Putative surface antigen protein 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen protein 2, putative

Species:

Leishmania mexicana

UniProt:

E9AP00_LEIMU

TriTrypDb:

LmxM.12.0850

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 1
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	5
GO:0016020	membrane	2	3
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0110165	cellular anatomical entity	1	5
GO:0120025	plasma membrane bounded cell projection	3	5

Expansion

Sequence features

E9AP00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SPOP_SBC_1	101	105	PF00917	0.697
DEG_SPOP_SBC_1	109	113	PF00917	0.672
DEG_SPOP_SBC_1	121	125	PF00917	0.653
DEG_SPOP_SBC_1	130	134	PF00917	0.656
DEG_SPOP_SBC_1	139	143	PF00917	0.664
DEG_SPOP_SBC_1	148	152	PF00917	0.650
DEG_SPOP_SBC_1	157	161	PF00917	0.658
DEG_SPOP_SBC_1	166	170	PF00917	0.648
DEG_SPOP_SBC_1	175	179	PF00917	0.665
DEG_SPOP_SBC_1	184	188	PF00917	0.645
DEG_SPOP_SBC_1	192	196	PF00917	0.641
DOC_MAPK_gen_1	73	80	PF00069	0.539
DOC_MAPK_MEF2A_6	73	80	PF00069	0.609
DOC_USP7_MATH_1	158	162	PF00917	0.659
DOC_USP7_MATH_1	176	180	PF00917	0.666
DOC_USP7_MATH_1	191	195	PF00917	0.642
DOC_WW_Pin1_4	105	110	PF00397	0.686
DOC_WW_Pin1_4	187	192	PF00397	0.702
DOC_WW_Pin1_4	193	198	PF00397	0.699
LIG_14-3-3_CanoR_1	96	101	PF00244	0.601
LIG_BRCT_BRCA1_1	2	6	PF00533	0.489
LIG_Clathr_ClatBox_1	30	34	PF01394	0.470
LIG_FHA_1	231	237	PF00498	0.590
LIG_FHA_2	69	75	PF00498	0.528
LIG_FHA_2	77	83	PF00498	0.537
LIG_LIR_Gen_1	3	14	PF02991	0.556
LIG_LIR_Gen_1	45	52	PF02991	0.629
LIG_LIR_Nem_3	3	9	PF02991	0.514
LIG_PDZ_Class_2	261	266	PF00595	0.368
LIG_SH2_SRC	8	11	PF00017	0.489
LIG_SH2_STAT5	237	240	PF00017	0.642
LIG_SH2_STAT5	8	11	PF00017	0.520
LIG_TRAF2_1	79	82	PF00917	0.507
MOD_CK1_1	161	167	PF00069	0.656
MOD_CK1_1	179	185	PF00069	0.663
MOD_CK1_1	195	201	PF00069	0.624
MOD_CK1_1	23	29	PF00069	0.603
MOD_CK1_1	45	51	PF00069	0.587
MOD_CK2_1	198	204	PF00069	0.696
MOD_CK2_1	68	74	PF00069	0.504
MOD_CK2_1	76	82	PF00069	0.498
MOD_GlcNHglycan	14	17	PF01048	0.436
MOD_GlcNHglycan	200	203	PF01048	0.453
MOD_GlcNHglycan	214	217	PF01048	0.477
MOD_GlcNHglycan	22	25	PF01048	0.368
MOD_GlcNHglycan	244	247	PF01048	0.386
MOD_GlcNHglycan	37	41	PF01048	0.319
MOD_GlcNHglycan	57	60	PF01048	0.253
MOD_GSK3_1	104	111	PF00069	0.684
MOD_GSK3_1	112	119	PF00069	0.648
MOD_GSK3_1	120	127	PF00069	0.645
MOD_GSK3_1	129	136	PF00069	0.657
MOD_GSK3_1	138	145	PF00069	0.657
MOD_GSK3_1	14	21	PF00069	0.566
MOD_GSK3_1	147	154	PF00069	0.648
MOD_GSK3_1	156	163	PF00069	0.658
MOD_GSK3_1	165	172	PF00069	0.648
MOD_GSK3_1	174	181	PF00069	0.674
MOD_GSK3_1	183	190	PF00069	0.675
MOD_GSK3_1	191	198	PF00069	0.643
MOD_GSK3_1	226	233	PF00069	0.643
MOD_GSK3_1	38	45	PF00069	0.506
MOD_GSK3_1	96	103	PF00069	0.690
MOD_N-GLC_2	93	95	PF02516	0.417
MOD_NEK2_1	38	43	PF00069	0.595
MOD_NEK2_1	9	14	PF00069	0.544
MOD_PKA_2	12	18	PF00069	0.494
MOD_PKA_2	95	101	PF00069	0.588
MOD_Plk_1	224	230	PF00069	0.598
MOD_Plk_1	76	82	PF00069	0.502
MOD_Plk_2-3	224	230	PF00069	0.543
MOD_Plk_4	2	8	PF00069	0.569
MOD_ProDKin_1	105	111	PF00069	0.686
MOD_ProDKin_1	187	193	PF00069	0.684
MOD_ProDKin_1	195	201	PF00069	0.662
MOD_SUMO_rev_2	82	92	PF00179	0.573
TRG_DiLeu_BaEn_1	231	236	PF01217	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9A6	Leishmania donovani	35%	69%
E9AGH0	Leishmania infantum	36%	71%
Q4QGL4	Leishmania major	32%	67%