Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANZ2_LEIMU

TriTrypDb:

LmxM.12.0650

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANZ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004843	cysteine-type deubiquitinase activity	5	7
GO:0008233	peptidase activity	3	7
GO:0008234	cysteine-type peptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	7
GO:0101005	deubiquitinase activity	5	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1990380	K48-linked deubiquitinase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.488
CLV_C14_Caspase3-7	282	286	PF00656	0.661
CLV_C14_Caspase3-7	582	586	PF00656	0.492
CLV_NRD_NRD_1	146	148	PF00675	0.483
CLV_NRD_NRD_1	172	174	PF00675	0.575
CLV_NRD_NRD_1	180	182	PF00675	0.520
CLV_NRD_NRD_1	187	189	PF00675	0.582
CLV_NRD_NRD_1	236	238	PF00675	0.688
CLV_NRD_NRD_1	246	248	PF00675	0.610
CLV_NRD_NRD_1	289	291	PF00675	0.660
CLV_NRD_NRD_1	40	42	PF00675	0.449
CLV_NRD_NRD_1	608	610	PF00675	0.600
CLV_NRD_NRD_1	612	614	PF00675	0.596
CLV_PCSK_FUR_1	178	182	PF00082	0.478
CLV_PCSK_KEX2_1	118	120	PF00082	0.639
CLV_PCSK_KEX2_1	146	148	PF00082	0.466
CLV_PCSK_KEX2_1	180	182	PF00082	0.546
CLV_PCSK_KEX2_1	189	191	PF00082	0.654
CLV_PCSK_KEX2_1	236	238	PF00082	0.640
CLV_PCSK_KEX2_1	245	247	PF00082	0.597
CLV_PCSK_KEX2_1	289	291	PF00082	0.695
CLV_PCSK_KEX2_1	40	42	PF00082	0.449
CLV_PCSK_KEX2_1	612	614	PF00082	0.592
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.639
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.484
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.537
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.652
CLV_PCSK_PC7_1	178	184	PF00082	0.386
CLV_PCSK_SKI1_1	147	151	PF00082	0.468
CLV_PCSK_SKI1_1	290	294	PF00082	0.798
CLV_PCSK_SKI1_1	329	333	PF00082	0.574
CLV_PCSK_SKI1_1	612	616	PF00082	0.604
CLV_PCSK_SKI1_1	68	72	PF00082	0.487
DEG_SPOP_SBC_1	84	88	PF00917	0.616
DOC_ANK_TNKS_1	265	272	PF00023	0.517
DOC_CYCLIN_yCln2_LP_2	540	546	PF00134	0.515
DOC_MAPK_gen_1	440	448	PF00069	0.617
DOC_MAPK_gen_1	606	616	PF00069	0.600
DOC_MAPK_MEF2A_6	609	618	PF00069	0.600
DOC_MAPK_MEF2A_6	68	75	PF00069	0.467
DOC_PP2B_LxvP_1	71	74	PF13499	0.468
DOC_PP2B_PxIxI_1	478	484	PF00149	0.556
DOC_USP7_MATH_1	278	282	PF00917	0.575
DOC_USP7_MATH_1	354	358	PF00917	0.779
DOC_USP7_MATH_1	467	471	PF00917	0.515
DOC_USP7_MATH_1	5	9	PF00917	0.524
DOC_USP7_MATH_1	501	505	PF00917	0.778
DOC_USP7_MATH_1	511	515	PF00917	0.595
DOC_USP7_MATH_1	535	539	PF00917	0.730
DOC_USP7_MATH_1	560	564	PF00917	0.712
DOC_USP7_MATH_1	588	592	PF00917	0.760
DOC_USP7_MATH_1	605	609	PF00917	0.498
DOC_USP7_MATH_1	84	88	PF00917	0.598
DOC_USP7_UBL2_3	180	184	PF12436	0.550
DOC_USP7_UBL2_3	606	610	PF12436	0.679
DOC_WW_Pin1_4	369	374	PF00397	0.569
DOC_WW_Pin1_4	414	419	PF00397	0.663
DOC_WW_Pin1_4	51	56	PF00397	0.359
DOC_WW_Pin1_4	529	534	PF00397	0.729
DOC_WW_Pin1_4	542	547	PF00397	0.640
DOC_WW_Pin1_4	552	557	PF00397	0.616
LIG_14-3-3_CanoR_1	106	115	PF00244	0.473
LIG_14-3-3_CanoR_1	190	198	PF00244	0.553
LIG_14-3-3_CanoR_1	289	295	PF00244	0.817
LIG_14-3-3_CanoR_1	391	397	PF00244	0.637
LIG_14-3-3_CanoR_1	440	449	PF00244	0.622
LIG_14-3-3_CanoR_1	554	560	PF00244	0.517
LIG_14-3-3_CanoR_1	578	584	PF00244	0.494
LIG_14-3-3_CanoR_1	59	67	PF00244	0.446
LIG_Actin_WH2_2	31	46	PF00022	0.516
LIG_BIR_II_1	1	5	PF00653	0.487
LIG_BIR_III_1	1	5	PF00653	0.487
LIG_BIR_III_3	1	5	PF00653	0.487
LIG_BRCT_BRCA1_1	416	420	PF00533	0.680
LIG_BRCT_BRCA1_1	464	468	PF00533	0.664
LIG_BRCT_BRCA1_1	590	594	PF00533	0.644
LIG_Clathr_ClatBox_1	163	167	PF01394	0.407
LIG_FHA_1	11	17	PF00498	0.546
LIG_FHA_1	297	303	PF00498	0.712
LIG_FHA_1	397	403	PF00498	0.582
LIG_FHA_1	434	440	PF00498	0.634
LIG_FHA_1	535	541	PF00498	0.539
LIG_FHA_2	280	286	PF00498	0.711
LIG_FHA_2	580	586	PF00498	0.682
LIG_FHA_2	95	101	PF00498	0.455
LIG_Integrin_RGD_1	119	121	PF01839	0.500
LIG_LIR_Apic_2	414	418	PF02991	0.624
LIG_LIR_Gen_1	159	166	PF02991	0.528
LIG_LIR_Nem_3	110	115	PF02991	0.588
LIG_LIR_Nem_3	159	163	PF02991	0.528
LIG_PCNA_yPIPBox_3	31	44	PF02747	0.403
LIG_SH2_CRK	112	116	PF00017	0.462
LIG_SH2_CRK	415	419	PF00017	0.722
LIG_SH2_NCK_1	231	235	PF00017	0.629
LIG_SH2_NCK_1	464	468	PF00017	0.476
LIG_SH2_STAP1	160	164	PF00017	0.450
LIG_SH2_STAP1	464	468	PF00017	0.476
LIG_SH2_STAP1	505	509	PF00017	0.693
LIG_SH3_3	540	546	PF00018	0.515
LIG_SH3_3	90	96	PF00018	0.625
LIG_SH3_4	606	613	PF00018	0.678
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.387
LIG_SUMO_SIM_par_1	162	168	PF11976	0.405
LIG_WRC_WIRS_1	47	52	PF05994	0.534
LIG_WW_3	3	7	PF00397	0.441
MOD_CDK_SPK_2	51	56	PF00069	0.359
MOD_CK1_1	111	117	PF00069	0.595
MOD_CK1_1	232	238	PF00069	0.617
MOD_CK1_1	249	255	PF00069	0.662
MOD_CK1_1	288	294	PF00069	0.637
MOD_CK1_1	296	302	PF00069	0.725
MOD_CK1_1	371	377	PF00069	0.747
MOD_CK1_1	395	401	PF00069	0.559
MOD_CK1_1	462	468	PF00069	0.673
MOD_CK1_1	524	530	PF00069	0.661
MOD_CK1_1	534	540	PF00069	0.579
MOD_CK1_1	555	561	PF00069	0.573
MOD_CK1_1	580	586	PF00069	0.682
MOD_CK1_1	590	596	PF00069	0.584
MOD_CK1_1	87	93	PF00069	0.568
MOD_CK2_1	129	135	PF00069	0.531
MOD_CK2_1	18	24	PF00069	0.473
MOD_CK2_1	190	196	PF00069	0.463
MOD_CK2_1	202	208	PF00069	0.724
MOD_CK2_1	216	222	PF00069	0.737
MOD_CK2_1	5	11	PF00069	0.516
MOD_CK2_1	605	611	PF00069	0.599
MOD_CK2_1	94	100	PF00069	0.470
MOD_Cter_Amidation	116	119	PF01082	0.619
MOD_Cter_Amidation	243	246	PF01082	0.655
MOD_DYRK1A_RPxSP_1	531	535	PF00069	0.578
MOD_GlcNHglycan	242	245	PF01048	0.690
MOD_GlcNHglycan	248	251	PF01048	0.644
MOD_GlcNHglycan	253	256	PF01048	0.597
MOD_GlcNHglycan	290	293	PF01048	0.732
MOD_GlcNHglycan	295	298	PF01048	0.657
MOD_GlcNHglycan	420	423	PF01048	0.710
MOD_GlcNHglycan	424	427	PF01048	0.772
MOD_GlcNHglycan	450	454	PF01048	0.566
MOD_GlcNHglycan	465	468	PF01048	0.590
MOD_GlcNHglycan	469	472	PF01048	0.543
MOD_GlcNHglycan	486	489	PF01048	0.549
MOD_GlcNHglycan	513	516	PF01048	0.751
MOD_GlcNHglycan	537	540	PF01048	0.758
MOD_GlcNHglycan	562	565	PF01048	0.627
MOD_GlcNHglycan	568	571	PF01048	0.599
MOD_GlcNHglycan	590	593	PF01048	0.627
MOD_GlcNHglycan	89	92	PF01048	0.581
MOD_GSK3_1	101	108	PF00069	0.591
MOD_GSK3_1	368	375	PF00069	0.744
MOD_GSK3_1	392	399	PF00069	0.690
MOD_GSK3_1	414	421	PF00069	0.752
MOD_GSK3_1	455	462	PF00069	0.580
MOD_GSK3_1	463	470	PF00069	0.555
MOD_GSK3_1	501	508	PF00069	0.668
MOD_GSK3_1	516	523	PF00069	0.528
MOD_GSK3_1	531	538	PF00069	0.611
MOD_GSK3_1	542	549	PF00069	0.645
MOD_GSK3_1	576	583	PF00069	0.619
MOD_GSK3_1	584	591	PF00069	0.588
MOD_GSK3_1	82	89	PF00069	0.573
MOD_N-GLC_1	369	374	PF02516	0.516
MOD_N-GLC_1	411	416	PF02516	0.621
MOD_N-GLC_1	535	540	PF02516	0.601
MOD_NEK2_1	107	112	PF00069	0.387
MOD_NEK2_1	16	21	PF00069	0.441
MOD_NEK2_1	240	245	PF00069	0.563
MOD_NEK2_1	396	401	PF00069	0.558
MOD_NEK2_1	420	425	PF00069	0.691
MOD_NEK2_1	43	48	PF00069	0.462
MOD_NEK2_1	441	446	PF00069	0.632
MOD_NEK2_1	460	465	PF00069	0.664
MOD_NEK2_1	516	521	PF00069	0.699
MOD_NEK2_1	548	553	PF00069	0.605
MOD_NEK2_1	577	582	PF00069	0.609
MOD_NEK2_2	435	440	PF00069	0.507
MOD_NEK2_2	521	526	PF00069	0.494
MOD_PIKK_1	342	348	PF00454	0.643
MOD_PK_1	442	448	PF00069	0.633
MOD_PKA_1	246	252	PF00069	0.667
MOD_PKA_2	105	111	PF00069	0.480
MOD_PKA_2	246	252	PF00069	0.664
MOD_PKA_2	288	294	PF00069	0.704
MOD_PKA_2	392	398	PF00069	0.692
MOD_PKA_2	43	49	PF00069	0.544
MOD_PKA_2	5	11	PF00069	0.402
MOD_PKA_2	511	517	PF00069	0.676
MOD_PKA_2	577	583	PF00069	0.606
MOD_PKA_2	77	83	PF00069	0.567
MOD_PKB_1	188	196	PF00069	0.437
MOD_PKB_1	197	205	PF00069	0.488
MOD_PKB_1	335	343	PF00069	0.568
MOD_Plk_1	278	284	PF00069	0.586
MOD_Plk_1	505	511	PF00069	0.790
MOD_Plk_1	535	541	PF00069	0.646
MOD_Plk_1	57	63	PF00069	0.479
MOD_Plk_2-3	129	135	PF00069	0.523
MOD_Plk_2-3	208	214	PF00069	0.657
MOD_Plk_2-3	279	285	PF00069	0.526
MOD_Plk_4	24	30	PF00069	0.312
MOD_Plk_4	477	483	PF00069	0.553
MOD_Plk_4	94	100	PF00069	0.470
MOD_ProDKin_1	369	375	PF00069	0.570
MOD_ProDKin_1	414	420	PF00069	0.666
MOD_ProDKin_1	51	57	PF00069	0.361
MOD_ProDKin_1	529	535	PF00069	0.725
MOD_ProDKin_1	542	548	PF00069	0.640
MOD_ProDKin_1	552	558	PF00069	0.599
TRG_DiLeu_BaEn_1	159	164	PF01217	0.528
TRG_DiLeu_BaEn_1	24	29	PF01217	0.414
TRG_DiLeu_BaEn_4	222	228	PF01217	0.544
TRG_ENDOCYTIC_2	112	115	PF00928	0.573
TRG_ENDOCYTIC_2	160	163	PF00928	0.452
TRG_ER_diArg_1	236	238	PF00400	0.634
TRG_ER_diArg_1	246	248	PF00400	0.569
TRG_ER_diArg_1	612	614	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E7	Leptomonas seymouri	41%	97%
A0A3S7WRY5	Leishmania donovani	82%	100%
A4H6X8	Leishmania braziliensis	68%	98%
E9AGF2	Leishmania infantum	83%	100%
Q4QGM8	Leishmania major	81%	100%