Bardet-Biedl syndrome 5 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 5 protein

Species:

Leishmania mexicana

UniProt:

E9ANZ5_LEIMU

TriTrypDb:

LmxM.12.0680

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005815	microtubule organizing center	2	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0031253	cell projection membrane	4	11
GO:0032991	protein-containing complex	1	11
GO:0034464	BBSome	2	11
GO:0060170	ciliary membrane	5	11
GO:0098588	bounding membrane of organelle	4	11
GO:0098590	plasma membrane region	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0012506	vesicle membrane	4	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

E9ANZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANZ5

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030001	metal ion transport	6	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0033036	macromolecule localization	2	1
GO:0033572	transferrin transport	5	1
GO:0044782	cilium organization	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0032266	phosphatidylinositol-3-phosphate binding	6	1
GO:0035091	phosphatidylinositol binding	4	1
GO:1901981	phosphatidylinositol phosphate binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.328
CLV_NRD_NRD_1	19	21	PF00675	0.492
CLV_NRD_NRD_1	381	383	PF00675	0.265
CLV_NRD_NRD_1	387	389	PF00675	0.235
CLV_NRD_NRD_1	402	404	PF00675	0.329
CLV_PCSK_FUR_1	160	164	PF00082	0.297
CLV_PCSK_KEX2_1	162	164	PF00082	0.346
CLV_PCSK_KEX2_1	387	389	PF00082	0.280
CLV_PCSK_SKI1_1	314	318	PF00082	0.302
DOC_MAPK_gen_1	79	88	PF00069	0.490
DOC_MAPK_HePTP_8	76	88	PF00069	0.497
DOC_MAPK_MEF2A_6	314	323	PF00069	0.482
DOC_MAPK_MEF2A_6	388	397	PF00069	0.480
DOC_MAPK_MEF2A_6	79	88	PF00069	0.509
DOC_PP1_RVXF_1	239	246	PF00149	0.440
DOC_PP1_RVXF_1	27	34	PF00149	0.463
DOC_PP1_RVXF_1	73	79	PF00149	0.502
DOC_USP7_MATH_1	143	147	PF00917	0.383
DOC_USP7_MATH_1	185	189	PF00917	0.463
DOC_USP7_MATH_1	9	13	PF00917	0.523
DOC_USP7_UBL2_3	17	21	PF12436	0.460
LIG_14-3-3_CanoR_1	110	117	PF00244	0.452
LIG_14-3-3_CanoR_1	20	24	PF00244	0.360
LIG_14-3-3_CanoR_1	309	317	PF00244	0.558
LIG_APCC_ABBA_1	321	326	PF00400	0.497
LIG_APCC_ABBAyCdc20_2	320	326	PF00400	0.497
LIG_Clathr_ClatBox_1	207	211	PF01394	0.553
LIG_FHA_1	110	116	PF00498	0.466
LIG_FHA_1	217	223	PF00498	0.546
LIG_FHA_1	232	238	PF00498	0.367
LIG_FHA_1	325	331	PF00498	0.478
LIG_FHA_1	44	50	PF00498	0.524
LIG_FHA_1	66	72	PF00498	0.553
LIG_FHA_2	97	103	PF00498	0.553
LIG_HCF-1_HBM_1	47	50	PF13415	0.529
LIG_LIR_Gen_1	124	133	PF02991	0.451
LIG_LIR_Gen_1	169	179	PF02991	0.386
LIG_LIR_Gen_1	254	263	PF02991	0.457
LIG_LIR_Gen_1	299	307	PF02991	0.531
LIG_LIR_Gen_1	47	56	PF02991	0.520
LIG_LIR_Nem_3	124	129	PF02991	0.451
LIG_LIR_Nem_3	169	175	PF02991	0.460
LIG_LIR_Nem_3	189	195	PF02991	0.461
LIG_LIR_Nem_3	249	253	PF02991	0.465
LIG_LIR_Nem_3	254	260	PF02991	0.444
LIG_LIR_Nem_3	299	304	PF02991	0.503
LIG_LIR_Nem_3	47	53	PF02991	0.529
LIG_LIR_Nem_3	89	95	PF02991	0.480
LIG_PCNA_PIPBox_1	370	379	PF02747	0.345
LIG_Pex14_2	126	130	PF04695	0.450
LIG_Pex14_2	285	289	PF04695	0.492
LIG_SH2_CRK	172	176	PF00017	0.530
LIG_SH2_NCK_1	301	305	PF00017	0.529
LIG_SH2_SRC	301	304	PF00017	0.497
LIG_SH2_SRC	391	394	PF00017	0.512
LIG_SH2_STAT5	257	260	PF00017	0.481
LIG_SH2_STAT5	93	96	PF00017	0.513
LIG_SH3_3	250	256	PF00018	0.480
LIG_SH3_3	327	333	PF00018	0.428
LIG_SH3_3	387	393	PF00018	0.502
LIG_SUMO_SIM_par_1	206	211	PF11976	0.529
LIG_SUMO_SIM_par_1	67	72	PF11976	0.501
LIG_TRAF2_1	99	102	PF00917	0.529
LIG_TYR_ITIM	170	175	PF00017	0.156
LIG_TYR_ITIM	90	95	PF00017	0.345
LIG_UBA3_1	316	320	PF00899	0.447
LIG_WRC_WIRS_1	232	237	PF05994	0.340
LIG_WRC_WIRS_1	50	55	PF05994	0.401
MOD_CK1_1	166	172	PF00069	0.429
MOD_CK1_1	217	223	PF00069	0.363
MOD_CK1_1	265	271	PF00069	0.414
MOD_CK2_1	223	229	PF00069	0.393
MOD_CK2_1	96	102	PF00069	0.414
MOD_CMANNOS	308	311	PF00535	0.345
MOD_Cter_Amidation	380	383	PF01082	0.369
MOD_GlcNHglycan	145	148	PF01048	0.319
MOD_GlcNHglycan	198	201	PF01048	0.452
MOD_GlcNHglycan	219	222	PF01048	0.430
MOD_GlcNHglycan	339	342	PF01048	0.266
MOD_GlcNHglycan	5	8	PF01048	0.705
MOD_GSK3_1	109	116	PF00069	0.431
MOD_GSK3_1	216	223	PF00069	0.406
MOD_GSK3_1	231	238	PF00069	0.229
MOD_GSK3_1	3	10	PF00069	0.651
MOD_GSK3_1	303	310	PF00069	0.399
MOD_GSK3_1	403	410	PF00069	0.429
MOD_GSK3_1	411	418	PF00069	0.615
MOD_GSK3_1	65	72	PF00069	0.401
MOD_N-GLC_1	158	163	PF02516	0.369
MOD_N-GLC_1	251	256	PF02516	0.303
MOD_N-GLC_1	86	91	PF02516	0.303
MOD_N-GLC_2	63	65	PF02516	0.369
MOD_NEK2_1	128	133	PF00069	0.279
MOD_NEK2_1	13	18	PF00069	0.431
MOD_NEK2_1	175	180	PF00069	0.347
MOD_NEK2_1	235	240	PF00069	0.298
MOD_NEK2_1	251	256	PF00069	0.269
MOD_NEK2_1	307	312	PF00069	0.436
MOD_NEK2_1	411	416	PF00069	0.651
MOD_NEK2_1	69	74	PF00069	0.303
MOD_PIKK_1	262	268	PF00454	0.414
MOD_PKA_1	163	169	PF00069	0.445
MOD_PKA_1	403	409	PF00069	0.369
MOD_PKA_2	109	115	PF00069	0.313
MOD_PKA_2	163	169	PF00069	0.391
MOD_PKA_2	19	25	PF00069	0.343
MOD_PKA_2	217	223	PF00069	0.401
MOD_PKB_1	41	49	PF00069	0.272
MOD_Plk_1	186	192	PF00069	0.301
MOD_Plk_1	251	257	PF00069	0.307
MOD_Plk_1	276	282	PF00069	0.345
MOD_Plk_1	302	308	PF00069	0.345
MOD_Plk_1	412	418	PF00069	0.642
MOD_Plk_1	86	92	PF00069	0.303
MOD_Plk_4	231	237	PF00069	0.334
MOD_Plk_4	303	309	PF00069	0.303
MOD_Plk_4	407	413	PF00069	0.375
MOD_Plk_4	65	71	PF00069	0.455
MOD_SUMO_for_1	319	322	PF00179	0.407
MOD_SUMO_rev_2	102	108	PF00179	0.369
MOD_SUMO_rev_2	292	297	PF00179	0.447
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.447
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.375
TRG_ENDOCYTIC_2	172	175	PF00928	0.415
TRG_ENDOCYTIC_2	176	179	PF00928	0.404
TRG_ENDOCYTIC_2	192	195	PF00928	0.140
TRG_ENDOCYTIC_2	257	260	PF00928	0.375
TRG_ENDOCYTIC_2	301	304	PF00928	0.414
TRG_ENDOCYTIC_2	50	53	PF00928	0.401
TRG_ENDOCYTIC_2	92	95	PF00928	0.322
TRG_ER_diArg_1	160	163	PF00400	0.443
TRG_ER_diArg_1	195	198	PF00400	0.303
TRG_ER_diArg_1	387	389	PF00400	0.345
TRG_ER_diArg_1	40	43	PF00400	0.272
TRG_NES_CRM1_1	266	277	PF08389	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P9	Leptomonas seymouri	60%	100%
A0A0S4JE34	Bodo saltans	43%	100%
A0A1X0NMY8	Trypanosomatidae	42%	100%
A0A3Q8ICM0	Leishmania donovani	88%	97%
A0A3R7K3V6	Trypanosoma rangeli	37%	100%
A4H6Y1	Leishmania braziliensis	70%	97%
C9ZHY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AGF5	Leishmania infantum	88%	97%
Q21626	Caenorhabditis elegans	33%	100%
Q4QGM5	Leishmania major	88%	100%
Q4R649	Macaca fascicularis	36%	100%
Q66IS6	Xenopus laevis	39%	100%
Q7ZWB7	Danio rerio	37%	100%
Q8N3I7	Homo sapiens	36%	100%
Q9CZQ9	Mus musculus	37%	100%
V5BJR9	Trypanosoma cruzi	40%	100%