Sulfatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ANY7_LEIMU

TriTrypDb:

LmxM.12.0600

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9ANY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANY7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008484	sulfuric ester hydrolase activity	4	1
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.421
CLV_NRD_NRD_1	221	223	PF00675	0.491
CLV_NRD_NRD_1	286	288	PF00675	0.627
CLV_PCSK_KEX2_1	215	217	PF00082	0.551
CLV_PCSK_KEX2_1	439	441	PF00082	0.602
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.575
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.570
CLV_PCSK_SKI1_1	215	219	PF00082	0.620
CLV_PCSK_SKI1_1	449	453	PF00082	0.430
CLV_Separin_Metazoa	259	263	PF03568	0.414
DEG_APCC_KENBOX_2	395	399	PF00400	0.303
DEG_Nend_Nbox_1	1	3	PF02207	0.717
DEG_ODPH_VHL_1	444	456	PF01847	0.377
DOC_MAPK_DCC_7	74	82	PF00069	0.312
DOC_MAPK_gen_1	393	402	PF00069	0.305
DOC_MAPK_JIP1_4	245	251	PF00069	0.259
DOC_MAPK_MEF2A_6	396	404	PF00069	0.371
DOC_MAPK_MEF2A_6	74	82	PF00069	0.305
DOC_PP1_RVXF_1	235	241	PF00149	0.271
DOC_USP7_MATH_1	149	153	PF00917	0.449
DOC_USP7_MATH_1	177	181	PF00917	0.321
DOC_USP7_MATH_1	204	208	PF00917	0.351
DOC_USP7_MATH_1	278	282	PF00917	0.409
DOC_USP7_MATH_1	34	38	PF00917	0.707
DOC_USP7_MATH_1	415	419	PF00917	0.385
DOC_USP7_MATH_1	471	475	PF00917	0.356
DOC_USP7_MATH_1	509	513	PF00917	0.451
DOC_WW_Pin1_4	102	107	PF00397	0.457
DOC_WW_Pin1_4	183	188	PF00397	0.388
DOC_WW_Pin1_4	288	293	PF00397	0.414
DOC_WW_Pin1_4	418	423	PF00397	0.319
DOC_WW_Pin1_4	483	488	PF00397	0.403
DOC_WW_Pin1_4	505	510	PF00397	0.257
LIG_14-3-3_CanoR_1	151	161	PF00244	0.234
LIG_14-3-3_CanoR_1	222	227	PF00244	0.239
LIG_14-3-3_CanoR_1	352	358	PF00244	0.430
LIG_14-3-3_CanoR_1	391	400	PF00244	0.404
LIG_14-3-3_CanoR_1	449	458	PF00244	0.208
LIG_14-3-3_CanoR_1	492	499	PF00244	0.276
LIG_BRCT_BRCA1_1	72	76	PF00533	0.515
LIG_eIF4E_1	375	381	PF01652	0.331
LIG_FHA_1	21	27	PF00498	0.768
LIG_FHA_1	227	233	PF00498	0.265
LIG_FHA_1	306	312	PF00498	0.314
LIG_FHA_1	471	477	PF00498	0.393
LIG_FHA_2	164	170	PF00498	0.436
LIG_FHA_2	22	28	PF00498	0.718
LIG_FHA_2	330	336	PF00498	0.437
LIG_FHA_2	450	456	PF00498	0.276
LIG_FHA_2	55	61	PF00498	0.654
LIG_FHA_2	96	102	PF00498	0.528
LIG_GBD_Chelix_1	333	341	PF00786	0.521
LIG_GBD_Chelix_1	82	90	PF00786	0.234
LIG_LIR_Apic_2	411	417	PF02991	0.455
LIG_LIR_Gen_1	119	129	PF02991	0.315
LIG_LIR_Gen_1	397	404	PF02991	0.325
LIG_LIR_Gen_1	438	447	PF02991	0.271
LIG_LIR_Gen_1	462	471	PF02991	0.384
LIG_LIR_Nem_3	119	124	PF02991	0.296
LIG_LIR_Nem_3	179	185	PF02991	0.364
LIG_LIR_Nem_3	397	402	PF02991	0.283
LIG_LIR_Nem_3	438	444	PF02991	0.247
LIG_LIR_Nem_3	462	466	PF02991	0.376
LIG_LIR_Nem_3	73	79	PF02991	0.432
LIG_Pex14_2	342	346	PF04695	0.343
LIG_PTB_Apo_2	357	364	PF02174	0.301
LIG_PTB_Phospho_1	357	363	PF10480	0.304
LIG_SH2_CRK	414	418	PF00017	0.436
LIG_SH2_GRB2like	203	206	PF00017	0.330
LIG_SH2_GRB2like	94	97	PF00017	0.452
LIG_SH2_NCK_1	414	418	PF00017	0.402
LIG_SH2_SRC	414	417	PF00017	0.406
LIG_SH2_SRC	6	9	PF00017	0.670
LIG_SH2_STAT3	370	373	PF00017	0.293
LIG_SH2_STAT5	171	174	PF00017	0.344
LIG_SH2_STAT5	357	360	PF00017	0.481
LIG_SH2_STAT5	370	373	PF00017	0.313
LIG_SH2_STAT5	375	378	PF00017	0.251
LIG_SH2_STAT5	387	390	PF00017	0.382
LIG_SH2_STAT5	434	437	PF00017	0.286
LIG_SH2_STAT5	6	9	PF00017	0.704
LIG_SH2_STAT5	94	97	PF00017	0.438
LIG_SH3_3	126	132	PF00018	0.415
LIG_SH3_3	289	295	PF00018	0.425
LIG_SUMO_SIM_anti_2	452	459	PF11976	0.350
LIG_SUMO_SIM_par_1	109	114	PF11976	0.323
LIG_TRAF2_1	256	259	PF00917	0.373
LIG_TRAF2_1	50	53	PF00917	0.529
MOD_CDK_SPK_2	102	107	PF00069	0.390
MOD_CDK_SPK_2	183	188	PF00069	0.310
MOD_CK1_1	152	158	PF00069	0.453
MOD_CK1_1	180	186	PF00069	0.315
MOD_CK1_1	196	202	PF00069	0.391
MOD_CK1_1	321	327	PF00069	0.465
MOD_CK1_1	418	424	PF00069	0.416
MOD_CK1_1	508	514	PF00069	0.390
MOD_CK2_1	163	169	PF00069	0.399
MOD_CK2_1	183	189	PF00069	0.315
MOD_CK2_1	2	8	PF00069	0.660
MOD_CK2_1	21	27	PF00069	0.719
MOD_CK2_1	253	259	PF00069	0.471
MOD_CK2_1	261	267	PF00069	0.490
MOD_CK2_1	363	369	PF00069	0.401
MOD_CK2_1	391	397	PF00069	0.354
MOD_CK2_1	47	53	PF00069	0.627
MOD_CK2_1	54	60	PF00069	0.614
MOD_CK2_1	95	101	PF00069	0.418
MOD_Cter_Amidation	220	223	PF01082	0.467
MOD_GlcNHglycan	116	119	PF01048	0.569
MOD_GlcNHglycan	126	129	PF01048	0.665
MOD_GlcNHglycan	165	169	PF01048	0.599
MOD_GlcNHglycan	172	175	PF01048	0.491
MOD_GlcNHglycan	182	185	PF01048	0.481
MOD_GlcNHglycan	266	271	PF01048	0.631
MOD_GlcNHglycan	27	31	PF01048	0.437
MOD_GlcNHglycan	299	302	PF01048	0.643
MOD_GlcNHglycan	38	41	PF01048	0.453
MOD_GlcNHglycan	472	476	PF01048	0.592
MOD_GlcNHglycan	63	67	PF01048	0.501
MOD_GSK3_1	12	19	PF00069	0.671
MOD_GSK3_1	147	154	PF00069	0.428
MOD_GSK3_1	176	183	PF00069	0.341
MOD_GSK3_1	21	28	PF00069	0.723
MOD_GSK3_1	222	229	PF00069	0.371
MOD_GSK3_1	416	423	PF00069	0.548
MOD_GSK3_1	479	486	PF00069	0.450
MOD_GSK3_1	505	512	PF00069	0.403
MOD_N-GLC_1	12	17	PF02516	0.485
MOD_N-GLC_1	163	168	PF02516	0.627
MOD_N-GLC_1	193	198	PF02516	0.560
MOD_N-GLC_1	204	209	PF02516	0.542
MOD_N-GLC_1	363	368	PF02516	0.540
MOD_N-GLC_1	480	485	PF02516	0.658
MOD_N-GLC_1	95	100	PF02516	0.664
MOD_NEK2_1	116	121	PF00069	0.290
MOD_NEK2_1	12	17	PF00069	0.725
MOD_NEK2_1	124	129	PF00069	0.364
MOD_NEK2_1	137	142	PF00069	0.426
MOD_NEK2_1	2	7	PF00069	0.715
MOD_NEK2_1	232	237	PF00069	0.337
MOD_NEK2_1	277	282	PF00069	0.373
MOD_NEK2_1	329	334	PF00069	0.450
MOD_NEK2_1	337	342	PF00069	0.320
MOD_NEK2_1	430	435	PF00069	0.278
MOD_NEK2_2	177	182	PF00069	0.350
MOD_NEK2_2	509	514	PF00069	0.269
MOD_OFUCOSY	276	282	PF10250	0.522
MOD_PIKK_1	137	143	PF00454	0.403
MOD_PIKK_1	149	155	PF00454	0.250
MOD_PIKK_1	321	327	PF00454	0.471
MOD_PIKK_1	391	397	PF00454	0.395
MOD_PIKK_1	449	455	PF00454	0.372
MOD_PK_1	222	228	PF00069	0.257
MOD_PKA_1	222	228	PF00069	0.233
MOD_PKA_2	261	267	PF00069	0.444
MOD_PKA_2	491	497	PF00069	0.261
MOD_PKB_1	389	397	PF00069	0.396
MOD_Plk_1	26	32	PF00069	0.584
MOD_Plk_1	471	477	PF00069	0.383
MOD_Plk_4	116	122	PF00069	0.322
MOD_Plk_4	177	183	PF00069	0.278
MOD_Plk_4	198	204	PF00069	0.419
MOD_Plk_4	2	8	PF00069	0.759
MOD_Plk_4	222	228	PF00069	0.382
MOD_Plk_4	337	343	PF00069	0.320
MOD_Plk_4	353	359	PF00069	0.393
MOD_Plk_4	456	462	PF00069	0.292
MOD_ProDKin_1	102	108	PF00069	0.448
MOD_ProDKin_1	183	189	PF00069	0.393
MOD_ProDKin_1	288	294	PF00069	0.420
MOD_ProDKin_1	418	424	PF00069	0.306
MOD_ProDKin_1	483	489	PF00069	0.396
MOD_ProDKin_1	505	511	PF00069	0.258
TRG_NES_CRM1_1	455	470	PF08389	0.353
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I453	Leptomonas seymouri	62%	99%
A0A1X0NM85	Trypanosomatidae	38%	87%
A0A3Q8IHP7	Leishmania donovani	90%	100%
A0A422NA33	Trypanosoma rangeli	37%	97%
A4H6X3	Leishmania braziliensis	79%	100%
E9AGE7	Leishmania infantum	90%	100%
Q4QGN3	Leishmania major	89%	100%
V5AZS1	Trypanosoma cruzi	36%	95%