LeishMANIAdb
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Serine/threonine-protein phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase
Gene product:
ser/thr protein phosphatase, putative
Species:
Leishmania mexicana
UniProt:
E9ANZ3_LEIMU
TriTrypDb:
LmxM.12.0660
Length:
959

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9ANZ3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANZ3

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016311 dephosphorylation 5 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 14
GO:0004721 phosphoprotein phosphatase activity 3 14
GO:0004722 protein serine/threonine phosphatase activity 4 14
GO:0005488 binding 1 9
GO:0005509 calcium ion binding 5 9
GO:0016787 hydrolase activity 2 14
GO:0016788 hydrolase activity, acting on ester bonds 3 14
GO:0016791 phosphatase activity 5 14
GO:0017018 myosin phosphatase activity 5 14
GO:0042578 phosphoric ester hydrolase activity 4 14
GO:0043167 ion binding 2 9
GO:0043169 cation binding 3 9
GO:0046872 metal ion binding 4 9
GO:0140096 catalytic activity, acting on a protein 2 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 613 617 PF00656 0.492
CLV_MEL_PAP_1 337 343 PF00089 0.498
CLV_NRD_NRD_1 123 125 PF00675 0.531
CLV_NRD_NRD_1 190 192 PF00675 0.629
CLV_NRD_NRD_1 33 35 PF00675 0.730
CLV_NRD_NRD_1 473 475 PF00675 0.298
CLV_NRD_NRD_1 654 656 PF00675 0.434
CLV_NRD_NRD_1 671 673 PF00675 0.294
CLV_NRD_NRD_1 78 80 PF00675 0.516
CLV_NRD_NRD_1 819 821 PF00675 0.399
CLV_NRD_NRD_1 882 884 PF00675 0.479
CLV_NRD_NRD_1 922 924 PF00675 0.584
CLV_PCSK_KEX2_1 123 125 PF00082 0.581
CLV_PCSK_KEX2_1 190 192 PF00082 0.629
CLV_PCSK_KEX2_1 262 264 PF00082 0.547
CLV_PCSK_KEX2_1 33 35 PF00082 0.753
CLV_PCSK_KEX2_1 472 474 PF00082 0.278
CLV_PCSK_KEX2_1 654 656 PF00082 0.421
CLV_PCSK_KEX2_1 671 673 PF00082 0.296
CLV_PCSK_KEX2_1 819 821 PF00082 0.280
CLV_PCSK_KEX2_1 922 924 PF00082 0.632
CLV_PCSK_PC1ET2_1 262 264 PF00082 0.581
CLV_PCSK_PC7_1 667 673 PF00082 0.347
CLV_PCSK_SKI1_1 170 174 PF00082 0.532
CLV_PCSK_SKI1_1 217 221 PF00082 0.450
CLV_PCSK_SKI1_1 300 304 PF00082 0.449
CLV_PCSK_SKI1_1 305 309 PF00082 0.383
CLV_PCSK_SKI1_1 315 319 PF00082 0.211
CLV_PCSK_SKI1_1 410 414 PF00082 0.318
CLV_PCSK_SKI1_1 440 444 PF00082 0.291
CLV_PCSK_SKI1_1 565 569 PF00082 0.321
CLV_PCSK_SKI1_1 649 653 PF00082 0.550
CLV_PCSK_SKI1_1 700 704 PF00082 0.361
CLV_PCSK_SKI1_1 884 888 PF00082 0.431
CLV_PCSK_SKI1_1 96 100 PF00082 0.360
DEG_APCC_DBOX_1 712 720 PF00400 0.495
DEG_APCC_DBOX_1 849 857 PF00400 0.421
DEG_SPOP_SBC_1 275 279 PF00917 0.609
DOC_ANK_TNKS_1 190 197 PF00023 0.481
DOC_CDC14_PxL_1 725 733 PF14671 0.459
DOC_CYCLIN_RxL_1 644 656 PF00134 0.510
DOC_CYCLIN_yCln2_LP_2 705 711 PF00134 0.374
DOC_MAPK_gen_1 300 308 PF00069 0.519
DOC_MAPK_gen_1 472 478 PF00069 0.283
DOC_MAPK_gen_1 483 492 PF00069 0.283
DOC_MAPK_MEF2A_6 390 399 PF00069 0.295
DOC_MAPK_MEF2A_6 700 707 PF00069 0.392
DOC_MAPK_NFAT4_5 700 708 PF00069 0.390
DOC_PP1_RVXF_1 173 179 PF00149 0.637
DOC_PP2B_LxvP_1 705 708 PF13499 0.370
DOC_PP4_FxxP_1 192 195 PF00568 0.487
DOC_USP7_MATH_1 261 265 PF00917 0.550
DOC_USP7_MATH_1 275 279 PF00917 0.547
DOC_USP7_MATH_1 339 343 PF00917 0.501
DOC_USP7_MATH_1 375 379 PF00917 0.343
DOC_USP7_MATH_1 610 614 PF00917 0.495
DOC_USP7_MATH_1 626 630 PF00917 0.384
DOC_USP7_MATH_1 66 70 PF00917 0.603
DOC_USP7_UBL2_3 166 170 PF12436 0.539
DOC_USP7_UBL2_3 248 252 PF12436 0.452
DOC_USP7_UBL2_3 80 84 PF12436 0.531
DOC_WW_Pin1_4 331 336 PF00397 0.393
LIG_14-3-3_CanoR_1 263 268 PF00244 0.611
LIG_14-3-3_CanoR_1 315 324 PF00244 0.322
LIG_14-3-3_CanoR_1 33 37 PF00244 0.731
LIG_14-3-3_CanoR_1 747 751 PF00244 0.438
LIG_14-3-3_CanoR_1 858 866 PF00244 0.535
LIG_14-3-3_CanoR_1 883 889 PF00244 0.482
LIG_14-3-3_CanoR_1 922 926 PF00244 0.611
LIG_14-3-3_CanoR_1 929 935 PF00244 0.505
LIG_14-3-3_CanoR_1 948 953 PF00244 0.607
LIG_Actin_WH2_2 628 645 PF00022 0.401
LIG_BRCT_BRCA1_1 278 282 PF00533 0.474
LIG_BRCT_BRCA1_1 636 640 PF00533 0.529
LIG_BRCT_BRCA1_1 767 771 PF00533 0.503
LIG_BRCT_BRCA1_2 767 773 PF00533 0.504
LIG_CaM_IQ_9 209 224 PF13499 0.402
LIG_Clathr_ClatBox_1 716 720 PF01394 0.491
LIG_deltaCOP1_diTrp_1 706 711 PF00928 0.367
LIG_deltaCOP1_diTrp_1 740 746 PF00928 0.509
LIG_DLG_GKlike_1 948 955 PF00625 0.623
LIG_EH1_1 292 300 PF00400 0.394
LIG_FHA_1 183 189 PF00498 0.445
LIG_FHA_1 597 603 PF00498 0.260
LIG_FHA_1 630 636 PF00498 0.653
LIG_FHA_2 434 440 PF00498 0.267
LIG_FHA_2 62 68 PF00498 0.630
LIG_FHA_2 789 795 PF00498 0.372
LIG_FHA_2 858 864 PF00498 0.533
LIG_HP1_1 610 614 PF01393 0.330
LIG_Integrin_isoDGR_2 343 345 PF01839 0.496
LIG_LIR_Apic_2 506 512 PF02991 0.280
LIG_LIR_Apic_2 573 578 PF02991 0.379
LIG_LIR_Apic_2 604 610 PF02991 0.354
LIG_LIR_Apic_2 723 729 PF02991 0.426
LIG_LIR_Gen_1 242 249 PF02991 0.405
LIG_LIR_Gen_1 501 512 PF02991 0.280
LIG_LIR_Gen_1 599 607 PF02991 0.526
LIG_LIR_Gen_1 780 788 PF02991 0.359
LIG_LIR_Gen_1 892 903 PF02991 0.426
LIG_LIR_Gen_1 907 918 PF02991 0.409
LIG_LIR_LC3C_4 135 139 PF02991 0.308
LIG_LIR_Nem_3 227 233 PF02991 0.404
LIG_LIR_Nem_3 242 247 PF02991 0.328
LIG_LIR_Nem_3 278 284 PF02991 0.550
LIG_LIR_Nem_3 377 383 PF02991 0.261
LIG_LIR_Nem_3 580 585 PF02991 0.350
LIG_LIR_Nem_3 594 600 PF02991 0.386
LIG_LIR_Nem_3 706 712 PF02991 0.366
LIG_LIR_Nem_3 780 784 PF02991 0.362
LIG_LIR_Nem_3 907 913 PF02991 0.393
LIG_LIR_Nem_3 950 955 PF02991 0.509
LIG_MLH1_MIPbox_1 278 282 PF16413 0.450
LIG_PCNA_PIPBox_1 111 120 PF02747 0.433
LIG_Pex14_1 726 730 PF04695 0.358
LIG_Pex14_2 730 734 PF04695 0.319
LIG_PTB_Apo_2 177 184 PF02174 0.596
LIG_PTB_Apo_2 381 388 PF02174 0.259
LIG_PTB_Apo_2 422 429 PF02174 0.283
LIG_PTB_Apo_2 946 953 PF02174 0.552
LIG_PTB_Phospho_1 381 387 PF10480 0.421
LIG_PTB_Phospho_1 422 428 PF10480 0.283
LIG_SH2_CRK 575 579 PF00017 0.437
LIG_SH2_CRK 582 586 PF00017 0.356
LIG_SH2_GRB2like 36 39 PF00017 0.537
LIG_SH2_GRB2like 423 426 PF00017 0.280
LIG_SH2_NCK_1 495 499 PF00017 0.318
LIG_SH2_PTP2 411 414 PF00017 0.296
LIG_SH2_PTP2 916 919 PF00017 0.231
LIG_SH2_SRC 558 561 PF00017 0.385
LIG_SH2_SRC 607 610 PF00017 0.550
LIG_SH2_SRC 916 919 PF00017 0.231
LIG_SH2_STAP1 438 442 PF00017 0.303
LIG_SH2_STAT5 281 284 PF00017 0.382
LIG_SH2_STAT5 381 384 PF00017 0.279
LIG_SH2_STAT5 387 390 PF00017 0.264
LIG_SH2_STAT5 411 414 PF00017 0.301
LIG_SH2_STAT5 678 681 PF00017 0.360
LIG_SH2_STAT5 710 713 PF00017 0.351
LIG_SH2_STAT5 715 718 PF00017 0.320
LIG_SH2_STAT5 790 793 PF00017 0.383
LIG_SH2_STAT5 916 919 PF00017 0.448
LIG_SH3_3 255 261 PF00018 0.547
LIG_SH3_3 269 275 PF00018 0.468
LIG_SH3_3 303 309 PF00018 0.428
LIG_SH3_4 151 158 PF00018 0.584
LIG_SH3_5 82 86 PF00018 0.439
LIG_SUMO_SIM_anti_2 135 140 PF11976 0.314
LIG_SUMO_SIM_anti_2 396 403 PF11976 0.283
LIG_SUMO_SIM_par_1 135 140 PF11976 0.519
LIG_SUMO_SIM_par_1 351 357 PF11976 0.272
LIG_SUMO_SIM_par_1 396 403 PF11976 0.299
LIG_SUMO_SIM_par_1 565 571 PF11976 0.333
LIG_SUMO_SIM_par_1 608 617 PF11976 0.535
LIG_SUMO_SIM_par_1 715 721 PF11976 0.510
LIG_TYR_ITIM 914 919 PF00017 0.236
LIG_UBA3_1 298 303 PF00899 0.493
LIG_UBA3_1 401 410 PF00899 0.299
LIG_UBA3_1 894 899 PF00899 0.418
LIG_WRC_WIRS_1 585 590 PF05994 0.448
LIG_WRC_WIRS_1 615 620 PF05994 0.505
LIG_WRC_WIRS_1 628 633 PF05994 0.550
LIG_WRC_WIRS_1 801 806 PF05994 0.504
MOD_CK1_1 16 22 PF00069 0.701
MOD_CK1_1 37 43 PF00069 0.722
MOD_CK1_1 47 53 PF00069 0.654
MOD_CK1_1 479 485 PF00069 0.160
MOD_CK1_1 532 538 PF00069 0.423
MOD_CK1_1 56 62 PF00069 0.535
MOD_CK1_1 596 602 PF00069 0.456
MOD_CK1_1 6 12 PF00069 0.713
MOD_CK1_1 629 635 PF00069 0.652
MOD_CK1_1 645 651 PF00069 0.442
MOD_CK1_1 930 936 PF00069 0.559
MOD_CK2_1 2 8 PF00069 0.579
MOD_CK2_1 493 499 PF00069 0.289
MOD_CK2_1 553 559 PF00069 0.424
MOD_CK2_1 800 806 PF00069 0.475
MOD_CK2_1 810 816 PF00069 0.515
MOD_CMANNOS 101 104 PF00535 0.480
MOD_Cter_Amidation 121 124 PF01082 0.570
MOD_Cter_Amidation 31 34 PF01082 0.589
MOD_GlcNHglycan 15 18 PF01048 0.630
MOD_GlcNHglycan 371 374 PF01048 0.376
MOD_GlcNHglycan 46 49 PF01048 0.722
MOD_GlcNHglycan 55 58 PF01048 0.510
MOD_GlcNHglycan 555 558 PF01048 0.448
MOD_GlcNHglycan 570 573 PF01048 0.234
MOD_GlcNHglycan 767 770 PF01048 0.517
MOD_GlcNHglycan 812 815 PF01048 0.444
MOD_GlcNHglycan 952 955 PF01048 0.547
MOD_GSK3_1 2 9 PF00069 0.621
MOD_GSK3_1 225 232 PF00069 0.564
MOD_GSK3_1 34 41 PF00069 0.601
MOD_GSK3_1 369 376 PF00069 0.409
MOD_GSK3_1 610 617 PF00069 0.501
MOD_GSK3_1 627 634 PF00069 0.518
MOD_GSK3_1 66 73 PF00069 0.527
MOD_GSK3_1 682 689 PF00069 0.371
MOD_GSK3_1 761 768 PF00069 0.523
MOD_GSK3_1 848 855 PF00069 0.480
MOD_GSK3_1 928 935 PF00069 0.647
MOD_GSK3_1 943 950 PF00069 0.383
MOD_GSK3_1 96 103 PF00069 0.378
MOD_N-GLC_1 37 42 PF02516 0.602
MOD_N-GLC_1 493 498 PF02516 0.421
MOD_N-GLC_1 53 58 PF02516 0.573
MOD_N-GLC_1 642 647 PF02516 0.495
MOD_N-GLC_1 948 953 PF02516 0.580
MOD_NEK2_1 159 164 PF00069 0.489
MOD_NEK2_1 369 374 PF00069 0.421
MOD_NEK2_1 570 575 PF00069 0.331
MOD_NEK2_1 614 619 PF00069 0.448
MOD_NEK2_1 620 625 PF00069 0.460
MOD_NEK2_1 631 636 PF00069 0.638
MOD_NEK2_1 642 647 PF00069 0.624
MOD_NEK2_1 682 687 PF00069 0.370
MOD_NEK2_1 857 862 PF00069 0.479
MOD_NEK2_1 928 933 PF00069 0.668
MOD_NEK2_1 947 952 PF00069 0.667
MOD_NEK2_2 695 700 PF00069 0.440
MOD_NMyristoyl 1 7 PF02799 0.553
MOD_OFUCOSY 93 100 PF10250 0.367
MOD_PIKK_1 493 499 PF00454 0.299
MOD_PIKK_1 519 525 PF00454 0.363
MOD_PIKK_1 761 767 PF00454 0.484
MOD_PIKK_1 848 854 PF00454 0.448
MOD_PIKK_1 884 890 PF00454 0.434
MOD_PK_1 263 269 PF00069 0.524
MOD_PK_1 474 480 PF00069 0.376
MOD_PKA_2 144 150 PF00069 0.554
MOD_PKA_2 19 25 PF00069 0.600
MOD_PKA_2 32 38 PF00069 0.727
MOD_PKA_2 339 345 PF00069 0.508
MOD_PKA_2 519 525 PF00069 0.283
MOD_PKA_2 653 659 PF00069 0.498
MOD_PKA_2 746 752 PF00069 0.461
MOD_PKA_2 857 863 PF00069 0.563
MOD_PKA_2 921 927 PF00069 0.612
MOD_PKA_2 928 934 PF00069 0.536
MOD_PKA_2 947 953 PF00069 0.684
MOD_PKB_1 472 480 PF00069 0.324
MOD_Plk_1 225 231 PF00069 0.347
MOD_Plk_1 479 485 PF00069 0.318
MOD_Plk_1 532 538 PF00069 0.280
MOD_Plk_1 642 648 PF00069 0.481
MOD_Plk_1 66 72 PF00069 0.592
MOD_Plk_1 720 726 PF00069 0.423
MOD_Plk_1 906 912 PF00069 0.505
MOD_Plk_1 948 954 PF00069 0.575
MOD_Plk_1 96 102 PF00069 0.380
MOD_Plk_2-3 906 912 PF00069 0.530
MOD_Plk_4 168 174 PF00069 0.592
MOD_Plk_4 225 231 PF00069 0.416
MOD_Plk_4 454 460 PF00069 0.270
MOD_Plk_4 565 571 PF00069 0.309
MOD_Plk_4 584 590 PF00069 0.429
MOD_Plk_4 610 616 PF00069 0.402
MOD_Plk_4 686 692 PF00069 0.374
MOD_Plk_4 780 786 PF00069 0.341
MOD_Plk_4 852 858 PF00069 0.464
MOD_Plk_4 87 93 PF00069 0.432
MOD_ProDKin_1 331 337 PF00069 0.403
MOD_SPalmitoyl_4 1 7 PF01529 0.613
MOD_SUMO_for_1 239 242 PF00179 0.381
TRG_DiLeu_BaLyEn_6 441 446 PF01217 0.299
TRG_DiLeu_BaLyEn_6 671 676 PF01217 0.407
TRG_ENDOCYTIC_2 234 237 PF00928 0.498
TRG_ENDOCYTIC_2 281 284 PF00928 0.510
TRG_ENDOCYTIC_2 380 383 PF00928 0.261
TRG_ENDOCYTIC_2 411 414 PF00928 0.296
TRG_ENDOCYTIC_2 582 585 PF00928 0.393
TRG_ENDOCYTIC_2 600 603 PF00928 0.415
TRG_ENDOCYTIC_2 727 730 PF00928 0.312
TRG_ENDOCYTIC_2 778 781 PF00928 0.336
TRG_ENDOCYTIC_2 916 919 PF00928 0.335
TRG_ER_diArg_1 190 192 PF00400 0.498
TRG_ER_diArg_1 201 204 PF00400 0.379
TRG_ER_diArg_1 471 474 PF00400 0.283
TRG_ER_diArg_1 671 674 PF00400 0.433
TRG_ER_diArg_1 818 820 PF00400 0.292
TRG_NES_CRM1_1 227 242 PF08389 0.437
TRG_NES_CRM1_1 357 371 PF08389 0.283
TRG_NLS_MonoExtN_4 261 266 PF00514 0.554
TRG_Pf-PMV_PEXEL_1 662 666 PF00026 0.402
TRG_Pf-PMV_PEXEL_1 753 757 PF00026 0.488

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IGT4 Leptomonas seymouri 81% 99%
A0A0S4JAH8 Bodo saltans 31% 76%
A0A0S4JE35 Bodo saltans 58% 100%
A0A1X0NNZ8 Trypanosomatidae 61% 100%
A0A3Q8I989 Leishmania donovani 96% 100%
A0A422MRT7 Trypanosoma rangeli 59% 100%
A4H6X9 Leishmania braziliensis 90% 100%
C9ZHY0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
C9ZUN2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 67%
E9AGF3 Leishmania infantum 96% 100%
Q4QGM7 Leishmania major 95% 99%
V5BP95 Trypanosoma cruzi 65% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS