Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ANX8_LEIMU

TriTrypDb:

LmxM.12.0500

Length:

1002

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ANX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ANX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	623	627	PF00656	0.698
CLV_NRD_NRD_1	281	283	PF00675	0.525
CLV_NRD_NRD_1	387	389	PF00675	0.691
CLV_NRD_NRD_1	410	412	PF00675	0.705
CLV_NRD_NRD_1	491	493	PF00675	0.725
CLV_NRD_NRD_1	67	69	PF00675	0.633
CLV_NRD_NRD_1	804	806	PF00675	0.699
CLV_NRD_NRD_1	980	982	PF00675	0.705
CLV_PCSK_KEX2_1	280	282	PF00082	0.529
CLV_PCSK_KEX2_1	387	389	PF00082	0.691
CLV_PCSK_KEX2_1	490	492	PF00082	0.734
CLV_PCSK_KEX2_1	665	667	PF00082	0.521
CLV_PCSK_KEX2_1	67	69	PF00082	0.487
CLV_PCSK_KEX2_1	804	806	PF00082	0.699
CLV_PCSK_KEX2_1	980	982	PF00082	0.705
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.521
CLV_PCSK_PC7_1	486	492	PF00082	0.732
CLV_PCSK_SKI1_1	179	183	PF00082	0.712
CLV_PCSK_SKI1_1	401	405	PF00082	0.583
CLV_PCSK_SKI1_1	665	669	PF00082	0.673
CLV_PCSK_SKI1_1	67	71	PF00082	0.643
DEG_APCC_DBOX_1	178	186	PF00400	0.704
DEG_APCC_DBOX_1	257	265	PF00400	0.693
DEG_Nend_Nbox_1	1	3	PF02207	0.475
DEG_SPOP_SBC_1	196	200	PF00917	0.645
DEG_SPOP_SBC_1	502	506	PF00917	0.685
DEG_SPOP_SBC_1	667	671	PF00917	0.674
DEG_SPOP_SBC_1	692	696	PF00917	0.546
DOC_ANK_TNKS_1	203	210	PF00023	0.642
DOC_CKS1_1	1	6	PF01111	0.609
DOC_CKS1_1	236	241	PF01111	0.711
DOC_CKS1_1	414	419	PF01111	0.530
DOC_CKS1_1	612	617	PF01111	0.535
DOC_CKS1_1	862	867	PF01111	0.586
DOC_CYCLIN_RxL_1	176	184	PF00134	0.709
DOC_CYCLIN_yCln2_LP_2	414	420	PF00134	0.615
DOC_CYCLIN_yCln2_LP_2	463	469	PF00134	0.641
DOC_CYCLIN_yCln2_LP_2	602	608	PF00134	0.592
DOC_CYCLIN_yCln2_LP_2	990	996	PF00134	0.644
DOC_MAPK_DCC_7	600	610	PF00069	0.527
DOC_MAPK_FxFP_2	58	61	PF00069	0.483
DOC_MAPK_gen_1	280	286	PF00069	0.525
DOC_MAPK_MEF2A_6	323	330	PF00069	0.657
DOC_MAPK_MEF2A_6	419	426	PF00069	0.689
DOC_MAPK_MEF2A_6	89	98	PF00069	0.615
DOC_MAPK_NFAT4_5	323	331	PF00069	0.657
DOC_PP2B_LxvP_1	2	5	PF13499	0.451
DOC_PP2B_LxvP_1	333	336	PF13499	0.502
DOC_PP2B_LxvP_1	442	445	PF13499	0.704
DOC_PP2B_LxvP_1	475	478	PF13499	0.651
DOC_PP2B_LxvP_1	602	605	PF13499	0.584
DOC_PP2B_LxvP_1	935	938	PF13499	0.647
DOC_PP4_FxxP_1	350	353	PF00568	0.511
DOC_PP4_FxxP_1	426	429	PF00568	0.534
DOC_PP4_FxxP_1	58	61	PF00568	0.637
DOC_PP4_MxPP_1	240	243	PF00568	0.703
DOC_USP7_MATH_1	160	164	PF00917	0.740
DOC_USP7_MATH_1	196	200	PF00917	0.757
DOC_USP7_MATH_1	31	35	PF00917	0.647
DOC_USP7_MATH_1	346	350	PF00917	0.671
DOC_USP7_MATH_1	581	585	PF00917	0.659
DOC_USP7_MATH_1	620	624	PF00917	0.709
DOC_USP7_MATH_1	816	820	PF00917	0.655
DOC_USP7_MATH_1	849	853	PF00917	0.638
DOC_USP7_MATH_1	963	967	PF00917	0.560
DOC_USP7_MATH_1	970	974	PF00917	0.617
DOC_WW_Pin1_4	106	111	PF00397	0.709
DOC_WW_Pin1_4	117	122	PF00397	0.620
DOC_WW_Pin1_4	14	19	PF00397	0.503
DOC_WW_Pin1_4	143	148	PF00397	0.609
DOC_WW_Pin1_4	167	172	PF00397	0.552
DOC_WW_Pin1_4	228	233	PF00397	0.682
DOC_WW_Pin1_4	235	240	PF00397	0.676
DOC_WW_Pin1_4	288	293	PF00397	0.594
DOC_WW_Pin1_4	297	302	PF00397	0.676
DOC_WW_Pin1_4	308	313	PF00397	0.579
DOC_WW_Pin1_4	413	418	PF00397	0.579
DOC_WW_Pin1_4	477	482	PF00397	0.680
DOC_WW_Pin1_4	611	616	PF00397	0.686
DOC_WW_Pin1_4	720	725	PF00397	0.822
DOC_WW_Pin1_4	772	777	PF00397	0.572
DOC_WW_Pin1_4	847	852	PF00397	0.614
DOC_WW_Pin1_4	861	866	PF00397	0.594
DOC_WW_Pin1_4	874	879	PF00397	0.626
DOC_WW_Pin1_4	948	953	PF00397	0.686
LIG_14-3-3_CanoR_1	306	315	PF00244	0.533
LIG_14-3-3_CanoR_1	361	367	PF00244	0.687
LIG_14-3-3_CanoR_1	457	467	PF00244	0.659
LIG_14-3-3_CanoR_1	517	521	PF00244	0.597
LIG_14-3-3_CanoR_1	666	674	PF00244	0.521
LIG_14-3-3_CanoR_1	74	84	PF00244	0.648
LIG_14-3-3_CanoR_1	761	770	PF00244	0.582
LIG_14-3-3_CanoR_1	943	953	PF00244	0.528
LIG_AP2alpha_2	222	224	PF02296	0.536
LIG_APCC_ABBA_1	753	758	PF00400	0.672
LIG_APCC_ABBA_1	922	927	PF00400	0.657
LIG_BIR_III_4	276	280	PF00653	0.532
LIG_BRCT_BRCA1_1	119	123	PF00533	0.719
LIG_BRCT_BRCA1_1	422	426	PF00533	0.534
LIG_BRCT_BRCA1_1	55	59	PF00533	0.495
LIG_Clathr_ClatBox_1	659	663	PF01394	0.578
LIG_deltaCOP1_diTrp_1	735	741	PF00928	0.508
LIG_FHA_1	1	7	PF00498	0.555
LIG_FHA_1	14	20	PF00498	0.545
LIG_FHA_1	208	214	PF00498	0.757
LIG_FHA_1	266	272	PF00498	0.685
LIG_FHA_1	398	404	PF00498	0.747
LIG_FHA_1	458	464	PF00498	0.674
LIG_FHA_1	497	503	PF00498	0.631
LIG_FHA_1	668	674	PF00498	0.673
LIG_FHA_1	773	779	PF00498	0.568
LIG_FHA_1	787	793	PF00498	0.648
LIG_FHA_1	836	842	PF00498	0.652
LIG_FHA_1	91	97	PF00498	0.605
LIG_FHA_1	926	932	PF00498	0.583
LIG_FHA_2	124	130	PF00498	0.706
LIG_FHA_2	149	155	PF00498	0.647
LIG_FHA_2	446	452	PF00498	0.636
LIG_FHA_2	640	646	PF00498	0.673
LIG_FHA_2	693	699	PF00498	0.556
LIG_LIR_Apic_2	348	353	PF02991	0.513
LIG_LIR_Apic_2	423	429	PF02991	0.534
LIG_LIR_Apic_2	56	61	PF02991	0.632
LIG_LIR_Gen_1	574	581	PF02991	0.610
LIG_LIR_Gen_1	8	14	PF02991	0.482
LIG_LIR_Gen_1	838	848	PF02991	0.592
LIG_LIR_Nem_3	100	105	PF02991	0.514
LIG_LIR_Nem_3	222	227	PF02991	0.542
LIG_LIR_Nem_3	34	38	PF02991	0.497
LIG_LIR_Nem_3	56	62	PF02991	0.628
LIG_LIR_Nem_3	574	579	PF02991	0.617
LIG_LIR_Nem_3	8	12	PF02991	0.485
LIG_LIR_Nem_3	83	88	PF02991	0.625
LIG_LIR_Nem_3	838	843	PF02991	0.587
LIG_MLH1_MIPbox_1	55	59	PF16413	0.495
LIG_MYND_1	167	171	PF01753	0.635
LIG_MYND_1	616	620	PF01753	0.698
LIG_Pex14_1	530	534	PF04695	0.648
LIG_Pex14_1	708	712	PF04695	0.538
LIG_PTB_Apo_2	591	598	PF02174	0.519
LIG_SH2_CRK	655	659	PF00017	0.667
LIG_SH2_CRK	85	89	PF00017	0.623
LIG_SH2_SRC	252	255	PF00017	0.535
LIG_SH2_STAT5	105	108	PF00017	0.519
LIG_SH2_STAT5	830	833	PF00017	0.645
LIG_SH2_STAT5	840	843	PF00017	0.572
LIG_SH2_STAT5	85	88	PF00017	0.627
LIG_SH3_2	147	152	PF14604	0.636
LIG_SH3_2	251	256	PF14604	0.543
LIG_SH3_2	478	483	PF14604	0.633
LIG_SH3_2	604	609	PF14604	0.685
LIG_SH3_3	107	113	PF00018	0.714
LIG_SH3_3	144	150	PF00018	0.658
LIG_SH3_3	165	171	PF00018	0.612
LIG_SH3_3	180	186	PF00018	0.539
LIG_SH3_3	217	223	PF00018	0.629
LIG_SH3_3	230	236	PF00018	0.726
LIG_SH3_3	238	244	PF00018	0.705
LIG_SH3_3	248	254	PF00018	0.639
LIG_SH3_3	309	315	PF00018	0.528
LIG_SH3_3	475	481	PF00018	0.681
LIG_SH3_3	601	607	PF00018	0.673
LIG_SH3_3	610	616	PF00018	0.608
LIG_SH3_3	875	881	PF00018	0.689
LIG_SH3_3	976	982	PF00018	0.694
LIG_SUMO_SIM_anti_2	588	593	PF11976	0.524
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.611
LIG_SUMO_SIM_par_1	751	758	PF11976	0.667
LIG_SUMO_SIM_par_1	95	101	PF11976	0.632
LIG_TYR_ITSM	836	843	PF00017	0.500
LIG_UBA3_1	302	308	PF00899	0.540
LIG_WRC_WIRS_1	347	352	PF05994	0.521
LIG_WRC_WIRS_1	6	11	PF05994	0.486
LIG_WW_3	231	235	PF00397	0.642
LIG_WW_3	579	583	PF00397	0.681
MOD_CDC14_SPxK_1	231	234	PF00782	0.640
MOD_CDC14_SPxK_1	291	294	PF00782	0.515
MOD_CDC14_SPxK_1	480	483	PF00782	0.637
MOD_CDC14_SPxK_1	723	726	PF00782	0.681
MOD_CDK_SPxK_1	228	234	PF00069	0.640
MOD_CDK_SPxK_1	288	294	PF00069	0.516
MOD_CDK_SPxK_1	413	419	PF00069	0.531
MOD_CDK_SPxK_1	477	483	PF00069	0.627
MOD_CDK_SPxK_1	720	726	PF00069	0.682
MOD_CK1_1	143	149	PF00069	0.718
MOD_CK1_1	172	178	PF00069	0.811
MOD_CK1_1	341	347	PF00069	0.614
MOD_CK1_1	434	440	PF00069	0.711
MOD_CK1_1	447	453	PF00069	0.601
MOD_CK1_1	496	502	PF00069	0.568
MOD_CK1_1	574	580	PF00069	0.659
MOD_CK1_1	676	682	PF00069	0.541
MOD_CK1_1	720	726	PF00069	0.668
MOD_CK1_1	754	760	PF00069	0.596
MOD_CK1_1	772	778	PF00069	0.511
MOD_CK1_1	83	89	PF00069	0.623
MOD_CK1_1	908	914	PF00069	0.689
MOD_CK1_1	948	954	PF00069	0.653
MOD_CK1_1	973	979	PF00069	0.667
MOD_CK2_1	123	129	PF00069	0.709
MOD_CK2_1	692	698	PF00069	0.615
MOD_CMANNOS	734	737	PF00535	0.507
MOD_Cter_Amidation	278	281	PF01082	0.538
MOD_Cter_Amidation	409	412	PF01082	0.706
MOD_GlcNHglycan	162	165	PF01048	0.714
MOD_GlcNHglycan	171	174	PF01048	0.638
MOD_GlcNHglycan	187	190	PF01048	0.681
MOD_GlcNHglycan	228	231	PF01048	0.744
MOD_GlcNHglycan	246	249	PF01048	0.854
MOD_GlcNHglycan	340	343	PF01048	0.735
MOD_GlcNHglycan	438	441	PF01048	0.778
MOD_GlcNHglycan	495	498	PF01048	0.711
MOD_GlcNHglycan	51	54	PF01048	0.664
MOD_GlcNHglycan	514	517	PF01048	0.594
MOD_GlcNHglycan	551	554	PF01048	0.666
MOD_GlcNHglycan	583	586	PF01048	0.686
MOD_GlcNHglycan	675	678	PF01048	0.694
MOD_GlcNHglycan	698	701	PF01048	0.716
MOD_GlcNHglycan	719	723	PF01048	0.817
MOD_GlcNHglycan	771	774	PF01048	0.667
MOD_GlcNHglycan	819	822	PF01048	0.636
MOD_GlcNHglycan	827	830	PF01048	0.550
MOD_GlcNHglycan	851	854	PF01048	0.593
MOD_GlcNHglycan	858	861	PF01048	0.638
MOD_GlcNHglycan	997	1000	PF01048	0.600
MOD_GSK3_1	113	120	PF00069	0.635
MOD_GSK3_1	181	188	PF00069	0.743
MOD_GSK3_1	341	348	PF00069	0.694
MOD_GSK3_1	370	377	PF00069	0.734
MOD_GSK3_1	397	404	PF00069	0.682
MOD_GSK3_1	427	434	PF00069	0.779
MOD_GSK3_1	49	56	PF00069	0.509
MOD_GSK3_1	491	498	PF00069	0.718
MOD_GSK3_1	501	508	PF00069	0.600
MOD_GSK3_1	512	519	PF00069	0.645
MOD_GSK3_1	661	668	PF00069	0.659
MOD_GSK3_1	669	676	PF00069	0.605
MOD_GSK3_1	692	699	PF00069	0.623
MOD_GSK3_1	740	747	PF00069	0.730
MOD_GSK3_1	757	764	PF00069	0.523
MOD_GSK3_1	76	83	PF00069	0.650
MOD_GSK3_1	772	779	PF00069	0.502
MOD_GSK3_1	849	856	PF00069	0.633
MOD_GSK3_1	904	911	PF00069	0.698
MOD_GSK3_1	944	951	PF00069	0.660
MOD_N-GLC_1	595	600	PF02516	0.522
MOD_N-GLC_1	905	910	PF02516	0.697
MOD_NEK2_1	123	128	PF00069	0.639
MOD_NEK2_1	181	186	PF00069	0.723
MOD_NEK2_1	608	613	PF00069	0.672
MOD_NEK2_1	904	909	PF00069	0.701
MOD_NEK2_1	945	950	PF00069	0.609
MOD_NEK2_2	267	272	PF00069	0.530
MOD_NEK2_2	422	427	PF00069	0.689
MOD_NEK2_2	751	756	PF00069	0.675
MOD_NEK2_2	920	925	PF00069	0.592
MOD_PIKK_1	21	27	PF00454	0.526
MOD_PIKK_1	776	782	PF00454	0.650
MOD_PIKK_1	799	805	PF00454	0.732
MOD_PIKK_1	905	911	PF00454	0.696
MOD_PK_1	80	86	PF00069	0.639
MOD_PK_1	971	977	PF00069	0.695
MOD_PKA_1	490	496	PF00069	0.725
MOD_PKA_1	665	671	PF00069	0.518
MOD_PKA_1	804	810	PF00069	0.538
MOD_PKA_2	458	464	PF00069	0.590
MOD_PKA_2	490	496	PF00069	0.725
MOD_PKA_2	516	522	PF00069	0.682
MOD_PKA_2	581	587	PF00069	0.684
MOD_PKA_2	665	671	PF00069	0.518
MOD_PKA_2	804	810	PF00069	0.601
MOD_PKA_2	869	875	PF00069	0.683
MOD_PKB_1	455	463	PF00069	0.624
MOD_PKB_1	490	498	PF00069	0.721
MOD_Plk_1	259	265	PF00069	0.698
MOD_Plk_1	374	380	PF00069	0.629
MOD_Plk_1	538	544	PF00069	0.500
MOD_Plk_1	639	645	PF00069	0.672
MOD_Plk_2-3	640	646	PF00069	0.673
MOD_Plk_4	31	37	PF00069	0.494
MOD_Plk_4	346	352	PF00069	0.517
MOD_Plk_4	422	428	PF00069	0.723
MOD_Plk_4	459	465	PF00069	0.664
MOD_Plk_4	54	60	PF00069	0.649
MOD_Plk_4	669	675	PF00069	0.675
MOD_Plk_4	779	785	PF00069	0.661
MOD_Plk_4	80	86	PF00069	0.639
MOD_Plk_4	869	875	PF00069	0.683
MOD_Plk_4	92	98	PF00069	0.502
MOD_Plk_4	920	926	PF00069	0.657
MOD_ProDKin_1	106	112	PF00069	0.712
MOD_ProDKin_1	117	123	PF00069	0.620
MOD_ProDKin_1	14	20	PF00069	0.506
MOD_ProDKin_1	143	149	PF00069	0.603
MOD_ProDKin_1	167	173	PF00069	0.551
MOD_ProDKin_1	228	234	PF00069	0.685
MOD_ProDKin_1	235	241	PF00069	0.672
MOD_ProDKin_1	288	294	PF00069	0.601
MOD_ProDKin_1	297	303	PF00069	0.675
MOD_ProDKin_1	308	314	PF00069	0.575
MOD_ProDKin_1	413	419	PF00069	0.580
MOD_ProDKin_1	477	483	PF00069	0.685
MOD_ProDKin_1	611	617	PF00069	0.686
MOD_ProDKin_1	720	726	PF00069	0.823
MOD_ProDKin_1	772	778	PF00069	0.571
MOD_ProDKin_1	847	853	PF00069	0.615
MOD_ProDKin_1	861	867	PF00069	0.594
MOD_ProDKin_1	874	880	PF00069	0.625
MOD_ProDKin_1	948	954	PF00069	0.688
MOD_SUMO_rev_2	661	667	PF00179	0.658
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.618
TRG_ENDOCYTIC_2	576	579	PF00928	0.622
TRG_ENDOCYTIC_2	655	658	PF00928	0.667
TRG_ENDOCYTIC_2	840	843	PF00928	0.593
TRG_ENDOCYTIC_2	85	88	PF00928	0.627
TRG_ER_diArg_1	280	282	PF00400	0.529
TRG_ER_diArg_1	490	492	PF00400	0.734
TRG_ER_diArg_1	66	68	PF00400	0.477
TRG_ER_diArg_1	979	981	PF00400	0.695
TRG_Pf-PMV_PEXEL_1	981	985	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6K9	Leishmania donovani	75%	97%
E9AGD8	Leishmania infantum	75%	68%
Q4QGP2	Leishmania major	72%	97%