LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Promastigote surface antigen protein PSA

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Promastigote surface antigen protein PSA
Gene product:
promastigote surface antigen protein PSA
Species:
Leishmania mexicana
UniProt:
E9AP04_LEIMU
TriTrypDb:
LmxM.12.0910
Length:
697

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 90
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 35, no: 5
NetGPI no yes: 0, no: 40
Cellular components
Term Name Level Count
GO:0005929 cilium 4 41
GO:0042995 cell projection 2 41
GO:0043226 organelle 2 41
GO:0043227 membrane-bounded organelle 3 41
GO:0110165 cellular anatomical entity 1 41
GO:0120025 plasma membrane bounded cell projection 3 41
GO:0016020 membrane 2 22
GO:0005886 plasma membrane 3 5

Expansion

Sequence features

E9AP04
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP04

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 6 8 PF00675 0.767
CLV_PCSK_KEX2_1 6 8 PF00082 0.761
CLV_PCSK_SKI1_1 156 160 PF00082 0.381
CLV_PCSK_SKI1_1 230 234 PF00082 0.546
CLV_PCSK_SKI1_1 278 282 PF00082 0.327
CLV_PCSK_SKI1_1 7 11 PF00082 0.738
CLV_PCSK_SKI1_1 87 91 PF00082 0.517
DEG_SPOP_SBC_1 481 485 PF00917 0.550
DEG_SPOP_SBC_1 493 497 PF00917 0.790
DEG_SPOP_SBC_1 502 506 PF00917 0.711
DEG_SPOP_SBC_1 511 515 PF00917 0.804
DEG_SPOP_SBC_1 520 524 PF00917 0.785
DEG_SPOP_SBC_1 529 533 PF00917 0.858
DEG_SPOP_SBC_1 538 542 PF00917 0.794
DEG_SPOP_SBC_1 547 551 PF00917 0.692
DEG_SPOP_SBC_1 556 560 PF00917 0.811
DEG_SPOP_SBC_1 565 569 PF00917 0.869
DEG_SPOP_SBC_1 574 578 PF00917 0.544
DEG_SPOP_SBC_1 583 587 PF00917 0.692
DEG_SPOP_SBC_1 592 596 PF00917 0.811
DEG_SPOP_SBC_1 601 605 PF00917 0.556
DEG_SPOP_SBC_1 610 614 PF00917 0.733
DEG_SPOP_SBC_1 619 623 PF00917 0.801
DEG_SPOP_SBC_1 628 632 PF00917 0.802
DEG_SPOP_SBC_1 637 641 PF00917 0.838
DEG_SPOP_SBC_1 646 650 PF00917 0.586
DEG_SPOP_SBC_1 655 659 PF00917 0.797
DEG_SPOP_SBC_1 664 668 PF00917 0.813
DEG_SPOP_SBC_1 673 677 PF00917 0.788
DEG_SPOP_SBC_1 691 695 PF00917 0.583
DOC_CYCLIN_RxL_1 184 196 PF00134 0.402
DOC_CYCLIN_yCln2_LP_2 10 16 PF00134 0.425
DOC_MAPK_gen_1 445 452 PF00069 0.389
DOC_MAPK_MEF2A_6 445 452 PF00069 0.637
DOC_PP2B_LxvP_1 10 13 PF13499 0.451
DOC_USP7_MATH_1 214 218 PF00917 0.583
DOC_USP7_MATH_1 300 304 PF00917 0.410
DOC_USP7_MATH_1 33 37 PF00917 0.558
DOC_USP7_MATH_1 348 352 PF00917 0.384
DOC_USP7_MATH_1 521 525 PF00917 0.651
DOC_USP7_MATH_1 539 543 PF00917 0.582
DOC_USP7_MATH_1 566 570 PF00917 0.644
DOC_USP7_MATH_1 584 588 PF00917 0.546
DOC_USP7_MATH_1 59 63 PF00917 0.399
DOC_USP7_MATH_1 629 633 PF00917 0.703
DOC_USP7_MATH_1 647 651 PF00917 0.691
DOC_USP7_MATH_1 674 678 PF00917 0.665
DOC_USP7_MATH_2 174 180 PF00917 0.411
DOC_WW_Pin1_4 477 482 PF00397 0.702
LIG_14-3-3_CanoR_1 194 198 PF00244 0.510
LIG_14-3-3_CanoR_1 230 236 PF00244 0.331
LIG_14-3-3_CanoR_1 468 473 PF00244 0.651
LIG_14-3-3_CanoR_1 76 82 PF00244 0.449
LIG_14-3-3_CanoR_1 87 92 PF00244 0.282
LIG_Actin_WH2_2 179 196 PF00022 0.333
LIG_Actin_WH2_2 273 288 PF00022 0.274
LIG_BIR_II_1 1 5 PF00653 0.749
LIG_BRCT_BRCA1_1 135 139 PF00533 0.389
LIG_BRCT_BRCA1_1 374 378 PF00533 0.476
LIG_Clathr_ClatBox_1 402 406 PF01394 0.280
LIG_FHA_1 168 174 PF00498 0.462
LIG_FHA_1 183 189 PF00498 0.414
LIG_FHA_1 207 213 PF00498 0.424
LIG_FHA_1 217 223 PF00498 0.513
LIG_FHA_1 265 271 PF00498 0.436
LIG_FHA_1 279 285 PF00498 0.422
LIG_FHA_1 300 306 PF00498 0.432
LIG_FHA_1 33 39 PF00498 0.675
LIG_FHA_1 352 358 PF00498 0.437
LIG_FHA_1 44 50 PF00498 0.558
LIG_FHA_1 90 96 PF00498 0.404
LIG_FHA_2 441 447 PF00498 0.501
LIG_FHA_2 449 455 PF00498 0.536
LIG_FHA_2 63 69 PF00498 0.559
LIG_FHA_2 92 98 PF00498 0.565
LIG_LIR_Apic_2 113 118 PF02991 0.270
LIG_LIR_Gen_1 127 134 PF02991 0.445
LIG_LIR_Gen_1 176 183 PF02991 0.429
LIG_LIR_Gen_1 297 305 PF02991 0.361
LIG_LIR_Gen_1 375 386 PF02991 0.448
LIG_LIR_Gen_1 417 424 PF02991 0.564
LIG_LIR_Nem_3 103 107 PF02991 0.530
LIG_LIR_Nem_3 127 131 PF02991 0.455
LIG_LIR_Nem_3 375 381 PF02991 0.419
LIG_LIR_Nem_3 71 75 PF02991 0.474
LIG_SH2_CRK 104 108 PF00017 0.342
LIG_SH2_SRC 380 383 PF00017 0.410
LIG_SH2_STAT5 380 383 PF00017 0.363
LIG_SH2_STAT5 91 94 PF00017 0.583
LIG_SH3_3 93 99 PF00018 0.528
LIG_SUMO_SIM_anti_2 281 286 PF11976 0.506
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.498
LIG_TRAF2_1 451 454 PF00917 0.338
LIG_TYR_ITIM 102 107 PF00017 0.515
LIG_WRC_WIRS_1 304 309 PF05994 0.264
MOD_CK1_1 154 160 PF00069 0.506
MOD_CK1_1 206 212 PF00069 0.453
MOD_CK1_1 228 234 PF00069 0.465
MOD_CK1_1 299 305 PF00069 0.534
MOD_CK1_1 323 329 PF00069 0.496
MOD_CK1_1 351 357 PF00069 0.469
MOD_CK1_1 36 42 PF00069 0.569
MOD_CK1_1 371 377 PF00069 0.475
MOD_CK1_1 395 401 PF00069 0.519
MOD_CK1_1 417 423 PF00069 0.437
MOD_CK1_1 524 530 PF00069 0.578
MOD_CK1_1 542 548 PF00069 0.551
MOD_CK1_1 569 575 PF00069 0.621
MOD_CK1_1 587 593 PF00069 0.534
MOD_CK1_1 602 608 PF00069 0.569
MOD_CK1_1 62 68 PF00069 0.431
MOD_CK1_1 632 638 PF00069 0.690
MOD_CK1_1 650 656 PF00069 0.693
MOD_CK1_1 677 683 PF00069 0.722
MOD_CK1_1 71 77 PF00069 0.336
MOD_CK2_1 257 263 PF00069 0.527
MOD_CK2_1 440 446 PF00069 0.440
MOD_CK2_1 448 454 PF00069 0.472
MOD_CK2_1 91 97 PF00069 0.537
MOD_GlcNHglycan 120 123 PF01048 0.489
MOD_GlcNHglycan 139 142 PF01048 0.438
MOD_GlcNHglycan 144 147 PF01048 0.529
MOD_GlcNHglycan 242 245 PF01048 0.534
MOD_GlcNHglycan 25 28 PF01048 0.702
MOD_GlcNHglycan 290 293 PF01048 0.441
MOD_GlcNHglycan 297 301 PF01048 0.432
MOD_GlcNHglycan 314 317 PF01048 0.521
MOD_GlcNHglycan 338 341 PF01048 0.471
MOD_GlcNHglycan 346 349 PF01048 0.421
MOD_GlcNHglycan 357 360 PF01048 0.450
MOD_GlcNHglycan 362 365 PF01048 0.501
MOD_GlcNHglycan 369 373 PF01048 0.456
MOD_GlcNHglycan 386 389 PF01048 0.444
MOD_GlcNHglycan 394 397 PF01048 0.557
MOD_GlcNHglycan 409 413 PF01048 0.461
MOD_GlcNHglycan 429 432 PF01048 0.443
MOD_GSK3_1 120 127 PF00069 0.444
MOD_GSK3_1 133 140 PF00069 0.384
MOD_GSK3_1 150 157 PF00069 0.462
MOD_GSK3_1 159 166 PF00069 0.360
MOD_GSK3_1 202 209 PF00069 0.471
MOD_GSK3_1 214 221 PF00069 0.396
MOD_GSK3_1 224 231 PF00069 0.435
MOD_GSK3_1 238 245 PF00069 0.369
MOD_GSK3_1 296 303 PF00069 0.459
MOD_GSK3_1 32 39 PF00069 0.665
MOD_GSK3_1 344 351 PF00069 0.471
MOD_GSK3_1 368 375 PF00069 0.499
MOD_GSK3_1 386 393 PF00069 0.388
MOD_GSK3_1 410 417 PF00069 0.409
MOD_GSK3_1 468 475 PF00069 0.710
MOD_GSK3_1 476 483 PF00069 0.713
MOD_GSK3_1 484 491 PF00069 0.662
MOD_GSK3_1 492 499 PF00069 0.676
MOD_GSK3_1 501 508 PF00069 0.692
MOD_GSK3_1 510 517 PF00069 0.684
MOD_GSK3_1 519 526 PF00069 0.696
MOD_GSK3_1 528 535 PF00069 0.649
MOD_GSK3_1 537 544 PF00069 0.653
MOD_GSK3_1 546 553 PF00069 0.606
MOD_GSK3_1 555 562 PF00069 0.613
MOD_GSK3_1 564 571 PF00069 0.611
MOD_GSK3_1 573 580 PF00069 0.563
MOD_GSK3_1 582 589 PF00069 0.599
MOD_GSK3_1 591 598 PF00069 0.603
MOD_GSK3_1 599 606 PF00069 0.608
MOD_GSK3_1 60 67 PF00069 0.414
MOD_GSK3_1 609 616 PF00069 0.640
MOD_GSK3_1 618 625 PF00069 0.727
MOD_GSK3_1 627 634 PF00069 0.675
MOD_GSK3_1 636 643 PF00069 0.667
MOD_GSK3_1 645 652 PF00069 0.724
MOD_GSK3_1 654 661 PF00069 0.651
MOD_GSK3_1 663 670 PF00069 0.730
MOD_GSK3_1 672 679 PF00069 0.680
MOD_GSK3_1 681 688 PF00069 0.670
MOD_GSK3_1 690 697 PF00069 0.635
MOD_GSK3_1 71 78 PF00069 0.394
MOD_GSK3_1 87 94 PF00069 0.518
MOD_NEK2_1 120 125 PF00069 0.441
MOD_NEK2_1 133 138 PF00069 0.421
MOD_NEK2_1 193 198 PF00069 0.423
MOD_NEK2_1 21 26 PF00069 0.594
MOD_NEK2_1 240 245 PF00069 0.367
MOD_NEK2_1 266 271 PF00069 0.501
MOD_NEK2_1 285 290 PF00069 0.410
MOD_NEK2_1 309 314 PF00069 0.465
MOD_NEK2_1 333 338 PF00069 0.456
MOD_NEK2_1 355 360 PF00069 0.463
MOD_NEK2_1 381 386 PF00069 0.523
MOD_NEK2_1 410 415 PF00069 0.458
MOD_NEK2_1 60 65 PF00069 0.504
MOD_PIKK_1 357 363 PF00454 0.572
MOD_PKA_2 193 199 PF00069 0.441
MOD_PKA_2 285 291 PF00069 0.393
MOD_PKA_2 384 390 PF00069 0.299
MOD_PKA_2 467 473 PF00069 0.665
MOD_PKA_2 75 81 PF00069 0.288
MOD_PKB_1 255 263 PF00069 0.264
MOD_Plk_1 175 181 PF00069 0.487
MOD_Plk_1 238 244 PF00069 0.431
MOD_Plk_1 257 263 PF00069 0.465
MOD_Plk_1 296 302 PF00069 0.336
MOD_Plk_1 448 454 PF00069 0.500
MOD_Plk_2-3 68 74 PF00069 0.497
MOD_Plk_4 107 113 PF00069 0.362
MOD_Plk_4 124 130 PF00069 0.483
MOD_Plk_4 176 182 PF00069 0.443
MOD_Plk_4 278 284 PF00069 0.369
MOD_Plk_4 300 306 PF00069 0.416
MOD_Plk_4 374 380 PF00069 0.384
MOD_Plk_4 45 51 PF00069 0.467
MOD_Plk_4 77 83 PF00069 0.386
MOD_ProDKin_1 477 483 PF00069 0.704
MOD_SUMO_for_1 129 132 PF00179 0.272
MOD_SUMO_rev_2 306 315 PF00179 0.299
MOD_SUMO_rev_2 454 464 PF00179 0.424
TRG_ENDOCYTIC_2 104 107 PF00928 0.512
TRG_ER_diArg_1 254 257 PF00400 0.447
TRG_ER_diArg_1 5 7 PF00400 0.765

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IRQ2 Bodo saltans 30% 82%
A0A0S4IU91 Bodo saltans 28% 79%
A0A0S4IVU4 Bodo saltans 28% 68%
A0A0S4J100 Bodo saltans 27% 83%
A0A0S4J1D6 Bodo saltans 26% 71%
A0A0S4J206 Bodo saltans 33% 100%
A0A0S4J985 Bodo saltans 31% 70%
A0A0S4JB95 Bodo saltans 25% 100%
A0A0S4JDT0 Bodo saltans 30% 100%
A0A0S4JDX7 Bodo saltans 24% 68%
A0A0S4JTM6 Bodo saltans 28% 94%
A0A0S4KEC2 Bodo saltans 36% 79%
A0A1X0ND37 Trypanosomatidae 25% 73%
A0A3Q8IC27 Leishmania donovani 33% 100%
A0A3S5H6M3 Leishmania donovani 58% 100%
A0A3S5H6M4 Leishmania donovani 51% 100%
A0A3S7WS66 Leishmania donovani 52% 100%
A4HZ93 Leishmania infantum 33% 100%
D1GJ51 Leishmania infantum 49% 97%
E8NHG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 91%
E9AGG2 Leishmania infantum 58% 100%
E9AGG7 Leishmania infantum 64% 100%
E9AGG9 Leishmania infantum 55% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 100% 100%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
F4JTU7 Arabidopsis thaliana 23% 86%
F4K4T3 Arabidopsis thaliana 23% 74%
Q4QGI0 Leishmania major 55% 100%
Q4QGI2 Leishmania major 54% 100%
Q4QGI4 Leishmania major 51% 100%
Q4QGI6 Leishmania major 52% 100%
Q4QGI8 Leishmania major 51% 92%
Q4QGJ0 Leishmania major 60% 100%
Q4QGJ2 Leishmania major 53% 100%
Q4QGJ9 Leishmania major 56% 100%
Q4QGK0 Leishmania major 54% 100%
Q4QGK2 Leishmania major 56% 100%
Q4QGK4 Leishmania major 54% 100%
Q4QGK8 Leishmania major 57% 100%
Q4QGL2 Leishmania major 57% 100%
Q4QGL8 Leishmania major 55% 100%
Q8LPB4 Daucus carota 25% 68%
Q9SRL2 Arabidopsis thaliana 24% 73%
Q9SVM3 Arabidopsis thaliana 23% 83%
Q9SYQ8 Arabidopsis thaliana 23% 71%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS