Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANZ7_LEIMU

TriTrypDb:

LmxM.12.0700

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	14
GO:0042995	cell projection	2	14
GO:0043226	organelle	2	14
GO:0043227	membrane-bounded organelle	3	14
GO:0110165	cellular anatomical entity	1	14
GO:0120025	plasma membrane bounded cell projection	3	14

Expansion

Sequence features

E9ANZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.463
CLV_NRD_NRD_1	52	54	PF00675	0.405
CLV_NRD_NRD_1	806	808	PF00675	0.549
CLV_NRD_NRD_1	840	842	PF00675	0.773
CLV_PCSK_KEX2_1	182	184	PF00082	0.455
CLV_PCSK_KEX2_1	220	222	PF00082	0.411
CLV_PCSK_KEX2_1	33	35	PF00082	0.602
CLV_PCSK_KEX2_1	52	54	PF00082	0.540
CLV_PCSK_KEX2_1	687	689	PF00082	0.604
CLV_PCSK_KEX2_1	706	708	PF00082	0.491
CLV_PCSK_KEX2_1	789	791	PF00082	0.561
CLV_PCSK_KEX2_1	840	842	PF00082	0.772
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.427
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.411
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.602
CLV_PCSK_PC1ET2_1	687	689	PF00082	0.604
CLV_PCSK_PC1ET2_1	706	708	PF00082	0.482
CLV_PCSK_PC1ET2_1	789	791	PF00082	0.529
CLV_PCSK_PC1ET2_1	840	842	PF00082	0.763
CLV_PCSK_PC7_1	785	791	PF00082	0.542
CLV_PCSK_SKI1_1	217	221	PF00082	0.468
CLV_PCSK_SKI1_1	48	52	PF00082	0.479
CLV_PCSK_SKI1_1	535	539	PF00082	0.407
CLV_Separin_Metazoa	658	662	PF03568	0.527
DEG_APCC_DBOX_1	300	308	PF00400	0.246
DEG_APCC_DBOX_1	789	797	PF00400	0.540
DEG_Nend_Nbox_1	1	3	PF02207	0.517
DEG_SPOP_SBC_1	419	423	PF00917	0.700
DOC_CDC14_PxL_1	95	103	PF14671	0.398
DOC_CKS1_1	260	265	PF01111	0.481
DOC_CKS1_1	282	287	PF01111	0.557
DOC_CYCLIN_RxL_1	217	225	PF00134	0.403
DOC_CYCLIN_RxL_1	529	539	PF00134	0.332
DOC_MAPK_gen_1	182	189	PF00069	0.372
DOC_MAPK_HePTP_8	572	584	PF00069	0.426
DOC_MAPK_MEF2A_6	575	584	PF00069	0.327
DOC_MAPK_MEF2A_6	753	760	PF00069	0.637
DOC_USP7_MATH_1	142	146	PF00917	0.551
DOC_USP7_MATH_1	150	154	PF00917	0.615
DOC_USP7_MATH_1	156	160	PF00917	0.552
DOC_USP7_MATH_1	161	165	PF00917	0.421
DOC_USP7_MATH_1	247	251	PF00917	0.630
DOC_USP7_MATH_1	321	325	PF00917	0.443
DOC_USP7_MATH_1	419	423	PF00917	0.700
DOC_USP7_MATH_1	447	451	PF00917	0.730
DOC_USP7_MATH_1	802	806	PF00917	0.641
DOC_USP7_MATH_1	831	835	PF00917	0.668
DOC_USP7_UBL2_3	839	843	PF12436	0.630
DOC_WW_Pin1_4	135	140	PF00397	0.580
DOC_WW_Pin1_4	232	237	PF00397	0.606
DOC_WW_Pin1_4	259	264	PF00397	0.669
DOC_WW_Pin1_4	26	31	PF00397	0.624
DOC_WW_Pin1_4	281	286	PF00397	0.553
DOC_WW_Pin1_4	459	464	PF00397	0.644
DOC_WW_Pin1_4	513	518	PF00397	0.429
LIG_14-3-3_CanoR_1	162	168	PF00244	0.556
LIG_14-3-3_CanoR_1	294	300	PF00244	0.448
LIG_14-3-3_CanoR_1	301	305	PF00244	0.400
LIG_14-3-3_CanoR_1	34	44	PF00244	0.553
LIG_14-3-3_CanoR_1	594	602	PF00244	0.417
LIG_14-3-3_CanoR_1	724	732	PF00244	0.625
LIG_14-3-3_CanoR_1	753	757	PF00244	0.621
LIG_Actin_WH2_2	290	307	PF00022	0.425
LIG_Actin_WH2_2	69	86	PF00022	0.291
LIG_Actin_WH2_2	9	24	PF00022	0.393
LIG_Clathr_ClatBox_1	562	566	PF01394	0.459
LIG_Clathr_ClatBox_1	633	637	PF01394	0.391
LIG_EH_1	226	230	PF12763	0.570
LIG_eIF4E_1	664	670	PF01652	0.362
LIG_FHA_1	16	22	PF00498	0.578
LIG_FHA_1	27	33	PF00498	0.544
LIG_FHA_1	35	41	PF00498	0.522
LIG_FHA_1	476	482	PF00498	0.501
LIG_FHA_1	812	818	PF00498	0.626
LIG_FHA_2	36	42	PF00498	0.503
LIG_FHA_2	399	405	PF00498	0.497
LIG_FHA_2	695	701	PF00498	0.615
LIG_FHA_2	72	78	PF00498	0.193
LIG_LIR_Gen_1	606	612	PF02991	0.340
LIG_LIR_Gen_1	671	679	PF02991	0.271
LIG_LIR_Nem_3	606	611	PF02991	0.340
LIG_LIR_Nem_3	671	676	PF02991	0.267
LIG_NRBOX	288	294	PF00104	0.280
LIG_NRBOX	532	538	PF00104	0.332
LIG_PDZ_Class_1	842	847	PF00595	0.536
LIG_SH2_CRK	2	6	PF00017	0.621
LIG_SH2_GRB2like	167	170	PF00017	0.418
LIG_SH2_GRB2like	197	200	PF00017	0.381
LIG_SH2_SRC	167	170	PF00017	0.418
LIG_SH2_STAP1	17	21	PF00017	0.475
LIG_SH2_STAP1	36	40	PF00017	0.541
LIG_SH2_STAT3	197	200	PF00017	0.519
LIG_SH2_STAT3	725	728	PF00017	0.589
LIG_SH2_STAT5	103	106	PF00017	0.308
LIG_SH2_STAT5	167	170	PF00017	0.447
LIG_SH2_STAT5	17	20	PF00017	0.412
LIG_SH2_STAT5	197	200	PF00017	0.438
LIG_SH2_STAT5	36	39	PF00017	0.552
LIG_SH2_STAT5	493	496	PF00017	0.329
LIG_SH2_STAT5	673	676	PF00017	0.396
LIG_SH2_STAT5	725	728	PF00017	0.589
LIG_SH3_1	279	285	PF00018	0.618
LIG_SH3_3	257	263	PF00018	0.572
LIG_SH3_3	279	285	PF00018	0.596
LIG_SH3_3	555	561	PF00018	0.382
LIG_SUMO_SIM_anti_2	564	570	PF11976	0.331
LIG_SUMO_SIM_par_1	185	192	PF11976	0.355
LIG_SUMO_SIM_par_1	478	484	PF11976	0.426
LIG_SUMO_SIM_par_1	561	566	PF11976	0.464
LIG_TRAF2_1	764	767	PF00917	0.443
LIG_TRAF2_1	798	801	PF00917	0.632
LIG_TYR_ITIM	101	106	PF00017	0.321
MOD_CDK_SPxxK_3	26	33	PF00069	0.480
MOD_CK1_1	119	125	PF00069	0.684
MOD_CK1_1	134	140	PF00069	0.489
MOD_CK1_1	259	265	PF00069	0.747
MOD_CK1_1	422	428	PF00069	0.762
MOD_CK1_1	498	504	PF00069	0.436
MOD_CK1_1	834	840	PF00069	0.692
MOD_CK2_1	188	194	PF00069	0.570
MOD_CK2_1	258	264	PF00069	0.523
MOD_CK2_1	35	41	PF00069	0.509
MOD_GlcNHglycan	118	121	PF01048	0.678
MOD_GlcNHglycan	122	125	PF01048	0.688
MOD_GlcNHglycan	133	136	PF01048	0.658
MOD_GlcNHglycan	152	155	PF01048	0.691
MOD_GlcNHglycan	158	161	PF01048	0.668
MOD_GlcNHglycan	223	227	PF01048	0.512
MOD_GlcNHglycan	236	239	PF01048	0.684
MOD_GlcNHglycan	249	252	PF01048	0.510
MOD_GlcNHglycan	279	282	PF01048	0.599
MOD_GlcNHglycan	332	335	PF01048	0.442
MOD_GlcNHglycan	449	452	PF01048	0.767
MOD_GlcNHglycan	538	541	PF01048	0.332
MOD_GlcNHglycan	645	648	PF01048	0.482
MOD_GSK3_1	1	8	PF00069	0.491
MOD_GSK3_1	112	119	PF00069	0.616
MOD_GSK3_1	131	138	PF00069	0.522
MOD_GSK3_1	234	241	PF00069	0.604
MOD_GSK3_1	252	259	PF00069	0.685
MOD_GSK3_1	277	284	PF00069	0.587
MOD_GSK3_1	293	300	PF00069	0.318
MOD_GSK3_1	303	310	PF00069	0.384
MOD_GSK3_1	418	425	PF00069	0.700
MOD_GSK3_1	441	448	PF00069	0.752
MOD_GSK3_1	487	494	PF00069	0.493
MOD_GSK3_1	827	834	PF00069	0.677
MOD_N-GLC_1	330	335	PF02516	0.480
MOD_N-GLC_1	413	418	PF02516	0.510
MOD_N-GLC_1	513	518	PF02516	0.423
MOD_N-GLC_1	586	591	PF02516	0.325
MOD_N-GLC_1	642	647	PF02516	0.570
MOD_N-GLC_1	681	686	PF02516	0.411
MOD_NEK2_1	1	6	PF00069	0.504
MOD_NEK2_1	215	220	PF00069	0.440
MOD_NEK2_1	222	227	PF00069	0.357
MOD_NEK2_1	292	297	PF00069	0.394
MOD_NEK2_1	330	335	PF00069	0.462
MOD_NEK2_1	35	40	PF00069	0.515
MOD_NEK2_1	361	366	PF00069	0.553
MOD_NEK2_1	418	423	PF00069	0.641
MOD_NEK2_1	476	481	PF00069	0.513
MOD_NEK2_1	487	492	PF00069	0.473
MOD_NEK2_1	495	500	PF00069	0.374
MOD_NEK2_1	523	528	PF00069	0.441
MOD_NEK2_1	536	541	PF00069	0.265
MOD_NEK2_1	567	572	PF00069	0.347
MOD_NEK2_1	60	65	PF00069	0.470
MOD_NEK2_1	611	616	PF00069	0.376
MOD_NEK2_1	623	628	PF00069	0.412
MOD_PIKK_1	445	451	PF00454	0.626
MOD_PIKK_1	802	808	PF00454	0.647
MOD_PK_1	256	262	PF00069	0.484
MOD_PKA_2	161	167	PF00069	0.636
MOD_PKA_2	21	27	PF00069	0.554
MOD_PKA_2	293	299	PF00069	0.459
MOD_PKA_2	300	306	PF00069	0.432
MOD_PKA_2	386	392	PF00069	0.610
MOD_PKA_2	398	404	PF00069	0.774
MOD_PKA_2	593	599	PF00069	0.369
MOD_PKA_2	637	643	PF00069	0.467
MOD_PKA_2	723	729	PF00069	0.627
MOD_PKA_2	752	758	PF00069	0.623
MOD_PKA_2	834	840	PF00069	0.504
MOD_Plk_1	413	419	PF00069	0.521
MOD_Plk_1	487	493	PF00069	0.469
MOD_Plk_1	586	592	PF00069	0.340
MOD_Plk_1	745	751	PF00069	0.468
MOD_Plk_1	773	779	PF00069	0.503
MOD_Plk_2-3	752	758	PF00069	0.461
MOD_Plk_4	112	118	PF00069	0.559
MOD_Plk_4	163	169	PF00069	0.489
MOD_Plk_4	364	370	PF00069	0.399
MOD_Plk_4	413	419	PF00069	0.455
MOD_Plk_4	476	482	PF00069	0.474
MOD_Plk_4	500	506	PF00069	0.329
MOD_Plk_4	567	573	PF00069	0.422
MOD_Plk_4	745	751	PF00069	0.597
MOD_Plk_4	773	779	PF00069	0.503
MOD_ProDKin_1	135	141	PF00069	0.581
MOD_ProDKin_1	232	238	PF00069	0.610
MOD_ProDKin_1	259	265	PF00069	0.669
MOD_ProDKin_1	26	32	PF00069	0.619
MOD_ProDKin_1	281	287	PF00069	0.550
MOD_ProDKin_1	459	465	PF00069	0.631
MOD_ProDKin_1	513	519	PF00069	0.429
MOD_SUMO_for_1	655	658	PF00179	0.523
MOD_SUMO_for_1	730	733	PF00179	0.572
MOD_SUMO_for_1	737	740	PF00179	0.599
MOD_SUMO_rev_2	26	35	PF00179	0.538
MOD_SUMO_rev_2	41	50	PF00179	0.502
MOD_SUMO_rev_2	681	689	PF00179	0.502
MOD_SUMO_rev_2	722	730	PF00179	0.542
TRG_DiLeu_BaEn_1	344	349	PF01217	0.388
TRG_DiLeu_BaLyEn_6	532	537	PF01217	0.288
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.410
TRG_DiLeu_LyEn_5	344	349	PF01217	0.388
TRG_ENDOCYTIC_2	103	106	PF00928	0.301
TRG_ENDOCYTIC_2	13	16	PF00928	0.291
TRG_ENDOCYTIC_2	2	5	PF00928	0.602
TRG_ENDOCYTIC_2	667	670	PF00928	0.361
TRG_ENDOCYTIC_2	673	676	PF00928	0.335
TRG_ER_diArg_1	51	53	PF00400	0.526
TRG_NES_CRM1_1	200	211	PF08389	0.399
TRG_NES_CRM1_1	746	757	PF08389	0.606
TRG_NLS_MonoCore_2	838	843	PF00514	0.769
TRG_NLS_MonoExtC_3	838	843	PF00514	0.667
TRG_NLS_MonoExtN_4	839	845	PF00514	0.654
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.739
TRG_Pf-PMV_PEXEL_1	709	713	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P337	Leptomonas seymouri	55%	95%
A0A0S4IPG0	Bodo saltans	22%	100%
A0A0S4JDM4	Bodo saltans	26%	100%
A0A1X0NMB3	Trypanosomatidae	31%	100%
A0A3Q8IBH7	Leishmania donovani	90%	100%
A0A3R7RCX5	Trypanosoma rangeli	30%	100%
A4H6Y3	Leishmania braziliensis	77%	99%
A4I4Y7	Leishmania infantum	25%	100%
C9ZHZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AGF7	Leishmania infantum	90%	100%
Q4QGM3	Leishmania major	91%	100%
V5AZQ5	Trypanosoma cruzi	32%	100%