Cytochrome c oxidase subunit IV

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome oxidase subunit IV, putative

Species:

Leishmania mexicana

UniProt:

E9ANZ4_LEIMU

TriTrypDb:

LmxM.12.0670

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANZ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016491	oxidoreductase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.649
CLV_NRD_NRD_1	231	233	PF00675	0.489
CLV_NRD_NRD_1	25	27	PF00675	0.600
CLV_NRD_NRD_1	332	334	PF00675	0.477
CLV_NRD_NRD_1	4	6	PF00675	0.587
CLV_NRD_NRD_1	95	97	PF00675	0.557
CLV_PCSK_KEX2_1	25	27	PF00082	0.587
CLV_PCSK_KEX2_1	4	6	PF00082	0.587
CLV_PCSK_SKI1_1	154	158	PF00082	0.572
CLV_PCSK_SKI1_1	233	237	PF00082	0.499
CLV_PCSK_SKI1_1	257	261	PF00082	0.430
CLV_PCSK_SKI1_1	274	278	PF00082	0.466
CLV_PCSK_SKI1_1	334	338	PF00082	0.623
CLV_PCSK_SKI1_1	68	72	PF00082	0.546
DEG_Nend_Nbox_1	1	3	PF02207	0.603
DEG_SPOP_SBC_1	16	20	PF00917	0.717
DOC_CYCLIN_yClb5_NLxxxL_5	186	193	PF00134	0.684
DOC_MAPK_DCC_7	68	76	PF00069	0.568
DOC_MAPK_gen_1	232	238	PF00069	0.496
DOC_MAPK_MEF2A_6	68	76	PF00069	0.568
DOC_USP7_MATH_1	6	10	PF00917	0.578
DOC_USP7_UBL2_3	334	338	PF12436	0.508
DOC_USP7_UBL2_3	55	59	PF12436	0.715
DOC_WW_Pin1_4	174	179	PF00397	0.569
LIG_14-3-3_CanoR_1	204	210	PF00244	0.517
LIG_14-3-3_CanoR_1	274	279	PF00244	0.501
LIG_APCC_ABBA_1	70	75	PF00400	0.569
LIG_CSL_BTD_1	207	210	PF09270	0.519
LIG_FHA_1	204	210	PF00498	0.517
LIG_FHA_1	271	277	PF00498	0.535
LIG_FHA_2	126	132	PF00498	0.661
LIG_FHA_2	260	266	PF00498	0.567
LIG_FHA_2	58	64	PF00498	0.564
LIG_LIR_Gen_1	211	221	PF02991	0.530
LIG_LIR_Gen_1	78	87	PF02991	0.538
LIG_LIR_Nem_3	211	216	PF02991	0.531
LIG_LIR_Nem_3	219	224	PF02991	0.499
LIG_LIR_Nem_3	331	335	PF02991	0.537
LIG_LIR_Nem_3	78	83	PF02991	0.538
LIG_SH2_CRK	213	217	PF00017	0.526
LIG_SH2_NCK_1	310	314	PF00017	0.413
LIG_SH2_STAP1	246	250	PF00017	0.476
LIG_SH2_STAP1	255	259	PF00017	0.435
LIG_SH2_STAP1	310	314	PF00017	0.413
LIG_SH2_STAP1	80	84	PF00017	0.528
LIG_SH2_STAT5	155	158	PF00017	0.572
LIG_SH2_STAT5	217	220	PF00017	0.537
LIG_SH2_STAT5	246	249	PF00017	0.621
LIG_SUMO_SIM_anti_2	234	241	PF11976	0.544
LIG_SUMO_SIM_par_1	234	241	PF11976	0.579
LIG_TRAF2_1	60	63	PF00917	0.576
MOD_CK1_1	177	183	PF00069	0.541
MOD_CK2_1	177	183	PF00069	0.546
MOD_CK2_1	259	265	PF00069	0.536
MOD_CK2_1	57	63	PF00069	0.566
MOD_CK2_1	75	81	PF00069	0.545
MOD_GlcNHglycan	8	11	PF01048	0.651
MOD_GSK3_1	12	19	PF00069	0.623
MOD_GSK3_1	270	277	PF00069	0.448
MOD_GSK3_1	49	56	PF00069	0.615
MOD_GSK3_1	57	64	PF00069	0.546
MOD_NEK2_1	17	22	PF00069	0.502
MOD_NEK2_1	259	264	PF00069	0.566
MOD_NEK2_1	66	71	PF00069	0.552
MOD_PKA_2	203	209	PF00069	0.520
MOD_Plk_1	135	141	PF00069	0.539
MOD_Plk_1	182	188	PF00069	0.555
MOD_Plk_1	61	67	PF00069	0.622
MOD_Plk_4	12	18	PF00069	0.423
MOD_Plk_4	135	141	PF00069	0.539
MOD_Plk_4	49	55	PF00069	0.601
MOD_Plk_4	66	72	PF00069	0.496
MOD_ProDKin_1	174	180	PF00069	0.565
MOD_SUMO_for_1	58	61	PF00179	0.691
MOD_SUMO_rev_2	146	156	PF00179	0.559
MOD_SUMO_rev_2	252	262	PF00179	0.520
TRG_DiLeu_BaEn_1	321	326	PF01217	0.524
TRG_ENDOCYTIC_2	213	216	PF00928	0.525
TRG_ENDOCYTIC_2	80	83	PF00928	0.528
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRY9	Leptomonas seymouri	87%	100%
A0A0S4JH93	Bodo saltans	71%	97%
A0A1X0NMQ0	Trypanosomatidae	76%	99%
A0A3R7NBF6	Trypanosoma rangeli	77%	100%
A0A3S5H6L2	Leishmania donovani	95%	99%
A4H6Y0	Leishmania braziliensis	90%	100%
C9ZHY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	96%
E9AGF4	Leishmania infantum	95%	99%
Q4QGM6	Leishmania major	95%	100%
V5BF65	Trypanosoma cruzi	78%	100%