 PF00069 0.346
MOD_Plk_4 258 264 PF00069 0.381
MOD_Plk_4 303 309 PF00069 0.349
MOD_Plk_4 327 333 PF00069 0.401
MOD_Plk_4 351 357 PF00069 0.360
MOD_Plk_4 375 381 PF00069 0.491
MOD_Plk_4 45 51 PF00069 0.402
MOD_Plk_4 80 86 PF00069 0.361
TRG_DiLeu_BaEn_1 183 188 PF01217 0.348
TRG_DiLeu_BaLyEn_6 447 452 PF01217 0.247
TRG_ENDOCYTIC_2 104 107 PF00928 0.563
TRG_ENDOCYTIC_2 240 243 PF00928 0.358
TRG_ENDOCYTIC_2 384 387 PF00928 0.492
TRG_ER_diArg_1 310 312 PF00400 0.285
TRG_ER_diArg_1 5 7 PF00400 0.759
TRG_Pf-PMV_PEXEL_1 160 165 PF00026 0.444

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A5 Leptomonas seymouri 30% 81%
A0A0N1I121 Leptomonas seymouri 26% 100%
A0A0N1I661 Leptomonas seymouri 37% 90%
A0A0N1I7S5 Leptomonas seymouri 35% 100%
A0A0N1II82 Leptomonas seymouri 30% 75%
A0A0S4IHI7 Bodo saltans 29% 66%
A0A0S4IIK7 Bodo saltans 27% 100%
A0A0S4IJN2 Bodo saltans 28% 76%
A0A0S4ILC9 Bodo saltans 41% 93%
A0A0S4IN27 Bodo saltans 41% 95%
A0A0S4IQE4 Bodo saltans 26% 91%
A0A0S4ISU4 Bodo saltans 35% 78%
A0A0S4IT62 Bodo saltans 42% 69%
A0A0S4IU23 Bodo saltans 30% 87%
A0A0S4IU73 Bodo saltans 39% 100%
A0A0S4IV96 Bodo saltans 37% 85%
A0A0S4IVN7 Bodo saltans 36% 100%
A0A0S4IVQ8 Bodo saltans 36% 85%
A0A0S4IW93 Bodo saltans 27% 85%
A0A0S4IY44 Bodo saltans 26% 77%
A0A0S4IZC7 Bodo saltans 29% 100%
A0A0S4J014 Bodo saltans 28% 72%
A0A0S4J1A6 Bodo saltans 31% 100%
A0A0S4J206 Bodo saltans 34% 84%
A0A0S4J2H8 Bodo saltans 31% 88%
A0A0S4J3T7 Bodo saltans 34% 100%
A0A0S4J4L7 Bodo saltans 24% 70%
A0A0S4J5A0 Bodo saltans 36% 90%
A0A0S4J746 Bodo saltans 27% 74%
A0A0S4J954 Bodo saltans 27% 69%
A0A0S4JAQ6 Bodo saltans 30% 100%
A0A0S4JAS1 Bodo saltans 33% 81%
A0A0S4JAW7 Bodo saltans 28% 100%
A0A0S4JB95 Bodo saltans 24% 85%
A0A0S4JBV9 Bodo saltans 28% 100%
A0A0S4JCG7 Bodo saltans 40% 100%
A0A0S4JD35 Bodo saltans 30% 86%
A0A0S4JDS1 Bodo saltans 26% 97%
A0A0S4JDT0 Bodo saltans 30% 78%
A0A0S4JEK1 Bodo saltans 28% 100%
A0A0S4JFY5 Bodo saltans 34% 100%
A0A0S4JGN7 Bodo saltans 27% 73%
A0A0S4JL29 Bodo saltans 33% 100%
A0A0S4JQW3 Bodo saltans 23% 100%
A0A0S4JQZ0 Bodo saltans 27% 68%
A0A0S4JS89 Bodo saltans 25% 100%
A0A0S4JSB8 Bodo saltans 38% 92%
A0A0S4JTM6 Bodo saltans 39% 70%
A0A0S4JTQ7 Bodo saltans 38% 97%
A0A0S4JU95 Bodo saltans 33% 68%
A0A0S4JVI0 Bodo saltans 28% 72%
A0A0S4KGV4 Bodo saltans 24% 94%
A0A0S4KH41 Bodo saltans 29% 74%
A0A0S4KHE4 Bodo saltans 30% 100%
A0A0S4KJA7 Bodo saltans 25% 77%
A0A0S4KK37 Bodo saltans 31% 88%
A0A3Q8I9A6 Leishmania donovani 49% 100%
A0A3Q8IC27 Leishmania donovani 39% 100%
A0A3S5H6M3 Leishmania donovani 52% 75%
A0A3S5H6M4 Leishmania donovani 54% 78%
A0A3S7WS66 Leishmania donovani 54% 78%
A0N0X6 Bos taurus 24% 72%
A4HBX3 Leishmania braziliensis 34% 98%
A4HVB0 Leishmania infantum 46% 100%
A4HZ93 Leishmania infantum 40% 100%
A7SFP1 Nematostella vectensis 24% 89%
A8XWW4 Caenorhabditis briggsae 25% 92%
D1GJ51 Leishmania infantum 57% 100%
E8NHG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 67%
E9AGG2 Leishmania infantum 53% 77%
E9AGG5 Leishmania infantum 48% 100%
E9AGG7 Leishmania infantum 58% 82%
E9AGG9 Leishmania infantum 67% 95%
E9AGH0 Leishmania infantum 48% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 56% 100%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 100%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 56% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
O48851 Arabidopsis thaliana 23% 67%
O49325 Arabidopsis thaliana 23% 66%
O80809 Arabidopsis thaliana 25% 71%
P35859 Rattus norvegicus 22% 85%
Q1PEN0 Arabidopsis thaliana 23% 72%
Q22875 Caenorhabditis elegans 23% 92%
Q25331 Leishmania major 49% 100%
Q32Q07 Rattus norvegicus 23% 72%
Q4QC79 Leishmania major 37% 100%
Q4QGI0 Leishmania major 73% 100%
Q4QGI2 Leishmania major 52% 100%
Q4QGI4 Leishmania major 56% 100%
Q4QGI6 Leishmania major 53% 100%
Q4QGI8 Leishmania major 52% 100%
Q4QGJ0 Leishmania major 55% 100%
Q4QGJ2 Leishmania major 51% 100%
Q4QGJ4 Leishmania major 49% 100%
Q4QGJ6 Leishmania major 47% 100%
Q4QGJ7 Leishmania major 49% 100%
Q4QGJ9 Leishmania major 54% 100%
Q4QGK0 Leishmania major 51% 100%
Q4QGK1 Leishmania major 55% 100%
Q4QGK2 Leishmania major 49% 100%
Q4QGK4 Leishmania major 51% 100%
Q4QGK6 Leishmania major 50% 100%
Q4QGK8 Leishmania major 57% 100%
Q4QGL2 Leishmania major 57% 100%
Q4QGL4 Leishmania major 51% 100%
Q4QGL5 Leishmania major 44% 100%
Q4QGL8 Leishmania major 53% 100%
Q4QGM1 Leishmania major 57% 66%
Q54AX5 Dictyostelium discoideum 22% 100%
Q5F4C4 Gallus gallus 26% 97%
Q61809 Mus musculus 24% 72%
Q6P3Y9 Mus musculus 25% 92%
Q6UXK5 Homo sapiens 23% 72%
Q8AVI4 Xenopus laevis 25% 89%
Q8R5M3 Rattus norvegicus 23% 89%
Q940E8 Zea mays 26% 84%
Q9DBB9 Mus musculus 25% 94%
Q9LJW7 Arabidopsis thaliana 26% 72%
Q9SHI3 Arabidopsis thaliana 25% 71%
Q9SHI4 Arabidopsis thaliana 23% 68%
Q9SKK5 Arabidopsis thaliana 22% 77%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS