Putative surface antigen protein 2

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen protein 2, putative

Species:

Leishmania mexicana

UniProt:

E9AP01_LEIMU

TriTrypDb:

LmxM.12.0870partial

Length:

235

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0016020	membrane	2	2

Expansion

Sequence features

E9AP01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	26	30	PF00082	0.514
DEG_SPOP_SBC_1	152	156	PF00917	0.617
DEG_SPOP_SBC_1	160	164	PF00917	0.522
DOC_MAPK_gen_1	120	128	PF00069	0.439
DOC_MAPK_MEF2A_6	120	128	PF00069	0.440
DOC_USP7_MATH_1	159	163	PF00917	0.733
DOC_USP7_MATH_1	211	215	PF00917	0.629
DOC_WW_Pin1_4	155	160	PF00397	0.745
DOC_WW_Pin1_4	161	166	PF00397	0.621
LIG_14-3-3_CanoR_1	101	106	PF00244	0.341
LIG_14-3-3_CanoR_1	58	66	PF00244	0.549
LIG_Actin_WH2_2	45	60	PF00022	0.313
LIG_Clathr_ClatBox_1	30	34	PF01394	0.288
LIG_FHA_2	125	131	PF00498	0.539
LIG_FHA_2	143	149	PF00498	0.578
LIG_FHA_2	72	78	PF00498	0.423
LIG_LIR_Gen_1	93	102	PF02991	0.450
LIG_LIR_Nem_3	36	42	PF02991	0.490
LIG_LIR_Nem_3	82	86	PF02991	0.435
LIG_PDZ_Class_2	230	235	PF00595	0.623
LIG_PTAP_UEV_1	149	154	PF05743	0.580
LIG_SH2_CRK	83	87	PF00017	0.404
LIG_SH2_STAT5	83	86	PF00017	0.339
LIG_SH3_3	116	122	PF00018	0.517
LIG_SH3_3	147	153	PF00018	0.689
LIG_SUMO_SIM_par_1	101	106	PF11976	0.341
LIG_SUMO_SIM_par_1	124	131	PF11976	0.403
LIG_TYR_ITIM	81	86	PF00017	0.392
LIG_UBA3_1	30	37	PF00899	0.300
MOD_CK1_1	163	169	PF00069	0.653
MOD_CK1_1	47	53	PF00069	0.423
MOD_CK1_1	71	77	PF00069	0.422
MOD_CK2_1	142	148	PF00069	0.574
MOD_CK2_1	166	172	PF00069	0.739
MOD_CK2_1	71	77	PF00069	0.430
MOD_GlcNHglycan	105	108	PF01048	0.263
MOD_GlcNHglycan	110	113	PF01048	0.456
MOD_GlcNHglycan	14	17	PF01048	0.493
MOD_GlcNHglycan	168	171	PF01048	0.555
MOD_GlcNHglycan	182	185	PF01048	0.604
MOD_GlcNHglycan	214	217	PF01048	0.643
MOD_GlcNHglycan	62	65	PF01048	0.506
MOD_GlcNHglycan	70	73	PF01048	0.435
MOD_GlcNHglycan	74	77	PF01048	0.439
MOD_GlcNHglycan	86	89	PF01048	0.496
MOD_GlcNHglycan	93	97	PF01048	0.291
MOD_GSK3_1	132	139	PF00069	0.518
MOD_GSK3_1	144	151	PF00069	0.576
MOD_GSK3_1	155	162	PF00069	0.727
MOD_GSK3_1	194	201	PF00069	0.562
MOD_GSK3_1	44	51	PF00069	0.419
MOD_GSK3_1	68	75	PF00069	0.426
MOD_N-GLC_2	141	143	PF02516	0.612
MOD_NEK2_1	142	147	PF00069	0.513
MOD_NEK2_1	33	38	PF00069	0.581
MOD_NEK2_1	57	62	PF00069	0.398
MOD_NEK2_1	9	14	PF00069	0.534
MOD_PKA_2	57	63	PF00069	0.425
MOD_PKA_2	9	15	PF00069	0.479
MOD_Plk_1	198	204	PF00069	0.448
MOD_Plk_1	92	98	PF00069	0.355
MOD_Plk_2-3	192	198	PF00069	0.408
MOD_Plk_4	114	120	PF00069	0.470
MOD_Plk_4	26	32	PF00069	0.430
MOD_ProDKin_1	155	161	PF00069	0.739
MOD_ProDKin_1	163	169	PF00069	0.549
MOD_SUMO_rev_2	129	135	PF00179	0.449
MOD_SUMO_rev_2	192	201	PF00179	0.412
TRG_ENDOCYTIC_2	83	86	PF00928	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ17	Leptomonas seymouri	31%	81%
A0A0S4JCT9	Bodo saltans	30%	87%
A0A0S4JQB6	Bodo saltans	34%	92%
E9AGG1	Leishmania infantum	65%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	69%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	69%