PriCT_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANZ1_LEIMU

TriTrypDb:

LmxM.12.0640

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ANZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANZ1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006260	DNA replication	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0003896	DNA primase activity	7	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034062	5'-3' RNA polymerase activity	5	1
GO:0097747	RNA polymerase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.430
CLV_C14_Caspase3-7	318	322	PF00656	0.205
CLV_MEL_PAP_1	475	481	PF00089	0.343
CLV_NRD_NRD_1	197	199	PF00675	0.438
CLV_NRD_NRD_1	201	203	PF00675	0.438
CLV_NRD_NRD_1	218	220	PF00675	0.456
CLV_NRD_NRD_1	326	328	PF00675	0.416
CLV_NRD_NRD_1	403	405	PF00675	0.443
CLV_NRD_NRD_1	453	455	PF00675	0.434
CLV_NRD_NRD_1	512	514	PF00675	0.343
CLV_NRD_NRD_1	529	531	PF00675	0.251
CLV_PCSK_KEX2_1	197	199	PF00082	0.436
CLV_PCSK_KEX2_1	328	330	PF00082	0.360
CLV_PCSK_KEX2_1	382	384	PF00082	0.362
CLV_PCSK_KEX2_1	403	405	PF00082	0.508
CLV_PCSK_KEX2_1	453	455	PF00082	0.434
CLV_PCSK_KEX2_1	51	53	PF00082	0.480
CLV_PCSK_KEX2_1	529	531	PF00082	0.439
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.405
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.345
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.362
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.480
CLV_PCSK_SKI1_1	131	135	PF00082	0.363
CLV_PCSK_SKI1_1	174	178	PF00082	0.443
CLV_PCSK_SKI1_1	202	206	PF00082	0.400
CLV_PCSK_SKI1_1	271	275	PF00082	0.368
CLV_PCSK_SKI1_1	301	305	PF00082	0.368
CLV_PCSK_SKI1_1	353	357	PF00082	0.543
CLV_PCSK_SKI1_1	375	379	PF00082	0.596
CLV_PCSK_SKI1_1	453	457	PF00082	0.452
CLV_PCSK_SKI1_1	91	95	PF00082	0.443
DEG_APCC_DBOX_1	326	334	PF00400	0.443
DEG_Nend_Nbox_1	1	3	PF02207	0.405
DOC_CYCLIN_RxL_1	128	135	PF00134	0.480
DOC_CYCLIN_RxL_1	509	520	PF00134	0.205
DOC_CYCLIN_RxL_1	88	97	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	501	507	PF00134	0.480
DOC_MAPK_DCC_7	59	68	PF00069	0.428
DOC_MAPK_gen_1	327	333	PF00069	0.401
DOC_MAPK_gen_1	513	519	PF00069	0.443
DOC_MAPK_MEF2A_6	59	68	PF00069	0.404
DOC_MAPK_RevD_3	499	515	PF00069	0.443
DOC_PP1_RVXF_1	261	268	PF00149	0.343
DOC_PP1_RVXF_1	513	520	PF00149	0.330
DOC_PP1_RVXF_1	89	96	PF00149	0.368
DOC_PP4_FxxP_1	149	152	PF00568	0.343
DOC_USP7_MATH_1	122	126	PF00917	0.443
DOC_USP7_MATH_1	160	164	PF00917	0.456
DOC_USP7_MATH_1	183	187	PF00917	0.416
DOC_USP7_MATH_1	188	192	PF00917	0.405
DOC_USP7_MATH_1	208	212	PF00917	0.491
DOC_USP7_MATH_1	213	217	PF00917	0.380
DOC_USP7_MATH_1	389	393	PF00917	0.638
DOC_USP7_MATH_1	395	399	PF00917	0.598
DOC_USP7_MATH_1	469	473	PF00917	0.428
DOC_USP7_UBL2_3	195	199	PF12436	0.411
DOC_USP7_UBL2_3	203	207	PF12436	0.363
DOC_USP7_UBL2_3	378	382	PF12436	0.556
DOC_USP7_UBL2_3	413	417	PF12436	0.541
DOC_USP7_UBL2_3	502	506	PF12436	0.343
DOC_WW_Pin1_4	258	263	PF00397	0.455
DOC_WW_Pin1_4	500	505	PF00397	0.443
DOC_WW_Pin1_4	58	63	PF00397	0.446
DOC_WW_Pin1_4	74	79	PF00397	0.287
LIG_14-3-3_CanoR_1	174	183	PF00244	0.428
LIG_14-3-3_CanoR_1	301	311	PF00244	0.337
LIG_14-3-3_CanoR_1	344	352	PF00244	0.562
LIG_14-3-3_CanoR_1	353	358	PF00244	0.534
LIG_14-3-3_CanoR_1	383	388	PF00244	0.559
LIG_14-3-3_CanoR_1	498	502	PF00244	0.337
LIG_Actin_WH2_2	46	61	PF00022	0.405
LIG_Actin_WH2_2	490	508	PF00022	0.480
LIG_AP2alpha_1	149	153	PF02296	0.443
LIG_AP2alpha_2	151	153	PF02296	0.443
LIG_APCC_ABBA_1	92	97	PF00400	0.443
LIG_APCC_ABBAyCdc20_2	91	97	PF00400	0.443
LIG_BIR_III_4	436	440	PF00653	0.525
LIG_BRCT_BRCA1_1	8	12	PF00533	0.343
LIG_deltaCOP1_diTrp_1	494	499	PF00928	0.343
LIG_eIF4E_1	270	276	PF01652	0.368
LIG_FHA_1	156	162	PF00498	0.346
LIG_FHA_1	259	265	PF00498	0.423
LIG_FHA_1	346	352	PF00498	0.573
LIG_FHA_1	365	371	PF00498	0.252
LIG_FHA_1	372	378	PF00498	0.495
LIG_FHA_1	428	434	PF00498	0.596
LIG_FHA_1	457	463	PF00498	0.541
LIG_FHA_2	130	136	PF00498	0.330
LIG_FHA_2	333	339	PF00498	0.438
LIG_FHA_2	352	358	PF00498	0.271
LIG_LIR_Gen_1	114	122	PF02991	0.343
LIG_LIR_Gen_1	151	162	PF02991	0.480
LIG_LIR_Gen_1	175	184	PF02991	0.480
LIG_LIR_Gen_1	232	242	PF02991	0.446
LIG_LIR_Gen_1	474	483	PF02991	0.336
LIG_LIR_Gen_1	494	504	PF02991	0.155
LIG_LIR_Gen_1	9	19	PF02991	0.343
LIG_LIR_Nem_3	114	119	PF02991	0.343
LIG_LIR_Nem_3	150	156	PF02991	0.477
LIG_LIR_Nem_3	175	179	PF02991	0.280
LIG_LIR_Nem_3	232	238	PF02991	0.446
LIG_LIR_Nem_3	269	273	PF02991	0.328
LIG_LIR_Nem_3	434	438	PF02991	0.504
LIG_LIR_Nem_3	474	479	PF02991	0.324
LIG_LIR_Nem_3	494	499	PF02991	0.155
LIG_LIR_Nem_3	537	543	PF02991	0.478
LIG_LIR_Nem_3	83	87	PF02991	0.443
LIG_LIR_Nem_3	9	15	PF02991	0.343
LIG_LYPXL_yS_3	84	87	PF13949	0.443
LIG_Pex14_1	528	532	PF04695	0.425
LIG_Pex14_2	149	153	PF04695	0.443
LIG_PTB_Apo_2	310	317	PF02174	0.205
LIG_PTB_Phospho_1	310	316	PF10480	0.205
LIG_SH2_CRK	270	274	PF00017	0.368
LIG_SH2_CRK	438	442	PF00017	0.584
LIG_SH2_GRB2like	534	537	PF00017	0.434
LIG_SH2_NCK_1	116	120	PF00017	0.462
LIG_SH2_SRC	116	119	PF00017	0.462
LIG_SH2_SRC	139	142	PF00017	0.343
LIG_SH2_SRC	534	537	PF00017	0.490
LIG_SH2_STAP1	473	477	PF00017	0.339
LIG_SH2_STAP1	507	511	PF00017	0.438
LIG_SH2_STAT3	316	319	PF00017	0.465
LIG_SH2_STAT5	139	142	PF00017	0.343
LIG_SH2_STAT5	534	537	PF00017	0.434
LIG_SH2_STAT5	57	60	PF00017	0.443
LIG_SH2_STAT5	98	101	PF00017	0.355
LIG_SH3_3	139	145	PF00018	0.433
LIG_SH3_3	438	444	PF00018	0.563
LIG_SH3_4	199	206	PF00018	0.205
LIG_Sin3_3	153	160	PF02671	0.443
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.330
LIG_SUMO_SIM_par_1	359	364	PF11976	0.546
LIG_SxIP_EBH_1	55	69	PF03271	0.451
LIG_TRAF2_1	3	6	PF00917	0.443
LIG_TYR_ITIM	137	142	PF00017	0.343
LIG_WW_3	465	469	PF00397	0.368
MOD_CDC14_SPxK_1	503	506	PF00782	0.443
MOD_CDK_SPK_2	258	263	PF00069	0.427
MOD_CDK_SPxK_1	500	506	PF00069	0.443
MOD_CK1_1	165	171	PF00069	0.379
MOD_CK1_1	251	257	PF00069	0.480
MOD_CK1_1	258	264	PF00069	0.366
MOD_CK1_1	364	370	PF00069	0.415
MOD_CK1_1	500	506	PF00069	0.363
MOD_CK2_1	122	128	PF00069	0.286
MOD_CK2_1	129	135	PF00069	0.313
MOD_CK2_1	183	189	PF00069	0.405
MOD_CK2_1	343	349	PF00069	0.492
MOD_CK2_1	353	359	PF00069	0.402
MOD_GlcNHglycan	124	127	PF01048	0.362
MOD_GlcNHglycan	162	165	PF01048	0.241
MOD_GlcNHglycan	210	213	PF01048	0.275
MOD_GlcNHglycan	215	218	PF01048	0.222
MOD_GlcNHglycan	242	245	PF01048	0.459
MOD_GlcNHglycan	250	253	PF01048	0.418
MOD_GlcNHglycan	257	260	PF01048	0.382
MOD_GlcNHglycan	304	307	PF01048	0.431
MOD_GlcNHglycan	321	324	PF01048	0.331
MOD_GlcNHglycan	397	400	PF01048	0.623
MOD_GSK3_1	236	243	PF00069	0.494
MOD_GSK3_1	251	258	PF00069	0.328
MOD_GSK3_1	343	350	PF00069	0.597
MOD_GSK3_1	6	13	PF00069	0.332
MOD_LATS_1	172	178	PF00433	0.443
MOD_N-GLC_1	280	285	PF02516	0.343
MOD_N-GLC_1	484	489	PF02516	0.343
MOD_N-GLC_1	535	540	PF02516	0.408
MOD_NEK2_1	155	160	PF00069	0.424
MOD_NEK2_1	361	366	PF00069	0.395
MOD_NEK2_1	408	413	PF00069	0.557
MOD_NEK2_1	535	540	PF00069	0.420
MOD_NEK2_2	64	69	PF00069	0.443
MOD_PIKK_1	427	433	PF00454	0.630
MOD_PK_1	307	313	PF00069	0.205
MOD_PKA_1	198	204	PF00069	0.429
MOD_PKA_1	7	13	PF00069	0.443
MOD_PKA_2	343	349	PF00069	0.551
MOD_PKA_2	497	503	PF00069	0.345
MOD_Plk_1	129	135	PF00069	0.330
MOD_Plk_1	188	194	PF00069	0.205
MOD_Plk_1	280	286	PF00069	0.343
MOD_Plk_1	361	367	PF00069	0.458
MOD_Plk_1	535	541	PF00069	0.432
MOD_Plk_4	129	135	PF00069	0.405
MOD_Plk_4	347	353	PF00069	0.607
MOD_Plk_4	361	367	PF00069	0.302
MOD_Plk_4	383	389	PF00069	0.594
MOD_Plk_4	535	541	PF00069	0.432
MOD_Plk_4	64	70	PF00069	0.433
MOD_ProDKin_1	258	264	PF00069	0.455
MOD_ProDKin_1	500	506	PF00069	0.443
MOD_ProDKin_1	58	64	PF00069	0.448
MOD_ProDKin_1	74	80	PF00069	0.291
MOD_SUMO_rev_2	216	221	PF00179	0.245
MOD_SUMO_rev_2	371	377	PF00179	0.568
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.386
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.346
TRG_ENDOCYTIC_2	116	119	PF00928	0.480
TRG_ENDOCYTIC_2	139	142	PF00928	0.343
TRG_ENDOCYTIC_2	235	238	PF00928	0.443
TRG_ENDOCYTIC_2	270	273	PF00928	0.368
TRG_ENDOCYTIC_2	438	441	PF00928	0.595
TRG_ENDOCYTIC_2	84	87	PF00928	0.443
TRG_ER_diArg_1	327	330	PF00400	0.415
TRG_ER_diArg_1	402	404	PF00400	0.637
TRG_ER_diArg_1	419	422	PF00400	0.524
TRG_ER_diArg_1	452	454	PF00400	0.447
TRG_ER_diArg_1	528	530	PF00400	0.438
TRG_NLS_MonoExtN_4	195	201	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T3	Leptomonas seymouri	65%	71%
A0A1X0NMZ0	Trypanosomatidae	45%	71%
A0A3R7JWW2	Trypanosoma rangeli	46%	77%
A0A3S7WS08	Leishmania donovani	92%	100%
A4H6X7	Leishmania braziliensis	79%	100%
E9AGF1	Leishmania infantum	92%	100%
Q4QGM9	Leishmania major	90%	100%
V5DG34	Trypanosoma cruzi	45%	90%