LeishMANIAdb
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Lipoprotein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Lipoprotein
Gene product:
Protein of unknown function (DUF962), putative
Species:
Leishmania mexicana
UniProt:
E9ANZ8_LEIMU
TriTrypDb:
LmxM.12.0710
Length:
108

Annotations

LeishMANIAdb annotations

This small protein is closely similar to a large group of poorly-studied prokaryotic proteins (annotated as DUF962 domain proteins). Some members are also found in plants and slime molds.. Duplicated in Leishmaniids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3
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Expansion

Sequence features

E9ANZ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANZ8

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 32 34 PF00675 0.281
CLV_PCSK_KEX2_1 32 34 PF00082 0.293
DOC_ANK_TNKS_1 51 58 PF00023 0.313
DOC_MAPK_gen_1 28 36 PF00069 0.415
DOC_PP4_FxxP_1 84 87 PF00568 0.524
DOC_USP7_MATH_1 24 28 PF00917 0.557
DOC_USP7_MATH_1 46 50 PF00917 0.323
DOC_USP7_MATH_1 58 62 PF00917 0.349
DOC_USP7_UBL2_3 25 29 PF12436 0.602
LIG_BRCT_BRCA1_1 4 8 PF00533 0.633
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P2C1 Leptomonas seymouri 69% 100%
A0A0N1HYH1 Leptomonas seymouri 38% 100%
A0A0S4IVD1 Bodo saltans 35% 96%
A0A1X0NMC7 Trypanosomatidae 46% 99%
A0A3Q8IHQ7 Leishmania donovani 41% 100%
A0A3R7N4G9 Trypanosoma rangeli 44% 99%
A0A3S5H6L3 Leishmania donovani 94% 100%
A4H6Y4 Leishmania braziliensis 85% 100%
A4H6Y5 Leishmania braziliensis 41% 100%
E9AGF8 Leishmania infantum 94% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS